KEGG   ORTHOLOGY: K17690
Entry
K17690            Tight     KO                                     
Symbol
CYP3A5
Name
cytochrome P450 family 3 subfamily A5 [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map05204  Chemical carcinogenesis - DNA adducts
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
   00982 Drug metabolism - cytochrome P450
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP3 family
   K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
Other DBs
RN: R02356 R03408 R08286 R08287 R08390 R08391 R08392 R09404 R09408
Genes
HSA: 1577(CYP3A5)
PTR: 737374(CYP3A5)
PPS: 100976333(CYP3A5)
GGO: 101147010
PON: 100434899
NLE: 100591599
MCC: 678692(CYP3A5)
MCF: 102146134(CYP3A5)
MTHB: 126950477
CSAB: 103246770(CYP3A5)
PANU: 100997418
TGE: 112621194
RRO: 104672095
RBB: 108538163
TFN: 117072035
PTEH: 111526378
CJC: 100404952(CYP3A5) 100405792(CYP3A90)
SBQ: 101037736
 » show all
Reference
PMID:2732228
  Authors
Aoyama T, Yamano S, Waxman DJ, Lapenson DP, Meyer UA, Fischer V, Tyndale R, Inaba T, Kalow W, Gelboin HV, et al.
  Title
Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.
  Journal
J Biol Chem 264:10388-95 (1989)
  Sequence
[hsa:1577]
Reference
  Authors
McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC
  Title
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
  Journal
J Mol Evol 57:200-11 (2003)
DOI:10.1007/s00239-003-2466-x

KEGG   ORTHOLOGY: K07424
Entry
K07424                      KO                                     
Symbol
CYP3A
Name
cytochrome P450 family 3 subfamily A [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map01100  Metabolic pathways
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
   00591 Linoleic acid metabolism
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
   05207 Chemical carcinogenesis - receptor activation
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07424  CYP3A; cytochrome P450 family 3 subfamily A
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP3 family
   K07424  CYP3A; cytochrome P450 family 3 subfamily A
Other DBs
RN: R02356 R03408 R07055 R07056 R08390 R08391 R08392
Genes
CATY: 105584469
CSYR: 103261808 103277234
MMUR: 105868221 105868329 109729598
LCAT: 123631584 123631585 123631588 123631589
OGA: 100949611
MMU: 100041375(Cyp3a41b) 13112(Cyp3a11) 13113(Cyp3a13) 13114(Cyp3a16) 337924(Cyp3a44) 53973(Cyp3a41a) 56388(Cyp3a25)
MCAL: 110287807 110288178 110294273 110294771
MPAH: 110312811 110313181 110314995 110315701 110315884
RNO: 170509(Cyp3a62) 171352(Cyp3a9) 252931(Cyp3a18) 25642(Cyp3a23-3a1) 266682(Cyp3a2)
MCOC: 116070965 116071005 116071007 116104705 116104706 116104707
HGL: 101700489
CPOC: 100301487(Cyp3a17) 100379244(Cyp3a14) 100379245(Cyp3a15) 100719785 100734717 100734998
OCU: 100328954(CYP3A6)
TUP: 102494214
CFA: 415127(CYP3A26) 489851
ORO: 101368110
MLX: 117999383
NSU: 110571974
FCA: 100642187(CYP3A132) 100652377(CYP3A131)
PTG: 102957386(CYP3A131) 102957670
BTA: 282214(CYP3A5) 507988(CYP3A4) 517246(CYP3A24) 526682(CYP3A5)
SSC: 100126281(CYP3A46) 100144468(CYP3A22) 403324(CYP3A29)
BACU: 103014952
LVE: 103081108
PCAD: 102979137
PSIU: 116739882
ECB: 100067041(CYP3A93) 100067064(CYP3A89) 100067084(CYP3A94) 100067109(CYP3A95) 100067131(CYP3A96) 100067154(CYP3A97) 102149219
MYB: 102263738
PKL: 118703231
HAI: 109378053
TOD: 119241615
ETF: 101656690
GGA: 414832(CYP3A5) 416477(CYP3A4)
MGP: 678668(CYP3A80) 678669(CYP3A37)
SCAN: 103817855
TALA: 104362186
CCRI: 104158338
ACAR: 104523907
AVIT: 104269979
TEO: 104382772
NPD: 112959868
SCAM: 104153925
AMJ: 102570482(CYP3A) 102570712
CPOO: 109314709
XLA: 100037189(cyp3a4.2.L) 108718493 398964(cyp3a4.1.L) 495363(cyp3a5.L)
XTR: 100487054 100487846 100494419(cyp3a4.2) 548503(cyp3a4.3)
DRE: 324340(cyp3c1) 492759(cyp3c3) 553969(cyp3a65) 558473(cyp3c2) 558541(cyp3c4)
OLA: 100125817(cyp3a40) 101155293 101155406(cyp3a) 101155538
CVG: 107089887
CSEM: 103387006
POV: 109633951
MALB: 109970725
SALP: 112075201
LCM: 102365730
CMK: 103185125
RTP: 109917933
AJC: 117114624
CSET: 123309823
PRAP: 110992351
SLIU: 111348641
OBI: 106870822
TDC: 119344950
 » show all
Reference
PMID:3785219 (CYP3A2)
  Authors
Gonzalez FJ, Song BJ, Hardwick JP
  Title
Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation.
  Journal
Mol Cell Biol 6:2969-76 (1986)
DOI:10.1128/MCB.6.8.2969
  Sequence
[rno:266682]
Reference
PMID:1339292 (CYP3A11)
  Authors
Yanagimoto T, Itoh S, Muller-Enoch D, Kamataki T
  Title
Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone.
  Journal
Biochim Biophys Acta 1130:329-32 (1992)
DOI:10.1016/0167-4781(92)90447-8
  Sequence
[mmu:13112]
Reference
PMID:2001406 (CYP3A12)
  Authors
Ciaccio PJ, Graves PE, Bourque DP, Glinsmann-Gibson B, Halpert JR
  Title
cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily.
  Journal
Biochim Biophys Acta 1088:319-22 (1991)
DOI:10.1016/0167-4781(91)90072-t
  Sequence
[cfa:415127]
Reference
PMID:11284050 (CYP3A25)
  Authors
Dai D, Bai R, Hodgson E, Rose RL
  Title
Cloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6beta-hydroxylase.
  Journal
J Biochem Mol Toxicol 15:90-9 (2001)
DOI:10.1002/jbt.4
  Sequence
[mmu:56388]
Reference
PMID:21781753 (CYP3A28)
  Authors
Natsuhori M, van Raak M, Ligtenberg M, Kleij L, Ten Berge D, Zweers-Zeilmaker WM, de Groene EM, van Miert AS, Witkamp RF, Horbach GJ
  Title
Isolation of a bovine full length cytochrome P450 (CYP3A) cDNA sequence and its functional expression in V79 cells.
  Journal
Environ Toxicol Pharmacol 3:17-24 (1997)
DOI:10.1016/s1382-6689(96)00133-0
  Sequence
[bta:282214]
Reference
PMID:9682441 (CYP3A29)
  Authors
Nissen PH, Wintero AK, Fredholm M
  Title
Mapping of porcine genes belonging to two different cytochrome P450 subfamilies.
  Journal
Anim Genet 29:7-11 (1998)
DOI:10.1046/j.1365-2052.1998.00225.x
  Sequence
[ssc:403324]
Reference
PMID:10775455 (CYP3A41)
  Authors
Sakuma T, Takai M, Endo Y, Kuroiwa M, Ohara A, Jarukamjorn K, Honma R, Nemoto N
  Title
A novel female-specific member of the CYP3A gene subfamily in the mouse liver.
  Journal
Arch Biochem Biophys 377:153-62 (2000)
DOI:10.1006/abbi.2000.1747
  Sequence
[mmu:53973]
Reference
PMID:16414346 (CYP3C1)
  Authors
Corley-Smith GE, Su HT, Wang-Buhler JL, Tseng HP, Hu CH, Hoang T, Chung WG, Buhler DR
  Title
CYP3C1, the first member of a new cytochrome P450 subfamily found in zebrafish (Danio rerio).
  Journal
Biochem Biophys Res Commun 340:1039-46 (2006)
DOI:10.1016/j.bbrc.2005.12.110
  Sequence
[dre:324340]
Reference
  Authors
McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC
  Title
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
  Journal
J Mol Evol 57:200-11 (2003)
DOI:10.1007/s00239-003-2466-x

KEGG   ORTHOLOGY: K07408
Entry
K07408                      KO                                     
Symbol
CYP1A1
Name
cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00380  Tryptophan metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map01100  Metabolic pathways
map04913  Ovarian steroidogenesis
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
   05207 Chemical carcinogenesis - receptor activation
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP1 family
   K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Other DBs
RN: R02354 R02355 R03089 R03408 R03629 R07000 R07001 R07021 R07022 R07079 R07080 R07081 R07085 R07087 R07098 R07099 R08390 R08392 R09418 R09423 R09442
Genes
HSA: 1543(CYP1A1)
PTR: 453744(CYP1A1)
PPS: 100976184(CYP1A1)
GGO: 101129522
PON: 100457153
NLE: 100585507
MCC: 678694(CYP1A1)
MCF: 102129994(CYP1A1)
MTHB: 126960000
CSAB: 103245331(CYP1A1)
CATY: 105600061
PANU: 101001307
TGE: 112627760
RRO: 104672151
RBB: 108531476
TFN: 117070364
PTEH: 111529702
CJC: 100393083(CYP1A1)
SBQ: 101038217
CSYR: 103271646
MMUR: 105854864
LCAT: 123624369
OGA: 100955410
MMU: 13076(Cyp1a1)
MCAL: 110301270
MPAH: 110328033
RNO: 24296(Cyp1a1)
MCOC: 116071961
MUN: 110558545
CGE: 100751269
MAUA: 101844540
PLEU: 114690337
MORG: 121445349
MFOT: 126507531
AAMP: 119808952
NGI: 103736921
HGL: 101707509
CPOC: 100135512(Cyp1a1)
CCAN: 109701505
DORD: 105982352
DSP: 122098438
NCAR: 124977051
OCU: 100328613
OPI: 101533768
TUP: 102484009
GVR: 103588057
CFA: 100686778(CYP1A1)
CLUD: 112675585
VVP: 112908776
VLG: 121484958
AML: 100473028
UMR: 103678992
UAH: 113240972
UAR: 123790682
ELK: 111153267
LLV: 125105138
MPUF: 101676222
ORO: 101382250
EJU: 114206471
ZCA: 113910089
MLX: 118003748
NSU: 110583893
LWW: 102739666
FCA: 554347(CYP1A1)
PYU: 121041992
PBG: 122468425
LRUF: 124508019
PTG: 102966263
PPAD: 109262691
AJU: 106979443
HHV: 120235772
BTA: 282870(CYP1A1)
BOM: 102283235
BIU: 109575587
BBUB: 102399021
BBIS: 104990991
CHX: 102170823
OAS: 100170113(CYP1A1)
ODA: 120875451
CCAD: 122419730
SSC: 403103(CYP1A1)
CFR: 102518111
CBAI: 105069192
CDK: 105087262
VPC: 102530468
BACU: 103008057
LVE: 103071513
OOR: 101287158
DLE: 111177818
PCAD: 102984326
PSIU: 116749907
ECB: 100062285(CYP1A1)
EPZ: 103552317
EAI: 106831264
MYB: 102262349
MYD: 102762200
MMYO: 118675915
MLF: 102437172
MNA: 107535216
PKL: 118728867
HAI: 109396247
DRO: 112301821
SHON: 118987754
PDIC: 114492343
PHAS: 123825280
MMF: 118643668
RFQ: 117024155
PALE: 102892046
PGIG: 120597850
PVP: 105306836
RAY: 107510533
MJV: 108388606
TOD: 119237890
SARA: 101550604
LAV: 100665901
TMU: 101359275
ETF: 101661225
DNM: 101423437
MDO: 100029871
GAS: 123232970
SHR: 100927711
PCW: 110213927
OAA: 100080942(CYP1A1)
ZVI: 118084457
STOW: 125424760
BBEL: 109480286
GAE: 121368990
CRG: 105329067
 » show all
Reference
PMID:2989797
  Authors
Jaiswal AK, Gonzalez FJ, Nebert DW
  Title
Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism.
  Journal
Nucleic Acids Res 13:4503-20 (1985)
DOI:10.1093/nar/13.12.4503
  Sequence
[hsa:1543]
Reference
PMID:3019683
  Authors
Kawajiri K, Watanabe J, Gotoh O, Tagashira Y, Sogawa K, Fujii-Kuriyama Y
  Title
Structure and drug inducibility of the human cytochrome P-450c gene.
  Journal
Eur J Biochem 159:219-25 (1986)
DOI:10.1111/j.1432-1033.1986.tb09857.x
  Sequence
[hsa:1543]

KEGG   ORTHOLOGY: K17689
Entry
K17689            Tight     KO                                     
Symbol
CYP3A4
Name
cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
Pathway
map00140  Steroid hormone biosynthesis
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map00983  Drug metabolism - other enzymes
map01100  Metabolic pathways
map04976  Bile secretion
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
Disease
H01143  Vitamin D-dependent rickets
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   00591 Linoleic acid metabolism
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   00982 Drug metabolism - cytochrome P450
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   00983 Drug metabolism - other enzymes
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   05207 Chemical carcinogenesis - receptor activation
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.32  albendazole monooxygenase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.55  quinine 3-monooxygenase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.56  1,8-cineole 2-exo-monooxygenase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.57  taurochenodeoxycholate 6alpha-hydroxylase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.73  albendazole monooxygenase (sulfoxide-forming)
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.-
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP3 family
   K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
Other DBs
RN: R02356 R03408 R05727 R07000 R07001 R07055 R07056 R07079 R07080 R07081 R07085 R07087 R08256 R08257 R08264 R08268 R08269 R08271 R08272 R08274 R08275 R08276 R08277 R08285 R08286 R08287 R08293 R08294 R08303 R08304 R08312 R08313 R08318 R08339 R08340 R08341 R08342 R08343 R08390 R08391 R08392 R09404 R09408 R09423
GO: 0047638 0033780 0050591
Genes
HSA: 1576(CYP3A4)
PTR: 463582(CYP3A4)
PPS: 100976899(CYP3A4)
GGO: 101149513
PON: 100436782
NLE: 100593175
MCC: 678670(CYP3A4)
MCF: 102144258(CYP3A4)
MTHB: 126950475
CSAB: 103246766
CATY: 105584402
PANU: 101026757
TGE: 112621193
RRO: 104673585
RBB: 108538168
TFN: 117072034
CJC: 100404344(CYP3A4)
SBQ: 101037403
CSYR: 103252931
OGA: 100948865
 » show all
Reference
PMID:3267210 (CYP3A4)
  Authors
Gonzalez FJ, Schmid BJ, Umeno M, Mcbride OW, Hardwick JP, Meyer UA, Gelboin HV, Idle JR
  Title
Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.
  Journal
DNA 7:79-86 (1988)
DOI:10.1089/dna.1988.7.79
  Sequence
[hsa:1576]
Reference
  Authors
McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC
  Title
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
  Journal
J Mol Evol 57:200-11 (2003)
DOI:10.1007/s00239-003-2466-x
Reference
PMID:9056237 (CYP3A21)
  Authors
Igarashi T, Sakuma T, Isogai M, Nagata R, Kamataki T
  Title
Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs.
  Journal
Arch Biochem Biophys 339:85-91 (1997)
DOI:10.1006/abbi.1996.9852
  Sequence
[cjc:100404344]

KEGG   ORTHOLOGY: K17692
Entry
K17692            Tight     KO                                     
Symbol
CYP3A43
Name
cytochrome P450 family 3 subfamily A43 [EC:1.14.14.1]
Pathway
map05204  Chemical carcinogenesis - DNA adducts
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17692  CYP3A43; cytochrome P450 family 3 subfamily A43
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17692  CYP3A43; cytochrome P450 family 3 subfamily A43
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17692  CYP3A43; cytochrome P450 family 3 subfamily A43
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP3 family
   K17692  CYP3A43; cytochrome P450 family 3 subfamily A43
Genes
HSA: 64816(CYP3A43)
PTR: 472456(CYP3A43)
PPS: 100979695(CYP3A43)
GGO: 101127998
PON: 100437391
MCC: 709770(CYP3A43)
MCF: 102143360(CYP3A43)
MTHB: 126950478
CSAB: 103246765(CYP3A43)
CATY: 105584405
PANU: 101005341
RRO: 104673586
RBB: 108538222
TFN: 117072863
PTEH: 111530151
 » show all
Reference
  Authors
Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG
  Title
cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450.
  Journal
Mol Pharmacol 59:386-92 (2001)
DOI:10.1124/mol.59.2.386
  Sequence
[hsa:64816]
Reference
  Authors
McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC
  Title
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
  Journal
J Mol Evol 57:200-11 (2003)
DOI:10.1007/s00239-003-2466-x

KEGG   ORTHOLOGY: K17691
Entry
K17691            Tight     KO                                     
Symbol
CYP3A7
Name
cytochrome P450 family 3 subfamily A7 [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00830  Retinol metabolism
map01100  Metabolic pathways
map05204  Chemical carcinogenesis - DNA adducts
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K17691  CYP3A7; cytochrome P450 family 3 subfamily A7
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17691  CYP3A7; cytochrome P450 family 3 subfamily A7
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17691  CYP3A7; cytochrome P450 family 3 subfamily A7
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17691  CYP3A7; cytochrome P450 family 3 subfamily A7
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17691  CYP3A7; cytochrome P450 family 3 subfamily A7
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP3 family
   K17691  CYP3A7; cytochrome P450 family 3 subfamily A7
Other DBs
RN: R03408 R08390 R08392
Genes
HSA: 100861540(CYP3A7-CYP3A51P) 1551(CYP3A7)
PTR: 737263(CYP3A7)
PPS: 100967578 100975985(CYP3A67)
GGO: 101147362 115935323
PON: 100435763 100436403
NLE: 115830387
MCC: 100144394(CYP3A7)
MCF: 102144626 102145015(CYP3A7)
MTHB: 126950476
CSAB: 103246767 103246772(CYP3A7)
CATY: 105584398
PANU: 100997059
TGE: 112621196
TFN: 117072036
 » show all
Reference
PMID:2722762
  Authors
Komori M, Nishio K, Ohi H, Kitada M, Kamataki T
  Title
Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450.
  Journal
J Biochem 105:161-3 (1989)
DOI:10.1093/oxfordjournals.jbchem.a122632
  Sequence
[hsa:1551]
Reference
  Authors
McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC
  Title
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
  Journal
J Mol Evol 57:200-11 (2003)
DOI:10.1007/s00239-003-2466-x

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