KEGG   ORTHOLOGY: K17690
Entry
K17690            Tight     KO                                     
Symbol
CYP3A5
Name
cytochrome P450 family 3 subfamily A5 [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map05204  Chemical carcinogenesis - DNA adducts
Reaction
R02356  
R03408  
R08286  
R08287  
R08390  
R08391  
R08392  
R09404  
R09408  
Disease
H01633  High blood pressure
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
   00982 Drug metabolism - cytochrome P450
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP3 family
   K17690  CYP3A5; cytochrome P450 family 3 subfamily A5
Genes
HSA: 1577(CYP3A5)
PTR: 737374(CYP3A5)
PPS: 100976333(CYP3A5)
GGO: 101147010
PON: 100434899
PPYG: 129041703
NLE: 100591599
HMH: 116810915
SSYN: 129489601
MCC: 678692(CYP3A5)
MCF: 102146134(CYP3A5)
MTHB: 126950477
MNI: 105497418
CSAB: 103246770(CYP3A5)
PANU: 100997418
TGE: 112621194
MLEU: 105543710
RRO: 104672095
RBB: 108538163
TFN: 117072035
PTEH: 111526378
CANG: 105513065
CJC: 100404952(CYP3A5) 100405792(CYP3A90)
SBQ: 101037736
CIMI: 108308035(CYP3A5)
ANAN: 105719457(CYP3A90) 105719458(CYP3A5)
 » show all
Reference
PMID:2732228
  Authors
Aoyama T, Yamano S, Waxman DJ, Lapenson DP, Meyer UA, Fischer V, Tyndale R, Inaba T, Kalow W, Gelboin HV, et al.
  Title
Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.
  Journal
J Biol Chem 264:10388-95 (1989)
  Sequence
[hsa:1577]
Reference
PMID:14562963
  Authors
McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC
  Title
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
  Journal
J Mol Evol 57:200-11 (2003)
DOI:10.1007/s00239-003-2466-x

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (12)   
   KEGG PATHWAY (12)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (20)   
   KEGG ENZYME (1)   
   KEGG REACTION (9)   
   KEGG RCLASS (10)   
Gene (30)   
   KEGG GENES (28)   
   OC (2)   
Literature (2)   
   PubMed (2)   
All databases (69)   

Download RDF
KEGG   ORTHOLOGY: K07424
Entry
K07424                      KO                                     
Symbol
CYP3A
Name
cytochrome P450 family 3 subfamily A [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map01100  Metabolic pathways
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
Reaction
R02356  
R03408  
R07055  
R07056  
R08390  
R08391  
R08392  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
   00591 Linoleic acid metabolism
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
   05207 Chemical carcinogenesis - receptor activation
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07424  CYP3A; cytochrome P450 family 3 subfamily A
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP3 family
   K07424  CYP3A; cytochrome P450 family 3 subfamily A
Genes
CATY: 105584469
CSYR: 103261808 103277234
MMUR: 105868221 105868329 109729598
LCAT: 123631584 123631585 123631588 123631589
PCOQ: 105806022 105806023
OGA: 100949611
MMU: 100041375(Cyp3a41b) 100041449(Cyp3a59) 13112(Cyp3a11) 13113(Cyp3a13) 13114(Cyp3a16) 337924(Cyp3a44) 53973(Cyp3a41a) 56388(Cyp3a25) 622127(Cyp3a57)
MCAL: 110287807 110288178 110294273 110294771
MPAH: 110312811 110313181 110314995 110315701 110315884
RNO: 170509(Cyp3a62) 171352(Cyp3a9) 252931(Cyp3a18) 25642(Cyp3a23-3a1) 266682(Cyp3a2) 690383(Cyp3a71-ps)
MCOC: 116070965 116071005 116071007 116104705 116104706 116104707
ANU: 117697807 117697808 117697809 117697948 117698139 117698393
MUN: 110543942 110544068 110544433 110566940 110566943 132650676 132650978 132651015 132651152 132651158 132651174 132651235
CGE: 100766524 100767391 100773059 100773351
MAUA: 101831686 101831958 101832126 101836914 101839056
PROB: 127237130 127237200 127237281 127237283 127237293
PLEU: 114684379 114684384 114684395 114685030 114685037 114687273 114687275 114687326 114687328 114687403 114687726 114688299 114688300 114689169 114689336 119087101
MORG: 121445245 121445965 121446005 121446030 121446074 121464879 121464904 121464905 121464906 121464907 121464909 121464910
MFOT: 126492995 126492996 126492997 126495128 126495325 126495330 126495331 126495469
AAMP: 119824363 119824438 119824441 119824659 119824660 119824661 119825569 119825570
NGI: 103726479 103726480
HGL: 101700489
CPOC: 100301487(Cyp3a17) 100379244(Cyp3a14) 100379245(Cyp3a15) 100719785 100734717 100734998
CCAN: 109701918 109702004
DORD: 105990893 105990894 105990905 105997303 106001866
DSP: 122113684 122113686 122113687
PLOP: 125367229 125367244 125367253 125367258 125367481
NCAR: 124969866 124969867 124969879
MMMA: 107133689 107155930 107155932
OCU: 100328954(CYP3A6)
OPI: 101519834 101521480 101531312 101532260
TUP: 102494214
GVR: 103606316 103606317
CFA: 415127(CYP3A26) 489851
CLUD: 112646265 112646266 112663009
VVP: 112909983 112935742 112935745
VLG: 121486274 121488071
NPO: 129519424 129519425 129519426 129519435
AML: 100472647 105235077
UMR: 103669994 103669998 103669999
UAH: 113249444 113249757 113267901 113267902
UAR: 123777260 123777277 123777328
ELK: 111145601 111145602 111145608
LLV: 125090641 125090643 125090644
MPUF: 101673108 101676428 101676727 101682130
MNP: 132026519 132026526 132027276
MLK: 131819107 131819108 131819109 131819112
NVS: 122895350 122895351 122895359 122895360
ORO: 101368110
EJU: 114203387 114203610 114203807
ZCA: 113932025 113932071 118355995 118355996
MLX: 117999383
NSU: 110571974
LWW: 102725583 102745213
FCA: 100642187(CYP3A132) 100652377(CYP3A131)
PYU: 121017808 121017809
PCOO: 112860079
PBG: 122471975 122471976
PVIV: 125154085 125154086
LRUF: 124519213 124519264 124519355
PTG: 102957386(CYP3A131) 102957670
PPAD: 109251249 109251250
PUC: 125928549
AJU: 106981196 106981197
HHV: 120225539 120227384 120227978
BTA: 282214(CYP3A28) 507988(CYP3A74) 517246(CYP3A24) 526682(CYP3A76)
BOM: 102284132 102284405 102284686 102284966
BBUB: 102405595 102405926 102406240 102412400
BBIS: 104992728 104992729 104992730 104992731
CHX: 102168966 102181382 102191011 102191297
OAS: 100170111(CYP3A24) 101110202 101110727 114108597
BTAX: 128043210 128043211 128043212 128043215
ODA: 120879764 120879780 120879796 120879810
CCAD: 122432817 122432818 122432819 122432820 122432889
MBEZ: 129545708 129545709 129545710 129545713 129545715
SSC: 100126281(CYP3A46) 100144468(CYP3A22) 403324(CYP3A29)
CFR: 102505615 102512762 102514805
CBAI: 105077048 105077059 105077600
CDK: 105099349 105099350
VPC: 102525384 102527302 102538990
BACU: 103014952
BMUS: 118880767
LVE: 103081108
OOR: 117200989
PCAD: 102979137
PSIU: 116739882
NASI: 112399912
ECB: 100067041(CYP3A93) 100067064(CYP3A89) 100067084(CYP3A94) 100067109(CYP3A95) 100067131(CYP3A96) 100067154(CYP3A97) 102149219
EPZ: 103542550 103564390 103564391 103564392 103566374 103566375
EAI: 106825164 106825167 106832275 106832276 106832277
MYB: 102263738
MYD: 102756525 102762686
MMYO: 118656485 118656498 118662413
MLF: 102432141 102432464 111827801
MDT: 132232293 132232294 132232295 132232296
PKL: 118703231
EFUS: 103286223 103286224
MNA: 107540865 107540873
DRO: 112314814 112314817
SHON: 118975258 118981795 119002040
AJM: 119041580 119064049
PDIC: 114492349 114492360
PHAS: 123818103 123818117
MMF: 118641936 118642420
PPAM: 129083833 129083834
HAI: 109378053
RFQ: 117024570 117024571 117024573
PGIG: 120587429 120607798
PVP: 105309521 105310085
RAY: 107508095 107509342
MJV: 108386989
TOD: 119241615
SARA: 101542879 101543157 101543423 101543688
SETR: 126030421 126030427
LAV: 100658511 100658793 100677295 100677576
TMU: 101349229 101350229
ETF: 101656690
DNM: 101412004 101412143 101442567 101443605
MDO: 100010698 100010745 100010783 100010820 100013114 100013238
GAS: 123231169 123231171 123233944
SHR: 100918011 100930770
AFZ: 127563615 127563631
PCW: 110201906 110201912 110201914 110201917
TVP: 118830187 118833852 118833853 118833855 118833856 118833859 118833860 118833862 118841246 118841312 118858287
OAA: 100082218 100082250 100082275 100089880 100091970
GGA: 414832(CYP3A5) 416477(CYP3A4)
PCOC: 116237418 116237434
MGP: 678668(CYP3A80) 678669(CYP3A37)
CJO: 107320762 107320785
TPAI: 128079132 128079222
LMUT: 125700893 125700907
NMEL: 110405948 110406034
APLA: 101799374 101799795
ACYG: 106032071 106032170
CATA: 118249116 118249123
AFUL: 116495297 116495307
TGU: 100223162 100226034
LSR: 110481576 110481678
SCAN: 103817855
PMOA: 120513096 120513276
OTC: 121334460 121334499
PRUF: 121350797 121350802
GFR: 102042286 102042456
FAB: 101815550 101818071
OMA: 130259488 130259489
PHI: 102105124 102105300
PMAJ: 107210919 107211377
CCAE: 111936102 111936103
CCW: 104684806 104684807
CBRC: 103615418 103615579
ETL: 114060192 114060195
ZAB: 102061839 102065830
ZLE: 135454036 135454270
ACHL: 103804084 103804579
SVG: 106849722 106849729
MMEA: 130575723 130575724
HRT: 120759610 120759741
SATI: 136367916 136367917
FPG: 101911664 101911836
FCH: 102049918 102050092
CCRI: 104158338
NNT: 104409143 104409144
SHAB: 115606566 115607356
ACUN: 113485635 113485844
TALA: 104362186
ACHC: 115335935 115335988
HALD: 104317094 104323105
HLE: 104833569 104833570
AGEN: 126034276 126034277
GCL: 127022237 127022391
CSTI: 104563857 104563859
LDI: 104355107 104355108
MNB: 103768448 103768449
DPUB: 104297083 104297093
AVIT: 104269979
BRHI: 104489439 104495828
EGZ: 104132595 104132596
NNI: 104015095 104015219
PCRI: 104031415 104035981
PCAO: 104053499 104053500
PADL: 103913536 103913537
AFOR: 103904874 103904875
FGA: 104079087 104079088
GSTE: 104254938 104259688
CLV: 102087823 102088003
MUI: 104537429 104537430
PGUU: 104463044 104463510
PLET: 104620401 104621601
EHS: 104510560 104510695
CMAC: 104477935 104482323
CUCA: 104062520 104062521
TEO: 104382772
BREG: 104640169 104640176
OHA: 104331210 104331242
ACAR: 104523907
CPEA: 104385248 104385249
CVF: 104290883 104290884
RTD: 128914111 128914308
AAM: 106495217 106495220
AROW: 112974281 112974330
NPD: 112959868
TGT: 104576357 104580447
DNE: 112992903 112992936
SCAM: 104153925
ASN: 102368695 102368945 102369208
AMJ: 102570482(CYP3A) 102570712
CPOO: 109314709
GGN: 109294316 109294549
PSS: 102447293 102447714
CMY: 102939531 102943719 119567199 119567257
CCAY: 125643929 125644066 125644068
DCC: 119862703 119862704 119862865
CPIC: 101944980 101945909
TST: 117883793 117883831 117883976
CABI: 116817552 116817553 116817555
MRV: 120373865 120373952 120374095
ACS: 100555955 100557851 100558240 100558437
ASAO: 132782168 132782169 132782170 132782171
PVT: 110083729 110091550
SUND: 121914161 121914420 121914620 121937545 121937546
PBI: 103050164 103050666
PMUR: 107290607 107290608 107290609 107290618 107290631
CTIG: 120315615 120315616 120315617 120315618 120315772 120315817
TSR: 106538078 106556514
PGUT: 117660294 117676798 117676801 132709672
APRI: 131185220 131185221 131185343
PTEX: 113438804 113438806 113438972
NSS: 113426999 113427000 113430149
VKO: 123025019 123025020 123025117
PMUA: 114584054 114584055 114584056 114584534
PRAF: 128401308 128401309 128401310 128401653
ZVI: 118077805 118092624 118092626 118092751 118092845 118092916
HCG: 128336421 128336516 128336761 128336840
GJA: 107117318 107117320 107123864 107125821
STOW: 125431001 125431204 125431383
EMC: 129338280 129338423 129338495 129338607 129338698 129340197
XLA: 100037189(cyp3a4.2.L) 108718493 398964(cyp3a4.1.L) 495363(cyp3a5.L)
XTR: 100487054 100487846 100494419(cyp3a4.2) 548503(cyp3a4.3)
NPR: 108790579 108790580 108804467
RTEM: 120921209 120937082
BBUF: 120990135 120998158
BGAR: 122934027 122935596 122940690
MUO: 115476721 115476722
GSH: 117345596 117369093
DRE: 324340(cyp3c1) 492759(cyp3c3) 553969(cyp3a65) 558473(cyp3c2) 558541(cyp3c4)
SRX: 107720069 107740699 107748444 107748668 107758392
SANH: 107662714 107680745 107680747 107703406 107703407
SGH: 107574731 107575037 107581712 107591821
CCAR: 109061438 109061483 109081405 109081406
CAUA: 113038900 113083757 113091962 113100638 113100639
CGIB: 127949467 127949468 127951781 127951782 128018251
PTET: 122333178 122333197 122359260 122359579
LROH: 127160427 127160450 127161747 127164342
OMC: 131536899 131538018
PPRM: 120466740 120489978
RKG: 130088313 130088314 130095015
MAMB: 125269666 125269683 125269685 125271550
CIDE: 127508533 127508534 127508535 127508536 127508537 127518105
CERY: 137012543 137012551 137017785 137017787 137032020(cyp3a65)
MASI: 127443759 127444867 127450185 127452137
TROS: 130552779 130561008
TDW: 130426693 130426694 130432883
MANU: 129432564 129432577 129432579 129443796
IPU: 108257387 108258748 108258760 108258762 108258764
IFU: 128600579 128602479 128602482 128602484 128602486
PHYP: 113524841 113524842 113524843 113536086 113536087
SMEO: 124376214 124377941 124377943
TFD: 113650795 113650810 113658449 113658450 113658453 125140143
TVC: 132839163 132839166 132839222 132839599 132863970 132863971
TRN: 134328567 134329445 134329623 134331241
AMEX: 103024636 103030124 103031034 125780417
CMAO: 118797885 118797886 118797887 118797888 118797890 118797891 118797892 118805725 118805726
EEE: 113575193 113591419
CHAR: 105890717 105894071 105896823 105896847 105908606 122131936
TRU: 101067951 101069124 101075886 101076110 115246460
TFS: 130526852 130530109 130530550 130533604 130533819
TNG: GSTEN00006530G001 GSTEN00014304G001
LCO: 104925565 104931688 109139171
NCC: 104952908 104955725 104962336 104962345
TBEN: 117482177 117482178 117494023 117499753 117499755
CGOB: 115008590 115008600 115010822 115010832 115020285
PGEO: 117447762 117449153 117459686
GACU: 117540686 117556156 117560895
EMAC: 134864255 134864256 134870197
ELY: 117248526 117248527 117248593 117254556 117254557 117258895
EFO: 125882842 125882864 125892110 125903289 125903291 125903292
PLEP: 121941720 121941722 121946723 121954678
SLUC: 116043019 116061623 116062163
ECRA: 117947469 117952941 117960056
ESP: 116692833 116704014 116705067
PFLV: 114565538 114572351 114574051
GAT: 120820327 120825021 120825023 120825839 120828825
PPUG: 119199469 119214489 119217509 119217510 119217512 119222282
AFB: 129091966 129092282 129095409 129096529 129100336 129116791
CLUM: 117730623 117730648 117733538 117744269 117744286
PSWI: 130189610 130189611 130207472
MSAM: 119898745 119898746 119905426 119916942
SCHU: 122874047 122874050 122883225 122884459
CUD: 121507778 121507903 121507904 121508311 121510858 121511323 121518053
ALAT: 119023388 119027172 119027178 119027190 119027210 119033330 119033962
MZE: 101471241 101471528 101476506 101476786 101477063 101477343 101478178
ONL: 100700506 100700772 100702245 100702592 100703397 100703674 102077052
OAU: 116312360 116312361 116318820 116324823 116324841 116324864 116325740 116332155 116335296 116335305
OLA: 100125817(cyp3a40) 101155293 101155406(cyp3a) 101155538
OML: 112137328 112137329 112137330 112139012 112140211 112161368 112161722
CSAI: 133441902 133441909 133457119 133463364 133463436 133464180
XMA: 102219031 102222638 111606488 111606645 111606646 111608645
XCO: 114138344 114138479 114144494 114144495
XHE: 116713050 116713051 116719333 116719911 116719912
PRET: 103476433 103476434
PFOR: 103137413 103154817 103154825
PLAI: 106940464 106941173 106943212 106943213
PMEI: 106904953 106905839 106905841 106911665 106912355
GAF: 122829005 122829006 122829007 122842051 122842281 122842285
PPRL: 129359669 129360109 129376871 129376882
CVG: 107089887
CTUL: 119783709 119783710 119783711 119790264
GMU: 124859475 124868738 124868739
NFU: 107375867 107388844
KMR: 108244157 108244648
ALIM: 106515376 106519642
NWH: 119413204 119422463 119430470
AOCE: 111572716 111574386 111579974
MCEP: 125004587 125004588 125018446 125018447 125019812
CSEM: 103387006
POV: 109633951
SSEN: 122770520 122771328 122771329 122771349 122777362 122781646 122781800
HHIP: 117764331 117764332 117764333 117775167
HSP: 118111468 118111470 118111575 118118788 118118967
PPLT: 128430690 128441989 128441990 128441991 128441992 128441993 128441994 128453104
SMAU: 118283391 118283392 118311907 118317276 118317408
LCF: 108877940 108896255 108899374 108899376
SDU: 111216640 111216641 111227399
SLAL: 111645298 111663275 111663301
XGL: 120796826 120800946 120800947 120804233
HCQ: 109511276 109512513 109528492
SSCV: 125978516 125988913
SBIA: 133496530 133506524 133509982
PEE: 133404349 133409441 133413303
PTAO: 133485946 133489818
BPEC: 110156796 110158274
MALB: 109970725
BSPL: 114858441 114858446 114859104 114859105 114870618 114870620
SJO: 128357806 128373363 128373364 128377472 128377489 128377503 128377512 128377523
SASA: 106568073 106591782 106591899 106593341 106594168(CP3AR)
STRU: 115168548 115178486 115178487 115178488 115178489 115178667 115178668 115178669 115178672
OTW: 112214885 112221342 112222821 112239077
OMY: 110492562 110511934 110514644 110514645 110514797 110518927 118936632 118940217 118947742
OGO: 124002708 124002724 124003120 124023292 124023293 124025063 124045570
ONE: 115115032 115125444
OKI: 109869080 109879569 109879570 109879571 109879572 109879574 109879575 116353018 116359007 116359008 116371141
OKE: 118359571 118381063 118381482 127922813 127926754
SALP: 112075201
SNH: 120042124 120042129 120042130 120042131 120042132 120042133 120061442
CCLU: 121546081 121570147 123489043 123491268
ELS: 105009625 105009626 105009627
SFM: 108922555 108926524 108927524
PKI: 111845480 111854069
AANG: 118216635 118216713 118220759 118220761 118229823
LOC: 102684669 102684871 102693837
PSPA: 121301050 121320988 121330840
ARUT: 117405680 117418522 117431525
PSEX: 120541920 120543247
LCM: 102365730
CMK: 103185125
RTP: 109917931 109922256 125487134
CPLA: 122541976 122560449 122560798 122560799
HOC: 132825492 132825493 132825494
LERI: 129706648 129706649 129713715
PMRN: 116949655 116951671 116951672
LRJ: 133340949 133340950 133340951 133340952 133346278
BFO: 118406568 118414778 118414801 118426698 118427220 118428229
BBEL: 109463787 109464201 109467470 109468932 109469473 109470714 109471346 109471464 109475399 109476094 109477106 109478808 109484389 109485683 109485810 109485811 109485812 109485813 109486688
SCLV: 120332300 120332302 120332303 120332304 120332305 120332318 120332320 120332321 120340954 120344192 120344193 120344194 120344200 120344219 120344234 120344872 120344967 120347406 120347618
LPIC: 129256331 129264488 129265125 129265784 129265789 129266424 129266425 129267363 129267369 129267371 129269689 129269749
ARUN: 117288752 117288760 117288972 117289098 117289099 117289265 117289266 117295059 117299914 117300572 117305235
AJC: 117114624
BCOO: 119066914 119067186 119069853 119074078 119074427 119074939 119081225 119082306 119083480 119083786 119084267 119085713
OLG: 117604369
AROA: 105683931
SOY: 115882271 115887743 115888532 115888893
AGRG: 126733843 126734715 126737050 126737169 126746903
CSET: 123309823
AGB: 108904006 108904007 108910638 108916436
LDC: 111507913 111511395 111512159 111518298
PPYR: 116160074 116165566 116168351 116168967 116169445 116170548 116174035 116174328 116177747 116177853 116177854 116178557 116179633 116179793 116179836
OTU: 111428189 111428677
MJU: 123869601
PRAP: 110992351
ZCE: 119830198
SLIU: 111348641
CCRN: 123305527
HHAL: 106680993 106691458 106691459
NLU: 111051489 120356101
HVI: 124367652
MQU: 128982112
BROR: 134530302
IEL: 124159494
DMK: 116920246 116928047 116928048 116928049 116929127 116929158 116929172 116929574 123475190
PJA: 122242307 122248200 122248209 122248210 122256421 122262146 122262149 122265384 122267182 122267183
PCHN: 125025862 125028557 125041727 125041728 125041797 125041815 125041861 125042027 125042163 125042164 125042189 125042256
HAME: 121854946 121855268 121863787 121871947 121878761
PCLA: 123751244 123762231 123764970 123774302
CQD: 128685180 128689823 128692543 128696236 128696237 128696634 128697048 128697049 128700051 128703733 128704862
PTRU: 123500630 123502395 123506022 123511482 123514769 123514893 123518726
ESN: 126981786 126982537 126985756 126985761 126998828 126998829 126998830 126998831 126998886 126998887 126998943
MNZ: 135206798 135216150 135216154 135217409
EAF: 111712343 111712470
LSM: 121115942 121121551 121122879
TCF: 131882578 131882582 131882736 131891483 131891652
PPOI: 119091548 119091910 119092516 119095550 119095862 119096334 119096766 119096767 119096808 119097136 119097363 119103773 119105682 119108907 119112164 119113493 119114109 119114281 119114282 119114298 119114354 119114363 119114377 119114393
DSV: 119431959 119437320 119437467 119439984 119440080 119441397 119441753 119444791 119445714 119446100 119446101 119446102 119446103 119448902 119448927 119449670 119449672 119449675 119452771 119453582 119454247 119455653 119455670 119455672 119456161 119456162 119456163 119456164 119456180 119456182 119456244 119456533 119456756 119462278
RSAN: 119372212 119372213 119372260 119377827 119381582 119381583 119382948 119382950 119385600 119389244 119389357 119390062 119390063 119390949 119391230 119391235 119391811 119393442 119393443 119393452 119393662 119393913 119393975 119393981 119394821 119397365 119398625 119398626 119398977 119399528 119399630 119399658 119400363 119406578
RMP: 119160033 119160887 119160987 119161198 119161207 119161215 119167314 119168643 119169954 119171697 119171707 119171708 119171843 119172114 119172769 119172772 119173990 119174000 119179006 119179162 119179163 119179642 119182255 119183193 119185251 119185481 119186999 119187388
VDE: 111246682 111247963 111251253
VJA: 111260837 111261642 111269868 111272084
DFR: 124489972 124490590 124491405 124492684 124493771 124495984 124495985 124495987 124496224 124496225 124500531 124500532 124500570
CVS: 136968160 136971881 136972181 136973541 136974060 136974784 136974786 136974787 136978153 136978211 136981052 136983015 136983016 136983018 136983079 136983948 136986187 136986261 136986262 136986310 136986381 136986937 136986938 136986945 136986946 136986947 136986948 136986949 136987788 136988485 136988501 136988766 136988889 136988890 136988891 136988892 136988893 136988895 136988896 136988897 136988898 136990566 136990571 136990573
ABRU: 129960878 129962540 129962543 129963531 129964201 129965449 129965908 129971418 129971563 129972418 129980815 129980816 129980817 129981114 129981243 129981249 129981255 129981719 129981722 129981723 129990245 129991480
UDV: 129219841 129221989 129221990 129222144 129222876 129222877 129223057 129223061 129223073 129223416 129223442 129225125
SDM: 118184000 118189134 118199031
LPOL: 106460260 106472174
PMEO: 129591730 129591731 129592254 129593278 129596853 129596854 129597884 129597885
PVUL: 126807995 126807996 126809619 126815142 126815262 126815654 126815806 126825145 126828006 126828112 130010220
BGT: 106051039 106052179 106052498 106053436 106053957 106053958 106061608 106061610 106061612 106061620 106062365 106062679 106063357 106063676 106065086 106066214 106068469 106073255 106073257 106074587 106074589 106077913 106078832 106079470 106079585
GAE: 121372980 121376062 121379748 121381936
HRF: 124110308 124114395 124114676 124115565 124116408 124116440 124116794 124121587 124124725 124124819 124132691 124133885 124137120 124139642 124141696 124141698 124141708 124141762 124142422 124142992 124143001 124143013 124143022 124143023 124143073 124143074 124149278 124150323 124150346 124151330 124152675
HRJ: 124253624 124253866 124255864 124255889 124256900 124263719 124264464 124264465 124264466 124264470 124264471 124265082 124265814 124269548 124271109 124271110 124272227 124272229 124274142 124278061 124278062 124278084 124278086 124278495 124279834 124280060 124280961 124282708 124282768 124282769 124282777 124282778 124282779 124282887 124282890 124283644 124283767 124284397 124286777 124286779 124286783 124286795 124286802 124286806 124286809 124291272
CRG: 105320785 105320786 105322665 105325143 105331505 105335480 105335491 105343044 105344634 105345458 105347766 105348863 117685407 117687816
CANU: 128163032 128164766 128165030 128167428 128171763 128171764 128173243 128183523 128186881 128192209 128192210
CVN: 111102272 111111230 111111879 111111880 111111883 111111884 111115967 111119379 111120211 111121332 111121956 111121957 111127588 111127589 111136547
OED: 125645775 125647541 125666150 125666792 125668692 125668693 125671292 125671777 125674615 125674617 125674618 125674620 125674622 125680583
MYI: 110440738 110442381 110463252
PMAX: 117315082 117317854 117317855 117317884 117318186 117320939 117335613 117335747 117335779 117335780 117335781 117335782 117335783 117335874 117335984 117335988 117336095 117343439 117343440 117343496
MCAF: 127700684 127705384 127719044 127720136 127720457 127720458 127720497
MMER: 123522877 123531405 123539699 123540772 123542611 123542780 123543436 123555131 123563764 123564412 123564413 123564414
RPHI: 132717786 132724771 132725696 132733710 132734281 132740994 132740995 132745742 132750732
DPOL: 127835578 127841943 127841950 127847180 127855620 127857890 127858022 127862317 127866046 127868518 127870881 127872351 127882098
MAEA: 128213436 128214623 128218415 128218910 128218911 128221103 128221701 128222225 128225146 128225970 128228693 128229119 128233643 128233649 128235279 128239593 128242424 128244908
OBI: 106870822
OSN: 115220571 115220577 115224699 115224818 115224836 115228176
LJP: 135465697 135466057 135475471 135475555 135476099 135476100 135476101 135476332 135476380 135476439 135476591 135476674 135476870 135476872 135476881 135476901 135476902 135479544 135479583 135479720 135479721 135479722
LLON: 135483085 135486597
ATEN: 116288794 116289344 116289345 116294106 116296667 116297188 116297196 116298736 116303286 116305462
HSY: 130635775
RES: 135684278 135684281 135684282 135684284
TDC: 119344950
RIE: OCT59_005865 OCT59_010343 OCT59_015390 OCT59_021511
 » show all
Reference
PMID:3785219 (CYP3A2)
  Authors
Gonzalez FJ, Song BJ, Hardwick JP
  Title
Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation.
  Journal
Mol Cell Biol 6:2969-76 (1986)
DOI:10.1128/MCB.6.8.2969
  Sequence
[rno:266682]
Reference
PMID:1339292 (CYP3A11)
  Authors
Yanagimoto T, Itoh S, Muller-Enoch D, Kamataki T
  Title
Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone.
  Journal
Biochim Biophys Acta 1130:329-32 (1992)
DOI:10.1016/0167-4781(92)90447-8
  Sequence
[mmu:13112]
Reference
PMID:2001406 (CYP3A12)
  Authors
Ciaccio PJ, Graves PE, Bourque DP, Glinsmann-Gibson B, Halpert JR
  Title
cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily.
  Journal
Biochim Biophys Acta 1088:319-22 (1991)
DOI:10.1016/0167-4781(91)90072-t
  Sequence
[cfa:415127]
Reference
PMID:11284050 (CYP3A25)
  Authors
Dai D, Bai R, Hodgson E, Rose RL
  Title
Cloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6beta-hydroxylase.
  Journal
J Biochem Mol Toxicol 15:90-9 (2001)
DOI:10.1002/jbt.4
  Sequence
[mmu:56388]
Reference
PMID:21781753 (CYP3A28)
  Authors
Natsuhori M, van Raak M, Ligtenberg M, Kleij L, Ten Berge D, Zweers-Zeilmaker WM, de Groene EM, van Miert AS, Witkamp RF, Horbach GJ
  Title
Isolation of a bovine full length cytochrome P450 (CYP3A) cDNA sequence and its functional expression in V79 cells.
  Journal
Environ Toxicol Pharmacol 3:17-24 (1997)
DOI:10.1016/s1382-6689(96)00133-0
  Sequence
[bta:282214]
Reference
PMID:9682441 (CYP3A29)
  Authors
Nissen PH, Wintero AK, Fredholm M
  Title
Mapping of porcine genes belonging to two different cytochrome P450 subfamilies.
  Journal
Anim Genet 29:7-11 (1998)
DOI:10.1046/j.1365-2052.1998.00225.x
  Sequence
[ssc:403324]
Reference
PMID:10775455 (CYP3A41)
  Authors
Sakuma T, Takai M, Endo Y, Kuroiwa M, Ohara A, Jarukamjorn K, Honma R, Nemoto N
  Title
A novel female-specific member of the CYP3A gene subfamily in the mouse liver.
  Journal
Arch Biochem Biophys 377:153-62 (2000)
DOI:10.1006/abbi.2000.1747
  Sequence
[mmu:53973]
Reference
PMID:16414346 (CYP3C1)
  Authors
Corley-Smith GE, Su HT, Wang-Buhler JL, Tseng HP, Hu CH, Hoang T, Chung WG, Buhler DR
  Title
CYP3C1, the first member of a new cytochrome P450 subfamily found in zebrafish (Danio rerio).
  Journal
Biochem Biophys Res Commun 340:1039-46 (2006)
DOI:10.1016/j.bbrc.2005.12.110
  Sequence
[dre:324340]
Reference
PMID:14562963
  Authors
McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC
  Title
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
  Journal
J Mol Evol 57:200-11 (2003)
DOI:10.1007/s00239-003-2466-x

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (12)   
   KEGG PATHWAY (12)   
Chemical reaction (13)   
   KEGG ENZYME (1)   
   KEGG REACTION (7)   
   KEGG RCLASS (5)   
Gene (3702)   
   KEGG GENES (1978)   
   KEGG MGENES (204)   
   RefGene (1517)   
   OC (3)   
Literature (9)   
   PubMed (9)   
All databases (3739)   

Download RDF
KEGG   ORTHOLOGY: K07408
Entry
K07408                      KO                                     
Symbol
CYP1A1
Name
cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00380  Tryptophan metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map01100  Metabolic pathways
map04913  Ovarian steroidogenesis
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05417  Lipid and atherosclerosis
Reaction
R02354  
R02355  
R03089  
R03408  
R03629  melatonin,NADPH---hemoprotein reductase:oxygen oxidoreductase
R07000  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07001  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07021  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07022  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07079  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07080  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07081  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07085  benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07087  9-hydroxybenzo[a]pyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07098  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07099  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R08390  
R08392  
R09418  
R09423  
R09442  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
   05207 Chemical carcinogenesis - receptor activation
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP1 family
   K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Genes
HSA: 1543(CYP1A1)
PTR: 453744(CYP1A1)
PPS: 100976184(CYP1A1)
GGO: 101129522
PON: 100457153
PPYG: 129014419
NLE: 100585507
HMH: 116481900
SSYN: 129482256
MCC: 678694(CYP1A1)
MCF: 102129994(CYP1A1)
MTHB: 126960000
MNI: 105490958
CSAB: 103245331(CYP1A1)
CATY: 105600061
PANU: 101001307
TGE: 112627760
MLEU: 105530835
RRO: 104672151
RBB: 108531476
TFN: 117070364
PTEH: 111529702
CANG: 105505165
CJC: 100393083(CYP1A1)
SBQ: 101038217
CIMI: 108298444(CYP1A1)
ANAN: 105716625 135275116
CSYR: 103271646
MMUR: 105854864
LCAT: 123624369
PCOQ: 105807306
OGA: 100955410
MMU: 13076(Cyp1a1)
MCAL: 110301270
MPAH: 110328033
RNO: 24296(Cyp1a1)
MCOC: 116071961
ANU: 117698968
MUN: 110558545
CGE: 100751269
MAUA: 101844540
PROB: 127231800
PLEU: 114690337
MORG: 121445349
MFOT: 126507531
AAMP: 119808952
NGI: 103736921
HGL: 101707509
CPOC: 100135512(Cyp1a1)
CCAN: 109701505
DORD: 105982352
DSP: 122098438
NCAR: 124977051
MMMA: 107137939
OCU: 100328613
OPI: 101533768
TUP: 102484009
GVR: 103588057
CFA: 100686778(CYP1A1)
CLUD: 112675585
VVP: 112908776
VLG: 121484958
NPO: 129506483
AML: 100473028
UMR: 103678992
UAH: 113240972
UAR: 123790682
ELK: 111153267
LLV: 125105138
MPUF: 101676222
MNP: 131999167
MLK: 131835779
NVS: 122893452
ORO: 101382250
EJU: 114206471
ZCA: 113910089
MLX: 118003748
NSU: 110583893
LWW: 102739666
FCA: 554347(CYP1A1)
PYU: 121041992
PCOO: 112855107
PBG: 122468425
PVIV: 125168946
LRUF: 124508019
PTG: 102966263
PPAD: 109262691
PUC: 125910157
AJU: 106979443
HHV: 120235772
BTA: 282870(CYP1A1)
BOM: 102283235
BIU: 109575587
BBUB: 102399021
BBIS: 104990991
CHX: 102170823
OAS: 100170113(CYP1A1)
BTAX: 128066562
ODA: 120875451
CCAD: 122419730
MBEZ: 129550459
SSC: 403103(CYP1A1)
CFR: 102518111
CBAI: 105069192
CDK: 105087262
VPC: 102530468
BACU: 103008057
BMUS: 118891077
LVE: 103071513
OOR: 101287158
DLE: 111177818
PCAD: 102984326
PSIU: 116749907
NASI: 112410978
ECB: 100062285(CYP1A1)
EPZ: 103552317
EAI: 106831264
MYB: 102262349
MYD: 102762200
MMYO: 118675915
MLF: 102437172
MDT: 132212050
PKL: 118728867
EFUS: 103300190
MNA: 107535216
DRO: 112301821
SHON: 118987754
AJM: 119041322 119041329
PDIC: 114492343
PHAS: 123825280
MMF: 118643668
PPAM: 129064162
HAI: 109396247
RFQ: 117024155
PALE: 102892046
PGIG: 120597850
PVP: 105306836
RAY: 107510533
MJV: 108388606
TOD: 119237890
SARA: 101550604
SETR: 126015044
LAV: 100665901
TMU: 101359275
ETF: 101661225
DNM: 101423437
MDO: 100029871
GAS: 123232970
SHR: 100927711
AFZ: 127551979
PCW: 110213927
TVP: 118828075 118828076
OAA: 100080942(CYP1A1)
ZVI: 118084457
STOW: 125424760
BBEL: 109480286
SCLV: 120326955 120337706 120347324
LPIC: 129258591 129274985
PVUL: 126810086 126812565 126815240 126823790 126825192
GAE: 121368990
HRF: 124120352 124120359 124131529 124140277
HRJ: 124268175 124276990 124282406
CRG: 105329067
CANU: 128190897
OED: 125647398 125648732
MMER: 123540564 123540605 123541431 123546444 123546459 123546828 123549057 123557949 123562948 123562951
RPHI: 132713371 132719301 132727684 132731161 132731163 132733404 132733414 132736383 132738690 132744217 132754874 132757640
DPOL: 127850854
MAEA: 128206276 128206748 128228746 128236623
ATEN: 116286948 116286970 116287897
XEN: 124435028 124452841 124452890
HSY: 130646034
 » show all
Reference
PMID:2989797
  Authors
Jaiswal AK, Gonzalez FJ, Nebert DW
  Title
Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism.
  Journal
Nucleic Acids Res 13:4503-20 (1985)
DOI:10.1093/nar/13.12.4503
  Sequence
[hsa:1543]
Reference
PMID:3019683
  Authors
Kawajiri K, Watanabe J, Gotoh O, Tagashira Y, Sogawa K, Fujii-Kuriyama Y
  Title
Structure and drug inducibility of the human cytochrome P-450c gene.
  Journal
Eur J Biochem 159:219-25 (1986)
DOI:10.1111/j.1432-1033.1986.tb09857.x
  Sequence
[hsa:1543]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (20)   
   KEGG PATHWAY (20)   
Chemical reaction (33)   
   KEGG ENZYME (1)   
   KEGG REACTION (21)   
   KEGG RCLASS (11)   
Gene (447)   
   KEGG GENES (215)   
   KEGG MGENES (21)   
   RefGene (198)   
   OC (13)   
Literature (2)   
   PubMed (2)   
All databases (505)   

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KEGG   ORTHOLOGY: K17689
Entry
K17689            Tight     KO                                     
Symbol
CYP3A4
Name
cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
Pathway
map00140  Steroid hormone biosynthesis
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map00983  Drug metabolism - other enzymes
map01100  Metabolic pathways
map04976  Bile secretion
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
Reaction
R02356  
R03408  
R05727  quinine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
R07000  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07001  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07055  
R07056  
R07079  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07080  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07081  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07085  benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07087  9-hydroxybenzo[a]pyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R08256  
R08257  
R08264  
R08268  
R08269  
R08271  
R08272  
R08274  
R08275  
R08276  
R08277  
R08285  
R08286  
R08287  
R08293  
R08294  
R08303  
R08304  
R08312  
R08313  
R08318  
R08339  
R08340  
R08341  
R08342  
R08343  
R08390  
R08391  
R08392  
R09404  
R09408  
R09423  
Disease
H01143  Vitamin D-dependent rickets
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   00591 Linoleic acid metabolism
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   00982 Drug metabolism - cytochrome P450
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   00983 Drug metabolism - other enzymes
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   05207 Chemical carcinogenesis - receptor activation
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.32  albendazole monooxygenase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.55  quinine 3-monooxygenase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.56  1,8-cineole 2-exo-monooxygenase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.57  taurochenodeoxycholate 6alpha-hydroxylase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.73  albendazole monooxygenase (sulfoxide-forming)
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP3 family
   K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
Other DBs
GO: 0047638 0033780 0050591
Genes
HSA: 1576(CYP3A4)
PTR: 463582(CYP3A4)
PPS: 100976899(CYP3A4)
GGO: 101149513
PON: 100436782
PPYG: 129041698
NLE: 100593175
SSYN: 129489604
MCC: 678670(CYP3A4)
MCF: 102144258(CYP3A4)
MTHB: 126950475
MNI: 105497389
CSAB: 103246766
CATY: 105584402
PANU: 101026757
TGE: 112621193
MLEU: 105543708
RRO: 104673585
RBB: 108538168
TFN: 117072034
PTEH: 111530171 111534893
CANG: 105513064
CJC: 100404344(CYP3A4)
SBQ: 101037403
CIMI: 108308036(CYP3A4)
ANAN: 105719456(CYP3A4)
CSYR: 103252931
MMUR: 105868328 105868331
LCAT: 123631591 123631593
PCOQ: 105806078
OGA: 100948865
 » show all
Reference
PMID:3267210 (CYP3A4)
  Authors
Gonzalez FJ, Schmid BJ, Umeno M, Mcbride OW, Hardwick JP, Meyer UA, Gelboin HV, Idle JR
  Title
Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.
  Journal
DNA 7:79-86 (1988)
DOI:10.1089/dna.1988.7.79
  Sequence
[hsa:1576]
Reference
PMID:14562963
  Authors
McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC
  Title
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
  Journal
J Mol Evol 57:200-11 (2003)
DOI:10.1007/s00239-003-2466-x
Reference
PMID:9056237 (CYP3A21)
  Authors
Igarashi T, Sakuma T, Isogai M, Nagata R, Kamataki T
  Title
Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs.
  Journal
Arch Biochem Biophys 339:85-91 (1997)
DOI:10.1006/abbi.1996.9852
  Sequence
[cjc:100404344]

  All links  
Ontology (6)   
   KEGG BRITE (3)   
   GO (3)   
Pathway (20)   
   KEGG PATHWAY (20)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (88)   
   KEGG ENZYME (5)   
   KEGG REACTION (44)   
   KEGG RCLASS (39)   
Gene (35)   
   KEGG GENES (34)   
   OC (1)   
Literature (3)   
   PubMed (3)   
All databases (154)   

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KEGG   ORTHOLOGY: K17692
Entry
K17692            Tight     KO                                     
Symbol
CYP3A43
Name
cytochrome P450 family 3 subfamily A43 [EC:1.14.14.1]
Pathway
map05204  Chemical carcinogenesis - DNA adducts
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17692  CYP3A43; cytochrome P450 family 3 subfamily A43
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17692  CYP3A43; cytochrome P450 family 3 subfamily A43
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17692  CYP3A43; cytochrome P450 family 3 subfamily A43
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP3 family
   K17692  CYP3A43; cytochrome P450 family 3 subfamily A43
Genes
HSA: 64816(CYP3A43)
PTR: 472456(CYP3A43)
PPS: 100979695(CYP3A43)
GGO: 101127998
PON: 100437391
PPYG: 129041701
MCC: 709770(CYP3A43)
MCF: 102143360(CYP3A43)
MTHB: 126950478
MNI: 105497367
CSAB: 103246765(CYP3A43)
CATY: 105584405
PANU: 101005341
MLEU: 105543707
RRO: 104673586
RBB: 108538222
TFN: 117072863
PTEH: 111530151
CANG: 105513066
 » show all
Reference
PMID:11160876
  Authors
Domanski TL, Finta C, Halpert JR, Zaphiropoulos PG
  Title
cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450.
  Journal
Mol Pharmacol 59:386-92 (2001)
DOI:10.1124/mol.59.2.386
  Sequence
[hsa:64816]
Reference
PMID:14562963
  Authors
McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC
  Title
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
  Journal
J Mol Evol 57:200-11 (2003)
DOI:10.1007/s00239-003-2466-x

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (20)   
   KEGG GENES (19)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (29)   

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KEGG   ORTHOLOGY: K17691
Entry
K17691            Tight     KO                                     
Symbol
CYP3A7
Name
cytochrome P450 family 3 subfamily A7 [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00830  Retinol metabolism
map01100  Metabolic pathways
map05204  Chemical carcinogenesis - DNA adducts
Reaction
R03408  
R08390  
R08392  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K17691  CYP3A7; cytochrome P450 family 3 subfamily A7
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17691  CYP3A7; cytochrome P450 family 3 subfamily A7
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17691  CYP3A7; cytochrome P450 family 3 subfamily A7
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17691  CYP3A7; cytochrome P450 family 3 subfamily A7
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17691  CYP3A7; cytochrome P450 family 3 subfamily A7
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP3 family
   K17691  CYP3A7; cytochrome P450 family 3 subfamily A7
Genes
HSA: 100861540(CYP3A7-CYP3A51P) 1551(CYP3A7)
PTR: 129135235 737263(CYP3A7)
PPS: 100967578 100975985(CYP3A67)
GGO: 101147362 115935323
PON: 100435763 100436403
PPYG: 129041699 129041702
NLE: 115830387
HMH: 116810916
SSYN: 129489595 129489605
MCC: 100144394(CYP3A7)
MCF: 102145015(CYP3A7)
MTHB: 126950476
MNI: 105497398
CSAB: 103246767 103246772(CYP3A7)
CATY: 105584398
PANU: 100997059
TGE: 112621196
MLEU: 105543709 105543712
TFN: 117072036
 » show all
Reference
PMID:2722762
  Authors
Komori M, Nishio K, Ohi H, Kitada M, Kamataki T
  Title
Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450.
  Journal
J Biochem 105:161-3 (1989)
DOI:10.1093/oxfordjournals.jbchem.a122632
  Sequence
[hsa:1551]
Reference
PMID:14562963
  Authors
McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC
  Title
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
  Journal
J Mol Evol 57:200-11 (2003)
DOI:10.1007/s00239-003-2466-x

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (8)   
   KEGG PATHWAY (8)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (7)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (3)   
Gene (29)   
   KEGG GENES (28)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (50)   

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