KEGG ORTHOLOGY: K17712

ORTHOLOGY: K17712

Entry

K17712                      KO

Symbol

CYP2D6

Name

cytochrome P450 family 2 subfamily D6 [EC:1.14.14.1]

Pathway

map00980

Metabolism of xenobiotics by cytochrome P450

map00982

Drug metabolism - cytochrome P450

map01522

Endocrine resistance

map04726

Serotonergic synapse

Reaction

R03697

R08267

R08270

R08343

R08344

R08345

R09421

Disease

H01171

Poor drug metabolism

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
   00982 Drug metabolism - cytochrome P450
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP2 family
   K17712  CYP2D6; cytochrome P450 family 2 subfamily D6

Genes

HSA:	107987478 107987479(CYP2D6) 1564(CYP2D7) 1565(CYP2D6)

PTR:	112206755 470228(CYP2D6)

PPS:	100969627 100988273

GGO:	101142890 109025371 115931944

PON:	100453198 100458527

PPYG:

129023327 129023330

NLE:	100580051 100593769 100606221

SSYN:

129467430 129468045 129468047

MCC:	100424965 678691(CYP2D6)

MCF:	102140079(CYP2D8) 102143092(CYP2D6)

MTHB:

126963595 126963596

MNI:	105464350 105464352

CSAB:

103223410 103223412

CATY:

105572143 105573227

PANU:

101014319 101014919

TGE:	112632623 112632624

MLEU:

105538801 105539005

RRO:	104670080 104670158

RBB:	108543556 108543567

TFN:	117096386 117096388

PTEH:

111548933 111548934

CANG:

105514021 105514022

CJC:	100385343(CYP2D19) 100415600

SBQ:	101049800 101050356

CIMI:

108290468(CYP2D6) 108290469(CYP2D8)

ANAN:

105715239 135268096 135271250 135271261 135271267

CSYR:

103264338 103264339 103264340 103264341 103264342 103264346 103264347

MMUR:

105858587 105858588

LCAT:

123640281 123640282 123640283

PCOQ:

105805151

OGA:	100946358 105886367

CCAN:

109689341 109689342 109689343 109689344

DORD:

105992056

OPI:

101534880

GVR:

103591840

DNM:	101415786 101440010

GAS:

123250293

» show all

Reference

PMID:3410476 (CYP2D6)

Authors

Gonzalez FJ, Vilbois F, Hardwick JP, McBride OW, Nebert DW, Gelboin HV, Meyer UA

Title

Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.

Journal

Genomics 2:174-9 (1988)
DOI:10.1016/0888-7543(88)90100-0

Sequence

[hsa:1565]

Reference

PMID:15051713 (CYP2D7)

Authors

Pai HV, Kommaddi RP, Chinta SJ, Mori T, Boyd MR, Ravindranath V

Title

A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.

Journal

J Biol Chem 279:27383-9 (2004)
DOI:10.1074/jbc.M402337200

Sequence

[hsa:1564]

Reference

PMID:9056237 (CYP2D19)

Authors

Igarashi T, Sakuma T, Isogai M, Nagata R, Kamataki T

Title

Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs.

Journal

Arch Biochem Biophys 339:85-91 (1997)
DOI:10.1006/abbi.1996.9852

Sequence

[cjc:100385343]

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (8)   
   KEGG PATHWAY (8)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (15)   
   KEGG ENZYME (1)   
   KEGG REACTION (7)   
   KEGG RCLASS (7)   
Gene (88)   
   KEGG GENES (85)   
   OC (3)   
Literature (3)   
   PubMed (3)   
All databases (118)   

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