KEGG   ORTHOLOGY: K17718
Entry
K17718                      KO                                     
Symbol
CYP2C8
Name
cytochrome P450 family 2 subfamily C8 [EC:1.14.14.1]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
map05417  Lipid and atherosclerosis
Reaction
R07042  
R07043  
R07048  
R07050  
R07055  
R07056  
R08312  
R08390  
R08392  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
   00591 Linoleic acid metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
Genes
HSA: 1558(CYP2C8)
PTR: 450909(CYP2C8)
PPS: 100967379(CYP2C8)
GGO: 101127173
PON: 100447840(CYP2C8)
PPYG: 129006200
NLE: 100602226
HMH: 116457254
SSYN: 129462752
MCC: 100534648(CYP2C93) 678683(CYP2C8) 702239
MCF: 102116849 102117212(CYP2C8) 102119308(CYP2C93)
MTHB: 126962030 126962037
MNI: 105470206 105470207 105481168
CSAB: 103216303(CYP2C8) 103216308
CATY: 105576140 105576141 105587200
PANU: 101022842(CYP2C8) 101023648
TGE: 112631270 112631271
MLEU: 105535381 105553656 105553690
RRO: 104665592
RBB: 108541196
TFN: 117069764
PTEH: 111529253
CANG: 105504518 105527573
CJC: 100390915(CYP2C8) 100402764
SBQ: 101041387
CIMI: 108281688(CYP2C8)
ANAN: 105708272(CYP2C8)
CSYR: 103260641
LCAT: 123650043 123650045 123650047 123650048
PCOQ: 105822696
OGA: 100941864 100942590
GVR: 103597628 103609276 103609277 103610831 103610943
ASAO: 132781291
SUND: 121921666
CTIG: 120296912 120296913 120298508 120317800 120317801
APRI: 131192456
PRAF: 128407606
GSH: 117365670
HOC: 132836750
RMP: 119168129
CRG: 105344043
CANU: 128177588
CVN: 111128571
 » show all
Reference
PMID:3500169
  Authors
Okino ST, Quattrochi LC, Pendurthi UR, McBride OW, Tukey RH
  Title
Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing.
  Journal
J Biol Chem 262:16072-9 (1987)
  Sequence
[hsa:1558]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (16)   
   KEGG PATHWAY (16)   
Chemical reaction (16)   
   KEGG ENZYME (1)   
   KEGG REACTION (9)   
   KEGG RCLASS (6)   
Gene (72)   
   KEGG GENES (71)   
   OC (1)   
Literature (1)   
   PubMed (1)   
All databases (108)   

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KEGG   ORTHOLOGY: K17721
Entry
K17721                      KO                                     
Symbol
CYP2C19
Name
cytochrome P450 family 2 subfamily C19 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
Reaction
R07046  
R07055  
R07056  
R08275  
R08285  
R08343  
Disease
H01171  Poor drug metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
   00591 Linoleic acid metabolism
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.52  (S)-limonene 7-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.53  (R)-limonene 6-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.75  fenbendazole monooxygenase (4'-hydroxylating)
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Other DBs
GO: 0018675 0018676 0052741
Genes
HSA: 1557(CYP2C19)
PTR: 740956(CYP2C19)
PPS: 100995695(CYP2C19)
GGO: 101151965
PON: 100439483(CYP2C19)
PPYG: 129006337
NLE: 100601437
HMH: 116457271
SSYN: 129468985
CJC: 100389947(CYP2C19)
SBQ: 101041912
CIMI: 108281686(CYP2C19)
ANAN: 110568730 135273997
CSYR: 103277060
PCOQ: 105822723
OGA: 100950266
MMMA: 107149734
GAS: 123236335 123238232
 » show all
Reference
PMID:2009263
  Authors
Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA
  Title
Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.
  Journal
Biochemistry 30:3247-55 (1991)
DOI:10.1021/bi00227a012
  Sequence
[hsa:1557]

  All links  
Ontology (6)   
   KEGG BRITE (3)   
   GO (3)   
Pathway (12)   
   KEGG PATHWAY (12)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (15)   
   KEGG ENZYME (4)   
   KEGG REACTION (6)   
   KEGG RCLASS (5)   
Gene (21)   
   KEGG GENES (20)   
   OC (1)   
Literature (1)   
   PubMed (1)   
All databases (56)   

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KEGG   ORTHOLOGY: K17712
Entry
K17712                      KO                                     
Symbol
CYP2D6
Name
cytochrome P450 family 2 subfamily D6 [EC:1.14.14.1]
Pathway
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map01522  Endocrine resistance
map04726  Serotonergic synapse
Reaction
R03697  
R08267  
R08270  
R08343  
R08344  
R08345  
R09421  
Disease
H01171  Poor drug metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
   00982 Drug metabolism - cytochrome P450
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17712  CYP2D6; cytochrome P450 family 2 subfamily D6
Genes
HSA: 107987478 107987479(CYP2D6) 1564(CYP2D7) 1565(CYP2D6)
PTR: 112206755 470228(CYP2D6)
PPS: 100969627 100988273
GGO: 101142890 109025371 115931944
PON: 100453198 100458527
PPYG: 129023327 129023330
NLE: 100580051 100593769 100606221
SSYN: 129467430 129468045 129468047
MCC: 100424965 678691(CYP2D6)
MCF: 102140079(CYP2D8) 102143092(CYP2D6)
MTHB: 126963595 126963596
MNI: 105464350 105464352
CSAB: 103223410 103223412
CATY: 105572143 105573227
PANU: 101014319 101014919
TGE: 112632623 112632624
MLEU: 105538801 105539005
RRO: 104670080 104670158
RBB: 108543556 108543567
TFN: 117096386 117096388
PTEH: 111548933 111548934
CANG: 105514021 105514022
CJC: 100385343(CYP2D19) 100415600
SBQ: 101049800 101050356
CIMI: 108290468(CYP2D6) 108290469(CYP2D8)
ANAN: 105715239 135268096 135271250 135271261 135271267
CSYR: 103264338 103264339 103264340 103264341 103264342 103264346 103264347
MMUR: 105858587 105858588
LCAT: 123640281 123640282 123640283
PCOQ: 105805151
OGA: 100946358 105886367
CCAN: 109689341 109689342 109689343 109689344
DORD: 105992056
OPI: 101534880
GVR: 103591840
DNM: 101415786 101440010
GAS: 123250293
 » show all
Reference
PMID:3410476 (CYP2D6)
  Authors
Gonzalez FJ, Vilbois F, Hardwick JP, McBride OW, Nebert DW, Gelboin HV, Meyer UA
  Title
Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22.
  Journal
Genomics 2:174-9 (1988)
DOI:10.1016/0888-7543(88)90100-0
  Sequence
[hsa:1565]
Reference
PMID:15051713 (CYP2D7)
  Authors
Pai HV, Kommaddi RP, Chinta SJ, Mori T, Boyd MR, Ravindranath V
  Title
A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.
  Journal
J Biol Chem 279:27383-9 (2004)
DOI:10.1074/jbc.M402337200
  Sequence
[hsa:1564]
Reference
PMID:9056237 (CYP2D19)
  Authors
Igarashi T, Sakuma T, Isogai M, Nagata R, Kamataki T
  Title
Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs.
  Journal
Arch Biochem Biophys 339:85-91 (1997)
DOI:10.1006/abbi.1996.9852
  Sequence
[cjc:100385343]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (8)   
   KEGG PATHWAY (8)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (15)   
   KEGG ENZYME (1)   
   KEGG REACTION (7)   
   KEGG RCLASS (7)   
Gene (88)   
   KEGG GENES (85)   
   OC (3)   
Literature (3)   
   PubMed (3)   
All databases (118)   

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KEGG   ORTHOLOGY: K07418
Entry
K07418                      KO                                     
Symbol
CYP2J
Name
cytochrome P450 family 2 subfamily J [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map01100  Metabolic pathways
map04726  Serotonergic synapse
map04750  Inflammatory mediator regulation of TRP channels
map04913  Ovarian steroidogenesis
map05417  Lipid and atherosclerosis
Reaction
R07042  
R07043  
R07044  
R07045  
R07046  
R07048  
R07050  
R07051  
R07052  
R07055  
R07056  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K07418  CYP2J; cytochrome P450 family 2 subfamily J
   00591 Linoleic acid metabolism
    K07418  CYP2J; cytochrome P450 family 2 subfamily J
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K07418  CYP2J; cytochrome P450 family 2 subfamily J
  09156 Nervous system
   04726 Serotonergic synapse
    K07418  CYP2J; cytochrome P450 family 2 subfamily J
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K07418  CYP2J; cytochrome P450 family 2 subfamily J
 09160 Human Diseases
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K07418  CYP2J; cytochrome P450 family 2 subfamily J
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07418  CYP2J; cytochrome P450 family 2 subfamily J
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07418  CYP2J; cytochrome P450 family 2 subfamily J
    1.14.14.73  albendazole monooxygenase (sulfoxide-forming)
     K07418  CYP2J; cytochrome P450 family 2 subfamily J
    1.14.14.74  albendazole monooxygenase (hydroxylating)
     K07418  CYP2J; cytochrome P450 family 2 subfamily J
    1.14.14.75  fenbendazole monooxygenase (4'-hydroxylating)
     K07418  CYP2J; cytochrome P450 family 2 subfamily J
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07418  CYP2J; cytochrome P450 family 2 subfamily J
Genes
HSA: 1573(CYP2J2)
PTR: 456896(CYP2J2)
PPS: 100984148(CYP2J2)
GGO: 101148349
PON: 100447634
PPYG: 129016979
NLE: 100589053
HMH: 116457699
SSYN: 129458528
MCC: 693631
MCF: 102119662(CYP2J2)
MTHB: 126962785
MNI: 105495154
CSAB: 103224719(CYP2J2)
CATY: 105595967
PANU: 101015175 116276324 116276330
TGE: 112630798
MLEU: 105534929
RRO: 104668045
RBB: 108532916
TFN: 117091994
PTEH: 111522986
CANG: 105511111
CJC: 100397287(CYP2J2)
SBQ: 101041470
CIMI: 108314910(CYP2J2)
ANAN: 105710194(CYP2J2)
CSYR: 103256114
MMUR: 105882593 105882595 105882596
LCAT: 123635586 123635587 123635588
PCOQ: 105806372 105806374
OGA: 100950432 100950736 100951049 100951361
MMU: 100066(Cyp2j11) 13109(Cyp2j5) 13110(Cyp2j6) 230459(Cyp2j13) 242546(Cyp2j12) 546837(Cyp2j7) 665095(Cyp2j8) 74519(Cyp2j9)
MCAL: 110292385 110292662 110292766 110293055 110293363 110293364 110306650
MPAH: 110323111 110323251 110323340 110323372 110323386 110323498
RNO: 100912642 313373(Cyp2j10) 313375(Cyp2j3) 502969(Cyp2j16) 65210(Cyp2j4)
MCOC: 116095445 116095729 116095730 116096253 116096254 116096255 116096256
ANU: 117709291 117709292 117709294 117709295 117709296 117709297 117709298 117709299
MUN: 110560670 110560674 110560675 110562464 110562465 110562466 110562514
CGE: 100764171 100764471 100764768 100765057
MAUA: 101830438 101830700 101841191 101841462
PROB: 127224955 127224956 127224957 127224959
PLEU: 114681971 114681974 114681989 114681994 114689366 114693759 114693760 114693761 114693762 114693764
MORG: 121448178 121448207 121448212 121448217 121448239 121448362 121448363 121448623 121448757 121448759 121448836 121448885
MFOT: 126498042 126498043 126498046 126498047 126498076 126498100 126508049
AAMP: 119816658 119816659 119816660 119816661 119816663 119816664 119816666 119816978
NGI: 103730878 103730879 103730880 103737136
HGL: 101719021 101719368
CCAN: 109684284
DORD: 105989978 105990009
DSP: 122108987 122111431
PLOP: 125355228 125355229
NCAR: 124966849
MMMA: 107141706
OCU: 100301544(CYP2J1)
OPI: 101531357 101531516
TUP: 102490783 102491196 102491623 102492033 102492447
GVR: 103603536
CFA: 610195(CYP2J2)
CLUD: 112647122
VVP: 112926087
VLG: 121499260
NPO: 129497114
AML: 100482335
UMR: 103663082
UAH: 113254606
UAR: 123795371
ELK: 111143525
LLV: 125097704
MPUF: 101684683
MNP: 132000940
MLK: 131809515
NVS: 122900029
ORO: 101382939
EJU: 114212028
ZCA: 113926705
MLX: 118020215
NSU: 110571781
LWW: 102747983
FCA: 101097746(CYP2J2)
PYU: 121027220
PCOO: 112871803
PBG: 122480573
PVIV: 125173408
LRUF: 124516300
PTG: 102958105
PPAD: 109266776
PUC: 125912544
AJU: 106974984
HHV: 120236077
BTA: 107132327 510406(CYP2J30) 511936 521656 530929
BOM: 102283844 102284389
BIU: 109556228 109556861
BBUB: 102409898 102410549 102410893 102411225 102411786
BBIS: 105002568 105002577 105002593 105002602 105002609
CHX: 102184867 102190572 102190840 102191099
OAS: 101121563 101121820 768095(CYP2J)
BTAX: 128044628 128044629 128045187
ODA: 120856578 120857076 120857077 120857078 120857079
CCAD: 122436913 122436914 122436915 122436916
MBEZ: 129540345 129540908 129540938 129541372 129541501
SSC: 100524750(CYP2J34) 100524940 100525112 100621407 110261221
CFR: 102509190 102509309 102511878 102518893
CBAI: 105064824 105064834 105064844 105064851 105065015
CDK: 105092804 105092849 105096275 105096288
VPC: 102524867 102535306 102535561 102535809 102536059 102536560 102543101 102543350
BMUS: 118895900
LVE: 103072875
OOR: 101287985
DLE: 111175878
PCAD: 102995526
PSIU: 116764420
NASI: 112407074
ECB: 100067247
EPZ: 103564165
EAI: 106833456
MYB: 102259820
MYD: 102765527
MMYO: 118676695
MLF: 102439141
MDT: 132231009
PKL: 118723974 118723975
EFUS: 103284070
MNA: 107531748
AJM: 119042498
PDIC: 114496360 114496679 114497261 114497336
PHAS: 123816495 123830867 123831702
MMF: 118627182
PPAM: 129070802
HAI: 109371253 109389703 109389708
RFQ: 117026547 117026565 117027269
PALE: 102885276
PGIG: 120621913
PVP: 105303444
RAY: 107518358
TOD: 119236796 119236797
SARA: 101547147 101547409 101547677 101547951 101558147 101558420
SETR: 126010975 126010977 126010978 126010985 126010986 126011645
LAV: 100658115 100670142
TMU: 101350163
ETF: 101644960 101645270 101645590
DNM: 101411038 101437056 101438656 101439086 101439781 101440211 101440653 101447575
MDO: 100031902 100031907 100031914 100031960 100031971 100031975 100031980 100031984
GAS: 123243734 123245774 123245775 123245776 123247875 123247893
SHR: 100921692 100921949 100922209 100922468 100922742 100922989 116419008
AFZ: 127563232 127563233 127563234 127563235 127563236 127563237 127563238
PCW: 110212934 110212942 110212976 110212978
TVP: 118846138 118846140 118846141 118846143 118846144 118846152 118846466 118846467 118846468
OAA: 100087745
GGA: 101750603(CYP2J21) 424676(CYP2J23) 424677(CYP2J22) 424729(CYP2J19)
PCOC: 116235297 116236300 116236311
MGP: 100547794 104912427 104912428 104912494
CJO: 107317676 107317691 107317696
TPAI: 128072441 128072442 128072444 128072445 128072446 128072447
LMUT: 125692983 125693898 125693899
NMEL: 110402810 110402814
APLA: 101792912 101796247
CATA: 118243378 118243450
AFUL: 116491839 116491861
TGU: 100224220(CYP2J40) 100230439(CYP2J19A)
LSR: 110477035 110477061
SCAN: 103815060 103815209(CYP2J19)
PMOA: 120503273 120503274
OTC: 121345089 121345090
PRUF: 121362071 121362072
GFR: 102032779 102039653
FAB: 101811920 101817417
OMA: 130256010 130256011
PHI: 102099263 102112918
PMAJ: 107208256 107208257
CCAE: 111932992 111932994
CCW: 104695151 104695152
CBRC: 103615060 103615112
ETL: 114069063
ZAB: 102067922
ZLE: 135450762 135450763 135450766
ACHL: 103807106
SVG: 106849737 106849804
HRT: 120756468 120756532
SATI: 136365094 136365095
FPG: 101919387
CCRI: 104159712
SHAB: 115611484 115611485 115611814 115611815 115611982
ACUN: 113483076 113483077
TALA: 104356817 104369422 116964786 122152520
ACHC: 115349168 115349169
HALD: 104317809 104317810
AGEN: 126041970 126041971
GCL: 127018852 127019141
CSTI: 104561860 104561861
LDI: 104353037 104353038
MNB: 103769046 103769625 103776455 103779509 103780917
DPUB: 104301748 104301760 104308782
AVIT: 104278846
BRHI: 104488759
EGZ: 104123882 104123941
NNI: 104009259 104009336
PCRI: 104028699
PCAO: 104041925 104041927
PADL: 103913325 103913366
AFOR: 103905667 103905758
FGA: 104077513 104077514
GSTE: 104260318 104260319
CLV: 102088854 102089036 102093649 102094339
MUI: 104535857 104535919
PGUU: 104462916
PLET: 104623376 104623378
EHS: 104505453 104509239
CMAC: 104478964 104484601
CUCA: 104066545 104066584
TEO: 104371533 104377407 104382055
BREG: 104632733 104632734
OHA: 104328012 104328025
ACAR: 104520204
CPEA: 104385164 104385194
CVF: 104285547
RTD: 128913617 128913618
AROW: 112967651 112976566
NPD: 112942289 112948473 112948476 112948493
TGT: 104571164 104571376 104575346 104575680 104575681
DNE: 112991483 112991487
SCAM: 104152907 104153320
ASN: 102371261 102371780
AMJ: 102557714(CYP2P10)
CPOO: 109307018
GGN: 109305297
PSS: 102449417 102457302(CYP2J19) 102460777
CMY: 102936353 102940076(CYP2J19)
CCAY: 125640754 125640755
DCC: 119859977
CPIC: 101931915 101937882 101938148(CYP2J19) 101939779 103305685
TST: 117882110
CABI: 116833772
MRV: 120370576 120370577 120370720 120370721
ACS: 100567522
ASAO: 132772700 132772701 132772702 132773987
SUND: 121927978 121927980 121927981
VKO: 123018898 123019432 123019440 123019512 123025295 123025296 123025297 123025298 123025301
PMUA: 114598918 114598919 114598920 114598921 114598923 114598924 114598925
PRAF: 128410871 128410872 128410874 128410875 128410876 128410877 128410878 128415691 128415692 128415694 128415695 128415696 128415697 128415703
ZVI: 118088450 118088451 118088452 118088453 118088455 118088457
HCG: 128324567 128324673
GJA: 107111277 107114997
STOW: 125437750 125437751 125437990
EMC: 129329793
MUO: 115472051
GSH: 117346547
DRE: 100034366(cyp2p8) 100034406(cyp2p7) 393108(cyp2p6) 393592(cyp2p9) 399485(cyp2p10) 797309(cyp2j20)
SRX: 107737305
SANH: 107665313
SGH: 107556152 107556153
CCAR: 109081729 109112720 109112721 109112722
CAUA: 113059714 113062932 113062933 113062936 113077208
CGIB: 127939007 127939011 127939012 127944356 127944764 127956825
PTET: 122325384 122325385 122325386
LROH: 127163996 127182750 127182753 127182754 127182755
OMC: 131526777 131526778 131538917
PPRM: 120493435 120495341
RKG: 130070236 130091794
MAMB: 125271930 125277848 125277849 125277850 125277851 125277854 125277856
CIDE: 127502658
CERY: 137018370 137018936 137018939 137018940 137018941
MASI: 127415948
TROS: 130565655
TDW: 130434345
MANU: 129429259 129429260
AMEX: 103037239 125803022
CMAO: 118815408 118815409
EEE: 113568096 113586377
CHAR: 105900861 105900876
TRU: 101075700
TFS: 130529142
LCO: 104930795 104930796
CGOB: 115007060
PGEO: 117455593
GACU: 117556494
EMAC: 134864748
ELY: 117253502 117253503 117253504
EFO: 125895935 125895937 125895938
PLEP: 121939575 121939585
SLUC: 116063278
ECRA: 117950841
ESP: 116695040 116695044
PFLV: 114560939
PPUG: 119216714
AFB: 129094823
CLUM: 117729246
PSWI: 130194467
MSAM: 119900968 119900969 119900982 119901367
SCHU: 122878258
CUD: 121511981 121511983 121511984 121511985
ALAT: 119028085 119028086 119028087 119028088 119028090
MZE: 101469747 101471484 101471776 101472450 101472746 101473039 101473341 101473625 101474137 112429716 112430356 112430410
ONL: 100699361 100699634 100699898 100700165 100700439 100700441 100700978 100701255 100701799 109194408 109196838 109196840
OAU: 116315351 116327896 116327898 116331077 116331078 116331079 116331081 116331082 116331187 116331213 120436259 120436353
OLA: 100302452(cyp2p3) 105353996
OML: 112138317 112150360 112150361 112150362 118597890
CSAI: 133458178 133458179 133458180 133458188
XMA: 102216555 102216815 102224544 102235118 102238098 102238367
XCO: 114150919 114150920 114150922
XHE: 116725631 116725632 116725633 116725634 116725636 116725637 116725638 116725642 116725644
PRET: 103461257 103463736 103463738 103463739
PFOR: 103137021 103137022 103137164 103137165
PLAI: 106949663 106949692 106949693 106949694 106961243 106961249
PMEI: 106908422 106908423 106917754 106917779 106917780
GAF: 122838407 122838408 122838409 122838410 122838411
PPRL: 129377269 129377278 129377282 129377290
CVG: 107095777 107099581
CTUL: 119777086 119790019 119790034
GMU: 124873252 124873920
NFU: 107395372 107395373
KMR: 108230681 108230682 108230683 108230684 108230685
ALIM: 106517296 106517297 106517298
NWH: 119421487 119430737
AOCE: 111563453 111564682 111564718 111564989 111564993 111586280 111586281 111586282
MCEP: 125009824 125009825 125009826 125009827 125009828 125009830 125009831 125009832 125009834
CSEM: 103383190
POV: 109625616
SSEN: 122777824 122777825
HSP: 118121284
LCF: 108879066 108879067
SDU: 111232055 111232106
SLAL: 111653766 111656353
BPEC: 110173990
BSPL: 114852938 114853161 114853162 114853163 114854720 114854721 114854722 114854723
SASA: 106584062
STRU: 115157896 115192271
OTW: 112250281
OMY: 110521776
OGO: 124038052
ONE: 115145370
OKI: 109898106
OKE: 118358831
SALP: 111971193
SNH: 120052641
CCLU: 121533858
ELS: 105025359
SFM: 108923501 108923503 108927875 108934003 108935367 108935464 114909092 114911247 114911248 114911249 114911250 114911251 114911252 114911257 114911278
PKI: 111834855 111834857 111834858 111834859
AANG: 118224796 118224797 118224802
PSPA: 121327058 121330919
ARUT: 117409945 117409954 117417241 117417316
PSEX: 120514265 120514266 120514351 120514536 120514588 120514690 120514765
CMK: 103185273
RTP: 109921744
LERI: 129700975
PMRN: 116942349 116949610
LRJ: 133347001 133347343
BFO: 118405297 118407101 118419304 118428418 118429635 118432366
BBEL: 109461524 109461651 109461725 109461727 109462264 109465453 109465656 109466367 109467919 109471284 109472128 109472267 109472270 109475266 109477936 109480295 109482013 109482167 109483920 109483935 109483947 109483948 109485002
SCLV: 120333811 120334172 120334246 120343352
LPIC: 129255057 129255413 129259914 129260274 129261294 129263280 129267050 129267667 129272440 129272952 129272957 129273267 129274630 129276166 129276247 129281166 129281317 129281383 129281480 129281481 129281482 129281553 129282251
ARUN: 117287782 117288024 117288160 117288161 117288273 117288601 117289770 117294724 117298615 117299860 117299861 117301387 117303760 117304080 117304753 117304847 117304890 117305170 117307185
AJC: 117111890 117111891
BCOO: 119083310
PVM: 113807691
PJA: 122242547 122243682 122252347 122252348 122259834 122259836 122260679 122263851
PCHN: 125037284 125037285 125037286 125037288 125037553 125040652 125047318 125047985
HAME: 121853159 121857091 121874841
PCLA: 123746738 123751553 123756377 123767033 123767752 123770238 123770240
CQD: 128685195 128686126 128686746 128693801 128694775 128697090 128703751 128704994
PTRU: 123506617 123506674
ESN: 126984741 126987539 126992673
MNZ: 135202400 135214473 135220037 135223714
HAZT: 108665745 108667157 108667158 108674876 108676835
EAF: 111695177 111696904 111696905 111698334 111704925 111704939 111706377 111709242 111713706 111717082 111717477 111718077
LSM: 121115047 121119889 121121717
TCF: 131880430 131880431 131881008 131883247 131884276 131893305
PPOI: 119091992 119095707 119101079 119101087 119101104 119101111 119101120 119101130 119104411 119109569
DSV: 119441628 119457522 119461188 119461547 119462117
RSAN: 119374231 119383506 119383507 119386647 119390617 119397387 119406751
RMP: 119166963 119169660 119171404 119173720
VDE: 111244479
VJA: 111272117
CVS: 136969341 136972707
ABRU: 129957692 129964081 129964121 129968576 129968577 129972410 129972618 129973475 129973840 129980922
UDV: 129220639 129220886 129229762 129233369 129234350
SDM: 118180345 118189454 118190843 118190848 118202040 118203101 118206070
LPOL: 106459164 106475453
PMEO: 129583244 129584069 129586991 129587294 129588909 129588911 129590632 129591781 129596265 129598004 129599617 129599629 129599630 129600908 129600978 129600979 129600986
PVUL: 126809973 126810313 126811410 126811411 126811412 126811413 126811418 126825321 126832216
BGT: 106054491 106054493 106055467 106057592 106057638 106059997 106060000 106070555 106074975
GAE: 121374745 121382078
HRF: 124113283 124118458 124118459 124140343 124140344 124144343 124144711 124147838 124147839 124147840 124152329
HRJ: 124261308 124267336 124267348 124279341 124281198 124281746 124290622 124290663 124291032 124291033 124291034
CRG: 105329932 105332463 105333819 117689293 117689294
CANU: 128155298 128176608 128181027 128188649
CVN: 111108895 111110523 111110669 111122683 111123229 111128037 111132556
OED: 125650159 125650617 125651484 125651530 125652691 125652692 125652694 125652695 125654191 125656391 125681271 125683308 130046407 130054718
PMAX: 117316069 117343471
MCAF: 127723994
MMER: 123543547 123558935
RPHI: 132718487 132725871 132732507 132737309 132749504
DPOL: 127856874 127856875 127866967 127866970 127872507
MAEA: 128209932 128232792 128233722
OSN: 115217140 115217142 115220404 115224293 115227007 115232209
LJP: 135476777 135481015
LLON: 135489098 135494781 135498002 135500702 135503101
XEN: 124445682
 » show all
Reference
PMID:1717443 (CYP2J1)
  Authors
Kikuta Y, Sogawa K, Haniu M, Kinosaki M, Kusunose E, Nojima Y, Yamamoto S, Ichihara K, Kusunose M, Fujii-Kuriyama Y
  Title
A novel species of cytochrome P-450 (P-450ib) specific for the small intestine of rabbits. cDNA cloning and its expression in COS cells.
  Journal
J Biol Chem 266:17821-5 (1991)
  Sequence
[ocu:100301544]
Reference
PMID:8631948 (CYP2J2)
  Authors
Wu S, Moomaw CR, Tomer KB, Falck JR, Zeldin DC
  Title
Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart.
  Journal
J Biol Chem 271:3460-8 (1996)
DOI:10.1074/jbc.271.7.3460
  Sequence
[hsa:1573]
Reference
PMID:9139707 (CYP2J3)
  Authors
Wu S, Chen W, Murphy E, Gabel S, Tomer KB, Foley J, Steenbergen C, Falck JR, Moomaw CR, Zeldin DC
  Title
Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes.
  Journal
J Biol Chem 272:12551-9 (1997)
DOI:10.1074/jbc.272.19.12551
  Sequence
[rno:313375]
Reference
PMID:9570962 (CYP2J5)
  Authors
Ma J, Ramachandran S, Fiedorek FT Jr, Zeldin DC
  Title
Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4.
  Journal
Genomics 49:152-5 (1998)
DOI:10.1006/geno.1998.5235
  Sequence
[mmu:13109]
Reference
PMID:10065373
  Authors
Scarborough PE, Ma J, Qu W, Zeldin DC
  Title
P450 subfamily CYP2J and their role in the bioactivation of arachidonic acid in extrahepatic tissues.
  Journal
Drug Metab Rev 31:205-34 (1999)
DOI:10.1081/DMR-100101915

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (14)   
   KEGG PATHWAY (14)   
Chemical reaction (20)   
   KEGG ENZYME (4)   
   KEGG REACTION (11)   
   KEGG RCLASS (5)   
Gene (3786)   
   KEGG GENES (1247)   
   KEGG MGENES (51)   
   RefGene (2478)   
   OC (10)   
Literature (5)   
   PubMed (5)   
All databases (3828)   

Download RDF
KEGG   ORTHOLOGY: K07413
Entry
K07413                      KO                                     
Symbol
CYP2C
Name
cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map01100  Metabolic pathways
map04726  Serotonergic synapse
map04750  Inflammatory mediator regulation of TRP channels
map05204  Chemical carcinogenesis - DNA adducts
Reaction
R03408  
R07042  
R07043  
R07048  
R07050  
R07051  
R07052  
R07054  
R07055  
R07056  
R08390  
R08392  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
   00590 Arachidonic acid metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
   00591 Linoleic acid metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07413  CYP2C; cytochrome P450 family 2 subfamily C
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07413  CYP2C; cytochrome P450 family 2 subfamily C
Genes
PON: 100449185
PPYG: 129006201
MCC: 100424240(CYP2C76)
MCF: 102114994(CYP2C76) 135965165
MTHB: 126962035 126962036
MNI: 105470210
CATY: 105576142 105581754
PANU: 101012275 101026117
TGE: 112631566
MLEU: 105553702 105553718
RRO: 104664669 104664684
RBB: 108543807 108543808
TFN: 117069747 117069809
PTEH: 111538683 111538726
CANG: 105527570
CJC: 100391987
SBQ: 101040831
CIMI: 108282285(CYP2C76)
ANAN: 105708280(CYP2C76)
CSYR: 103250328 103254835 103255987 103265697 103270233 103277163 110596230
MMUR: 105872488 105873460
LCAT: 123650042 123650046 123650138
PCOQ: 105818461 105824363
OGA: 100941342 100944925 100949727
MMU: 100043108(Cyp2c69) 107141(Cyp2c50) 13095(Cyp2c29) 13096(Cyp2c37) 13097(Cyp2c38) 13098(Cyp2c39) 13099(Cyp2c40) 226105(Cyp2c70) 226143(Cyp2c23) 404195(Cyp2c54) 433247(Cyp2c68) 545288(Cyp2c67) 69888(Cyp2c66) 72082(Cyp2c55) 72303(Cyp2c65)
MCAL: 110285234 110285299 110285416 110285739 110286013 110288497
MPAH: 110318652 110321409 110323738 110329470 110333565
RNO: 100361492(Cyp2c55) 100361547(Cyp2c7l1) 100911718 100912265(Cyp2c66) 120093077 120098584 134483996 134485234 171518(Cyp2c22) 171521(Cyp2c13) 25011(Cyp2c12) 29277(Cyp2c11) 29298(Cyp2c7) 293989(Cyp2c6v1) 499353(Cyp2c24) 83790(Cyp2c23)
MCOC: 116072985 116072994 116101173 116103883
ANU: 117695924 117704125 117704160 117707817 117707833 117710720 117710944 117711779 117712125 117714049 117714760 117715357
MUN: 110540047 110540048 110540049 110540723 110541031 110541449 110546312 110552973 110554760
CGE: 100751491 100751762 100751778 100752064 100752358 100753681 100754177 100754462 100756757 100757240 100757723 100772776 100773851 113830663 113834830
MAUA: 101823450 101829294 101830378 101831088 101831527 101832144 101832611 101841752 101842021
PROB: 127233403 127233429 127233439 127233441 127233442 127233443 127233444
PLEU: 114687277 114687280 114702470 114706456 114706863 114706876 114706883 114706891 114706892
MORG: 121453776 121453777 121453779 121453780 121453915 121453926 121453935 121453936 121453949 121453973 121453987 121453988 121453999 121454098 121454106 121454325 121454361 121454788
MFOT: 126503086 126511077 126511085
AAMP: 119808112 119808461 119808473 119808480 119808972 119811688 119814029 119818815 119824915 119824922
NGI: 103729081 103732440 103732443 103732444 103732445 103732447 103744062 103749112 103752530
HGL: 101708592 101710990
CPOC: 100716044 100719102
CCAN: 109675594 109686866 109686867
DORD: 105999354 105999358 105999359 105999360 105999362 105999363 105999364 105999365 105999366 106001658 106001659 106001669
DSP: 122115684 122115686 122115687 122115688 122115689 122115690 122115692 122115694 122115695 122115696 122115698 122115699 122115821 122115856 122115857
PLOP: 125342134 125346230 125346232 125346233 125346234 125346235 125346236 125346238 125346239 125346241 125346243
NCAR: 124984664 124984711 124984718 124984740 124984981 124985051 124985100 124985193 124985263 124985323 124985911 124985912 124985914
MMMA: 107149731 107149732 107149742 107149743
OCU: 100328549(CYP2C5) 100328924(CYP2C2) 100328933(CYP2C) 100328935(CYP2C30) 100328936(CYP2C14) 100328938(CYP2C16) 100345193 100346305 100346743(CYP2C1) 100349436(CYP2C4) 100353460 103351405
OPI: 101519662 101519910 101520157 101520641 101524854 101525811 101526220 101526786 101527195 101527783 101528381 101528927 101529516 101529922
TUP: 102467726 102501371 102503066
GVR: 103609510 103609514 103609927 103610437 103610588
CFA: 100688697 415122(CYP2C18)
CLUD: 112672099 112672554 112672584
VVP: 112917651 112917654 112928780
VLG: 121484666 121485285 121485560
NPO: 129493642 129493856 129493884
AML: 100468534 100470213 100471407
UMR: 103659697 103670756
UAH: 113243099 113251748 125282749
UAR: 123777781 123783991 123783992 123783994 123791300 123800006 123800347
ELK: 111144935 111144947
LLV: 125085077 125085209
MPUF: 101687589 101688450
MNP: 132016643 132016644
MLK: 131828623 131828625
NVS: 122898982 122898983
ORO: 101365057 101365655 101383285
EJU: 114205328 114205474 114221836
ZCA: 113919561 113923367 113923499
MLX: 118024006 118024011
NSU: 110589090 110589295
LWW: 102741683 102742186
FCA: 101089396(CYP2C41) 101089804
PYU: 121037024 121037025
PCOO: 112854419 112854424
PBG: 122493051 122493053
PVIV: 125148038 125148039
LRUF: 124506212 124507012
PTG: 102957879 102958169
PPAD: 109264681 109264682
PUC: 125932819 125933400
AJU: 106965832 106965834
HHV: 120230588 120230589 120230594
BTA: 505468(CYP2C88) 510380(CYP2C89) 511498(CYP2C23) 535243(CYP2C90) 616593(CYP2C87) 785540(CYP2C281)
BOM: 102266046 102268262 102279786 102280731 102282716 102285833
BIU: 109553136 109553148 109553149 109553151 109553186 109579059
BBUB: 102391944 102392701 102398418 102401059 102401347
BBIS: 104983529 104983530 104985773 104990182 104990186 105002722
CHX: 100861186 102169851 102180722 102185708 102185739 102188304 106503891 108633308
OAS: 100534653(CYP2C19) 100568290(CYP2C18) 101106641 101107056 101107486 101120535
BTAX: 128067928 128067935 128067944 128067982 128067983 128067984 128068009
ODA: 120873493 120873494 120873527 120873718 120873719 120873724
CCAD: 122446106 122446108 122446110 122446562 122446680 122446729 122446733
MBEZ: 129555150 129555520 129555964 129555969 129555971 129555972 129555974 129555975
SSC: 100739741 403106(CYP2C32) 403107(CYP2C33) 403108(CYP2C34) 403110(CYP2C36) 403111(CYP2C42) 403215(CYP2C49)
CFR: 102505530 102520553 102520945 102521185 102521601
CBAI: 105081748 105081809 105081810 105081811 105081813
CDK: 105084249 105084251 105084253 105084254 105084313
VPC: 102533247 102534924 102535318 102535571 102541494
BACU: 103017669
BMUS: 118882389
LVE: 103084494
OOR: 101280390 101281073
DLE: 111172397
PCAD: 102978514 102990258
PSIU: 116741310 116741704
NASI: 112392977
ECB: 100061367 100061400 100061440(CYP2C92) 100061470 100061502 100061579(CYP2C113) 100061609 100070400
EPZ: 103555431 103555432 103559687 103559691 103563727 103564575
EAI: 106828038 106842115 106842116 106842117 106842118 106846082 106846096 106846703
MYB: 102259201 102262062
MYD: 102757298 102761651
MMYO: 118669861 118669862 118669933 118669936
MLF: 102425332 102439008 102439973
MDT: 132214162 132214163 132214164 132214227
PKL: 118719320 118719322 118719385
EFUS: 103288419 103288420 103288471
MNA: 107542552 107542558 107543271
DRO: 112300219
SHON: 118988005 118999525
AJM: 119064549
PDIC: 114496070 114496071 114496072 114497455
PHAS: 123828810 123828873 123829140 123829141 123829142
MMF: 118632032 118632707
PPAM: 129077061 129077108
HAI: 109379576 109380905 109380969 109380970
RFQ: 117036205 117036207 117036211 117036262 117036412
PALE: 102891905
PGIG: 120608941 120609277 120609279
PVP: 105301394
MJV: 108409895
TOD: 119234464 119234519
SARA: 101538594 101538863 101539126 101539748 101540186 101541249 101541695 101542671 101545907 101546049 101546518 101547469 101548282 101548987 101549253 101549522 101550043 105943477
SETR: 125994861 125994862 125994864 126033411 126033848
LAV: 100666635 100675653 100676133 100676880
TMU: 101340781 101346446 101346874 101350013 101350258
ETF: 101650213 101650523 101655109 101655637 101655958
DNM: 101414777 101433008 101433204 101434138 101434218 101435423 101436676 101437101 101437727
MDO: 100020348 100023149 100023204 100023235 100026569 100026598 100026618 100026637 100028608
GAS: 123232993 123233004 123233006 123236366 123236629 123238227 123238228 123238230 123238233 123238234 123238235 123238257
SHR: 100915447 100918856 100919120 100920607 100927632 100928062 100933015 100933766
AFZ: 127551720 127551721 127551783 127552019 127552033 127552034
PCW: 110192769 110200600 110200601 110213986 110215468
TVP: 118828026 118828039 118828040 118828042 118828043 118828044 118828045 118828046 118828051 118828056 118828058 118828060 118828118 118828175 118828284 118828583 118828771 118828830 118830249 118830250 118859159
GGA: 100858007(RP11-400G3.5) 414833(CYP2C45)
PCOC: 116234486
MGP: 100544448
CJO: 107315788
TPAI: 128077571 128077572 128077573
LMUT: 125694067 125694068 125694069 125694070 125694071
NMEL: 110399446
APLA: 101797318 101805432 113844003
ACYG: 106034197 106046725
CATA: 118243351 118255579
AFUL: 116491444 116491640 116491641 116491642 116496669
TGU: 100219254 100228872
LSR: 110475152 110480306
SCAN: 103813978 103819903
PMOA: 120499733
OTC: 121338316 121341821
PRUF: 121354193 121357631
GFR: 102041497 102043152
FAB: 101806491 101815619
OMA: 130255070 130260372
PHI: 102100933 102107291
PMAJ: 107207028 107212622
CCAE: 111931097 111937179
CCW: 104695623 104697085
CBRC: 103613784 103624459
ETL: 114065370
ZAB: 102067353 102073503 102074741
ZLE: 135449336 135455550 135460995
ACHL: 103805798
SVG: 106855352 106862297
MMEA: 130581013
HRT: 120748109
SATI: 136364239 136369197 136369528
FPG: 101913238 101916760
FCH: 102048002 102059256
CCRI: 104159509 104168852
NNT: 104399782 104405230
SHAB: 115608667 115608730 115608831 115616648
ACUN: 113481765 113486792
TALA: 104360444 104363792
ACHC: 115341565 115348476
HALD: 104315668
HLE: 104831888
AGEN: 126042554 126043766
GCL: 127017485 127023938
CSTI: 104561375
LDI: 104343172 104353803
MNB: 103771400
DPUB: 104297684 104301981
AVIT: 104273142
BRHI: 104492082
EGZ: 104125355 104129118
NNI: 104010978 104018935
PCRI: 104034656 104037972
PCAO: 104045589 104049798
PADL: 103915567 103918695
AFOR: 103897610 103903595
FGA: 104073873 104081578
GSTE: 104260632 104264065
CLV: 102087915 102098038
MUI: 104534424
PGUU: 104461775 104467274
PLET: 104623081 104626155
EHS: 104504230 104516609
CMAC: 104476783
CUCA: 104060040 104060777 104067911
TEO: 104374656
BREG: 104630155 104637583
OHA: 104329922
ACAR: 104529274
CPEA: 104391477 104398212
CVF: 104281946 104289750
RTD: 128911029 128911351 128911515 128911560 128911561 128917900
AAM: 106498947 106499405
AROW: 112961017 112970877
NPD: 112950986 112956875
TGT: 104566795
DNE: 112980237 112995565
SCAM: 104141787 104143382
ASN: 102372575 102385966 102386218
AMJ: 102572949 102573559 102573618
CPOO: 109315166
GGN: 109287335 109287406
CMY: 102931882
CCAY: 125621101
DCC: 119842814 119847395
CPIC: 101945572 101950120
TST: 117887460 117888580 117888938
CABI: 116822417 116822898
MRV: 120382954 120388953
ACS: 100552964 100554667 100560019 100561903 100562097 100562300 100562499 100565059
ASAO: 132761864 132761881 132763575 132764077 132768594 132769293 132780888 132781058 132781361 132781421 132781507 132781595 132781659 132781729
PVT: 110070438 110084010 110090724
SUND: 121915628 121918763 121918778 121918807 121927308 121927315
PBI: 103054127 103067414
PMUR: 107286792 107296151
CTIG: 120296915 120298505 120298506 120317803
TSR: 106538299
PGUT: 117659140
APRI: 131190555 131190557
PTEX: 113435173 113437257
NSS: 113414159 113426274
VKO: 123035026 123035029
PMUA: 114590635 114590640 114590645 114590724 114590725 114590727 114590728
PRAF: 128407548 128407555 128407562 128407576 128407585 128407593 128407603 128407604 128408551
ZVI: 118079426 118079919 118079920 118079922 118080863 118080874
HCG: 128343349
EMC: 129324116
XLA: 108699286 379297(cyp2a6.1.S) 444542(cyp2c8.2.L)
XTR: 448236(cyp2c8.2)
NPR: 108800780
RTEM: 120913341 120936065 120936220
BBUF: 120978128 121009418
BGAR: 122923772 122923881 122940043 122941761 122945938 122946510
CPLA: 122542870
HOC: 132836798
LERI: 129714142 129714143
LRJ: 133341215 133341226
BFO: 118416246
BBEL: 109470437
SCLV: 120338348 120339246 120345724 120346076
MNZ: 135219059
HAZT: 108665260
DSV: 119449464 119459204
RSAN: 119373421
PMEO: 129596816 129596855
HRF: 124113633
HRJ: 124262364 124281202 124291019
CRG: 105333836
CANU: 128179353
CVN: 111099468 111099985 111137423
RPHI: 132743744
OSN: 115231110
LJP: 135468420 135468424
AG: AAC08738(CYP2C41) BAA02001(CYP2C26) BAA02002(CYP2C27) BAA02003(CYP2C28) CAA44753(CYP2C25)
 » show all
Reference
PMID:2831965 (CYP2C2)
  Authors
Imai Y, Komori M, Sato R
  Title
Comparison of primary structures deduced from cDNA nucleotide sequences for various forms of liver microsomal cytochrome P-450 from phenobarbital-treated rabbits.
  Journal
Biochemistry 27:80-8 (1988)
DOI:10.1021/bi00401a014
  Sequence
[ocu:100328924]
Reference
PMID:3335521 (CYP2C7)
  Authors
Kimura H, Yoshioka H, Sogawa K, Sakai Y, Fujii-Kuriyama Y
  Title
Complementary DNA cloning of cytochrome P-450s related to P-450(M-1) from the complementary DNA library of female rat livers. Predicted primary structures for  P-450f, PB-1, and PB-1-related protein with a bizarre replacement block and their mode of transcriptional expression.
  Journal
J Biol Chem 263:701-7 (1988)
  Sequence
[rno:29298]
Reference
PMID:8611037 (CYP2C11)
  Authors
Biagini C, Celier C
  Title
cDNA-directed expression of two allelic variants of cytochrome P450 2C11 using COS1 and SF21 insect cells.
  Journal
Arch Biochem Biophys 326:298-305 (1996)
DOI:10.1006/abbi.1996.0079
  Sequence
[rno:29277]
Reference
PMID:2820951 (CYP2C14)
  Authors
Imai Y
  Title
Cytochrome P-450 related to P-4504 from phenobarbital-treated rabbit liver: molecular cloning of cDNA and characterization of cytochrome P-450 obtained by its expression in yeast cells.
  Journal
J Biochem 101:1129-39 (1987)
DOI:10.1093/oxfordjournals.jbchem.a121977
  Sequence
[ocu:100328936]
Reference
PMID:2263487 (CYP2C23)
  Authors
Cook EA, Groenewegen WA, Gloger IS, Piggott JR, Suckling KE, Wolf CR
  Title
cDNA and deduced amino acid sequence of a novel cytochrome P-450 from female rat liver mRNA with high homology to P-450 IIC family.
  Journal
Nucleic Acids Res 18:7156 (1990)
DOI:10.1093/nar/18.23.7156
  Sequence
[rno:83790]
Reference
PMID:8114672 (CYP2C25 CYP2C26 CYP2C27)
  Authors
Sakuma T, Masaki K, Itoh S, Yokoi T, Kamataki T
  Title
Sex-related differences in the expression of cytochrome P450 in hamsters: cDNA cloning and examination of the expression of three distinct CYP2C cDNAs.
  Journal
Mol Pharmacol 45:228-36 (1994)
  Sequence
[ag:CAA44753 BAA02001 BAA02002]
Reference
PMID:7771794 (CYP2C28)
  Authors
Sakuma T, Yokoi T, Kamataki T
  Title
Isolation and characterization of a new cDNA clone belonging to the cytochrome P450 2C gene subfamily in hamsters.
  Journal
Arch Biochem Biophys 319:267-73 (1995)
DOI:10.1006/abbi.1995.1291
  Sequence
[ag:BAA02003]
Reference
PMID:8130255 (CYP2C29)
  Authors
Matsunaga T, Watanabe K, Yamamoto I, Negishi M, Gonzalez FJ, Yoshimura H
  Title
cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2, a microsomal aldehyde oxygenase.
  Journal
Biochim Biophys Acta 1184:299-301 (1994)
DOI:10.1016/0005-2728(94)90237-2
  Sequence
[mmu:13095]
Reference
PMID:9721182 (CYP2C37)
  Authors
Luo G, Zeldin DC, Blaisdell JA, Hodgson E, Goldstein JA
  Title
Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid.
  Journal
Arch Biochem Biophys 357:45-57 (1998)
DOI:10.1006/abbi.1998.0806
  Sequence
[mmu:13096]
Reference
PMID:9492393 (CYP2C41)
  Authors
Blaisdell J, Goldstein JA, Bai SA
  Title
Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression.
  Journal
Drug Metab Dispos 26:278-83 (1998)
  Sequence
[ag:AAC08738]
Reference
PMID:15102943 (CYP2C50)
  Authors
Wang H, Zhao Y, Bradbury JA, Graves JP, Foley J, Blaisdell JA, Goldstein JA, Zeldin DC
  Title
Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities.
  Journal
Mol Pharmacol 65:1148-58 (2004)
DOI:10.1124/mol.65.5.1148
  Sequence
[mmu:107141]
Reference
PMID:2263625 (CYP2C70)
  Authors
Emi Y, Chijiiwa C, Omura T
  Title
A different cytochrome P450 form is induced in primary cultures of rat hepatocytes.
  Journal
Proc Natl Acad Sci U S A 87:9746-50 (1990)
DOI:10.1073/pnas.87.24.9746
  Sequence
[rno:171518]

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (16)   
   KEGG PATHWAY (16)   
Chemical reaction (20)   
   KEGG ENZYME (1)   
   KEGG REACTION (12)   
   KEGG RCLASS (7)   
Gene (1111)   
   KEGG GENES (966)   
   KEGG MGENES (93)   
   RefGene (50)   
   OC (2)   
Literature (12)   
   PubMed (12)   
All databases (1162)   

Download RDF
KEGG   ORTHOLOGY: K07428
Entry
K07428                      KO                                     
Symbol
CYP4X
Name
cytochrome P450 family 4 subfamily X [EC:1.14.14.1]
Pathway
map04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K07428  CYP4X; cytochrome P450 family 4 subfamily X
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07428  CYP4X; cytochrome P450 family 4 subfamily X
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07428  CYP4X; cytochrome P450 family 4 subfamily X
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP4 family
   K07428  CYP4X; cytochrome P450 family 4 subfamily X
Genes
HSA: 260293(CYP4X1)
PTR: 456833(CYP4X1)
PPS: 100978561(CYP4X1)
GGO: 101141065
PON: 100441499
PPYG: 129041220
NLE: 100580500
HMH: 116473121
SSYN: 129468837
MCC: 709535
MCF: 102125667(CYP4X1)
MTHB: 126961403
MNI: 105494982
CSAB: 103224873(CYP4X1)
CATY: 105571708
PANU: 101014098
TGE: 112621265
MLEU: 105536683
RRO: 104662102
RBB: 108529622
TFN: 117092642
PTEH: 111548793
CANG: 105515243
CJC: 100413928(CYP4X1)
SBQ: 101042931
CIMI: 108312794(CYP4X1)
ANAN: 105705111(CYP4X1)
CSYR: 103249749
MMUR: 105877512
LCAT: 123634165
PCOQ: 105814051
OGA: 100958138
MMU: 81906(Cyp4x1)
MCAL: 110293095
MPAH: 110322973
RNO: 246767(Cyp4x1)
MCOC: 116096432
ANU: 117708828
MUN: 110542842
CGE: 100766854
MAUA: 101823991
PROB: 127225181
PLEU: 114706699
MORG: 121448317
MFOT: 126497995
AAMP: 119816746
NGI: 103732815
HGL: 101706848
CPOC: 100715178
CCAN: 109679796
DORD: 105986095
DSP: 122108548
PLOP: 125355119
NCAR: 124992327
MMMA: 107141791
OCU: 100338914
OPI: 101531303 101531548
TUP: 102472827
GVR: 103595376
CFA: 482505(CYP4X1)
CLUD: 112642528
VVP: 112914748
VLG: 121481290
NPO: 129520787
AML: 100471717
UMR: 103670744
UAH: 113254711
UAR: 123793726
ELK: 111143307
LLV: 125098946
MPUF: 101672065
MNP: 132000829
MLK: 131809735
NVS: 122899940
ORO: 101379970
EJU: 114212146
ZCA: 113912514
MLX: 118019452
NSU: 110575026
LWW: 102725996
FCA: 101096906(CYP4X1)
PYU: 121027070
PCOO: 112872103
PBG: 122480468
PVIV: 125172293
LRUF: 124516047
PTG: 102968150
PPAD: 109266929
PUC: 125912636
AJU: 106973491
HHV: 120227404
BTA: 100847677
BOM: 102270361 102274990
BIU: 109557089
BBUB: 102410132
BBIS: 104984606
CHX: 102174897
OAS: 101106121
BTAX: 128045296
ODA: 120856187
CCAD: 122437017
MBEZ: 129541059
SSC: 100627093 110255328
CFR: 102523731
CBAI: 105065850
CDK: 105092931
VPC: 102540367
ECB: 100051552(CYP4X1)
EPZ: 103565687
EAI: 106833866
MYB: 102262973
MYD: 102768850
MMYO: 118675010
MLF: 102417369
MDT: 132231119
PKL: 118724856
EFUS: 103284047
MNA: 107526777
DRO: 112314510 112314512
SHON: 118985056
AJM: 119039830
PDIC: 114496555
PHAS: 123823289 123830945
MMF: 118626315
PPAM: 129069988
HAI: 109371958
RFQ: 117026837
PALE: 102895522
PGIG: 120620411
PVP: 105297195
RAY: 107514032
MJV: 108404960
TOD: 119237233
SARA: 101550807
SETR: 126011096
LAV: 100672903
TMU: 101345691
ETF: 101652047
DNM: 101423706
MDO: 100023529
GAS: 123247492
SHR: 100930522 100930785
AFZ: 127563363 127563364
PCW: 110209311
TVP: 118846636
CANU: 128183126
CVN: 111138426
MAEA: 128208438
 » show all
Reference
PMID:12176035 (CYP4X1)
  Authors
Bylund J, Zhang C, Harder DR
  Title
Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain.
  Journal
Biochem Biophys Res Commun 296:677-84 (2002)
DOI:10.1016/S0006-291X(02)00918-X
  Sequence
[rno:246767]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (187)   
   KEGG GENES (155)   
   KEGG MGENES (5)   
   RefGene (20)   
   OC (7)   
Literature (1)   
   PubMed (1)   
All databases (194)   

Download RDF
KEGG   ORTHOLOGY: K07414
Entry
K07414                      KO                                     
Symbol
CYP2D
Name
cytochrome P450 family 2 subfamily D [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map04726  Serotonergic synapse
Reaction
R03408  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07414  CYP2D; cytochrome P450 family 2 subfamily D
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K07414  CYP2D; cytochrome P450 family 2 subfamily D
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07414  CYP2D; cytochrome P450 family 2 subfamily D
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07414  CYP2D; cytochrome P450 family 2 subfamily D
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07414  CYP2D; cytochrome P450 family 2 subfamily D
Genes
MMU: 13101(Cyp2d10) 13105(Cyp2d9) 223706(Cyp2d34) 380997(Cyp2d12) 545123(Cyp2d11) 56448(Cyp2d22) 68444(Cyp2d13) 71754(Cyp2d40) 76279(Cyp2d26)
MCAL: 110288527 110288999 110289146 110310240 110310283 110310469 110310542
MPAH: 110334675 110334761 110334795 110334832 110334835 110334854 110334866 110334867 110334914
RNO: 171522(Cyp2d4) 24303(Cyp2d3) 25053(Cyp2d2) 266684(Cyp2d1) 286963(Cyp2d5)
MCOC: 116076713 116081639 116104676
ANU: 117718541 117718592 117718616 117718617 117718815 117718837 117719282 117719283 117719285
MUN: 110552077 110552090 110552092 110554094 110554095 110554097 110554122 132646027 132655789
CGE: 100750508 100771066 100774408 100774698
MAUA: 101840984 110340366 121142578 121142579 121142580
PROB: 127225857 127225862 127225863
PLEU: 114688909 114689233 114689234 114694310 114694323 114694324 114694388
MORG: 121461043 121461044 121461045 121461047 121461174 121461196 121461216 121461217 121461277 121461358
MFOT: 126492060 126492074 126492078 126492091 126492101 126492113 126492121
AAMP: 119823022 119823023 119823024 119823025 119823027 119823028 119823358
NGI: 103743450 103743452 103743453 103743454 103743455 103743515
HGL: 101722985 101723802 101724171 101724763
CPOC: 100169696(Cyp2d16) 100714485 100715041 100715321 100715799 100716263 100716545 100717002 100717652 100717930 100718401 100718679 100718953 100719230 100719511 100722262 100722818
DORD: 105992055 105992057 105992059
DSP: 122123535 122123536 122123537 122123538 122123539
PLOP: 125357495 125357505 125357517 125357560
NCAR: 124982053 124982056
MMMA: 107134215 107134216 107155828
OCU: 100316858(CYP2D24) 100348527
OPI: 101535122 101535375 101535547
TUP: 102487958
CFA: 415120(CYP2D15)
CLUD: 112666661
VVP: 112934002
VLG: 121490798
NPO: 129511717
AML: 100472452
UMR: 103674066
UAH: 113241702
UAR: 123780676
ELK: 111157504
LLV: 125106071
MPUF: 101672586
MNP: 132020449
MLK: 131839562
NVS: 122891125
ORO: 101372264
EJU: 114218371
ZCA: 113921588
NSU: 110578248
FCA: 100500743(CYP2D6)
PYU: 121040241
PCOO: 112863693
PBG: 122472841
PVIV: 125171245
LRUF: 124501756
PTG: 102964225(CYP2D6)
PPAD: 109265656
PUC: 125920374
AJU: 106979940
HHV: 120234310
BTA: 282211(CYP2D14) 785824(CYP2D43)
BOM: 102287765
BIU: 109559878 109559879
BBUB: 102406860 102410630
BBIS: 104991248
CHX: 102169002 102177333 102179192 108634669
OAS: 100568286(CYP2D6) 101112384 114114084 114114086
BTAX: 128047526 128047527 128047529 128047530 128048265 128048268 128048328 128048332
ODA: 120859250 120859306
CCAD: 122423707
MBEZ: 129536920 129537031
SSC: 397687(CYP2D25)
CFR: 102510557
CBAI: 105073057
CDK: 105091879
VPC: 102542551
BACU: 103007607
BMUS: 118902635
OOR: 101276966
DLE: 111186231
PCAD: 102987821
PSIU: 116760501
NASI: 112394613
ECB: 100056087 100070895 100070905 100070945(CYP2D50) 100070962 100070990 100146596 100147428 100147480
EPZ: 103542204 103543525 103544255
EAI: 106845102 106845104 106848497 106848498 106848499 106848501
MYB: 102241505
MYD: 102753093
MMYO: 118651850 118651851
MLF: 102419632 102420161 102420688
MDT: 132225850 132225851 132225852
PKL: 118712077 118712078
EFUS: 129149863 129149865
MNA: 107534962
DRO: 112321792
SHON: 119002464
AJM: 119060173
PDIC: 114512883
PHAS: 123816041
MMF: 118624451
PPAM: 129077874
HAI: 109371456
RFQ: 117029426 117029427
PALE: 102886763
PGIG: 120602932
PVP: 105298024
RAY: 107505566
TOD: 119247190 119247197
SARA: 101546292 101553347
SETR: 126006237 126006364 126006365 126006366
LAV: 100655392 100656155
TMU: 101341338
ETF: 101653633 101654377
MDO: 100018032
SHR: 100926939
AFZ: 127538463
PCW: 110205862
TVP: 118851388
OAA: 100086809
GGA: 417981(CYP2D6)
PCOC: 116233524 116233525
MGP: 100548322
CJO: 107313299
TPAI: 128073448
LMUT: 125688268
NMEL: 110390936
APLA: 101804496
ACYG: 106046243(CYP2D6)
CATA: 118246669
AFUL: 116502036
TGU: 100222415
LSR: 110483129
SCAN: 103813311
PMOA: 120510076
OTC: 121342311
PRUF: 121361070
GFR: 102041048
FAB: 101821306
OMA: 130262301
PHI: 102108095
PMAJ: 107205209
CCAE: 111934339
CCW: 104696362
CBRC: 103618122
ETL: 114058074
ZLE: 135442458 135442459
ACHL: 103803233
SVG: 106856930
MMEA: 130588366
HRT: 120752195
SATI: 136361709(CYP2D6)
FPG: 101921852
FCH: 102048029
CCRI: 104161789
NNT: 104404490
SHAB: 115605360
ACUN: 113491562
TALA: 104365310
ACHC: 115352853
HALD: 104311000
HLE: 104833067
AGEN: 126047854
GCL: 127014896
CSTI: 104554977
LDI: 104351498
MNB: 103770438
DPUB: 104301982
AVIT: 104268282
BRHI: 104493764
EGZ: 104134346
NNI: 104021654
PCRI: 104034188
PCAO: 104048996
PADL: 103915260
AFOR: 103907790
FGA: 104070428
GSTE: 104254569
CLV: 102097622
MUI: 104544992
PGUU: 104468401
PLET: 104625226
EHS: 104503834
CMAC: 104485742
CUCA: 104055481
TEO: 104370504
BREG: 104634153
OHA: 104329836
ACAR: 104526639
CVF: 104295477
RTD: 128904057
AAM: 106488892
AROW: 112967724
DNE: 112984474
SCAM: 104137916
ASN: 102370106
AMJ: 102569264(CYP2D6)
CPOO: 109315960
GGN: 109295812
PSS: 102462176 102462423
CMY: 102929592 102934237 119564132 119564149 119564152
CCAY: 125629947 125629953
DCC: 119845208 119857069 119859094 119863104
CPIC: 101933422 101938829 101939092 101951050
TST: 117879730 117884169 117884792
CABI: 116828623 116829297 116832008 116838146
MRV: 120375915 120384786 120387859
ACS: 100558940
ASAO: 132769716 132775782 132775791 132776006 132776008
SUND: 121930834 121930835 121930836 121930926 121930928
VKO: 123019452 123033076
PMUA: 114605492 114605761
PRAF: 128422220 128422221 128422542
ZVI: 118091460
HCG: 128326384 128326385 128327536
GJA: 107122924 107123018
STOW: 125435351 125435354
EMC: 129335276 129335278 129335279 129335541 129335663 129336068
XLA: 108714516 108715021 108715777 108715778 379479(XB5769266.L) 444392 446878(cyp2d6.S)
XTR: 100145323 100494106 100495359 100495518 101731511 116410450 548436(cyp2d6)
NPR: 108794296 108804494
RTEM: 120941277 120945468
BBUF: 120978913 121001277
BGAR: 122938404 122943639
MUO: 115473043 115473053 115473059
GSH: 117353425 117353427 117353429 117353431
CMK: 103180618
RTP: 109920361
CPLA: 122564142 122564144
HOC: 132830269 132830353 132830397
LERI: 129694571 129710461 129710710 129710711 129710712
BFO: 118415899
BBEL: 109462641 109462737 109463451 109474841 109478605
SCLV: 120328227 120328855
LPIC: 129281320 129282009
ARUN: 117289920 117291149 117304831 117304898
BCOO: 119080033
HAZT: 108680212
TCF: 131883746
DSV: 119459121
SDM: 118190842
PMEO: 129581189 129585256
PVUL: 126817714 126818508 126821255 126821667 126821944
BGT: 106054490
GAE: 121366491 121381858 121389421
HRJ: 124257561 124266965 124291035
CRG: 105321692
CANU: 128160333 128161281 128161282 128186341 128192867
CVN: 111102456 111107265 111115387 111117535 111137052
OED: 125679044
PMAX: 117340548
MMER: 123531314 123542934 123547463 123559538
RPHI: 132717033 132717036 132718497 132722365 132722367 132743595 132747303 132747622 132751859 132753271
DPOL: 127832023 127847240 127867649
MAEA: 128210266 128231581 128233662 128235857
LJP: 135463059 135475195 135476667
LLON: 135483152
XEN: 124445683 124445684 124445685 124452615 124455699 124455827
 » show all
Reference
PMID:3582092 (CYP2D1 CYP2D2)
  Authors
Gonzalez FJ, Matsunaga T, Nagata K, Meyer UA, Nebert DW, Pastewka J, Kozak CA, Gillette J, Gelboin HV, Hardwick JP
  Title
Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism.
  Journal
DNA 6:149-61 (1987)
DOI:10.1089/dna.1987.6.149
  Sequence
[rno:266684 25053]
Reference
PMID:2831949 (CYP2D9)
  Authors
Wong G, Kawajiri K, Negishi M
  Title
Gene family of male-specific testosterone 16 alpha-hydroxylase (C-P-450(16) alpha) in mouse liver: cDNA sequences, neonatal imprinting, and reversible regulation by androgen.
  Journal
Biochemistry 26:8683-90 (1987)
DOI:10.1021/bi00400a029
  Sequence
[mmu:13105]
Reference
PMID:1396678 (CYP2D14)
  Authors
Tsuneoka Y, Matsuo Y, Higuchi R, Ichikawa Y
  Title
Characterization of the cytochrome P-450IID subfamily in bovine liver. Nucleotide sequences and microheterogeneity.
  Journal
Eur J Biochem 208:739-46 (1992)
DOI:10.1111/j.1432-1033.1992.tb17242.x
  Sequence
[bta:282211]
Reference
PMID:7786018 (CYP2D15)
  Authors
Sakamoto K, Kirita S, Baba T, Nakamura Y, Yamazoe Y, Kato R, Takanaka A, Matsubara T
  Title
A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning, and enzyme characterization.
  Journal
Arch Biochem Biophys 319:372-82 (1995)
DOI:10.1006/abbi.1995.1307
  Sequence
[cfa:415120]
Reference
PMID:7733969 (CYP2D16)
  Authors
Jiang Q, Voigt JM, Colby HD
  Title
Molecular cloning and sequencing of a guinea pig cytochrome P4502D (CYP2D16): high level expression in adrenal microsomes.
  Journal
Biochem Biophys Res Commun 209:1149-56 (1995)
DOI:10.1006/bbrc.1995.1617
  Sequence
[cpoc:100169696]
Reference
PMID:8910433 (CYP2D18)
  Authors
Kawashima H, Sequeira DJ, Nelson DR, Strobel HW
  Title
Genomic cloning and protein expression of a novel rat brain cytochrome P-450 CYP2D18* catalyzing imipramine N-demethylation.
  Journal
J Biol Chem 271:28176-80 (1996)
DOI:10.1074/jbc.271.45.28176
  Sequence
[rno:171522]
Reference
PMID:9425298 (CYP2D25)
  Authors
Postlind H, Axen E, Bergman T, Wikvall K
  Title
Cloning, structure, and expression of a cDNA encoding vitamin D3 25-hydroxylase.
  Journal
Biochem Biophys Res Commun 241:491-7 (1997)
DOI:10.1006/bbrc.1997.7551
  Sequence
[ssc:397687]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (803)   
   KEGG GENES (539)   
   KEGG MGENES (31)   
   RefGene (229)   
   OC (4)   
Literature (7)   
   PubMed (7)   
All databases (820)   

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KEGG   ORTHOLOGY: K17719
Entry
K17719                      KO                                     
Symbol
CYP2C9
Name
cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
map05417  Lipid and atherosclerosis
Reaction
R07048  
R07050  
R07051  
R07055  
R07056  
R07079  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07080  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07081  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07085  benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07087  9-hydroxybenzo[a]pyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R08267  
R08275  
R08285  
R08324  
R08325  
R08326  
R08390  
R08392  
Disease
H01205  Coumarin resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
   00591 Linoleic acid metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
   00982 Drug metabolism - cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
    1.14.14.52  (S)-limonene 7-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
    1.14.14.53  (R)-limonene 6-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Other DBs
GO: 0018675 0018676 0052741
Genes
HSA: 1559(CYP2C9)
PTR: 100616515(CYP2C9)
PPS: 100996034(CYP2C9)
GGO: 101126456
PON: 100450749(CYP2C9)
PPYG: 129006530
NLE: 100591471
HMH: 116457268
SSYN: 129468897
MCC: 678686(CYP2C75) 678695(CYP2C9)
MCF: 102115450(CYP2C9) 102147103(CYP2C19)
MTHB: 126962028 126962032
MNI: 105479916 105479949
CSAB: 103216299(CYP2C19) 103216301(CYP2C9)
CATY: 105575618 105581138 105586929 105586938
PANU: 100997824 101012978
TGE: 112631549 112631550
MLEU: 105534699 105534700 105535382 105536626
RRO: 104665355 104666123
TFN: 117083900 117092015
PTEH: 111531037 111552212
CANG: 105501587 105504516 105504517
DORD: 106001520
NCAR: 124985776
TVP: 118828297 118828298 118828299 118828301 118828302
 » show all
Reference
PMID:3196692
  Authors
Ged C, Umbenhauer DR, Bellew TM, Bork RW, Srivastava PK, Shinriki N, Lloyd RS, Guengerich FP
  Title
Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.
  Journal
Biochemistry 27:6929-40 (1988)
DOI:10.1021/bi00418a039
  Sequence
[hsa:1559]

  All links  
Ontology (6)   
   KEGG BRITE (3)   
   GO (3)   
Pathway (18)   
   KEGG PATHWAY (18)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (33)   
   KEGG ENZYME (3)   
   KEGG REACTION (18)   
   KEGG RCLASS (12)   
Gene (49)   
   KEGG GENES (47)   
   OC (2)   
Literature (1)   
   PubMed (1)   
All databases (108)   

Download RDF
KEGG   ORTHOLOGY: K17720
Entry
K17720                      KO                                     
Symbol
CYP2C18
Name
cytochrome P450 family 2 subfamily C18 [EC:1.14.14.1]
Pathway
map00830  Retinol metabolism
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
Reaction
R08390  
R08392  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
Genes
HSA: 1562(CYP2C18)
GGO: 134756383
HMH: 116480603
MCC: 701855(CYP2C18)
MCF: 102145601(CYP2C18)
MTHB: 126962034 126962041
MNI: 105479956
CSAB: 103216300(CYP2C18)
CATY: 105586945
PANU: 101021773
TGE: 112631551
MLEU: 105545510
TFN: 117083693 117083932
CJC: 100389345(CYP2C18)
SBQ: 101042223
CIMI: 108298685(CYP2C18)
ANAN: 105718959(CYP2C18)
CSYR: 103277155
MMUR: 105872416
LCAT: 123649683
PCOQ: 105822660
PLEU: 114689432
MFOT: 126511071
NCAR: 124984715 124985913
MMMA: 107149729
OPI: 101524463 101530346
SHON: 118988004
MMF: 118632033
 » show all
Reference
PMID:2009263
  Authors
Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA
  Title
Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.
  Journal
Biochemistry 30:3247-55 (1991)
DOI:10.1021/bi00227a012
  Sequence
[hsa:1562]

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