KEGG   ORTHOLOGY: K17720
Entry
K17720                      KO                                     
Symbol
CYP2C18
Name
cytochrome P450 family 2 subfamily C18 [EC:1.14.14.1]
Pathway
map00830  Retinol metabolism
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
Other DBs
RN: R08390 R08392
Genes
HSA: 1562(CYP2C18)
GGO: 101151604
PON: 100446370
MCC: 701855(CYP2C18)
MCF: 102145601(CYP2C18)
MTHB: 126962034 126962041
CSAB: 103216300(CYP2C18)
CATY: 105586945
PANU: 101021773
TGE: 112631551
CJC: 100389345(CYP2C18)
SBQ: 101042223
CSYR: 103277155
MMUR: 105872416
LCAT: 123649683
PLEU: 114689432
MFOT: 126511071
SHON: 118988004
MMF: 118632033
 » show all
Reference
PMID:2009263
  Authors
Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA
  Title
Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.
  Journal
Biochemistry 30:3247-55 (1991)
DOI:10.1021/bi00227a012
  Sequence
[hsa:1562]

KEGG   ORTHOLOGY: K17718
Entry
K17718                      KO                                     
Symbol
CYP2C8
Name
cytochrome P450 family 2 subfamily C8 [EC:1.14.14.1]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
   00591 Linoleic acid metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
Other DBs
RN: R07042 R07043 R07048 R07050 R07055 R07056 R08312 R08390 R08392
Genes
HSA: 1558(CYP2C8)
PTR: 450909(CYP2C8)
PPS: 100967379(CYP2C8)
GGO: 101127173
PON: 100447840
NLE: 100602226
MCC: 100534648(CYP2C93) 678683(CYP2C8) 702239
MCF: 102116849 102117212(CYP2C8) 102119308(CYP2C93)
MTHB: 126962030 126962037
CSAB: 103216303(CYP2C8) 103216308
PANU: 101022842(CYP2C8) 101023648
RRO: 104665592
RBB: 108541196
TFN: 117069764
PTEH: 111529253
CJC: 100390915(CYP2C8)
SBQ: 101041387
CSYR: 103260641
SUND: 121921666
RMP: 119168129
CRG: 105344043
 » show all
Reference
PMID:3500169
  Authors
Okino ST, Quattrochi LC, Pendurthi UR, McBride OW, Tukey RH
  Title
Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing.
  Journal
J Biol Chem 262:16072-9 (1987)
  Sequence
[hsa:1558]

KEGG   ORTHOLOGY: K07408
Entry
K07408                      KO                                     
Symbol
CYP1A1
Name
cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00380  Tryptophan metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map01100  Metabolic pathways
map04913  Ovarian steroidogenesis
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
   05207 Chemical carcinogenesis - receptor activation
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP1 family
   K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Other DBs
RN: R02354 R02355 R03089 R03408 R03629 R07000 R07001 R07021 R07022 R07079 R07080 R07081 R07085 R07087 R07098 R07099 R08390 R08392 R09418 R09423 R09442
Genes
HSA: 1543(CYP1A1)
PTR: 453744(CYP1A1)
PPS: 100976184(CYP1A1)
GGO: 101129522
PON: 100457153
NLE: 100585507
MCC: 678694(CYP1A1)
MCF: 102129994(CYP1A1)
MTHB: 126960000
CSAB: 103245331(CYP1A1)
CATY: 105600061
PANU: 101001307
TGE: 112627760
RRO: 104672151
RBB: 108531476
TFN: 117070364
PTEH: 111529702
CJC: 100393083(CYP1A1)
SBQ: 101038217
CSYR: 103271646
MMUR: 105854864
LCAT: 123624369
OGA: 100955410
MMU: 13076(Cyp1a1)
MCAL: 110301270
MPAH: 110328033
RNO: 24296(Cyp1a1)
MCOC: 116071961
MUN: 110558545
CGE: 100751269
MAUA: 101844540
PLEU: 114690337
MORG: 121445349
MFOT: 126507531
AAMP: 119808952
NGI: 103736921
HGL: 101707509
CPOC: 100135512(Cyp1a1)
CCAN: 109701505
DORD: 105982352
DSP: 122098438
NCAR: 124977051
OCU: 100328613
OPI: 101533768
TUP: 102484009
GVR: 103588057
CFA: 100686778(CYP1A1)
CLUD: 112675585
VVP: 112908776
VLG: 121484958
AML: 100473028
UMR: 103678992
UAH: 113240972
UAR: 123790682
ELK: 111153267
LLV: 125105138
MPUF: 101676222
ORO: 101382250
EJU: 114206471
ZCA: 113910089
MLX: 118003748
NSU: 110583893
LWW: 102739666
FCA: 554347(CYP1A1)
PYU: 121041992
PBG: 122468425
LRUF: 124508019
PTG: 102966263
PPAD: 109262691
AJU: 106979443
HHV: 120235772
BTA: 282870(CYP1A1)
BOM: 102283235
BIU: 109575587
BBUB: 102399021
BBIS: 104990991
CHX: 102170823
OAS: 100170113(CYP1A1)
ODA: 120875451
CCAD: 122419730
SSC: 403103(CYP1A1)
CFR: 102518111
CBAI: 105069192
CDK: 105087262
VPC: 102530468
BACU: 103008057
LVE: 103071513
OOR: 101287158
DLE: 111177818
PCAD: 102984326
PSIU: 116749907
ECB: 100062285(CYP1A1)
EPZ: 103552317
EAI: 106831264
MYB: 102262349
MYD: 102762200
MMYO: 118675915
MLF: 102437172
MNA: 107535216
PKL: 118728867
HAI: 109396247
DRO: 112301821
SHON: 118987754
PDIC: 114492343
PHAS: 123825280
MMF: 118643668
RFQ: 117024155
PALE: 102892046
PGIG: 120597850
PVP: 105306836
RAY: 107510533
MJV: 108388606
TOD: 119237890
SARA: 101550604
LAV: 100665901
TMU: 101359275
ETF: 101661225
DNM: 101423437
MDO: 100029871
GAS: 123232970
SHR: 100927711
PCW: 110213927
OAA: 100080942(CYP1A1)
ZVI: 118084457
STOW: 125424760
BBEL: 109480286
GAE: 121368990
CRG: 105329067
 » show all
Reference
PMID:2989797
  Authors
Jaiswal AK, Gonzalez FJ, Nebert DW
  Title
Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism.
  Journal
Nucleic Acids Res 13:4503-20 (1985)
DOI:10.1093/nar/13.12.4503
  Sequence
[hsa:1543]
Reference
PMID:3019683
  Authors
Kawajiri K, Watanabe J, Gotoh O, Tagashira Y, Sogawa K, Fujii-Kuriyama Y
  Title
Structure and drug inducibility of the human cytochrome P-450c gene.
  Journal
Eur J Biochem 159:219-25 (1986)
DOI:10.1111/j.1432-1033.1986.tb09857.x
  Sequence
[hsa:1543]

KEGG   ORTHOLOGY: K17721
Entry
K17721                      KO                                     
Symbol
CYP2C19
Name
cytochrome P450 family 2 subfamily C19 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
Disease
H01171  Poor drug metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
   00591 Linoleic acid metabolism
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.52  (S)-limonene 7-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.53  (R)-limonene 6-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.75  fenbendazole monooxygenase (4'-hydroxylating)
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.-
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Other DBs
RN: R07046 R07055 R07056 R08275 R08285 R08343
GO: 0018675 0018676 0052741
Genes
HSA: 1557(CYP2C19)
PTR: 740956(CYP2C19)
PPS: 100995695(CYP2C19)
GGO: 101151965
PON: 100439483
NLE: 100601437
PTEH: 111552212
CJC: 100389947(CYP2C19)
SBQ: 101041912
CSYR: 103277060
OGA: 100950266
 » show all
Reference
PMID:2009263
  Authors
Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA
  Title
Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.
  Journal
Biochemistry 30:3247-55 (1991)
DOI:10.1021/bi00227a012
  Sequence
[hsa:1557]

KEGG   ORTHOLOGY: K17689
Entry
K17689            Tight     KO                                     
Symbol
CYP3A4
Name
cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
Pathway
map00140  Steroid hormone biosynthesis
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map00983  Drug metabolism - other enzymes
map01100  Metabolic pathways
map04976  Bile secretion
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
Disease
H01143  Vitamin D-dependent rickets
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   00591 Linoleic acid metabolism
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   00982 Drug metabolism - cytochrome P450
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   00983 Drug metabolism - other enzymes
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   05207 Chemical carcinogenesis - receptor activation
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.32  albendazole monooxygenase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.55  quinine 3-monooxygenase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.56  1,8-cineole 2-exo-monooxygenase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.57  taurochenodeoxycholate 6alpha-hydroxylase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.73  albendazole monooxygenase (sulfoxide-forming)
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.-
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP3 family
   K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
Other DBs
RN: R02356 R03408 R05727 R07000 R07001 R07055 R07056 R07079 R07080 R07081 R07085 R07087 R08256 R08257 R08264 R08268 R08269 R08271 R08272 R08274 R08275 R08276 R08277 R08285 R08286 R08287 R08293 R08294 R08303 R08304 R08312 R08313 R08318 R08339 R08340 R08341 R08342 R08343 R08390 R08391 R08392 R09404 R09408 R09423
GO: 0047638 0033780 0050591
Genes
HSA: 1576(CYP3A4)
PTR: 463582(CYP3A4)
PPS: 100976899(CYP3A4)
GGO: 101149513
PON: 100436782
NLE: 100593175
MCC: 678670(CYP3A4)
MCF: 102144258(CYP3A4)
MTHB: 126950475
CSAB: 103246766
CATY: 105584402
PANU: 101026757
TGE: 112621193
RRO: 104673585
RBB: 108538168
TFN: 117072034
CJC: 100404344(CYP3A4)
SBQ: 101037403
CSYR: 103252931
OGA: 100948865
 » show all
Reference
PMID:3267210 (CYP3A4)
  Authors
Gonzalez FJ, Schmid BJ, Umeno M, Mcbride OW, Hardwick JP, Meyer UA, Gelboin HV, Idle JR
  Title
Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.
  Journal
DNA 7:79-86 (1988)
DOI:10.1089/dna.1988.7.79
  Sequence
[hsa:1576]
Reference
  Authors
McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC
  Title
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
  Journal
J Mol Evol 57:200-11 (2003)
DOI:10.1007/s00239-003-2466-x
Reference
PMID:9056237 (CYP3A21)
  Authors
Igarashi T, Sakuma T, Isogai M, Nagata R, Kamataki T
  Title
Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs.
  Journal
Arch Biochem Biophys 339:85-91 (1997)
DOI:10.1006/abbi.1996.9852
  Sequence
[cjc:100404344]

KEGG   ORTHOLOGY: K07413
Entry
K07413                      KO                                     
Symbol
CYP2C
Name
cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map01100  Metabolic pathways
map04726  Serotonergic synapse
map04750  Inflammatory mediator regulation of TRP channels
map05204  Chemical carcinogenesis - DNA adducts
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
   00590 Arachidonic acid metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
   00591 Linoleic acid metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07413  CYP2C; cytochrome P450 family 2 subfamily C
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07413  CYP2C; cytochrome P450 family 2 subfamily C
Other DBs
RN: R03408 R07042 R07043 R07048 R07050 R07051 R07052 R07054 R07055 R07056 R08390 R08392
Genes
PON: 100449185
MCC: 100424240(CYP2C76)
MCF: 102114994(CYP2C76)
MTHB: 126962035 126962036
CATY: 105576142 105581754
PANU: 101012275 101026117
TGE: 112631566
RRO: 104664669 104664684
RBB: 108543807 108543808
TFN: 117069747 117069809
CJC: 100391987(CYP2C76)
SBQ: 101040831
MMU: 107141(Cyp2c50) 13095(Cyp2c29) 13096(Cyp2c37) 13097(Cyp2c38) 13098(Cyp2c39) 13099(Cyp2c40) 226105(Cyp2c70) 226143(Cyp2c23) 404195(Cyp2c54) 433247(Cyp2c68) 69888(Cyp2c66) 72082(Cyp2c55) 72303(Cyp2c65)
RNO: 171518(Cyp2c22) 171521(Cyp2c13) 25011(Cyp2c12) 29277(Cyp2c11) 29298(Cyp2c7) 293989(Cyp2c6v1) 499353(Cyp2c24) 83790(Cyp2c23)
OCU: 100328549(CYP2C5) 100328924(CYP2C2) 100328933(CYP2C) 100328935(CYP2C30) 100328936(CYP2C14) 100328938(CYP2C16) 100345193 100346305 100346743(CYP2C1) 100349436(CYP2C4) 100353460 103351405
CFA: 100688697 415122(CYP2C18)
BTA: 505468 510380(CYP2C19) 511498 535243(CYP2C18) 616593(CYP2C87) 785540
SSC: 100739741 403106(CYP2C32) 403107(CYP2C33) 403108(CYP2C34) 403110(CYP2C36) 403111(CYP2C42) 403215(CYP2C49)
BACU: 103017669
LVE: 103084494
DLE: 111172397
DRO: 112300219
AJM: 119064549
PALE: 102891905
PVP: 105301394
MJV: 108409895
GGA: 100858007(RP11-400G3.5) 414833(CYP2C45)
PCOC: 116234486
MGP: 100544448
CJO: 107315788
NMEL: 110399446
PMOA: 120499733
ETL: 114065370
ACHL: 103805798
HALD: 104315668
HLE: 104831888
CSTI: 104561375
CMAC: 104476783
MUI: 104534424
MNB: 103771400
OHA: 104329922
ACAR: 104529274
AVIT: 104273142
TEO: 104374656
BRHI: 104492082
TGT: 104566795
CPOO: 109315166
CMY: 102931882
TSR: 106538299
XLA: 108699286 379297(cyp2a6.1.S) 444542(cyp2c8.2.L)
XTR: 448236(cyp2c8.2)
NPR: 108800780
RTP: 109917556
BFO: 118416246
BBEL: 109470437
HAZT: 108665260
RSAN: 119373421
RMP: 119167648
HRF: 124113633
CRG: 105333836
OSN: 115231110
AG: AAC08738(CYP2C41) BAA02001(CYP2C26) BAA02002(CYP2C27) BAA02003(CYP2C28) CAA44753(CYP2C25)
 » show all
Reference
PMID:2831965 (CYP2C2)
  Authors
Imai Y, Komori M, Sato R
  Title
Comparison of primary structures deduced from cDNA nucleotide sequences for various forms of liver microsomal cytochrome P-450 from phenobarbital-treated rabbits.
  Journal
Biochemistry 27:80-8 (1988)
DOI:10.1021/bi00401a014
  Sequence
[ocu:100328924]
Reference
PMID:3335521 (CYP2C7)
  Authors
Kimura H, Yoshioka H, Sogawa K, Sakai Y, Fujii-Kuriyama Y
  Title
Complementary DNA cloning of cytochrome P-450s related to P-450(M-1) from the complementary DNA library of female rat livers. Predicted primary structures for  P-450f, PB-1, and PB-1-related protein with a bizarre replacement block and their mode of transcriptional expression.
  Journal
J Biol Chem 263:701-7 (1988)
  Sequence
[rno:29298]
Reference
PMID:8611037 (CYP2C11)
  Authors
Biagini C, Celier C
  Title
cDNA-directed expression of two allelic variants of cytochrome P450 2C11 using COS1 and SF21 insect cells.
  Journal
Arch Biochem Biophys 326:298-305 (1996)
DOI:10.1006/abbi.1996.0079
  Sequence
[rno:29277]
Reference
PMID:2820951 (CYP2C14)
  Authors
Imai Y
  Title
Cytochrome P-450 related to P-4504 from phenobarbital-treated rabbit liver: molecular cloning of cDNA and characterization of cytochrome P-450 obtained by its expression in yeast cells.
  Journal
J Biochem 101:1129-39 (1987)
DOI:10.1093/oxfordjournals.jbchem.a121977
  Sequence
[ocu:100328936]
Reference
PMID:2263487 (CYP2C23)
  Authors
Cook EA, Groenewegen WA, Gloger IS, Piggott JR, Suckling KE, Wolf CR
  Title
cDNA and deduced amino acid sequence of a novel cytochrome P-450 from female rat liver mRNA with high homology to P-450 IIC family.
  Journal
Nucleic Acids Res 18:7156 (1990)
DOI:10.1093/nar/18.23.7156
  Sequence
[rno:83790]
Reference
PMID:8114672 (CYP2C25 CYP2C26 CYP2C27)
  Authors
Sakuma T, Masaki K, Itoh S, Yokoi T, Kamataki T
  Title
Sex-related differences in the expression of cytochrome P450 in hamsters: cDNA cloning and examination of the expression of three distinct CYP2C cDNAs.
  Journal
Mol Pharmacol 45:228-36 (1994)
  Sequence
Reference
PMID:7771794 (CYP2C28)
  Authors
Sakuma T, Yokoi T, Kamataki T
  Title
Isolation and characterization of a new cDNA clone belonging to the cytochrome P450 2C gene subfamily in hamsters.
  Journal
Arch Biochem Biophys 319:267-73 (1995)
DOI:10.1006/abbi.1995.1291
  Sequence
Reference
PMID:8130255 (CYP2C29)
  Authors
Matsunaga T, Watanabe K, Yamamoto I, Negishi M, Gonzalez FJ, Yoshimura H
  Title
cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2, a microsomal aldehyde oxygenase.
  Journal
Biochim Biophys Acta 1184:299-301 (1994)
DOI:10.1016/0005-2728(94)90237-2
  Sequence
[mmu:13095]
Reference
PMID:9721182 (CYP2C37)
  Authors
Luo G, Zeldin DC, Blaisdell JA, Hodgson E, Goldstein JA
  Title
Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid.
  Journal
Arch Biochem Biophys 357:45-57 (1998)
DOI:10.1006/abbi.1998.0806
  Sequence
[mmu:13096]
Reference
PMID:9492393 (CYP2C41)
  Authors
Blaisdell J, Goldstein JA, Bai SA
  Title
Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression.
  Journal
Drug Metab Dispos 26:278-83 (1998)
  Sequence
Reference
PMID:15102943 (CYP2C50)
  Authors
Wang H, Zhao Y, Bradbury JA, Graves JP, Foley J, Blaisdell JA, Goldstein JA, Zeldin DC
  Title
Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities.
  Journal
Mol Pharmacol 65:1148-58 (2004)
DOI:10.1124/mol.65.5.1148
  Sequence
[mmu:107141]
Reference
PMID:2263625 (CYP2C70)
  Authors
Emi Y, Chijiiwa C, Omura T
  Title
A different cytochrome P450 form is induced in primary cultures of rat hepatocytes.
  Journal
Proc Natl Acad Sci U S A 87:9746-50 (1990)
DOI:10.1073/pnas.87.24.9746
  Sequence
[rno:171518]

KEGG   ORTHOLOGY: K17719
Entry
K17719                      KO                                     
Symbol
CYP2C9
Name
cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
map05417  Lipid and atherosclerosis
Disease
H01205  Coumarin resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
   00591 Linoleic acid metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
   00982 Drug metabolism - cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
    1.14.14.52  (S)-limonene 7-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
    1.14.14.53  (R)-limonene 6-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
    1.14.14.-
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Other DBs
RN: R07048 R07050 R07051 R07055 R07056 R07079 R07080 R07081 R07085 R07087 R08267 R08275 R08285 R08324 R08325 R08326 R08390 R08392
GO: 0018675 0018676 0052741
Genes
HSA: 1559(CYP2C9)
PTR: 100616515(CYP2C9)
PPS: 100996034(CYP2C9)
GGO: 101126456
PON: 100450749
NLE: 100591471
MCC: 678686(CYP2C75) 678695(CYP2C9)
MCF: 102115450(CYP2C9) 102147103(CYP2C19)
MTHB: 126962028 126962032
CSAB: 103216299(CYP2C19) 103216301(CYP2C9)
PTEH: 111531037
DORD: 106001520
NCAR: 124985776
 » show all
Reference
PMID:3196692
  Authors
Ged C, Umbenhauer DR, Bellew TM, Bork RW, Srivastava PK, Shinriki N, Lloyd RS, Guengerich FP
  Title
Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.
  Journal
Biochemistry 27:6929-40 (1988)
DOI:10.1021/bi00418a039
  Sequence
[hsa:1559]

KEGG   ORTHOLOGY: K07410
Entry
K07410                      KO                                     
Symbol
CYP1B1
Name
cytochrome P450 family 1 subfamily B1 [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00380  Tryptophan metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map04913  Ovarian steroidogenesis
map05204  Chemical carcinogenesis - DNA adducts
map05206  MicroRNAs in cancer
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
Disease
H01159  Anterior segment dysgenesis
H01203  Primary congenital glaucoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
   05204 Chemical carcinogenesis - DNA adducts
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
   05207 Chemical carcinogenesis - receptor activation
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP1 family
   K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
Other DBs
RN: R03088 R03090 R03629 R07079 R07080 R07081 R07085 R07087 R09416 R09418 R09442
Genes
HSA: 1545(CYP1B1)
PTR: 459163(CYP1B1)
PPS: 100989599(CYP1B1)
GGO: 101134278
PON: 100172192(CYP1B1)
NLE: 100583040
MCC: 710385(CYP1B1)
MCF: 102146810(CYP1B1)
MTHB: 126933548
CSAB: 103220462(CYP1B1)
CATY: 105597190
PANU: 101014578
TGE: 112637014
RRO: 104680972
RBB: 108520884
TFN: 117062450
PTEH: 111545371
CJC: 100395270(CYP1B1)
SBQ: 101049264
CSYR: 103271895
MMUR: 105884508
LCAT: 123636812
OGA: 100949593
MMU: 13078(Cyp1b1)
MCAL: 110312728
MPAH: 110335735
RNO: 25426(Cyp1b1)
MCOC: 116079592
MUN: 110547086
CGE: 100759241
MAUA: 101839568
PLEU: 114683578
MORG: 121432953
MFOT: 126514555
AAMP: 119807802
NGI: 103725278
HGL: 101701066
CPOC: 100719054
CCAN: 109685237
DORD: 105986861
DSP: 122104563
NCAR: 124962692
OCU: 100358590
OPI: 101531725
TUP: 102492978
GVR: 103600797
CFA: 483038(CYP1B1)
CLUD: 112664509
VVP: 112935290
VLG: 121491956
AML: 100466967
UMR: 103671894
UAH: 113241453
UAR: 123799824
LLV: 125109142
MPUF: 101676151
ORO: 101365942
EJU: 114219641
ZCA: 113937594
MLX: 118007783
NSU: 110587203
LWW: 102734979
FCA: 101099873
PYU: 121044356
PBG: 122497249
LRUF: 124502968
PTG: 102950579
PPAD: 109265731
AJU: 106978960
HHV: 120244637
BTA: 511470(CYP1B1)
BOM: 102283377
BIU: 109565990
BBUB: 102406111
BBIS: 104999966
CHX: 102184252
OAS: 101119706
ODA: 120851684
CCAD: 122441577
SSC: 100625479
CFR: 102510682
CBAI: 105078974
CDK: 105103641
VPC: 102527799
BACU: 103004066
LVE: 103083349
OOR: 101289532
DLE: 111174870
PCAD: 102981351
PSIU: 116764271
ECB: 100070088(CYP1B1)
EPZ: 103548412
EAI: 106825888
MYB: 102251701
MYD: 102767262
MMYO: 118669092
MLF: 102417339
MNA: 107541766
PKL: 118717247
HAI: 109385488
DRO: 112298126
SHON: 119001228
AJM: 119063849
PDIC: 114500131
PHAS: 123811584
MMF: 118631254
RFQ: 117033397
PALE: 102885732
PGIG: 120621764
PVP: 105292959
RAY: 107519646
MJV: 108387118
TOD: 119259388
SARA: 101541021
LAV: 100655003
TMU: 101340605
ETF: 101642387
DNM: 101414120
MDO: 100011610
GAS: 123234682
SHR: 100935353
PCW: 110201392
OAA: 100079784(CYP1B1)
GGA: 421466(CYP1B1)
PCOC: 116233159
MGP: 100542888
CJO: 107311343
NMEL: 110396658
APLA: 101797494
ACYG: 106029463
AFUL: 116488292
TGU: 100230258
LSR: 110469414
SCAN: 103821707
PMOA: 120506903
OTC: 121335862
PRUF: 121358603
FAB: 101808257
PHI: 102104659
PMAJ: 107202509
CCW: 104684373
CBRC: 103624139
ETL: 114065190
ZAB: 102068269
FPG: 101910938
FCH: 102051876
CLV: 102085752
EGZ: 104124112
NNI: 104018708
ACUN: 113478680
TALA: 104365716
PADL: 103922881
AFOR: 103902731
ACHC: 115350101
HLE: 104840371
AGEN: 126051773
GCL: 127015235
DPUB: 104310306
CPEA: 104394945
CUCA: 104057920
AAM: 106485484
AROW: 112973407
NPD: 112957572
DNE: 112984647
AMJ: 102560255(CYP1B1)
CPOO: 109319889
GGN: 109304747
PSS: 102451045
CMY: 114019062
CPIC: 101941680
TST: 117874620
CABI: 116822556
MRV: 120400195
ACS: 100561291
PVT: 110083935
SUND: 121924964
PBI: 103059588
PMUR: 107287481
CTIG: 120312077
TSR: 106557416
PGUT: 117671886
VKO: 123033875
PMUA: 114594484
ZVI: 118082704
GJA: 107120817
STOW: 125426126
XLA: 108716653(cyp1b1.L) 108717803(cyp1b1.S)
XTR: 100490477(cyp1b1)
RTEM: 120937478
BBUF: 120998783
BGAR: 122934643
DRE: 100150054(cyp1b1)
PPRM: 120468625
MAMB: 125277247
IPU: 100313516(cyp1b)
PHYP: 113545523
SMEO: 124378272
TFD: 113661120
AMEX: 103036816
EEE: 113579900
TRU: 101073188
LCO: 104921916
CGOB: 115020443
ELY: 117248681
EFO: 125903589
PLEP: 121954937
SLUC: 116047866
ECRA: 117960939
ESP: 116705258
PFLV: 114571967
GAT: 120820387
PPUG: 119214523
MSAM: 119916912
CUD: 121510615
ALAT: 119034148
MZE: 101487279
ONL: 100653403(cyp1b1)
OAU: 116318802
OLA: 101159216
OML: 112140813
XMA: 102221787
XCO: 114138595
XHE: 116713268
PRET: 103477101
PFOR: 103148258
PLAI: 106951802
PMEI: 106920957
GAF: 122842251
CVG: 107088618
CTUL: 119782895
GMU: 124858669
NFU: 107375515
KMR: 108247157
ALIM: 106525583
NWH: 119410756
AOCE: 111586556
MCEP: 125019270
CSEM: 103387492
POV: 109629221
SSEN: 122781479
HHIP: 117775246
HSP: 118119456
LCF: 108886282
SDU: 111220624
SLAL: 111669388
XGL: 120796037
HCQ: 109523136
MALB: 109962476
BSPL: 114842071
OMY: 100381269(cyp1b1) 110502297
OGO: 124041418
ELS: 105029712
SFM: 108925836
PKI: 111849531
AANG: 118218479
LOC: 102695612
PSEX: 120516625
LCM: 102362765
CMK: 103178928
RTP: 109922910
CRG: 105345597
 » show all
Reference
PMID:8175734
  Authors
Sutter TR, Tang YM, Hayes CL, Wo YY, Jabs EW, Li X, Yin H, Cody CW, Greenlee WF
  Title
Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.
  Journal
J Biol Chem 269:13092-9 (1994)
DOI:10.1016/S0021-9258(17)36803-5
  Sequence
[hsa:1545]

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