KEGG   ORTHOLOGY: K17720
Entry
K17720                      KO                                     
Symbol
CYP2C18
Name
cytochrome P450 family 2 subfamily C18 [EC:1.14.14.1]
Pathway
map00830  Retinol metabolism
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
Reaction
R08390  
R08392  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17720  CYP2C18; cytochrome P450 family 2 subfamily C18
Genes
HSA: 1562(CYP2C18)
GGO: 134756383
HMH: 116480603
MCC: 701855(CYP2C18)
MCF: 102145601(CYP2C18)
MTHB: 126962034 126962041
MNI: 105479956
CSAB: 103216300(CYP2C18)
CATY: 105586945
PANU: 101021773
TGE: 112631551
MLEU: 105545510
TFN: 117083693 117083932
CJC: 100389345(CYP2C18)
SBQ: 101042223
CIMI: 108298685(CYP2C18)
ANAN: 105718959(CYP2C18)
CSYR: 103277155
MMUR: 105872416
LCAT: 123649683
PCOQ: 105822660
PLEU: 114689432
MFOT: 126511071
NCAR: 124984715 124985913
MMMA: 107149729
OPI: 101524463 101530346
SHON: 118988004
MMF: 118632033
 » show all
Reference
PMID:2009263
  Authors
Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA
  Title
Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.
  Journal
Biochemistry 30:3247-55 (1991)
DOI:10.1021/bi00227a012
  Sequence
[hsa:1562]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (8)   
   KEGG PATHWAY (8)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (34)   
   KEGG GENES (32)   
   OC (2)   
Literature (1)   
   PubMed (1)   
All databases (51)   

Download RDF
KEGG   ORTHOLOGY: K17718
Entry
K17718                      KO                                     
Symbol
CYP2C8
Name
cytochrome P450 family 2 subfamily C8 [EC:1.14.14.1]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
map05417  Lipid and atherosclerosis
Reaction
R07042  
R07043  
R07048  
R07050  
R07055  
R07056  
R08312  
R08390  
R08392  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
   00591 Linoleic acid metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17718  CYP2C8; cytochrome P450 family 2 subfamily C8
Genes
HSA: 1558(CYP2C8)
PTR: 450909(CYP2C8)
PPS: 100967379(CYP2C8)
GGO: 101127173
PON: 100447840(CYP2C8)
PPYG: 129006200
NLE: 100602226
HMH: 116457254
SSYN: 129462752
MCC: 100534648(CYP2C93) 678683(CYP2C8) 702239
MCF: 102116849 102117212(CYP2C8) 102119308(CYP2C93)
MTHB: 126962030 126962037
MNI: 105470206 105470207 105481168
CSAB: 103216303(CYP2C8) 103216308
CATY: 105576140 105576141 105587200
PANU: 101022842(CYP2C8) 101023648
TGE: 112631270 112631271
MLEU: 105535381 105553656 105553690
RRO: 104665592
RBB: 108541196
TFN: 117069764
PTEH: 111529253
CANG: 105504518 105527573
CJC: 100390915(CYP2C8) 100402764
SBQ: 101041387
CIMI: 108281688(CYP2C8)
ANAN: 105708272(CYP2C8)
CSYR: 103260641
LCAT: 123650043 123650045 123650047 123650048
PCOQ: 105822696
OGA: 100941864 100942590
GVR: 103597628 103609276 103609277 103610831 103610943
ASAO: 132781291
SUND: 121921666
CTIG: 120296912 120296913 120298508 120317800 120317801
APRI: 131192456
PRAF: 128407606
GSH: 117365670
HOC: 132836750
RMP: 119168129
CRG: 105344043
CANU: 128177588
CVN: 111128571
 » show all
Reference
PMID:3500169
  Authors
Okino ST, Quattrochi LC, Pendurthi UR, McBride OW, Tukey RH
  Title
Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing.
  Journal
J Biol Chem 262:16072-9 (1987)
  Sequence
[hsa:1558]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (16)   
   KEGG PATHWAY (16)   
Chemical reaction (16)   
   KEGG ENZYME (1)   
   KEGG REACTION (9)   
   KEGG RCLASS (6)   
Gene (72)   
   KEGG GENES (71)   
   OC (1)   
Literature (1)   
   PubMed (1)   
All databases (108)   

Download RDF
KEGG   ORTHOLOGY: K07408
Entry
K07408                      KO                                     
Symbol
CYP1A1
Name
cytochrome P450 family 1 subfamily A1 [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00380  Tryptophan metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map01100  Metabolic pathways
map04913  Ovarian steroidogenesis
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05417  Lipid and atherosclerosis
Reaction
R02354  
R02355  
R03089  
R03408  
R03629  melatonin,NADPH---hemoprotein reductase:oxygen oxidoreductase
R07000  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07001  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07021  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07022  1-nitronaphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07079  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07080  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07081  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07085  benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07087  9-hydroxybenzo[a]pyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07098  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07099  trichloroethene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R08390  
R08392  
R09418  
R09423  
R09442  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
   05207 Chemical carcinogenesis - receptor activation
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP1 family
   K07408  CYP1A1; cytochrome P450 family 1 subfamily A1
Genes
HSA: 1543(CYP1A1)
PTR: 453744(CYP1A1)
PPS: 100976184(CYP1A1)
GGO: 101129522
PON: 100457153
PPYG: 129014419
NLE: 100585507
HMH: 116481900
SSYN: 129482256
MCC: 678694(CYP1A1)
MCF: 102129994(CYP1A1)
MTHB: 126960000
MNI: 105490958
CSAB: 103245331(CYP1A1)
CATY: 105600061
PANU: 101001307
TGE: 112627760
MLEU: 105530835
RRO: 104672151
RBB: 108531476
TFN: 117070364
PTEH: 111529702
CANG: 105505165
CJC: 100393083(CYP1A1)
SBQ: 101038217
CIMI: 108298444(CYP1A1)
ANAN: 105716625 135275116
CSYR: 103271646
MMUR: 105854864
LCAT: 123624369
PCOQ: 105807306
OGA: 100955410
MMU: 13076(Cyp1a1)
MCAL: 110301270
MPAH: 110328033
RNO: 24296(Cyp1a1)
MCOC: 116071961
ANU: 117698968
MUN: 110558545
CGE: 100751269
MAUA: 101844540
PROB: 127231800
PLEU: 114690337
MORG: 121445349
MFOT: 126507531
AAMP: 119808952
NGI: 103736921
HGL: 101707509
CPOC: 100135512(Cyp1a1)
CCAN: 109701505
DORD: 105982352
DSP: 122098438
NCAR: 124977051
MMMA: 107137939
OCU: 100328613
OPI: 101533768
TUP: 102484009
GVR: 103588057
CFA: 100686778(CYP1A1)
CLUD: 112675585
VVP: 112908776
VLG: 121484958
NPO: 129506483
AML: 100473028
UMR: 103678992
UAH: 113240972
UAR: 123790682
ELK: 111153267
LLV: 125105138
MPUF: 101676222
MNP: 131999167
MLK: 131835779
NVS: 122893452
ORO: 101382250
EJU: 114206471
ZCA: 113910089
MLX: 118003748
NSU: 110583893
LWW: 102739666
FCA: 554347(CYP1A1)
PYU: 121041992
PCOO: 112855107
PBG: 122468425
PVIV: 125168946
LRUF: 124508019
PTG: 102966263
PPAD: 109262691
PUC: 125910157
AJU: 106979443
HHV: 120235772
BTA: 282870(CYP1A1)
BOM: 102283235
BIU: 109575587
BBUB: 102399021
BBIS: 104990991
CHX: 102170823
OAS: 100170113(CYP1A1)
BTAX: 128066562
ODA: 120875451
CCAD: 122419730
MBEZ: 129550459
SSC: 403103(CYP1A1)
CFR: 102518111
CBAI: 105069192
CDK: 105087262
VPC: 102530468
BACU: 103008057
BMUS: 118891077
LVE: 103071513
OOR: 101287158
DLE: 111177818
PCAD: 102984326
PSIU: 116749907
NASI: 112410978
ECB: 100062285(CYP1A1)
EPZ: 103552317
EAI: 106831264
MYB: 102262349
MYD: 102762200
MMYO: 118675915
MLF: 102437172
MDT: 132212050
PKL: 118728867
EFUS: 103300190
MNA: 107535216
DRO: 112301821
SHON: 118987754
AJM: 119041322 119041329
PDIC: 114492343
PHAS: 123825280
MMF: 118643668
PPAM: 129064162
HAI: 109396247
RFQ: 117024155
PALE: 102892046
PGIG: 120597850
PVP: 105306836
RAY: 107510533
MJV: 108388606
TOD: 119237890
SARA: 101550604
SETR: 126015044
LAV: 100665901
TMU: 101359275
ETF: 101661225
DNM: 101423437
MDO: 100029871
GAS: 123232970
SHR: 100927711
AFZ: 127551979
PCW: 110213927
TVP: 118828075 118828076
OAA: 100080942(CYP1A1)
ZVI: 118084457
STOW: 125424760
BBEL: 109480286
SCLV: 120326955 120337706 120347324
LPIC: 129258591 129274985
PVUL: 126810086 126812565 126815240 126823790 126825192
GAE: 121368990
HRF: 124120352 124120359 124131529 124140277
HRJ: 124268175 124276990 124282406
CRG: 105329067
CANU: 128190897
OED: 125647398 125648732
MMER: 123540564 123540605 123541431 123546444 123546459 123546828 123549057 123557949 123562948 123562951
RPHI: 132713371 132719301 132727684 132731161 132731163 132733404 132733414 132736383 132738690 132744217 132754874 132757640
DPOL: 127850854
MAEA: 128206276 128206748 128228746 128236623
ATEN: 116286948 116286970 116287897
XEN: 124435028 124452841 124452890
HSY: 130646034
 » show all
Reference
PMID:2989797
  Authors
Jaiswal AK, Gonzalez FJ, Nebert DW
  Title
Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism.
  Journal
Nucleic Acids Res 13:4503-20 (1985)
DOI:10.1093/nar/13.12.4503
  Sequence
[hsa:1543]
Reference
PMID:3019683
  Authors
Kawajiri K, Watanabe J, Gotoh O, Tagashira Y, Sogawa K, Fujii-Kuriyama Y
  Title
Structure and drug inducibility of the human cytochrome P-450c gene.
  Journal
Eur J Biochem 159:219-25 (1986)
DOI:10.1111/j.1432-1033.1986.tb09857.x
  Sequence
[hsa:1543]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (20)   
   KEGG PATHWAY (20)   
Chemical reaction (33)   
   KEGG ENZYME (1)   
   KEGG REACTION (21)   
   KEGG RCLASS (11)   
Gene (447)   
   KEGG GENES (215)   
   KEGG MGENES (21)   
   RefGene (198)   
   OC (13)   
Literature (2)   
   PubMed (2)   
All databases (505)   

Download RDF
KEGG   ORTHOLOGY: K17721
Entry
K17721                      KO                                     
Symbol
CYP2C19
Name
cytochrome P450 family 2 subfamily C19 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
Reaction
R07046  
R07055  
R07056  
R08275  
R08285  
R08343  
Disease
H01171  Poor drug metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
   00591 Linoleic acid metabolism
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.52  (S)-limonene 7-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.53  (R)-limonene 6-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.75  fenbendazole monooxygenase (4'-hydroxylating)
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Other DBs
GO: 0018675 0018676 0052741
Genes
HSA: 1557(CYP2C19)
PTR: 740956(CYP2C19)
PPS: 100995695(CYP2C19)
GGO: 101151965
PON: 100439483(CYP2C19)
PPYG: 129006337
NLE: 100601437
HMH: 116457271
SSYN: 129468985
CJC: 100389947(CYP2C19)
SBQ: 101041912
CIMI: 108281686(CYP2C19)
ANAN: 110568730 135273997
CSYR: 103277060
PCOQ: 105822723
OGA: 100950266
MMMA: 107149734
GAS: 123236335 123238232
 » show all
Reference
PMID:2009263
  Authors
Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA
  Title
Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.
  Journal
Biochemistry 30:3247-55 (1991)
DOI:10.1021/bi00227a012
  Sequence
[hsa:1557]

  All links  
Ontology (6)   
   KEGG BRITE (3)   
   GO (3)   
Pathway (12)   
   KEGG PATHWAY (12)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (15)   
   KEGG ENZYME (4)   
   KEGG REACTION (6)   
   KEGG RCLASS (5)   
Gene (21)   
   KEGG GENES (20)   
   OC (1)   
Literature (1)   
   PubMed (1)   
All databases (56)   

Download RDF
KEGG   ORTHOLOGY: K17689
Entry
K17689            Tight     KO                                     
Symbol
CYP3A4
Name
cytochrome P450 family 3 subfamily A4 [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
Pathway
map00140  Steroid hormone biosynthesis
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map00983  Drug metabolism - other enzymes
map01100  Metabolic pathways
map04976  Bile secretion
map05204  Chemical carcinogenesis - DNA adducts
map05207  Chemical carcinogenesis - receptor activation
Reaction
R02356  
R03408  
R05727  quinine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
R07000  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07001  naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07055  
R07056  
R07079  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07080  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07081  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07085  benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07087  9-hydroxybenzo[a]pyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R08256  
R08257  
R08264  
R08268  
R08269  
R08271  
R08272  
R08274  
R08275  
R08276  
R08277  
R08285  
R08286  
R08287  
R08293  
R08294  
R08303  
R08304  
R08312  
R08313  
R08318  
R08339  
R08340  
R08341  
R08342  
R08343  
R08390  
R08391  
R08392  
R09404  
R09408  
R09423  
Disease
H01143  Vitamin D-dependent rickets
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   00591 Linoleic acid metabolism
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   00982 Drug metabolism - cytochrome P450
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   00983 Drug metabolism - other enzymes
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
 09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   05207 Chemical carcinogenesis - receptor activation
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.32  albendazole monooxygenase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.55  quinine 3-monooxygenase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.56  1,8-cineole 2-exo-monooxygenase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.57  taurochenodeoxycholate 6alpha-hydroxylase
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
    1.14.14.73  albendazole monooxygenase (sulfoxide-forming)
     K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP3 family
   K17689  CYP3A4; cytochrome P450 family 3 subfamily A4
Other DBs
GO: 0047638 0033780 0050591
Genes
HSA: 1576(CYP3A4)
PTR: 463582(CYP3A4)
PPS: 100976899(CYP3A4)
GGO: 101149513
PON: 100436782
PPYG: 129041698
NLE: 100593175
SSYN: 129489604
MCC: 678670(CYP3A4)
MCF: 102144258(CYP3A4)
MTHB: 126950475
MNI: 105497389
CSAB: 103246766
CATY: 105584402
PANU: 101026757
TGE: 112621193
MLEU: 105543708
RRO: 104673585
RBB: 108538168
TFN: 117072034
PTEH: 111530171 111534893
CANG: 105513064
CJC: 100404344(CYP3A4)
SBQ: 101037403
CIMI: 108308036(CYP3A4)
ANAN: 105719456(CYP3A4)
CSYR: 103252931
MMUR: 105868328 105868331
LCAT: 123631591 123631593
PCOQ: 105806078
OGA: 100948865
 » show all
Reference
PMID:3267210 (CYP3A4)
  Authors
Gonzalez FJ, Schmid BJ, Umeno M, Mcbride OW, Hardwick JP, Meyer UA, Gelboin HV, Idle JR
  Title
Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase.
  Journal
DNA 7:79-86 (1988)
DOI:10.1089/dna.1988.7.79
  Sequence
[hsa:1576]
Reference
PMID:14562963
  Authors
McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC
  Title
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
  Journal
J Mol Evol 57:200-11 (2003)
DOI:10.1007/s00239-003-2466-x
Reference
PMID:9056237 (CYP3A21)
  Authors
Igarashi T, Sakuma T, Isogai M, Nagata R, Kamataki T
  Title
Marmoset liver cytochrome P450s: study for expression and molecular cloning of their cDNAs.
  Journal
Arch Biochem Biophys 339:85-91 (1997)
DOI:10.1006/abbi.1996.9852
  Sequence
[cjc:100404344]

  All links  
Ontology (6)   
   KEGG BRITE (3)   
   GO (3)   
Pathway (20)   
   KEGG PATHWAY (20)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (1)   
   KEGG DRUG (1)   
Chemical reaction (88)   
   KEGG ENZYME (5)   
   KEGG REACTION (44)   
   KEGG RCLASS (39)   
Gene (35)   
   KEGG GENES (34)   
   OC (1)   
Literature (3)   
   PubMed (3)   
All databases (154)   

Download RDF
KEGG   ORTHOLOGY: K07413
Entry
K07413                      KO                                     
Symbol
CYP2C
Name
cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map01100  Metabolic pathways
map04726  Serotonergic synapse
map04750  Inflammatory mediator regulation of TRP channels
map05204  Chemical carcinogenesis - DNA adducts
Reaction
R03408  
R07042  
R07043  
R07048  
R07050  
R07051  
R07052  
R07054  
R07055  
R07056  
R08390  
R08392  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
   00590 Arachidonic acid metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
   00591 Linoleic acid metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07413  CYP2C; cytochrome P450 family 2 subfamily C
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07413  CYP2C; cytochrome P450 family 2 subfamily C
Genes
PON: 100449185
PPYG: 129006201
MCC: 100424240(CYP2C76)
MCF: 102114994(CYP2C76) 135965165
MTHB: 126962035 126962036
MNI: 105470210
CATY: 105576142 105581754
PANU: 101012275 101026117
TGE: 112631566
MLEU: 105553702 105553718
RRO: 104664669 104664684
RBB: 108543807 108543808
TFN: 117069747 117069809
PTEH: 111538683 111538726
CANG: 105527570
CJC: 100391987
SBQ: 101040831
CIMI: 108282285(CYP2C76)
ANAN: 105708280(CYP2C76)
CSYR: 103250328 103254835 103255987 103265697 103270233 103277163 110596230
MMUR: 105872488 105873460
LCAT: 123650042 123650046 123650138
PCOQ: 105818461 105824363
OGA: 100941342 100944925 100949727
MMU: 100043108(Cyp2c69) 107141(Cyp2c50) 13095(Cyp2c29) 13096(Cyp2c37) 13097(Cyp2c38) 13098(Cyp2c39) 13099(Cyp2c40) 226105(Cyp2c70) 226143(Cyp2c23) 404195(Cyp2c54) 433247(Cyp2c68) 545288(Cyp2c67) 69888(Cyp2c66) 72082(Cyp2c55) 72303(Cyp2c65)
MCAL: 110285234 110285299 110285416 110285739 110286013 110288497
MPAH: 110318652 110321409 110323738 110329470 110333565
RNO: 100361492(Cyp2c55) 100361547(Cyp2c7l1) 100911718 100912265(Cyp2c66) 120093077 120098584 134483996 134485234 171518(Cyp2c22) 171521(Cyp2c13) 25011(Cyp2c12) 29277(Cyp2c11) 29298(Cyp2c7) 293989(Cyp2c6v1) 499353(Cyp2c24) 83790(Cyp2c23)
MCOC: 116072985 116072994 116101173 116103883
ANU: 117695924 117704125 117704160 117707817 117707833 117710720 117710944 117711779 117712125 117714049 117714760 117715357
MUN: 110540047 110540048 110540049 110540723 110541031 110541449 110546312 110552973 110554760
CGE: 100751491 100751762 100751778 100752064 100752358 100753681 100754177 100754462 100756757 100757240 100757723 100772776 100773851 113830663 113834830
MAUA: 101823450 101829294 101830378 101831088 101831527 101832144 101832611 101841752 101842021
PROB: 127233403 127233429 127233439 127233441 127233442 127233443 127233444
PLEU: 114687277 114687280 114702470 114706456 114706863 114706876 114706883 114706891 114706892
MORG: 121453776 121453777 121453779 121453780 121453915 121453926 121453935 121453936 121453949 121453973 121453987 121453988 121453999 121454098 121454106 121454325 121454361 121454788
MFOT: 126503086 126511077 126511085
AAMP: 119808112 119808461 119808473 119808480 119808972 119811688 119814029 119818815 119824915 119824922
NGI: 103729081 103732440 103732443 103732444 103732445 103732447 103744062 103749112 103752530
HGL: 101708592 101710990
CPOC: 100716044 100719102
CCAN: 109675594 109686866 109686867
DORD: 105999354 105999358 105999359 105999360 105999362 105999363 105999364 105999365 105999366 106001658 106001659 106001669
DSP: 122115684 122115686 122115687 122115688 122115689 122115690 122115692 122115694 122115695 122115696 122115698 122115699 122115821 122115856 122115857
PLOP: 125342134 125346230 125346232 125346233 125346234 125346235 125346236 125346238 125346239 125346241 125346243
NCAR: 124984664 124984711 124984718 124984740 124984981 124985051 124985100 124985193 124985263 124985323 124985911 124985912 124985914
MMMA: 107149731 107149732 107149742 107149743
OCU: 100328549(CYP2C5) 100328924(CYP2C2) 100328933(CYP2C) 100328935(CYP2C30) 100328936(CYP2C14) 100328938(CYP2C16) 100345193 100346305 100346743(CYP2C1) 100349436(CYP2C4) 100353460 103351405
OPI: 101519662 101519910 101520157 101520641 101524854 101525811 101526220 101526786 101527195 101527783 101528381 101528927 101529516 101529922
TUP: 102467726 102501371 102503066
GVR: 103609510 103609514 103609927 103610437 103610588
CFA: 100688697 415122(CYP2C18)
CLUD: 112672099 112672554 112672584
VVP: 112917651 112917654 112928780
VLG: 121484666 121485285 121485560
NPO: 129493642 129493856 129493884
AML: 100468534 100470213 100471407
UMR: 103659697 103670756
UAH: 113243099 113251748 125282749
UAR: 123777781 123783991 123783992 123783994 123791300 123800006 123800347
ELK: 111144935 111144947
LLV: 125085077 125085209
MPUF: 101687589 101688450
MNP: 132016643 132016644
MLK: 131828623 131828625
NVS: 122898982 122898983
ORO: 101365057 101365655 101383285
EJU: 114205328 114205474 114221836
ZCA: 113919561 113923367 113923499
MLX: 118024006 118024011
NSU: 110589090 110589295
LWW: 102741683 102742186
FCA: 101089396(CYP2C41) 101089804
PYU: 121037024 121037025
PCOO: 112854419 112854424
PBG: 122493051 122493053
PVIV: 125148038 125148039
LRUF: 124506212 124507012
PTG: 102957879 102958169
PPAD: 109264681 109264682
PUC: 125932819 125933400
AJU: 106965832 106965834
HHV: 120230588 120230589 120230594
BTA: 505468(CYP2C88) 510380(CYP2C89) 511498(CYP2C23) 535243(CYP2C90) 616593(CYP2C87) 785540(CYP2C281)
BOM: 102266046 102268262 102279786 102280731 102282716 102285833
BIU: 109553136 109553148 109553149 109553151 109553186 109579059
BBUB: 102391944 102392701 102398418 102401059 102401347
BBIS: 104983529 104983530 104985773 104990182 104990186 105002722
CHX: 100861186 102169851 102180722 102185708 102185739 102188304 106503891 108633308
OAS: 100534653(CYP2C19) 100568290(CYP2C18) 101106641 101107056 101107486 101120535
BTAX: 128067928 128067935 128067944 128067982 128067983 128067984 128068009
ODA: 120873493 120873494 120873527 120873718 120873719 120873724
CCAD: 122446106 122446108 122446110 122446562 122446680 122446729 122446733
MBEZ: 129555150 129555520 129555964 129555969 129555971 129555972 129555974 129555975
SSC: 100739741 403106(CYP2C32) 403107(CYP2C33) 403108(CYP2C34) 403110(CYP2C36) 403111(CYP2C42) 403215(CYP2C49)
CFR: 102505530 102520553 102520945 102521185 102521601
CBAI: 105081748 105081809 105081810 105081811 105081813
CDK: 105084249 105084251 105084253 105084254 105084313
VPC: 102533247 102534924 102535318 102535571 102541494
BACU: 103017669
BMUS: 118882389
LVE: 103084494
OOR: 101280390 101281073
DLE: 111172397
PCAD: 102978514 102990258
PSIU: 116741310 116741704
NASI: 112392977
ECB: 100061367 100061400 100061440(CYP2C92) 100061470 100061502 100061579(CYP2C113) 100061609 100070400
EPZ: 103555431 103555432 103559687 103559691 103563727 103564575
EAI: 106828038 106842115 106842116 106842117 106842118 106846082 106846096 106846703
MYB: 102259201 102262062
MYD: 102757298 102761651
MMYO: 118669861 118669862 118669933 118669936
MLF: 102425332 102439008 102439973
MDT: 132214162 132214163 132214164 132214227
PKL: 118719320 118719322 118719385
EFUS: 103288419 103288420 103288471
MNA: 107542552 107542558 107543271
DRO: 112300219
SHON: 118988005 118999525
AJM: 119064549
PDIC: 114496070 114496071 114496072 114497455
PHAS: 123828810 123828873 123829140 123829141 123829142
MMF: 118632032 118632707
PPAM: 129077061 129077108
HAI: 109379576 109380905 109380969 109380970
RFQ: 117036205 117036207 117036211 117036262 117036412
PALE: 102891905
PGIG: 120608941 120609277 120609279
PVP: 105301394
MJV: 108409895
TOD: 119234464 119234519
SARA: 101538594 101538863 101539126 101539748 101540186 101541249 101541695 101542671 101545907 101546049 101546518 101547469 101548282 101548987 101549253 101549522 101550043 105943477
SETR: 125994861 125994862 125994864 126033411 126033848
LAV: 100666635 100675653 100676133 100676880
TMU: 101340781 101346446 101346874 101350013 101350258
ETF: 101650213 101650523 101655109 101655637 101655958
DNM: 101414777 101433008 101433204 101434138 101434218 101435423 101436676 101437101 101437727
MDO: 100020348 100023149 100023204 100023235 100026569 100026598 100026618 100026637 100028608
GAS: 123232993 123233004 123233006 123236366 123236629 123238227 123238228 123238230 123238233 123238234 123238235 123238257
SHR: 100915447 100918856 100919120 100920607 100927632 100928062 100933015 100933766
AFZ: 127551720 127551721 127551783 127552019 127552033 127552034
PCW: 110192769 110200600 110200601 110213986 110215468
TVP: 118828026 118828039 118828040 118828042 118828043 118828044 118828045 118828046 118828051 118828056 118828058 118828060 118828118 118828175 118828284 118828583 118828771 118828830 118830249 118830250 118859159
GGA: 100858007(RP11-400G3.5) 414833(CYP2C45)
PCOC: 116234486
MGP: 100544448
CJO: 107315788
TPAI: 128077571 128077572 128077573
LMUT: 125694067 125694068 125694069 125694070 125694071
NMEL: 110399446
APLA: 101797318 101805432 113844003
ACYG: 106034197 106046725
CATA: 118243351 118255579
AFUL: 116491444 116491640 116491641 116491642 116496669
TGU: 100219254 100228872
LSR: 110475152 110480306
SCAN: 103813978 103819903
PMOA: 120499733
OTC: 121338316 121341821
PRUF: 121354193 121357631
GFR: 102041497 102043152
FAB: 101806491 101815619
OMA: 130255070 130260372
PHI: 102100933 102107291
PMAJ: 107207028 107212622
CCAE: 111931097 111937179
CCW: 104695623 104697085
CBRC: 103613784 103624459
ETL: 114065370
ZAB: 102067353 102073503 102074741
ZLE: 135449336 135455550 135460995
ACHL: 103805798
SVG: 106855352 106862297
MMEA: 130581013
HRT: 120748109
SATI: 136364239 136369197 136369528
FPG: 101913238 101916760
FCH: 102048002 102059256
CCRI: 104159509 104168852
NNT: 104399782 104405230
SHAB: 115608667 115608730 115608831 115616648
ACUN: 113481765 113486792
TALA: 104360444 104363792
ACHC: 115341565 115348476
HALD: 104315668
HLE: 104831888
AGEN: 126042554 126043766
GCL: 127017485 127023938
CSTI: 104561375
LDI: 104343172 104353803
MNB: 103771400
DPUB: 104297684 104301981
AVIT: 104273142
BRHI: 104492082
EGZ: 104125355 104129118
NNI: 104010978 104018935
PCRI: 104034656 104037972
PCAO: 104045589 104049798
PADL: 103915567 103918695
AFOR: 103897610 103903595
FGA: 104073873 104081578
GSTE: 104260632 104264065
CLV: 102087915 102098038
MUI: 104534424
PGUU: 104461775 104467274
PLET: 104623081 104626155
EHS: 104504230 104516609
CMAC: 104476783
CUCA: 104060040 104060777 104067911
TEO: 104374656
BREG: 104630155 104637583
OHA: 104329922
ACAR: 104529274
CPEA: 104391477 104398212
CVF: 104281946 104289750
RTD: 128911029 128911351 128911515 128911560 128911561 128917900
AAM: 106498947 106499405
AROW: 112961017 112970877
NPD: 112950986 112956875
TGT: 104566795
DNE: 112980237 112995565
SCAM: 104141787 104143382
ASN: 102372575 102385966 102386218
AMJ: 102572949 102573559 102573618
CPOO: 109315166
GGN: 109287335 109287406
CMY: 102931882
CCAY: 125621101
DCC: 119842814 119847395
CPIC: 101945572 101950120
TST: 117887460 117888580 117888938
CABI: 116822417 116822898
MRV: 120382954 120388953
ACS: 100552964 100554667 100560019 100561903 100562097 100562300 100562499 100565059
ASAO: 132761864 132761881 132763575 132764077 132768594 132769293 132780888 132781058 132781361 132781421 132781507 132781595 132781659 132781729
PVT: 110070438 110084010 110090724
SUND: 121915628 121918763 121918778 121918807 121927308 121927315
PBI: 103054127 103067414
PMUR: 107286792 107296151
CTIG: 120296915 120298505 120298506 120317803
TSR: 106538299
PGUT: 117659140
APRI: 131190555 131190557
PTEX: 113435173 113437257
NSS: 113414159 113426274
VKO: 123035026 123035029
PMUA: 114590635 114590640 114590645 114590724 114590725 114590727 114590728
PRAF: 128407548 128407555 128407562 128407576 128407585 128407593 128407603 128407604 128408551
ZVI: 118079426 118079919 118079920 118079922 118080863 118080874
HCG: 128343349
EMC: 129324116
XLA: 108699286 379297(cyp2a6.1.S) 444542(cyp2c8.2.L)
XTR: 448236(cyp2c8.2)
NPR: 108800780
RTEM: 120913341 120936065 120936220
BBUF: 120978128 121009418
BGAR: 122923772 122923881 122940043 122941761 122945938 122946510
CPLA: 122542870
HOC: 132836798
LERI: 129714142 129714143
LRJ: 133341215 133341226
BFO: 118416246
BBEL: 109470437
SCLV: 120338348 120339246 120345724 120346076
MNZ: 135219059
HAZT: 108665260
DSV: 119449464 119459204
RSAN: 119373421
PMEO: 129596816 129596855
HRF: 124113633
HRJ: 124262364 124281202 124291019
CRG: 105333836
CANU: 128179353
CVN: 111099468 111099985 111137423
RPHI: 132743744
OSN: 115231110
LJP: 135468420 135468424
AG: AAC08738(CYP2C41) BAA02001(CYP2C26) BAA02002(CYP2C27) BAA02003(CYP2C28) CAA44753(CYP2C25)
 » show all
Reference
PMID:2831965 (CYP2C2)
  Authors
Imai Y, Komori M, Sato R
  Title
Comparison of primary structures deduced from cDNA nucleotide sequences for various forms of liver microsomal cytochrome P-450 from phenobarbital-treated rabbits.
  Journal
Biochemistry 27:80-8 (1988)
DOI:10.1021/bi00401a014
  Sequence
[ocu:100328924]
Reference
PMID:3335521 (CYP2C7)
  Authors
Kimura H, Yoshioka H, Sogawa K, Sakai Y, Fujii-Kuriyama Y
  Title
Complementary DNA cloning of cytochrome P-450s related to P-450(M-1) from the complementary DNA library of female rat livers. Predicted primary structures for  P-450f, PB-1, and PB-1-related protein with a bizarre replacement block and their mode of transcriptional expression.
  Journal
J Biol Chem 263:701-7 (1988)
  Sequence
[rno:29298]
Reference
PMID:8611037 (CYP2C11)
  Authors
Biagini C, Celier C
  Title
cDNA-directed expression of two allelic variants of cytochrome P450 2C11 using COS1 and SF21 insect cells.
  Journal
Arch Biochem Biophys 326:298-305 (1996)
DOI:10.1006/abbi.1996.0079
  Sequence
[rno:29277]
Reference
PMID:2820951 (CYP2C14)
  Authors
Imai Y
  Title
Cytochrome P-450 related to P-4504 from phenobarbital-treated rabbit liver: molecular cloning of cDNA and characterization of cytochrome P-450 obtained by its expression in yeast cells.
  Journal
J Biochem 101:1129-39 (1987)
DOI:10.1093/oxfordjournals.jbchem.a121977
  Sequence
[ocu:100328936]
Reference
PMID:2263487 (CYP2C23)
  Authors
Cook EA, Groenewegen WA, Gloger IS, Piggott JR, Suckling KE, Wolf CR
  Title
cDNA and deduced amino acid sequence of a novel cytochrome P-450 from female rat liver mRNA with high homology to P-450 IIC family.
  Journal
Nucleic Acids Res 18:7156 (1990)
DOI:10.1093/nar/18.23.7156
  Sequence
[rno:83790]
Reference
PMID:8114672 (CYP2C25 CYP2C26 CYP2C27)
  Authors
Sakuma T, Masaki K, Itoh S, Yokoi T, Kamataki T
  Title
Sex-related differences in the expression of cytochrome P450 in hamsters: cDNA cloning and examination of the expression of three distinct CYP2C cDNAs.
  Journal
Mol Pharmacol 45:228-36 (1994)
  Sequence
[ag:CAA44753 BAA02001 BAA02002]
Reference
PMID:7771794 (CYP2C28)
  Authors
Sakuma T, Yokoi T, Kamataki T
  Title
Isolation and characterization of a new cDNA clone belonging to the cytochrome P450 2C gene subfamily in hamsters.
  Journal
Arch Biochem Biophys 319:267-73 (1995)
DOI:10.1006/abbi.1995.1291
  Sequence
[ag:BAA02003]
Reference
PMID:8130255 (CYP2C29)
  Authors
Matsunaga T, Watanabe K, Yamamoto I, Negishi M, Gonzalez FJ, Yoshimura H
  Title
cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2, a microsomal aldehyde oxygenase.
  Journal
Biochim Biophys Acta 1184:299-301 (1994)
DOI:10.1016/0005-2728(94)90237-2
  Sequence
[mmu:13095]
Reference
PMID:9721182 (CYP2C37)
  Authors
Luo G, Zeldin DC, Blaisdell JA, Hodgson E, Goldstein JA
  Title
Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid.
  Journal
Arch Biochem Biophys 357:45-57 (1998)
DOI:10.1006/abbi.1998.0806
  Sequence
[mmu:13096]
Reference
PMID:9492393 (CYP2C41)
  Authors
Blaisdell J, Goldstein JA, Bai SA
  Title
Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression.
  Journal
Drug Metab Dispos 26:278-83 (1998)
  Sequence
[ag:AAC08738]
Reference
PMID:15102943 (CYP2C50)
  Authors
Wang H, Zhao Y, Bradbury JA, Graves JP, Foley J, Blaisdell JA, Goldstein JA, Zeldin DC
  Title
Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities.
  Journal
Mol Pharmacol 65:1148-58 (2004)
DOI:10.1124/mol.65.5.1148
  Sequence
[mmu:107141]
Reference
PMID:2263625 (CYP2C70)
  Authors
Emi Y, Chijiiwa C, Omura T
  Title
A different cytochrome P450 form is induced in primary cultures of rat hepatocytes.
  Journal
Proc Natl Acad Sci U S A 87:9746-50 (1990)
DOI:10.1073/pnas.87.24.9746
  Sequence
[rno:171518]

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (16)   
   KEGG PATHWAY (16)   
Chemical reaction (20)   
   KEGG ENZYME (1)   
   KEGG REACTION (12)   
   KEGG RCLASS (7)   
Gene (1111)   
   KEGG GENES (966)   
   KEGG MGENES (93)   
   RefGene (50)   
   OC (2)   
Literature (12)   
   PubMed (12)   
All databases (1162)   

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KEGG   ORTHOLOGY: K17719
Entry
K17719                      KO                                     
Symbol
CYP2C9
Name
cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
map05417  Lipid and atherosclerosis
Reaction
R07048  
R07050  
R07051  
R07055  
R07056  
R07079  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07080  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07081  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07085  benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07087  9-hydroxybenzo[a]pyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R08267  
R08275  
R08285  
R08324  
R08325  
R08326  
R08390  
R08392  
Disease
H01205  Coumarin resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
   00591 Linoleic acid metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
   00982 Drug metabolism - cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
    1.14.14.52  (S)-limonene 7-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
    1.14.14.53  (R)-limonene 6-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Other DBs
GO: 0018675 0018676 0052741
Genes
HSA: 1559(CYP2C9)
PTR: 100616515(CYP2C9)
PPS: 100996034(CYP2C9)
GGO: 101126456
PON: 100450749(CYP2C9)
PPYG: 129006530
NLE: 100591471
HMH: 116457268
SSYN: 129468897
MCC: 678686(CYP2C75) 678695(CYP2C9)
MCF: 102115450(CYP2C9) 102147103(CYP2C19)
MTHB: 126962028 126962032
MNI: 105479916 105479949
CSAB: 103216299(CYP2C19) 103216301(CYP2C9)
CATY: 105575618 105581138 105586929 105586938
PANU: 100997824 101012978
TGE: 112631549 112631550
MLEU: 105534699 105534700 105535382 105536626
RRO: 104665355 104666123
TFN: 117083900 117092015
PTEH: 111531037 111552212
CANG: 105501587 105504516 105504517
DORD: 106001520
NCAR: 124985776
TVP: 118828297 118828298 118828299 118828301 118828302
 » show all
Reference
PMID:3196692
  Authors
Ged C, Umbenhauer DR, Bellew TM, Bork RW, Srivastava PK, Shinriki N, Lloyd RS, Guengerich FP
  Title
Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.
  Journal
Biochemistry 27:6929-40 (1988)
DOI:10.1021/bi00418a039
  Sequence
[hsa:1559]

  All links  
Ontology (6)   
   KEGG BRITE (3)   
   GO (3)   
Pathway (18)   
   KEGG PATHWAY (18)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (33)   
   KEGG ENZYME (3)   
   KEGG REACTION (18)   
   KEGG RCLASS (12)   
Gene (49)   
   KEGG GENES (47)   
   OC (2)   
Literature (1)   
   PubMed (1)   
All databases (108)   

Download RDF
KEGG   ORTHOLOGY: K07410
Entry
K07410                      KO                                     
Symbol
CYP1B1
Name
cytochrome P450 family 1 subfamily B1 [EC:1.14.14.1]
Pathway
map00140  Steroid hormone biosynthesis
map00380  Tryptophan metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map04913  Ovarian steroidogenesis
map05204  Chemical carcinogenesis - DNA adducts
map05206  MicroRNAs in cancer
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
Reaction
R03088  
R03090  
R03629  melatonin,NADPH---hemoprotein reductase:oxygen oxidoreductase
R07079  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07080  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07081  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07085  benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07087  9-hydroxybenzo[a]pyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R09416  
R09418  
R09442  
Disease
H01159  Anterior segment dysgenesis
H01203  Primary congenital glaucoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
   05204 Chemical carcinogenesis - DNA adducts
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
   05207 Chemical carcinogenesis - receptor activation
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP1 family
   K07410  CYP1B1; cytochrome P450 family 1 subfamily B1
Genes
HSA: 1545(CYP1B1)
PTR: 459163(CYP1B1)
PPS: 100989599(CYP1B1)
GGO: 101134278
PPYG: 129030233
NLE: 100583040
HMH: 116483024
SSYN: 129461983
MCC: 710385(CYP1B1)
MCF: 102146810(CYP1B1)
MTHB: 126933548
MNI: 105464862
CSAB: 103220462(CYP1B1)
CATY: 105597190
PANU: 101014578
TGE: 112637014
MLEU: 105551910
RRO: 104680972
RBB: 108520884
TFN: 117062450
PTEH: 111545371
CANG: 105507461
CJC: 100395270(CYP1B1)
SBQ: 101049264
CIMI: 108293778(CYP1B1)
ANAN: 105733181(CYP1B1)
CSYR: 103271895
MMUR: 105884508
LCAT: 123636812
PCOQ: 105818018
OGA: 100949593
MMU: 13078(Cyp1b1)
MCAL: 110312728
MPAH: 110335735
RNO: 25426(Cyp1b1)
MCOC: 116079592
ANU: 117716952
MUN: 110547086
CGE: 100759241
MAUA: 101839568
PROB: 127217018
PLEU: 114683578
MORG: 121432953
MFOT: 126514555
AAMP: 119807802
NGI: 103725278
HGL: 101701066
CPOC: 100719054
CCAN: 109685237
DORD: 105986861
DSP: 122104563
PLOP: 125356549
NCAR: 124962692
MMMA: 107137344
OCU: 100358590
OPI: 101531725
TUP: 102492978
GVR: 103600797
CFA: 483038(CYP1B1)
CLUD: 112664509
VVP: 112935290
VLG: 121491956
NPO: 129511133
AML: 100466967
UMR: 103671894
UAH: 113241453
UAR: 123799824
ELK: 111158468 111158469
LLV: 125109142
MPUF: 101676151
MNP: 132021297
MLK: 131840517
NVS: 122915146
ORO: 101365942
EJU: 114219641
ZCA: 113937594
MLX: 118007783
NSU: 110587203
LWW: 102734979
FCA: 101099873(CYP1B1)
PYU: 121044356
PCOO: 112864309
PBG: 122497249
PVIV: 125162246
LRUF: 124502968
PTG: 102950579
PPAD: 109265731
PUC: 125937522
AJU: 106978960
HHV: 120244637
BTA: 511470(CYP1B1)
BOM: 102283377
BIU: 109565990
BBUB: 102406111
BBIS: 104999966
CHX: 102184252
OAS: 101119706
BTAX: 128056850
ODA: 120851684
CCAD: 122441577
MBEZ: 129539617
SSC: 100625479
CFR: 102510682
CBAI: 105078974
CDK: 105103641
VPC: 102527799
BACU: 103004066
BMUS: 118906405
LVE: 103083349
OOR: 101289532
DLE: 111174870
PCAD: 102981351
PSIU: 116764271
NASI: 112405151
ECB: 100070088(CYP1B1)
EPZ: 103548412
EAI: 106825888
MYB: 102251701
MYD: 102767262
MMYO: 118669092
MLF: 102417339
MDT: 132213463
PKL: 118717247
EFUS: 103305457
MNA: 107541766
DRO: 112298126
SHON: 119001228
AJM: 119063849
PDIC: 114500131
PHAS: 123811584
MMF: 118631254
PPAM: 129066174
HAI: 109385488
RFQ: 117033397
PALE: 102885732
PGIG: 120621764
PVP: 105292959
RAY: 107519646
MJV: 108387118
TOD: 119259388
SARA: 101541021
SETR: 126024319
LAV: 100655003
TMU: 101340605
ETF: 101642387
DNM: 101414120
MDO: 100011610
GAS: 123234682
SHR: 100935353
AFZ: 127547991
PCW: 110201392
TVP: 118840815
OAA: 100079784(CYP1B1)
GGA: 421466(CYP1B1)
PCOC: 116233159
MGP: 100542888
CJO: 107311343
TPAI: 128075828
LMUT: 125689921
NMEL: 110396658
APLA: 101797494
ACYG: 106029463(CYP1B1)
CATA: 118256369
AFUL: 116488292
TGU: 100230258
LSR: 110469414
SCAN: 103821707
PMOA: 120506903
OTC: 121335862
PRUF: 121358603
FAB: 101808257
OMA: 130250635
PHI: 102104659
PMAJ: 107202509
CCW: 104684373
CBRC: 103624139
ETL: 114065190
ZAB: 102068269
ZLE: 135445756
SVG: 106853380
MMEA: 130588841
HRT: 120749971
SATI: 136359346(CYP1B1)
FPG: 101910938
FCH: 102051876
SHAB: 115613974
ACUN: 113478680
TALA: 104365716
ACHC: 115350101
HLE: 104840371
AGEN: 126051773
GCL: 127015235
DPUB: 104310306
EGZ: 104124112
NNI: 104018708
PADL: 103922881
AFOR: 103902731
CLV: 102085752
CUCA: 104057920
CPEA: 104394945
RTD: 128907848
AAM: 106485484
AROW: 112973407
NPD: 112957572
DNE: 112984647
ASN: 102377626 102384287
AMJ: 102560255(CYP1B1)
CPOO: 109319889
GGN: 109304747
PSS: 102451045
CMY: 114019062
CCAY: 125633811
DCC: 119853199
CPIC: 101941680
TST: 117874620
CABI: 116822556
MRV: 120400195
ACS: 100561291
ASAO: 132761265
PVT: 110083935
SUND: 121924964
PBI: 103059588
PMUR: 107287481
CTIG: 120312077
TSR: 106557416
PGUT: 117671886
APRI: 131188812
PTEX: 113433135
NSS: 113420648
VKO: 123033875
PMUA: 114594484
PRAF: 128410934
ZVI: 118082704
HCG: 128348029
GJA: 107120817
STOW: 125426126
EMC: 129332247
XLA: 108716653(cyp1b1.L) 108717803(cyp1b1.S)
XTR: 100490477(cyp1b1)
RTEM: 120937478
BBUF: 120998783
BGAR: 122934643
MUO: 115465046
GSH: 117357799
DRE: 100150054(cyp1b1)
SRX: 107719205 107747251
SANH: 107665613 107676394
SGH: 107549156 107586077
CCAR: 109100547 109100558
CAUA: 113092372 113112441
CGIB: 127970242 128025950
PTET: 122356348
LROH: 127174914
OMC: 131551981
PPRM: 120468625
RKG: 130106379
MAMB: 125277247
CIDE: 127525467
CERY: 137020866(cyp1b1)
MASI: 127411871 127414411
TROS: 130559519
TDW: 130432018
MANU: 129416488
IPU: 100313516(cyp1b)
IFU: 128605886
PHYP: 113545523
SMEO: 124378272
TFD: 113661120
TVC: 132847483
TRN: 134315182
AMEX: 103036816
CMAO: 118810623
EEE: 113579900
CHAR: 122131797
TRU: 101073188
TFS: 130534129
LCO: 104921916
NCC: 104946527 104949720
TBEN: 117475682
CGOB: 115020443
PGEO: 117459262
GACU: 117551219
EMAC: 134859020
ELY: 117248681
EFO: 125903589
PLEP: 121954937
SLUC: 116047866
ECRA: 117960939
ESP: 116705258
PFLV: 114571967
GAT: 120820387
PPUG: 119214523
AFB: 129092225
CLUM: 117744395
MSAM: 119916912
SCHU: 122884819
CUD: 121510615
ALAT: 119034148
MZE: 101487279
ONL: 100653403(cyp1b1)
OAU: 116318802
OLA: 101159216
OML: 112140813
CSAI: 133464182
XMA: 102221787
XCO: 114138595
XHE: 116713268
PRET: 103477101
PFOR: 103148258
PLAI: 106951802
PMEI: 106920957
GAF: 122842251
PPRL: 129352646
CVG: 107088618
CTUL: 119782895
GMU: 124858669
NFU: 107375515
KMR: 108247157
ALIM: 106525583
NWH: 119410756
AOCE: 111586556
MCEP: 125019270
CSEM: 103387492
POV: 109629221
SSEN: 122781479
HHIP: 117775246
HSP: 118119456
PPLT: 128453164
SMAU: 118284036
LCF: 108886282
SDU: 111220624
SLAL: 111669388
XGL: 120796037
HCQ: 109523136
SSCV: 125978233
SBIA: 133509672
PEE: 133409881
PTAO: 133486069
MALB: 109962476
BSPL: 114842071
SJO: 128372829
SASA: 106576803 106604807
STRU: 115153034 115193979
OTW: 112252828 112252866
OMY: 100381269(cyp1b1) 110502297
OGO: 124041418
ONE: 115113365 115135284
OKI: 109889798 109899606
OKE: 118369530 118401769
SALP: 111952066 111978757
SNH: 120017899 120045592
CCLU: 121553509 121582677
ELS: 105029712
SFM: 108925836
PKI: 111849531
AANG: 118218479
LOC: 102695612
PSPA: 121315656 121316728
ARUT: 117403234 117410677
PSEX: 120516625
LCM: 102362765
CMK: 103178928
RTP: 109922910
CPLA: 122548483
HOC: 132831043
LERI: 129697626
PMRN: 116939745 116943149 116948393
LRJ: 133339223 133347278 133352819
SCLV: 120340657 120340658
CRG: 105345597
CANU: 128187749
CVN: 111133558
OED: 125657726 125670494
MMER: 123544838
RPHI: 132723153 132751856 132757626
MAEA: 128228812
XEN: 124445177 124446641
 » show all
Reference
PMID:8175734
  Authors
Sutter TR, Tang YM, Hayes CL, Wo YY, Jabs EW, Li X, Yin H, Cody CW, Greenlee WF
  Title
Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.
  Journal
J Biol Chem 269:13092-9 (1994)
DOI:10.1016/S0021-9258(17)36803-5
  Sequence
[hsa:1545]

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