KEGG ORTHOLOGY: K17721

ORTHOLOGY: K17721

Entry

K17721                      KO

Symbol

CYP2C19

Name

cytochrome P450 family 2 subfamily C19 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.75 1.14.14.-]

Pathway

map00590

Arachidonic acid metabolism

map00591

Linoleic acid metabolism

map00982

Drug metabolism - cytochrome P450

map01100

Metabolic pathways

map04726

Serotonergic synapse

map05204

Chemical carcinogenesis - DNA adducts

Disease

H01171

Poor drug metabolism

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
   00591 Linoleic acid metabolism
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.52  (S)-limonene 7-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.53  (R)-limonene 6-monooxygenase
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.75  fenbendazole monooxygenase (4'-hydroxylating)
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
    1.14.14.-
     K17721  CYP2C19; cytochrome P450 family 2 subfamily C19
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP2 family
   K17721  CYP2C19; cytochrome P450 family 2 subfamily C19

Other DBs

RN:	R07046 R07055 R07056 R08275 R08285 R08343

GO:	0018675 0018676 0052741

Genes

HSA:	1557(CYP2C19)

PTR:	740956(CYP2C19)

PPS:	100995695(CYP2C19)

GGO:

PON:

NLE:

HMH:

PTEH:

CJC:	100389947(CYP2C19)

SBQ:

101041912

CIMI:

108281686(CYP2C19)

CSYR:

103277060

PCOQ:

105822723

OGA:

100950266

GAS:	123236335 123238232

» show all

Reference

PMID:2009263

Authors

Romkes M, Faletto MB, Blaisdell JA, Raucy JL, Goldstein JA

Title

Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.

Journal

Biochemistry 30:3247-55 (1991)
DOI:10.1021/bi00227a012

Sequence

[hsa:1557]

All links

Ontology (6)   
   KEGG BRITE (3)   
   GO (3)   
Pathway (12)   
   KEGG PATHWAY (12)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (15)   
   KEGG ENZYME (4)   
   KEGG REACTION (6)   
   KEGG RCLASS (5)   
Gene (17)   
   KEGG GENES (16)   
   OC (1)   
Literature (1)   
   PubMed (1)   
All databases (52)   

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ORTHOLOGY: K17719

Entry

K17719                      KO

Symbol

CYP2C9

Name

cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]

Pathway

map00590

Arachidonic acid metabolism

map00591

Linoleic acid metabolism

map00830

Retinol metabolism

map00980

Metabolism of xenobiotics by cytochrome P450

map00982

Drug metabolism - cytochrome P450

map01100

Metabolic pathways

map04726

Serotonergic synapse

map05204

Chemical carcinogenesis - DNA adducts

map05417

Lipid and atherosclerosis

Disease

H01205

Coumarin resistance

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
   00591 Linoleic acid metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
   00982 Drug metabolism - cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
    1.14.14.52  (S)-limonene 7-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
    1.14.14.53  (R)-limonene 6-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
    1.14.14.-
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP2 family
   K17719  CYP2C9; cytochrome P450 family 2 subfamily C9

Other DBs

RN:	R07048 R07050 R07051 R07055 R07056 R07079 R07080 R07081 R07085 R07087 R08267 R08275 R08285 R08324 R08325 R08326 R08390 R08392

GO:	0018675 0018676 0052741

Genes

HSA:	1559(CYP2C9)

PTR:	100616515(CYP2C9)

PPS:	100996034(CYP2C9)

GGO:

PON:

NLE:

HMH:

MCC:	678686(CYP2C75) 678695(CYP2C9)

MCF:	102115450(CYP2C9) 102147103(CYP2C19)

MTHB:

126962028 126962032

MNI:	105479916 105479949

CSAB:

103216299(CYP2C19) 103216301(CYP2C9)

CATY:

105575618 105581138 105586929 105586938

PANU:

100997824 101012978

TGE:	112631549 112631550

MLEU:

105534699 105534700 105535382 105536626

RRO:	104665355 104666123

TFN:	117083900 117092015

PTEH:

111531037

CANG:

105501587 105504516 105504517

DORD:

106001520

NCAR:

124985776

» show all

Reference

PMID:3196692

Authors

Ged C, Umbenhauer DR, Bellew TM, Bork RW, Srivastava PK, Shinriki N, Lloyd RS, Guengerich FP

Title

Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.

Journal

Biochemistry 27:6929-40 (1988)
DOI:10.1021/bi00418a039

Sequence

[hsa:1559]

All links

Ontology (6)   
   KEGG BRITE (3)   
   GO (3)   
Pathway (18)   
   KEGG PATHWAY (18)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (33)   
   KEGG ENZYME (3)   
   KEGG REACTION (18)   
   KEGG RCLASS (12)   
Gene (41)   
   KEGG GENES (39)   
   OC (2)   
Literature (1)   
   PubMed (1)   
All databases (100)   

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