KEGG   ORTHOLOGY: K17741
Entry
K17741                      KO                                     

Name
GRE2
Definition
NADPH-dependent methylglyoxal reductase [EC:1.1.1.283]
Pathway
ko00620  Pyruvate metabolism
ko00640  Propanoate metabolism
ko01100  Metabolic pathways
ko04011  MAPK signaling pathway - yeast
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K17741  GRE2; NADPH-dependent methylglyoxal reductase
   00640 Propanoate metabolism
    K17741  GRE2; NADPH-dependent methylglyoxal reductase
 09130 Environmental Information Processing
  09132 Signal transduction
   04011 MAPK signaling pathway - yeast
    K17741  GRE2; NADPH-dependent methylglyoxal reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.283  methylglyoxal reductase (NADPH)
     K17741  GRE2; NADPH-dependent methylglyoxal reductase
Other DBs
RN: R02260
COG: COG0451
GO: 0043892
Genes
SCE: YOL151W(GRE2)
KLA: KLLA0_D11000g
KMX: KLMA_30018(ARI1) KLMA_40628 KLMA_60425(GRE2) KLMA_80004 KLMA_80060
LTH: KLTH0B06182g KLTH0B06402g KLTH0E09680g KLTH0F04026g
VPO: Kpol_1030p19 Kpol_1057p21 Kpol_416p7 Kpol_529p27
ZRO: ZYRO0A13574g ZYRO0B00330g ZYRO0B16742g ZYRO0C18546g ZYRO0E10362g ZYRO0F05214g ZYRO0F18656g ZYRO0G00242g ZYRO0G15400g ZYRO0G22506g
CGR: CAGL0E05170g CAGL0E05280g
NCS: NCAS_0A03090(NCAS0A03090) NCAS_0A03400(NCAS0A03400) NCAS_0A07210(NCAS0A07210) NCAS_0C05270(NCAS0C05270) NCAS_0C05980(NCAS0C05980) NCAS_0D02420(NCAS0D02420) NCAS_0D03480(NCAS0D03480) NCAS_0D04850(NCAS0D04850) NCAS_0G03820(NCAS0G03820) NCAS_0H00790(NCAS0H00790)
NDI: NDAI_0D00910(NDAI0D00910) NDAI_0D05090(NDAI0D05090) NDAI_0F01560(NDAI0F01560) NDAI_0I02450(NDAI0I02450)
TPF: TPHA_0A00590(TPHA0A00590) TPHA_0F03690(TPHA0F03690) TPHA_0M01160(TPHA0M01160) TPHA_0N01940(TPHA0N01940) TPHA_0O00640(TPHA0O00640) TPHA_0O01220(TPHA0O01220)
TBL: TBLA_0A01590(TBLA0A01590) TBLA_0C00270(TBLA0C00270) TBLA_0C00280(TBLA0C00280) TBLA_0C03410(TBLA0C03410) TBLA_0C03420(TBLA0C03420) TBLA_0C03430(TBLA0C03430) TBLA_0D00750(TBLA0D00750)
TDL: TDEL_0A00160(TDEL0A00160) TDEL_0C00230(TDEL0C00230) TDEL_0C02800(TDEL0C02800) TDEL_0D00270(TDEL0D00270)
KAF: KAFR_0A08710(KAFR0A08710) KAFR_0A08720(KAFR0A08720) KAFR_0C00150(KAFR0C00150)
PIC: PICST_32463(GRP3.1) PICST_58065(GRP3.3) PICST_72153(GRE2)
CAL: CAALFM_C205560WA(CaO19.6868) CAALFM_C206710WA(CaO19.3151) CAALFM_C206720WA(GRE2) CAALFM_C502860CA(GRP2) CAALFM_C603240WA(CaO19.5611) CAALFM_CR01810CA(CaO19.2581)
 » show all
Reference
  Authors
Chen CN, Porubleva L, Shearer G, Svrakic M, Holden LG, Dover JL, Johnston M, Chitnis PR, Kohl DH
  Title
Associating protein activities with their genes: rapid identification of a gene encoding a methylglyoxal reductase in the yeast Saccharomyces cerevisiae.
  Journal
Yeast 20:545-54 (2003)
DOI:10.1002/yea.979
  Sequence
[sce:YOL151W]

KEGG   ORTHOLOGY: K23257
Entry
K23257                      KO                                     

Name
yvgN
Definition
methylglyoxal/glyoxal reductase [EC:1.1.1.283 1.1.1.-]
Pathway
ko00620  Pyruvate metabolism
ko00640  Propanoate metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K23257  yvgN; methylglyoxal/glyoxal reductase
   00640 Propanoate metabolism
    K23257  yvgN; methylglyoxal/glyoxal reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.283  methylglyoxal reductase (NADPH)
     K23257  yvgN; methylglyoxal/glyoxal reductase
    1.1.1.-  
     K23257  yvgN; methylglyoxal/glyoxal reductase
Other DBs
RN: R02260
COG: COG0656
GO: 0043892
Genes
ROR: RORB6_02415
RAO: DSD31_08780
PRAG: EKN56_09940
ASU: Asuc_1306
SBJ: CF168_09640
APEL: CA267_005885
GPS: C427_2672
SALM: D0Y50_02660
SALK: FBQ74_14455
MICC: AUP74_03319
LPH: LPV_0621(ytbE)
LPO: LPO_0588(ytbE)
LPM: LP6_0510(ytbE)
LPF: lpl0556
LPP: lpp0580
LPC: LPC_2827(ytbE)
LPA: lpa_00779(ara1)
LPE: lp12_0522
LLO: LLO_1579
LFA: LFA_0182
LLG: 44548918_00519(ytbE)
LJR: NCTC11533_00574(ytbE)
LWA: SAMEA4504053_2963(ara1)
TMC: LMI_0057
METL: U737_23860
MAH: MEALZ_0489(ytbE)
DNO: DNO_0829
SVA: SVA_2858
HHE: HH_1471
SULR: B649_03920
CCUN: CCUN_1892
AMYT: AMYT_1325
HBV: ABIV_1078
SHAL: SHALO_0490
SCL: sce8343(dkgB)
CAK: Caul_5283
CID: P73_3722
RHC: RGUI_3078
RID: RIdsm_01149(yvgN)
MAGX: XM1_3211
MAGN: WV31_07235
BSU: BSU33400(yvgN)
BSH: BSU6051_29050(ytbE) BSU6051_33400(yvgN)
BSUT: BSUB_03093(ytbE) BSUB_03568(yvgN)
BSUL: BSUA_03093(ytbE) BSUA_03568(yvgN)
BSS: BSUW23_14120(ytbE) BSUW23_16365(yvgN)
BSO: BSNT_09325(ytbE) BSNT_09856(yvgN)
BSQ: B657_29050(ytbE) B657_33400(yvgN)
BSX: C663_2750(ytbE) C663_3209(yvgN)
BLI: BL00701(yvgN)
BLD: BLi03528(yvgN)
BLH: BaLi_c35910(yvgN)
BAQ: BACAU_2626(ytbE) BACAU_3082(yvgN)
BYA: BANAU_2824(ytbE) BANAU_3247(yvgN)
BAML: BAM5036_2549(ytbE) BAM5036_2970(yvgN)
BAMA: RBAU_2746(ytbE) RBAU_3189(yvgN)
BAMN: BASU_2552(ytbE) BASU_2975(yvgN)
BAMB: BAPNAU_0944(ytbE) BAPNAU_3254(yvgN)
BAMY: V529_28970(ytbE) V529_33190
BMP: NG74_02751(ytbE) NG74_03226(yvgN)
BAO: BAMF_2708(ytbE) BAMF_3187(yvgN)
BAZ: BAMTA208_14265(ytbE) BAMTA208_16930(yvgN)
BQL: LL3_02993(ytbE) LL3_03470(yvgN)
BXH: BAXH7_02921(ytbE) BAXH7_03457(yvgN)
BQY: MUS_3180(ytbE) MUS_3654(yvgN)
BWW: bwei_0852(yvgN) bwei_4697(dkgA) bwei_5541
BMYC: DJ92_1192
BCL: ABC2110
BMEG: BG04_3206
BCOA: BF29_1246
BACO: OXB_0365
BACL: BS34A_31680(ytbE) BS34A_36460(yvgN)
BGY: BGLY_3917(yvgN)
GKA: GK0562
GTN: GTNG_0505
GGH: GHH_c05420(ytbE)
GEA: GARCT_00563(yvgN)
AFL: Aflv_1208
AAMY: GFC30_947
LSP: Bsph_0089(ytbE) Bsph_0361
HLI: HLI_10340
VPN: A21D_00639(dkgA) A21D_02538(yvgN)
PSYO: PB01_15695
SAU: SA1606
SUZ: MS7_0754(yvgN) MS7_1787
SER: SERP1350
SDT: SPSE_1010
SSCH: LH95_04920
SSCZ: RN70_05115
SAGQ: EP23_04670
SDP: NCTC12225_01215(yvgN)
MCL: MCCL_0460
MCAK: MCCS_06630
LMO: lmo0823
LMOQ: LM6179_1137(yvgN) LM6179_3027(ytbE)
LMR: LMR479A_0841(yvgN) LMR479A_2361(ytbE)
LMOG: BN389_08530(yvgN) BN389_22780(ytbE)
LMQ: LMM7_0854(dkgA) LMM7_2349(dkgA)
LIN: lin0819
LGZ: NCTC10812_02018(yvgN_2) NCTC10812_02214(yvgN_3)
ESI: Exig_0413
GHA: NCTC10459_01005(yvgN)
PPM: PPSC2_01645(ytbE) PPSC2_04330(yvgN)
PPO: PPM_0311(ytbE) PPM_0809(yvgN)
PMS: KNP414_03688(yvgN) KNP414_07911(ytbE)
PRI: PRIO_2517(yvgN1) PRIO_5501(ytbE1) PRIO_6536(ytbE3)
PSWU: SY83_16510
ASOC: CB4_02589(yvgN)
AAC: Aaci_0848
AAD: TC41_0849
BTS: Btus_0334
SIV: SSIL_0674
KZO: NCTC404_01393(yvgN_1)
LLK: LLKF_2067(yteC)
LLT: CVCAS_1813(yteC)
LLS: lilo_1878(yteC)
LLX: NCDO2118_1994(yteC)
LLC: LACR_2068
LLR: llh_2700
LLJ: LG36_1829(yteC)
SAG: SAG0429
SAK: SAK_0513
SGC: A964_0440
SAGM: BSA_5180
SAGR: SAIL_5230
SAGP: V193_02350
SAGC: DN94_02350
SAGE: EN72_02550
SAGN: W903_0532
SIK: K710_0814
LJH: LJP_0999c
LAC: LBA1427
LSI: HN6_00624
LSJ: LSJ_0771
LCA: LSEI_0443
LCS: LCBD_0508
LCE: LC2W_0510
LPAP: LBPC_0409
LCW: BN194_05160(P100_11E_2)
LGA: LGAS_0964
LHL: LBHH_0642
LRH: LGG_00259(dkgA) LGG_00541(ycgG)
LRL: LC705_00250(dkgA) LC705_00531(ycgG)
LAM: LA2_08205
PPE: PEPE_0051
PPEN: T256_00255
EFA: EF1138
EFL: EF62_1588
EFI: OG1RF_10915(dkgB)
EFS: EFS1_0965
EFQ: DR75_209
ECAS: ECBG_00801
WKO: WKK_01690
CRN: CAR_c05880(yvgN2) CAR_c13360(yvgN4) CAR_c15930(yvgN5) CAR_c23350(yvgN6)
CML: BN424_1113(yvgN) BN424_3458(ytbE)
JDA: BW727_100319(yvgN_1) BW727_100820(yvgN_2) BW727_101925(ytbE)
CAC: CA_C1958
CAE: SMB_G1990(yvgN)
CAY: CEA_G1975
CBO: CBO0984(dkgA)
CBA: CLB_1023
CBH: CLC_1037
CBL: CLK_0430
CBK: CLL_A1844
CBI: CLJ_B1026
CBT: CLH_1658
CBE: Cbei_3512
CBZ: Cbs_3512
CLT: CM240_2814(yvgN)
CSQ: CSCA_0059
ASF: SFBM_0589
HSC: HVS_10975(yvgN)
CSD: Clst_0450
FPA: FPR_27380
COO: CCU_19270
CPY: Cphy_1752
HSD: SD1D_1902(P100_11E)
EHL: EHLA_1609
PUF: UFO1_0239
ERH: ERH_0073
MPE: MYPE4720(MYPE4720)
MGA: MGA_0093
MGH: MGAH_0093
MGF: MGF_2916
MGZ: GCW_02500
MHA: HF1_10850(ytbE)
MHF: MHF_1174
MWE: WEN_01605
MPV: PRV_01760
ABRA: BN85308370
APAL: BN85405070
AAXA: NCTC10138_00770(yvgN_1) NCTC10138_01144(yvgN_2)
AHK: NCTC10172_00286(yvgN_1) NCTC10172_00638(yvgN_2)
CGB: cg1192
CGU: WA5_1003
CGM: cgp_1192
CGJ: AR0_05740
CVA: CVAR_0272
ROP: ROP_34220
GOM: D7316_01975(yvgN)
PFRE: RM25_2308
PAUS: NCTC13651_00878(yvgN)
ACIJ: JS278_03000(yvgN)
NAL: B005_4996
BLJ: BLD_0149(akrA1)
BLN: Blon_0820
BLF: BLIF_1357
BLL: BLJ_1332
BLB: BBMN68_177(akrA1)
BLA: BLA_1215(morA)
BBB: BIF_01116
BBC: BLC1_0660
BLV: BalV_0664
BLW: W7Y_0691
BLS: W91_0714
BANI: Bl12_0644
BANL: BLAC_03455
BANM: EN10_03495
BBP: BBPR_0519
BBI: BBIF_0543
BBF: BBB_0497
BAST: BAST_0618
BTP: D805_1704
BCOR: BCOR_0524
BPSP: AH67_03765
SIJ: SCIP_1358
ELE: Elen_1699
PRC: EW14_1496
ATM: ANT_26770
ABAT: CFX1CAM_2214(yvgN)
TPED: TPE_1379
SMF: Smon_1288
PMUC: ING2E5A_0516(yvgN)
BACC: BRDCF_p694(yvgN)
CPI: Cpin_6724
FLM: MY04_1612
GFO: GFO_0840
ZPR: ZPR_1260
MARM: YQ22_08605
CBAL: M667_10625
CBAT: M666_10630
MLT: VC82_1415
EAO: BD94_1842
ELB: VO54_00900(yvgN)
SPON: HME9304_01592(dkgA)
PMO: Pmob_1501
DTN: DTL3_1551(yvgN1)
NJA: NSJP_3497
HUT: Huta_0858
HLA: Hlac_1561
SALI: L593_15055
 » show all
Reference
  Authors
Sakai A, Katayama K, Katsuragi T, Tani Y
  Title
Glycolaldehyde-forming route in Bacillus subtilis in relation to vitamin B6 biosynthesis.
  Journal
J Biosci Bioeng 91:147-52 (2001)
DOI:10.1016/S1389-1723(01)80057-8
  Sequence
[bsu:BSU33400]

KEGG   ENZYME: 1.1.1.283
Entry
EC 1.1.1.283                Enzyme                                 

Name
methylglyoxal reductase (NADPH);
lactaldehyde dehydrogenase (NADP+);
GRE2 (gene name);
methylglyoxal reductase (NADPH-dependent);
lactaldehyde:NADP+ oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(S)-lactaldehyde:NADP+ oxidoreductase
Reaction(IUBMB)
(S)-lactaldehyde + NADP+ = 2-oxopropanal + NADPH + H+ [RN:R02260]
Reaction(KEGG)
R02260
Substrate
(S)-lactaldehyde [CPD:C00424];
NADP+ [CPD:C00006]
Product
2-oxopropanal [CPD:C00546];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme from the yeast Saccharomyces cerevisiae catalyses the reduction of a keto group in a number of compounds, forming enantiopure products. Among the substrates are methylglyoxal (which is reduced to (S)-lactaldehyde) [1,2], 3-methylbutanal [3], hexane-2,5-dione [4] and 3-chloro-1-phenylpropan-1-one [5]. The enzyme differs from EC 1.1.1.78, methylglyoxal reductase (NADH), which is found in mammals, by its coenzyme requirement, reaction direction, and enantiomeric preference.
History
EC 1.1.1.283 created 2005, modified 2013
Pathway
ec00620  Pyruvate metabolism
ec00640  Propanoate metabolism
ec01100  Metabolic pathways
Orthology
K17741  NADPH-dependent methylglyoxal reductase
K23257  methylglyoxal/glyoxal reductase
Genes
SCE: YOL151W(GRE2)
KLA: KLLA0_D11000g
KMX: KLMA_30018(ARI1) KLMA_40628 KLMA_60425(GRE2) KLMA_80004 KLMA_80060
LTH: KLTH0B06182g KLTH0B06402g KLTH0E09680g KLTH0F04026g
VPO: Kpol_1030p19 Kpol_1057p21 Kpol_416p7 Kpol_529p27
ZRO: ZYRO0A13574g ZYRO0B00330g ZYRO0B16742g ZYRO0C18546g ZYRO0E10362g ZYRO0F05214g ZYRO0F18656g ZYRO0G00242g ZYRO0G15400g ZYRO0G22506g
CGR: CAGL0E05170g CAGL0E05280g
NCS: NCAS_0A03090(NCAS0A03090) NCAS_0A03400(NCAS0A03400) NCAS_0A07210(NCAS0A07210) NCAS_0C05270(NCAS0C05270) NCAS_0C05980(NCAS0C05980) NCAS_0D02420(NCAS0D02420) NCAS_0D03480(NCAS0D03480) NCAS_0D04850(NCAS0D04850) NCAS_0G03820(NCAS0G03820) NCAS_0H00790(NCAS0H00790)
NDI: NDAI_0D00910(NDAI0D00910) NDAI_0D05090(NDAI0D05090) NDAI_0F01560(NDAI0F01560) NDAI_0I02450(NDAI0I02450)
TPF: TPHA_0A00590(TPHA0A00590) TPHA_0F03690(TPHA0F03690) TPHA_0M01160(TPHA0M01160) TPHA_0N01940(TPHA0N01940) TPHA_0O00640(TPHA0O00640) TPHA_0O01220(TPHA0O01220)
TBL: TBLA_0A01590(TBLA0A01590) TBLA_0C00270(TBLA0C00270) TBLA_0C00280(TBLA0C00280) TBLA_0C03410(TBLA0C03410) TBLA_0C03420(TBLA0C03420) TBLA_0C03430(TBLA0C03430) TBLA_0D00750(TBLA0D00750)
TDL: TDEL_0A00160(TDEL0A00160) TDEL_0C00230(TDEL0C00230) TDEL_0C02800(TDEL0C02800) TDEL_0D00270(TDEL0D00270)
KAF: KAFR_0A08710(KAFR0A08710) KAFR_0A08720(KAFR0A08720) KAFR_0C00150(KAFR0C00150)
PIC: PICST_32463(GRP3.1) PICST_58065(GRP3.3) PICST_72153(GRE2)
CAL: CAALFM_C205560WA(CaO19.6868) CAALFM_C206710WA(CaO19.3151) CAALFM_C206720WA(GRE2) CAALFM_C502860CA(GRP2) CAALFM_C603240WA(CaO19.5611) CAALFM_CR01810CA(CaO19.2581)
ASU: Asuc_1306
GPS: C427_2672
LPH: LPV_0621(ytbE)
LPO: LPO_0588(ytbE)
LPM: LP6_0510(ytbE)
LPF: lpl0556
LPP: lpp0580
LPC: LPC_2827(ytbE)
LPA: lpa_00779(ara1)
LPE: lp12_0522
LLO: LLO_1579
LFA: LFA_0182
LLG: 44548918_00519(ytbE)
LJR: NCTC11533_00574(ytbE)
LWA: SAMEA4504053_2963(ara1)
TMC: LMI_0057
METL: U737_23860
MAH: MEALZ_0489(ytbE)
DNO: DNO_0829
SVA: SVA_2858
HHE: HH_1471
SULR: B649_03920
CCUN: CCUN_1892
AMYT: AMYT_1325
HBV: ABIV_1078
SHAL: SHALO_0490
SCL: sce8343(dkgB)
CAK: Caul_5283
CID: P73_3722
RHC: RGUI_3078
RID: RIdsm_01149(yvgN)
MAGX: XM1_3211
MAGN: WV31_07235
BSU: BSU33400(yvgN)
BSH: BSU6051_29050(ytbE) BSU6051_33400(yvgN)
BSUT: BSUB_03093(ytbE) BSUB_03568(yvgN)
BSUL: BSUA_03093(ytbE) BSUA_03568(yvgN)
BSS: BSUW23_14120(ytbE) BSUW23_16365(yvgN)
BSO: BSNT_09325(ytbE) BSNT_09856(yvgN)
BSQ: B657_29050(ytbE) B657_33400(yvgN)
BSX: C663_2750(ytbE) C663_3209(yvgN)
BLI: BL00701(yvgN)
BLD: BLi03528(yvgN)
BLH: BaLi_c35910(yvgN)
BAQ: BACAU_2626(ytbE) BACAU_3082(yvgN)
BYA: BANAU_2824(ytbE) BANAU_3247(yvgN)
BAML: BAM5036_2549(ytbE) BAM5036_2970(yvgN)
BAMA: RBAU_2746(ytbE) RBAU_3189(yvgN)
BAMN: BASU_2552(ytbE) BASU_2975(yvgN)
BAMB: BAPNAU_0944(ytbE) BAPNAU_3254(yvgN)
BAMY: V529_28970(ytbE) V529_33190
BMP: NG74_02751(ytbE) NG74_03226(yvgN)
BAO: BAMF_2708(ytbE) BAMF_3187(yvgN)
BAZ: BAMTA208_14265(ytbE) BAMTA208_16930(yvgN)
BQL: LL3_02993(ytbE) LL3_03470(yvgN)
BXH: BAXH7_02921(ytbE) BAXH7_03457(yvgN)
BQY: MUS_3180(ytbE) MUS_3654(yvgN)
BWW: bwei_0852(yvgN) bwei_4697(dkgA) bwei_5541
BMYC: DJ92_1192
BCL: ABC2110
BMEG: BG04_3206
BCOA: BF29_1246
BACO: OXB_0365
BACL: BS34A_31680(ytbE) BS34A_36460(yvgN)
BGY: BGLY_3917(yvgN)
GKA: GK0562
GTN: GTNG_0505
GGH: GHH_c05420(ytbE)
GEA: GARCT_00563(yvgN)
AFL: Aflv_1208
AAMY: GFC30_947
LSP: Bsph_0089(ytbE) Bsph_0361
HLI: HLI_10340
VPN: A21D_00639(dkgA) A21D_02538(yvgN)
PSYO: PB01_15695
SAU: SA1606
SUZ: MS7_0754(yvgN) MS7_1787
SER: SERP1350
SDT: SPSE_1010
SSCH: LH95_04920
SSCZ: RN70_05115
SAGQ: EP23_04670
SDP: NCTC12225_01215(yvgN)
MCL: MCCL_0460
MCAK: MCCS_06630
LMO: lmo0823
LMOQ: LM6179_1137(yvgN) LM6179_3027(ytbE)
LMR: LMR479A_0841(yvgN) LMR479A_2361(ytbE)
LMOG: BN389_08530(yvgN) BN389_22780(ytbE)
LMQ: LMM7_0854(dkgA) LMM7_2349(dkgA)
LIN: lin0819
LGZ: NCTC10812_02018(yvgN_2) NCTC10812_02214(yvgN_3)
ESI: Exig_0413
GHA: NCTC10459_01005(yvgN)
PPM: PPSC2_01645(ytbE) PPSC2_04330(yvgN)
PPO: PPM_0311(ytbE) PPM_0809(yvgN)
PMS: KNP414_03688(yvgN) KNP414_07911(ytbE)
PRI: PRIO_2517(yvgN1) PRIO_5501(ytbE1) PRIO_6536(ytbE3)
PSWU: SY83_16510
ASOC: CB4_02589(yvgN)
AAC: Aaci_0848
AAD: TC41_0849
BTS: Btus_0334
SIV: SSIL_0674
KZO: NCTC404_01393(yvgN_1)
LLK: LLKF_2067(yteC)
LLT: CVCAS_1813(yteC)
LLS: lilo_1878(yteC)
LLX: NCDO2118_1994(yteC)
LLC: LACR_2068
LLR: llh_2700
LLJ: LG36_1829(yteC)
SAG: SAG0429
SAK: SAK_0513
SGC: A964_0440
SAGM: BSA_5180
SAGR: SAIL_5230
SAGP: V193_02350
SAGC: DN94_02350
SAGE: EN72_02550
SAGN: W903_0532
SIK: K710_0814
LJH: LJP_0999c
LAC: LBA1427
LSI: HN6_00624
LSJ: LSJ_0771
LCA: LSEI_0443
LCS: LCBD_0508
LCE: LC2W_0510
LPAP: LBPC_0409
LCW: BN194_05160(P100_11E_2)
LGA: LGAS_0964
LHL: LBHH_0642
LRH: LGG_00259(dkgA) LGG_00541(ycgG)
LRL: LC705_00250(dkgA) LC705_00531(ycgG)
LAM: LA2_08205
PPE: PEPE_0051
PPEN: T256_00255
EFA: EF1138
EFL: EF62_1588
EFI: OG1RF_10915(dkgB)
EFS: EFS1_0965
EFQ: DR75_209
ECAS: ECBG_00801
WKO: WKK_01690
CRN: CAR_c05880(yvgN2) CAR_c13360(yvgN4) CAR_c15930(yvgN5) CAR_c23350(yvgN6)
CML: BN424_1113(yvgN) BN424_3458(ytbE)
JDA: BW727_100319(yvgN_1) BW727_100820(yvgN_2) BW727_101925(ytbE)
CAC: CA_C1958
CAE: SMB_G1990(yvgN)
CAY: CEA_G1975
CBO: CBO0984(dkgA)
CBA: CLB_1023
CBH: CLC_1037
CBL: CLK_0430
CBK: CLL_A1844
CBI: CLJ_B1026
CBT: CLH_1658
CBE: Cbei_3512
CBZ: Cbs_3512
CLT: CM240_2814(yvgN)
CSQ: CSCA_0059
ASF: SFBM_0589
HSC: HVS_10975(yvgN)
CSD: Clst_0450
FPA: FPR_27380
COO: CCU_19270
CPY: Cphy_1752
HSD: SD1D_1902(P100_11E)
EHL: EHLA_1609
PUF: UFO1_0239
ERH: ERH_0073
MPE: MYPE4720(MYPE4720)
MGA: MGA_0093
MGH: MGAH_0093
MGF: MGF_2916
MGZ: GCW_02500
MHA: HF1_10850(ytbE)
MHF: MHF_1174
MWE: WEN_01605
MPV: PRV_01760
ABRA: BN85308370
APAL: BN85405070
AAXA: NCTC10138_00770(yvgN_1) NCTC10138_01144(yvgN_2)
AHK: NCTC10172_00286(yvgN_1) NCTC10172_00638(yvgN_2)
CGB: cg1192
CGU: WA5_1003
CGM: cgp_1192
CGJ: AR0_05740
CVA: CVAR_0272
ROP: ROP_34220
GOM: D7316_01975(yvgN)
PFRE: RM25_2308
PAUS: NCTC13651_00878(yvgN)
ACIJ: JS278_03000(yvgN)
NAL: B005_4996
BLJ: BLD_0149(akrA1)
BLN: Blon_0820
BLF: BLIF_1357
BLL: BLJ_1332
BLB: BBMN68_177(akrA1)
BLA: BLA_1215(morA)
BBB: BIF_01116
BBC: BLC1_0660
BLV: BalV_0664
BLW: W7Y_0691
BLS: W91_0714
BANI: Bl12_0644
BANL: BLAC_03455
BANM: EN10_03495
BBP: BBPR_0519
BBI: BBIF_0543
BBF: BBB_0497
BAST: BAST_0618
BTP: D805_1704
BCOR: BCOR_0524
BPSP: AH67_03765
SIJ: SCIP_1358
ELE: Elen_1699
PRC: EW14_1496
ATM: ANT_26770
ABAT: CFX1CAM_2214(yvgN)
TPED: TPE_1379
SMF: Smon_1288
PMUC: ING2E5A_0516(yvgN)
BACC: BRDCF_p694(yvgN)
CPI: Cpin_6724
FLM: MY04_1612
GFO: GFO_0840
ZPR: ZPR_1260
MARM: YQ22_08605
CBAL: M667_10625
CBAT: M666_10630
MLT: VC82_1415
EAO: BD94_1842
ELB: VO54_00900(yvgN)
SPON: HME9304_01592(dkgA)
PMO: Pmob_1501
DTN: DTL3_1551(yvgN1)
NJA: NSJP_3497
HUT: Huta_0858
HLA: Hlac_1561
SALI: L593_15055
 » show all
Reference
1  [PMID:3896793]
  Authors
Murata K, Fukuda Y, Simosaka M, Watanabe K, Saikusa T, Kimura A.
  Title
Metabolism of 2-oxoaldehyde in yeasts. Purification and characterization of NADPH-dependent methylglyoxal-reducing enzyme from Saccharomyces cerevisiae.
  Journal
Eur J Biochem 151:631-6 (1985)
DOI:10.1111/j.1432-1033.1985.tb09151.x
  Sequence
[sce:YOL151W]
Reference
2  [PMID:12722185]
  Authors
Chen CN, Porubleva L, Shearer G, Svrakic M, Holden LG, Dover JL, Johnston M, Chitnis PR, Kohl DH.
  Title
Associating protein activities with their genes: rapid identification of a gene encoding a methylglyoxal reductase in the yeast Saccharomyces cerevisiae.
  Journal
Yeast 20:545-54 (2003)
DOI:10.1002/yea.979
  Sequence
[sce:YOL151W]
Reference
3  [PMID:16999827]
  Authors
Hauser M, Horn P, Tournu H, Hauser NC, Hoheisel JD, Brown AJ, Dickinson JR
  Title
A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase.
  Journal
FEMS Yeast Res 7:84-92 (2007)
DOI:10.1111/j.1567-1364.2006.00151.x
  Sequence
[sce:YOL151W]
Reference
4  [PMID:20237665]
  Authors
Muller M, Katzberg M, Bertau M, Hummel W
  Title
Highly efficient and stereoselective biosynthesis of (2S,5S)-hexanediol with a dehydrogenase from Saccharomyces cerevisiae.
  Journal
Org Biomol Chem 8:1540-50 (2010)
DOI:10.1039/b920869k
  Sequence
[sce:YOL151W]
Reference
5  [PMID:20111861]
  Authors
Choi YH, Choi HJ, Kim D, Uhm KN, Kim HK
  Title
Asymmetric synthesis of (S)-3-chloro-1-phenyl-1-propanol using Saccharomyces cerevisiae reductase with high enantioselectivity.
  Journal
Appl Microbiol Biotechnol 87:185-93 (2010)
DOI:10.1007/s00253-010-2442-5
  Sequence
[sce:YOL151W]
Reference
6  [PMID:20606287]
  Authors
Breicha K, Muller M, Hummel W, Niefind K
  Title
Crystallization and preliminary crystallographic analysis of Gre2p, an NADP(+)-dependent alcohol dehydrogenase from Saccharomyces cerevisiae.
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 66:838-41 (2010)
DOI:10.1107/S1744309110018889
  Sequence
[sce:YOL151W]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.283
IUBMB Enzyme Nomenclature: 1.1.1.283
ExPASy - ENZYME nomenclature database: 1.1.1.283
BRENDA, the Enzyme Database: 1.1.1.283
CAS: 78310-66-4

KEGG   REACTION: R02260
Entry
R02260                      Reaction                               

Name
(S)-lactaldehyde:NADP+ oxidoreductase
Definition
(S)-Lactaldehyde + NADP+ <=> Methylglyoxal + NADPH + H+
Equation
Reaction class
RC00001  C00005_C00006
RC00670  C00424_C00546
Enzyme
1.1.1.283       1.2.1.49
Pathway
rn00620  Pyruvate metabolism
rn00640  Propanoate metabolism
rn01100  Metabolic pathways
Orthology
K17741  NADPH-dependent methylglyoxal reductase [EC:1.1.1.283]
K23257  methylglyoxal/glyoxal reductase [EC:1.1.1.283 1.1.1.-]

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