KEGG   ORTHOLOGY: K17746Help
Entry
K17746                      KO                                     

Name
ChaDH
Definition
chanoclavine-I dehydrogenase [EC:1.1.1.332]
Pathway
ko00901  Indole alkaloid biosynthesis
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K17746  ChaDH; chanoclavine-I dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.332  chanoclavine-I dehydrogenase
     K17746  ChaDH; chanoclavine-I dehydrogenase
BRITE hierarchy
Other DBs
RN: R10128
Genes
MGR: MGG_02225 MGG_09087
NHE: NECHADRAFT_80607
MAW: MAC_06985
MAJ: MAA_06739
GLZ: GLAREA_05925
AFM: AFUA_2G18000
ABE: ARB_04646
TVE: TRV_01860
TaxonomyKoalaUniProt
Reference
  Authors
Wallwey C, Matuschek M, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH.
  Journal
Arch Microbiol 192:127-34 (2010)
DOI:10.1007/s00203-009-0536-1
  Sequence
Reference
  Authors
Wallwey C, Heddergott C, Xie X, Brakhage AA, Li SM
  Title
Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae.
  Journal
Microbiology 158:1634-44 (2012)
DOI:10.1099/mic.0.056796-0
  Sequence
[abe:ARB_04646]

KEGG   ENZYME: 1.1.1.332Help
Entry
EC 1.1.1.332                Enzyme                                 

Name
chanoclavine-I dehydrogenase;
easD (gene name);
fgaDH (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
chanoclavine-I:NAD+ oxidoreductase
Reaction(IUBMB)
chanoclavine-I + NAD+ = chanoclavine-I aldehyde + NADH + H+ [RN:R10128]
Reaction(KEGG)
Substrate
chanoclavine-I [CPD:C09131];
NAD+ [CPD:C00003]
Product
chanoclavine-I aldehyde [CPD:C20379];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme catalyses a step in the pathway of ergot alkaloid biosynthesis in certain fungi.
History
EC 1.1.1.332 created 2012
Pathway
ec00901  Indole alkaloid biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K17746  chanoclavine-I dehydrogenase
Genes
MGR: MGG_02225 MGG_09087
NHE: NECHADRAFT_80607
MAW: MAC_06985
MAJ: MAA_06739
GLZ: GLAREA_05925
AFM: AFUA_2G18000
ABE: ARB_04646
TVE: TRV_01860
Taxonomy
Reference
1  [PMID:20039019]
  Authors
Wallwey C, Matuschek M, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus: conversion of chanoclavine-I to chanoclavine-I aldehyde catalyzed by a short-chain alcohol dehydrogenase FgaDH.
  Journal
Arch Microbiol 192:127-34 (2010)
DOI:10.1007/s00203-009-0536-1
  Sequence
Reference
2  [PMID:22403186]
  Authors
Wallwey C, Heddergott C, Xie X, Brakhage AA, Li SM
  Title
Genome mining reveals the presence of a conserved gene cluster for the biosynthesis of ergot alkaloid precursors in the fungal family Arthrodermataceae.
  Journal
Microbiology 158:1634-44 (2012)
DOI:10.1099/mic.0.056796-0
  Sequence
[abe:ARB_04646]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.332
IUBMB Enzyme Nomenclature: 1.1.1.332
ExPASy - ENZYME nomenclature database: 1.1.1.332
BRENDA, the Enzyme Database: 1.1.1.332

KEGG   REACTION: R10128Help
Entry
R10128                      Reaction                               

Name
chanoclavine-I:NAD+ oxidoreductase
Definition
Chanoclavine-I + NAD+ <=> Chanoclavine-I aldehyde + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC02561  C09131_C20379
Enzyme
Pathway
rn00901  Indole alkaloid biosynthesis
rn01130  Biosynthesis of antibiotics
Orthology
K17746  chanoclavine-I dehydrogenase [EC:1.1.1.332]
Other DBs
RHEA: 33894

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