KEGG   ORTHOLOGY: K17753
Entry
K17753                      KO                                     

Name
HICDH
Definition
isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
Pathway
ko00020  Citrate cycle (TCA cycle)
ko00300  Lysine biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01210  2-Oxocarboxylic acid metabolism
ko01230  Biosynthesis of amino acids
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.286  isocitrate---homoisocitrate dehydrogenase
     K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
Other DBs
RN: R00709 R01934 R01936 R04862
COG: COG0473
GO: 0033708
Genes
PHO: PH1722(PH1722)
PAB: PAB0289(leuB-2)
PYN: PNA2_0331
PYS: Py04_1638
TKO: TK0280
THS: TES1_0505
THV: ADU37_CDS10030
TCH: CHITON_1981
Reference
  Authors
Miyazaki K
  Title
Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase.
  Journal
Biochem Biophys Res Commun 331:341-6 (2005)
DOI:10.1016/j.bbrc.2005.03.169
  Sequence
[pho:PH1722]

KEGG   ENZYME: 1.1.1.286
Entry
EC 1.1.1.286                Enzyme                                 

Name
isocitrate---homoisocitrate dehydrogenase;
homoisocitrate---isocitrate dehydrogenase;
PH1722
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(1) isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH [RN:R00709];
(2) (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+ [RN:R01934]
Reaction(KEGG)
R00709 R01934;
(other) R01936 R04862
Substrate
isocitrate [CPD:C00311];
NAD+ [CPD:C00003];
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate [CPD:C05662]
Product
2-oxoglutarate [CPD:C00026];
CO2 [CPD:C00011];
NADH [CPD:C00004];
2-oxoadipate [CPD:C00322];
H+ [CPD:C00080]
Comment
Requires Mn2+ and K+ or NH4+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+) and EC 1.1.1.87, homoisocitrate dehydrogenase, this enzyme, from Pyrococcus horikoshii, can use both isocitrate and homoisocitrate as substrates. The enzyme may play a role in both the lysine and glutamate biosynthesis pathways.
History
EC 1.1.1.286 created 2005
Pathway
ec00020  Citrate cycle (TCA cycle)
ec00300  Lysine biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K17753  isocitrate--homoisocitrate dehydrogenase
Genes
PHO: PH1722(PH1722)
PAB: PAB0289(leuB-2)
PYN: PNA2_0331
PYS: Py04_1638
TKO: TK0280
THS: TES1_0505
THV: ADU37_CDS10030
TCH: CHITON_1981
Reference
1  [PMID:15845397]
  Authors
Miyazaki K.
  Title
Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase.
  Journal
Biochem Biophys Res Commun 331:341-6 (2005)
DOI:10.1016/j.bbrc.2005.03.169
  Sequence
[pho:PH1722]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.286
IUBMB Enzyme Nomenclature: 1.1.1.286
ExPASy - ENZYME nomenclature database: 1.1.1.286
BRENDA, the Enzyme Database: 1.1.1.286

KEGG   REACTION: R00709
Entry
R00709                      Reaction                               

Name
isocitrate:NAD+ oxidoreductase (decarboxylating)
Definition
Isocitrate + NAD+ <=> 2-Oxoglutarate + CO2 + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00114  C00026_C00311
RC02801  C00011_C00311
Enzyme
1.1.1.41        1.1.1.286
Pathway
rn00020  Citrate cycle (TCA cycle)
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00009  Citrate cycle (TCA cycle, Krebs cycle)
M00010  Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
Orthology
K00030  isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]
K17753  isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
Other DBs
RHEA: 23635

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