KEGG   ORTHOLOGY: K17753
Entry
K17753                      KO                                     

Name
HICDH
Definition
isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
Pathway
ko00020  Citrate cycle (TCA cycle)
ko00300  Lysine biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01210  2-Oxocarboxylic acid metabolism
ko01230  Biosynthesis of amino acids
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00020 Citrate cycle (TCA cycle)
    K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.286  isocitrate---homoisocitrate dehydrogenase
     K17753  HICDH; isocitrate--homoisocitrate dehydrogenase
Other DBs
RN: R00709 R01934 R01936 R04862
COG: COG0473
GO: 0033708
Genes
PHO: PH1722(PH1722)
PAB: PAB0289(leuB-2)
PYN: PNA2_0331
PYS: Py04_1638
TKO: TK0280
THS: TES1_0505
THV: ADU37_CDS10030
TCH: CHITON_1981
Reference
  Authors
Miyazaki K
  Title
Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase.
  Journal
Biochem Biophys Res Commun 331:341-6 (2005)
DOI:10.1016/j.bbrc.2005.03.169
  Sequence
[pho:PH1722]

KEGG   ENZYME: 1.1.1.286
Entry
EC 1.1.1.286                Enzyme                                 

Name
isocitrate---homoisocitrate dehydrogenase;
homoisocitrate---isocitrate dehydrogenase;
PH1722
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
isocitrate(homoisocitrate):NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(1) isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH [RN:R00709];
(2) (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+ [RN:R01934]
Reaction(KEGG)
R00709 R01934;
(other) R01936 R04862
Substrate
isocitrate [CPD:C00311];
NAD+ [CPD:C00003];
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate [CPD:C05662]
Product
2-oxoglutarate [CPD:C00026];
CO2 [CPD:C00011];
NADH [CPD:C00004];
2-oxoadipate [CPD:C00322];
H+ [CPD:C00080]
Comment
Requires Mn2+ and K+ or NH4+ for activity. Unlike EC 1.1.1.41, isocitrate dehydrogenase (NAD+) and EC 1.1.1.87, homoisocitrate dehydrogenase, this enzyme, from Pyrococcus horikoshii, can use both isocitrate and homoisocitrate as substrates. The enzyme may play a role in both the lysine and glutamate biosynthesis pathways.
History
EC 1.1.1.286 created 2005
Pathway
ec00020  Citrate cycle (TCA cycle)
ec00300  Lysine biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K17753  isocitrate--homoisocitrate dehydrogenase
Genes
PHO: PH1722(PH1722)
PAB: PAB0289(leuB-2)
PYN: PNA2_0331
PYS: Py04_1638
TKO: TK0280
THS: TES1_0505
THV: ADU37_CDS10030
TCH: CHITON_1981
Reference
1  [PMID:15845397]
  Authors
Miyazaki K
  Title
Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase.
  Journal
Biochem Biophys Res Commun 331:341-6 (2005)
DOI:10.1016/j.bbrc.2005.03.169
  Sequence
[pho:PH1722]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.286
IUBMB Enzyme Nomenclature: 1.1.1.286
ExPASy - ENZYME nomenclature database: 1.1.1.286
BRENDA, the Enzyme Database: 1.1.1.286

KEGG   REACTION: R01934
Entry
R01934                      Reaction                               

Name
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating);
homoisocitrate:NAD+ oxidoreductase (decarboxylating)
Definition
Homoisocitrate + NAD+ <=> 2-Oxoadipate + CO2 + NADH + H+
Equation
Comment
two-step reaction (see R04862+R01936), reversible
Reaction class
RC00001  C00003_C00004
RC00114  C00322_C05662
Enzyme
1.1.1.87        1.1.1.286
Pathway
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
rn01240  Biosynthesis of cofactors
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Orthology
K05824  homoisocitrate dehydrogenase [EC:1.1.1.87]
K10978  methanogen homoisocitrate dehydrogenase [EC:1.1.1.87 1.1.1.-]
K17753  isocitrate--homoisocitrate dehydrogenase [EC:1.1.1.286]
Reference
1  [PMID:4395693]
  Authors
Rowley B, Tucci AF
  Title
Homoisocitric dehydrogenase from yeast.
  Journal
Arch Biochem Biophys 141:499-510 (1970)
DOI:10.1016/0003-9861(70)90167-0
Reference
2  [PMID:5808337]
  Authors
Chilina K, Thomas U, Tucci AF, McMichael KD, Stevens CM.
  Title
Synthesis and absolute configuration of the isomers of homoisocitric acid (1-hydroxy-1,2,4-butanetricarboxylic acid) and the stereochemistry of lysine biosynthesis.
  Journal
Biochemistry 8:2846-55 (1969)
DOI:10.1021/bi00835a023
Other DBs
RHEA: 11903

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