KEGG   ORTHOLOGY: K17825
Entry
K17825                      KO                                     
Symbol
FTMF
Name
verruculogen synthase [EC:1.14.11.38]
Pathway
map00404  Staurosporine biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
Reaction
R10445  fumitremorgin B,2-oxoglutarate:oxygen oxidoreductase (verruculogen-forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K17825  FTMF; verruculogen synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.38  verruculogen synthase
     K17825  FTMF; verruculogen synthase
Genes
AFM: AFUA_8G00230
NFI: NFIA_045530 NFIA_093740
URE: UREG_04217 UREG_07661
Reference
PMID:19763315
  Authors
Steffan N, Grundmann A, Afiyatullov S, Ruan H, Li SM
  Title
FtmOx1, a non-heme Fe(II) and alpha-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus.
  Journal
Org Biomol Chem 7:4082-7 (2009)
DOI:10.1039/b908392h
  Sequence
[afm:AFUA_8G00230]

  All links  
Gene (1)   
   OC (1)   
All databases (1)   

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