KEGG   ORTHOLOGY: K17826
Entry
K17826                      KO                                     

Name
FTMG, CYP5067A
Definition
fumitremorgin C monooxygenase [EC:1.14.14.119]
Pathway
ko00404  Staurosporine biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K17826  FTMG, CYP5067A; fumitremorgin C monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17826  FTMG, CYP5067A; fumitremorgin C monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.119  fumitremorgin C monooxygenase
     K17826  FTMG, CYP5067A; fumitremorgin C monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, fungi type
  CYP5067 family
   K17826  FTMG, CYP5067A; fumitremorgin C monooxygenase
Other DBs
RN: R10414
COG: COG2124
Genes
AFM: AFUA_8G00240
NFI: NFIA_093750
Reference
  Authors
Kato N, Suzuki H, Takagi H, Asami Y, Kakeya H, Uramoto M, Usui T, Takahashi S, Sugimoto Y, Osada H
  Title
Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.
  Journal
Chembiochem 10:920-8 (2009)
DOI:10.1002/cbic.200800787
  Sequence

KEGG   ENZYME: 1.14.14.119
Entry
EC 1.14.14.119              Enzyme                                 

Name
fumitremorgin C monooxygenase;
ftmG (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
fumitremorgin C,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12alpha,13alpha-dihydroxyfumitremorgin C-forming)
Reaction(IUBMB)
fumitremorgin C + 2 [reduced NADPH---hemoprotein reductase] + 2 O2 = 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH---hemoprotein reductase] + 2 H2O [RN:R10414]
Reaction(KEGG)
R10414
Substrate
fumitremorgin C [CPD:C20604];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
12alpha,13alpha-dihydroxyfumitremorgin C [CPD:C20605];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathway of the indole alkaloid verruculogen.
History
EC 1.14.14.119 created 2013 as EC 1.14.13.177, transferred 2018 to EC 1.14.14.119
Pathway
ec00404  Staurosporine biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K17826  fumitremorgin C monooxygenase
Genes
AFM: AFUA_8G00240
NFI: NFIA_093750
Reference
1  [PMID:19226505]
  Authors
Kato N, Suzuki H, Takagi H, Asami Y, Kakeya H, Uramoto M, Usui T, Takahashi S, Sugimoto Y, Osada H
  Title
Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.
  Journal
Chembiochem 10:920-8 (2009)
DOI:10.1002/cbic.200800787
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.119
IUBMB Enzyme Nomenclature: 1.14.14.119
ExPASy - ENZYME nomenclature database: 1.14.14.119
BRENDA, the Enzyme Database: 1.14.14.119

KEGG   REACTION: R10414
Entry
R10414                      Reaction                               

Name
fumitremorgin C,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (12alpha,13alpha-dihydroxyfumitremorgin C-forming)
Definition
Fumitremorgin C + 2 [Reduced NADPH---hemoprotein reductase] + 2 Oxygen <=> 12alpha,13alpha-Dihydroxyfumitremorgin C + 2 [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Equation
C20604 + 2 C03024 + 2 C00007 <=> C20605 + 2 C03161 + 2 C00001
Reaction class
RC03173  C20604_C20605
Enzyme
Pathway
rn00404  Staurosporine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
Orthology
K17826  fumitremorgin C monooxygenase [EC:1.14.14.119]
Other DBs
RHEA: 35970

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