KEGG   ORTHOLOGY: K17827Help
Entry
K17827                      KO                                     

Name
FTME, CYP5066A
Definition
fumitremorgin C synthase [EC:1.14.19.71]
Pathway
ko00404  Staurosporine biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K17827  FTME, CYP5066A; fumitremorgin C synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17827  FTME, CYP5066A; fumitremorgin C synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.71  fumitremorgin C synthase
     K17827  FTME, CYP5066A; fumitremorgin C synthase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, fungi type
  CYP5066 family
   K17827  FTME, CYP5066A; fumitremorgin C synthase
BRITE hierarchy
Other DBs
RN: R10416
COG: COG2124
Genes
AFM: AFUA_8G00220
NFI: NFIA_093730
TaxonomyKoalaUniProt
Reference
  Authors
Kato N, Suzuki H, Takagi H, Asami Y, Kakeya H, Uramoto M, Usui T, Takahashi S, Sugimoto Y, Osada H
  Title
Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.
  Journal
Chembiochem 10:920-8 (2009)
DOI:10.1002/cbic.200800787
  Sequence

KEGG   ENZYME: 1.14.19.71Help
Entry
EC 1.14.19.71               Enzyme                                 

Name
fumitremorgin C synthase;
ftmE (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
BRITE hierarchy
Sysname
tryprostatin A,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Reaction(IUBMB)
tryprostatin A + [reduced NADPH---hemoprotein reductase] + O2 = fumitremorgin C + [oxidized NADPH---hemoprotein reductase] + 2 H2O [RN:R10416]
Reaction(KEGG)
Substrate
tryprostatin A [CPD:C20607];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
fumitremorgin C [CPD:C20604];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. The protein from the fungus Aspergillus fumigatus also has activity with tryprostatin B forming demethoxyfumitremorgin C. Involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen.
History
EC 1.14.19.71 created 2013 as EC 1.14.21.10, transferred 2018 to EC 1.14.19.71
Pathway
ec00404  Staurosporine biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K17827  fumitremorgin C synthase
Genes
AFM: AFUA_8G00220
NFI: NFIA_093730
Taxonomy
Reference
1  [PMID:19226505]
  Authors
Kato N, Suzuki H, Takagi H, Asami Y, Kakeya H, Uramoto M, Usui T, Takahashi S, Sugimoto Y, Osada H
  Title
Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.
  Journal
Chembiochem 10:920-8 (2009)
DOI:10.1002/cbic.200800787
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.19.71
IUBMB Enzyme Nomenclature: 1.14.19.71
ExPASy - ENZYME nomenclature database: 1.14.19.71
BRENDA, the Enzyme Database: 1.14.19.71

KEGG   REACTION: R10416Help
Entry
R10416                      Reaction                               

Name
tryprostatin A,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase
Definition
Tryprostatin A + [Reduced NADPH---hemoprotein reductase] + Oxygen <=> Fumitremorgin C + [Oxidized NADPH---hemoprotein reductase] + 2 H2O
Equation
Reaction class
RC03175  C20604_C20607
Enzyme
Pathway
rn00404  Staurosporine biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
Orthology
K17827  fumitremorgin C synthase [EC:1.14.19.71]
Other DBs
RHEA: 35966

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