KEGG   ORTHOLOGY: K17837
Entry
K17837                      KO                                     

Name
bla2, blm, ccrA, blaB
Definition
metallo-beta-lactamase class B [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K17837  bla2, blm, ccrA, blaB; metallo-beta-lactamase class B
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K17837  bla2, blm, ccrA, blaB; metallo-beta-lactamase class B
Other DBs
RN: R06363
COG: COG0491
GO: 0008800
Genes
STY: STY4057
STT: t3781
SEX: STBHUCCB_39910
SENT: TY21A_19215
STM: STM3737
SEO: STM14_4500
SEV: STMMW_37261
SEY: SL1344_3703
SEM: STMDT12_C37940
SEJ: STMUK_3723
SENI: CY43_19390
SPT: SPA3589
SEK: SSPA3352
SEI: SPC_3818
SEC: SCH_3660
SHB: SU5_04214
SENS: Q786_18275
SED: SeD_A4124
SEG: SG3694
SEL: SPUL_3827
SET: SEN3559
SENA: AU38_18175
SENO: AU37_18365
SENV: AU39_18370
SENQ: AU40_20460
SENL: IY59_18810
SEEP: I137_18355
SENE: IA1_18170
SBG: SBG_3318
SBZ: A464_3814
ESA: ESA_02372
CSK: ES15_2471
SPE: Spro_3259
SERF: L085_11860
ECA: ECA2849
PATR: EV46_13955
PATO: GZ59_17110
DDQ: DDI_2245
PHAU: PH4a_15100
SML: Smlt2667
SMT: Smal_2146
SMZ: SMD_2343
STES: MG068_11265(blaL1)
PSUW: WQ53_14490
LEZ: GLE_2717
LEM: LEN_2308
LYT: DWG18_05965(bla)
LUE: DCD74_03810(bla)
LYJ: FKV23_05395(bla)
LSOL: GOY17_05520(bla)
LUS: E5843_01550(bla)
THES: FHQ07_01410(bla)
THEH: G7079_08185(bla)
XBC: ELE36_02985(bla)
RGL: CS053_09660(bla)
LPY: FIV34_20185(bla)
VAG: N646_4198
PAGR: E2H98_08500(blaSMB)
AGU: AS4_09470
MBAH: HYN46_14405(bla)
SFR: Sfri_0887
SAZ: Sama_1178
SSE: Ssed_3414
SWD: Swoo_3595
SPSW: Sps_04278
SLJ: EGC82_06115(blaDIM)
SMAI: EXU30_04345(bla)
THT: E2K93_08135(bla)
PSEO: OM33_15650
PSPO: PSPO_b0130(bla2)
PDJ: D0907_09110(bla)
AMAC: MASE_12080
ASP: AOR13_929
APEL: CA267_004750(bla)
FBL: Fbal_1462
CEK: D0B88_03670(blaKHM)
SAGA: M5M_14960
MII: BTJ40_01025(bla)
HALC: EY643_16110(bla)
LHA: LHA_2968
AHA: AHA_0740
ASA: ASA_3612(cphA5)
AVR: B565_0732
AEL: NCTC12917_00788(cphA5)
SINI: GT972_09490(bla)
CVI: CV_3150
CHRI: DK842_00660(bla)
CHRB: DK843_05940(bla)
AMIM: MIM_c01210
AAA: Acav_3017
JAG: GJA_2842
JAS: FJQ89_00650(bla) FJQ89_01255(bla) FJQ89_20865(bla)
MASZ: C9I28_12925(bla)
MASY: DPH57_08695(bla)
MALI: EYF70_15750(bla)
MUM: FCL38_02695(bla)
MFLA: GO485_28030(bla)
MPLI: E1742_00500(bla)
DUG: HH213_29770(bla)
HEBR: AEBR_2205
ADE: Adeh_0354
MXA: MXAN_0432
CCX: COCOR_07012(ccrA)
HOH: Hoch_6144
SAT: SYN_02851
MES: Meso_2500
BJA: blr6230
BBT: BBta_2483
BRS: S23_20590(BJP-1)
AOL: S58_53610
BRAD: BF49_1597
BBET: F8237_25185(blaBJP)
CCR: CC_2139
CAK: Caul_3408
CSE: Cseg_1281
CAUF: CSW63_09645(blaCAU)
PHB: HYN04_08315(bla)
HBA: Hbal_3075
NAR: Saro_1743
NOR: FA702_03745(bla)
NGF: FRF71_10620(bla)
NOG: GKE62_01330(bla)
SAL: Sala_1904
SPHP: LH20_13740
SMAZ: LH19_00965
SGI: SGRAN_3373(blaTHIN-B)
SPHO: C3E99_11635(bla)
SPHX: E5675_08150(bla)
SPHU: SPPYR_1125
SPHM: G432_14630
STAX: MC45_04335
SPMI: K663_06310
SPHR: BSY17_3133
SINB: SIDU_11385
SUFL: FIL70_23085(bla)
BLAS: BSY18_3708
SPHS: ETR14_16780(bla) ETR14_21240(bla)
ELI: ELI_07580
ERR: DVR09_10755(bla)
AAY: WYH_00262
ALB: AEB_P1596
ALH: G6N82_00160(bla)
ECOG: FIV45_15805(bla)
BAY: RBAM_011860(bla)
BAQ: BACAU_1147(bla2)
BYA: BANAU_1092(blm)
BAMP: B938_05770
BAML: BAM5036_1086(blm)
BAMA: RBAU_1148(blm)
BAMN: BASU_1125(blm)
BAMB: BAPNAU_2608(bla2)
BAMT: AJ82_06660
BAMY: V529_11350(blm)
BMP: NG74_01201(blm)
BAO: BAMF_1259(blm)
BAZ: BAMTA208_11670(blm)
BQL: LL3_01268(blm)
BXH: BAXH7_02383(blm)
BQY: MUS_1230(blm)
BAMI: KSO_013910
BAMC: U471_11840
BAMF: U722_06050
BSON: S101395_03540(bla2)
BAN: BA_3500(bla2)
BAR: GBAA_3500(bla2)
BAT: BAS3245
BAH: BAMEG_1128(bla2)
BAI: BAA_3532(bla2)
BANT: A16_35120
BANR: A16R_35550
BANS: BAPAT_3350
BANV: DJ46_2228(blm)
BCE: BC3440
BCA: BCE_3452(bla2)
BCZ: BCE33L3155(bla)
BCR: BCAH187_A3473(bla2)
BCB: BCB4264_A3447(bla2)
BCU: BCAH820_3460(bla2)
BCQ: BCQ_3246(bla)
BCX: BCA_3524(bla2)
BNC: BCN_3264
BCF: bcf_17010
BCER: BCK_18045
BTK: BT9727_3218(bla)
BTL: BALH_3094(bla)
BTT: HD73_3687
BTHI: BTK_18160
BTM: MC28_2588
BTI: BTG_02370
BTW: BF38_4605(blm)
BWW: bwei_1496(blm)
BMYO: BG05_2562(blm)
BMYC: DJ92_67(blm)
BACP: SB24_03940
BACB: OY17_08630
BGY: BGLY_2409
KPUL: GXN76_01420(bla) GXN76_03710(bla)
CTC: CTC_01204
CBT: CLH_2501
CSQ: CSCA_2331
MCHE: BB28_00325
MSTE: MSTE_00066
BSD: BLASA_3133(gloB)
AMD: AMED_7248(ampC)
AMN: RAM_37230
AMM: AMES_7138(ampC)
AMZ: B737_7138(ampC)
OTE: Oter_1111
ROO: G5S37_05070(bla)
LBF: LBF_0939
BRM: Bmur_0220
BPW: WESB_2018
BIP: Bint_1886
GRW: FTO74_11530(bla)
TALB: FTW19_04870(bla)
ABAS: ACPOL_3962
EDA: GWR55_16955(bla)
GAU: GAU_3231
PSAC: PSM36_3182
DYS: G7050_04625(bla)
AFD: Alfi_1264
CPI: Cpin_4572
CHIH: GWR21_02165(bla)
ARK: D6B99_01095(bla)
AGI: FSB73_06490(bla)
ARAC: E0W69_003475(bla)
FLN: FLA_2422
PSEG: D3H65_21305(bla)
PGIN: FRZ67_01600(bla)
PGO: FSB84_10100(bla)
FLS: GLV81_10715(bla)
PEK: FFJ24_007600(bla) FFJ24_009000(blaB3PEDO)
SPSC: E2P86_13065(bla)
SPDR: G6053_20620(bla)
MRUB: DEO27_004185(bla)
AGD: FRZ59_05675(bla)
OLI: FKG96_14015(bla)
EST: DN752_19240(bla)
ECHI: FKX85_12650(bla)
SLI: Slin_3261
SPIK: EXU85_03030(bla) EXU85_24035(bla)
SPIB: G8759_02935(bla)
FAE: FAES_4700
PSEZ: HME7025_00005(bla2)
ALS: DJ013_12170(bla)
RHOZ: GXP67_03530(bla)
HSW: Hsw_3848
HYH: D3Y59_10080(bla)
FLM: MY04_1485(bla)
FLL: EI427_23610(bla)
CHK: D4L85_28045(bla)
FJO: Fjoh_3485
FJG: BB050_04308(blaB1)
FSE: DI487_02370(bla)
CBAL: M667_08315
CBAT: M666_08355
DDO: I597_1670
DOD: DCS32_12510(bla)
ZGA: ZOBELLIA_806(ccrA)
ELT: FGE20_08170(bla)
MPW: MPR_3496
CHZ: CHSO_4374
CIO: CEQ15_13595(bla)
CHRS: EAG08_15730(bla)
CARH: EGY05_14910(bla)
CSHA: EG350_06440(bla)
CNK: EG343_10580(bla)
CJT: EG359_03600(blaIND) EG359_11695(bla)
CLAC: EG342_00115(bla)
AALG: AREALGSMS7_01852(ccrA)
FEK: C1H87_13510(bla)
SPON: HME9304_03340(bla2)
AQB: D1818_04155(bla)
AQA: D1815_03440(bla)
AQD: D1816_25470(bla)
EMAR: D1013_05715(bla)
EBV: F0358_10305(blaEBR)
FBU: UJ101_00231(bla2|blm|ccrA|blaB)
FBE: FF125_15685(bla)
MARN: LN42_10150
DTN: DTL3_0107
MTP: Mthe_1345
MHI: Mhar_1311
 » show all
Reference
  Authors
Bebrone C
  Title
Metallo-beta-lactamases (classification, activity, genetic organization, structure, zinc coordination) and their superfamily.
  Journal
Biochem Pharmacol 74:1686-701 (2007)
DOI:10.1016/j.bcp.2007.05.021
Reference
  Authors
Hall BG, Salipante SJ, Barlow M
  Title
The metallo-beta-lactamases fall into two distinct phylogenetic groups.
  Journal
J Mol Evol 57:249-54 (2003)
DOI:10.1007/s00239-003-2471-0

KEGG   ORTHOLOGY: K18782
Entry
K18782            Tight     KO                                     

Name
blaIMP
Definition
metallo-beta-lactamase class B IMP [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18782  blaIMP; metallo-beta-lactamase class B IMP
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18782  blaIMP; metallo-beta-lactamase class B IMP
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18782  blaIMP; metallo-beta-lactamase class B IMP
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class B [MT]
    K18782  blaIMP; metallo-beta-lactamase class B IMP
Other DBs
COG: COG0491
GO: 0008800
Genes
METY: MRY16398_p20060(blaIMP-6)
SMAR: SM39_pSMC1_38(blaIMP-1)
PRQ: CYG50_00315 CYG50_00715
PNC: NCGM2_1757(bla_IMP)
PAEB: NCGM1900_1412(blaIMP-34) NCGM1900_3685(blaIMP-34)
AG: AAB30289(IMP-1) AAK12087(IMP-7) AAK13078(IMP-4) AAK13430(IMP-8) AAK27847(IMP-5) AAT49070(IMP-15) AAV49162(IMP-18) ABC88434(IMP-22) ABF70513(IMP-30) ABM67078(IMP-19) ABM68358(IMP-24) ACB41775(IMP-25) ACY01749(IMP-26) ADT63777(IMP-29) AEH41427(IMP-27) AEU17778(IMP-33) AFG73659(IMP-28) AFO59566(IMP-35) AFP97028(IMP-37) AGL46523(IMP-9) AGS82587(IMP-31) AIA58910(IMP-45) AOE46845(IMP-62) APM84539(IMP-65) BAA77393(IMP-3) BAB15941(IMP-6) BAB72069(IMP-10) BAM98935(IMP-43) BAM98942(IMP-44) BAP75826(IMP-34) CAB94707(IMP-2) CAD12765(IMP-12) CAD80251(IMP-13) CAE48334(IMP-16)
Reference
PMID:8141584
  Authors
Osano E, Arakawa Y, Wacharotayankun R, Ohta M, Horii T, Ito H, Yoshimura F, Kato N
  Title
Molecular characterization of an enterobacterial metallo beta-lactamase found in a clinical isolate of Serratia marcescens that shows imipenem resistance.
  Journal
Antimicrob Agents Chemother 38:71-8 (1994)
DOI:10.1128/AAC.38.1.71
  Sequence

KEGG   ORTHOLOGY: K18781
Entry
K18781            Tight     KO                                     

Name
blaVIM
Definition
metallo-beta-lactamase class B VIM [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18781  blaVIM; metallo-beta-lactamase class B VIM
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18781  blaVIM; metallo-beta-lactamase class B VIM
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18781  blaVIM; metallo-beta-lactamase class B VIM
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class B [MT]
    K18781  blaVIM; metallo-beta-lactamase class B VIM
Other DBs
COG: COG0491
GO: 0008800
Genes
PAEU: BN889_07249
PPUH: B479_26994
PSEM: TO66_31820
AG: AAF61483(VIM-2) AAG27703(VIM-3) AAN04257(VIM-4) AAN84550(VIM-6) AAR20999(VIM-5) AAS13759(VIM-8) AAT36613(VIM-11) AAZ73123(VIM-12) ABC94518(VIM-13) ABW90721(VIM-17) ACB54702(VIM-15) ACB54703(VIM-16) ACL50513(VIM-14) ACT33323(VIM-23) ACY29468(VIM-19) ADL27533(VIM-24) ADX78234(VIM-27) AEI25539(VIM-28) AFK24647(VIM-31) AFN88953(VIM-34) AFP99175(VIM-33) AGC50805(VIM-35) AGC50806(VIM-36) AGC50807(VIM-37) AGE83081(VIM-38) AGS82586(VIM-39) CAB46686(VIM-1) CAD61201(VIM-7) CAO83029(VIM-18) CBY80143(VIM-26)
Reference
  Authors
Lauretti L, Riccio ML, Mazzariol A, Cornaglia G, Amicosante G, Fontana R, Rossolini GM
  Title
Cloning and characterization of blaVIM, a new integron-borne metallo-beta-lactamase gene from a Pseudomonas aeruginosa clinical isolate.
  Journal
Antimicrob Agents Chemother 43:1584-90 (1999)
  Sequence

KEGG   ORTHOLOGY: K18780
Entry
K18780            Tight     KO                                     

Name
blaNDM
Definition
metallo-beta-lactamase class B NDM [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18780  blaNDM; metallo-beta-lactamase class B NDM
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18780  blaNDM; metallo-beta-lactamase class B NDM
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18780  blaNDM; metallo-beta-lactamase class B NDM
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class B [MT]
    K18780  blaNDM; metallo-beta-lactamase class B NDM
Other DBs
COG: COG0491
GO: 0008800
Genes
KPX: PMK1_ndm00067(blaNDM-1_1) PMK1_ndm00076(blaNDM-1_2) PMK1_ndm00085(blaNDM-1_3)
KPB: FH42_25895
KOE: A225_NDM1p0330
CIE: AN232_29410
PRG: RB151_P104578(blaNDM-1)
PVC: G3341_20200
ABAZ: AFM77866.1(blaNDM-1)
ANO: RR32_18615
ADV: DJ533_14545
AWU: BEN71_10660
AG: AEA41876(NDM-2) AEN03071(NDM-5) AEX08599(NDM-6) AFB82585(NDM-4) AFK80349(NDM-3) AGK06434(NDM-7) AGU91756(NDM-9) AJP18054(NDM-14) AOT73359(NDM-17) AQY45923(NDM-20) BAM84089(NDM-8) BAO79439(NDM-12) BAQ02518(NDM-13) CAZ39946(NDM-1)
 » show all
Reference
  Authors
Yong D, Toleman MA, Giske CG, Cho HS, Sundman K, Lee K, Walsh TR
  Title
Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India.
  Journal
Antimicrob Agents Chemother 53:5046-54 (2009)
DOI:10.1128/AAC.00774-09
  Sequence

KEGG   ORTHOLOGY: K19099
Entry
K19099            Tight     KO                                     

Name
blaGIM
Definition
metallo-beta-lactamase class B GIM [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K19099  blaGIM; metallo-beta-lactamase class B GIM
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19099  blaGIM; metallo-beta-lactamase class B GIM
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K19099  blaGIM; metallo-beta-lactamase class B GIM
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class B [MT]
    K19099  blaGIM; metallo-beta-lactamase class B GIM
Other DBs
COG: COG0491
GO: 0008800
Genes
AG: AIY26289(GIM-2) CAF05908(GIM-1)
Reference
  Authors
Castanheira M, Toleman MA, Jones RN, Schmidt FJ, Walsh TR
  Title
Molecular characterization of a beta-lactamase gene, blaGIM-1, encoding a new subclass of metallo-beta-lactamase.
  Journal
Antimicrob Agents Chemother 48:4654-61 (2004)
DOI:10.1128/AAC.48.12.4654-4661.2004
  Sequence

KEGG   ORTHOLOGY: K19216
Entry
K19216            Tight     KO                                     

Name
blaIND
Definition
metallo-beta-lactamase class B IND [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K19216  blaIND; metallo-beta-lactamase class B IND
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19216  blaIND; metallo-beta-lactamase class B IND
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K19216  blaIND; metallo-beta-lactamase class B IND
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class B [MT]
    K19216  blaIND; metallo-beta-lactamase class B IND
Other DBs
COG: COG0491
GO: 0008800
Genes
CHZ: CHSO_2691(blaB1)
CIO: CEQ15_07190
CARH: EGY05_09730(blaIND)
CNK: EG343_02100(blaIND)
AG: AAD20273(IND-1) AAG29757(IND-2) AAG29760(IND-2a) AAG29761(IND-3) AAG29765(IND-4) AAS78754(IND-5) BAJ05825(IND-7) CAJ32373(IND-6)
Reference
  Authors
Bellais S, Leotard S, Poirel L, Naas T, Nordmann P
  Title
Molecular characterization of a carbapenem-hydrolyzing beta-lactamase from Chryseobacterium (Flavobacterium) indologenes.
  Journal
FEMS Microbiol Lett 171:127-32 (1999)
DOI:10.1111/j.1574-6968.1999.tb13422.x
  Sequence

DBGET integrated database retrieval system