KEGG   ORTHOLOGY: K17838
Entry
K17838                      KO                                     

Name
oxa
Definition
beta-lactamase class D [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K17838  oxa; beta-lactamase class D
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K17838  oxa; beta-lactamase class D
Other DBs
RN: R06363
COG: COG2602
GO: 0008800 0008658
Genes
PAP: PSPA7_6316
PSA: PST_2699
PSZ: PSTAB_2684
PSR: PSTAA_2824
PSC: A458_08840
PSH: Psest_1611
PSTU: UIB01_07535
SLO: Shew_3220
SPC: Sputcn32_3157
SHP: Sput200_3270
SPL: Spea_2637
SHL: Shal_2710
SWP: swp_4470
ILO: IL1808
CPS: CPS_0483
MCA: MCA2220
GPB: HDN1F_04970(oxa9)
RSO: RSp0030
RSE: F504_3535
REH: H16_B1495(h16_B1495)
CNC: CNE_2c14940(lcr)
BTD: BTI_4996
BCN: Bcen_4788
BCJ: BCAM0393
BCEN: DM39_4747
BCEO: I35_4298
BMK: DM80_4415
BCT: GEM_5327
BCED: DM42_4759
BCON: NL30_24010
BGU: KS03_4399
LIMN: HKT17_05285(blaOXA)
MFA: Mfla_2477
DSU: Dsui_1823
AZA: AZKH_1955(bla)
AELL: AELL_1853
AAQI: AAQM_1689
PACO: AACT_1959
ARC: ABLL_1963
SULT: FA592_12500(blaOXA)
GUR: Gura_3505
GLO: Glov_0120
PPD: Ppro_0184
DVM: DvMF_0389
DMA: DMR_04670
DGG: DGI_2558
RBE: RBE_0107(blaD)
RBO: A1I_07395
RFE: RF_1275(blaD)
MLO: mll0916
MHUA: MCHK_2584(blaOXA)
PLA: Plav_3016
ATU: Atu0933
ATF: Ach5_08530(oxa)
AVI: Avi_1053
AGR: AGROH133_04800(oxa)
RIR: BN877_I0921(bla)
RPUS: CFBP5875_03255(blaOXA)
BJA: bll5360
BRA: BRADO4627(oxa5)
BBT: BBta_5028(oxa5)
BRS: S23_29200
AOL: S58_30420
RPB: RPB_2340
RPC: RPC_3398
RPD: RPD_3124
RPE: RPE_3542
XAU: Xaut_1441
NOH: G5V57_18630(blaOXA)
SIL: SPO2592
HNE: HNE_2763
RCE: RC1_2760(bla)
TMO: TMO_3399
MGM: Mmc1_0424
BBA: Bd3212
BBAT: Bdt_3141
BSU: BSU02090(ybxI)
BSR: I33_0246
BSL: A7A1_3273
BSH: BSU6051_02090(ybxI)
BSUT: BSUB_00257(ybxI)
BSUL: BSUA_00257(ybxI)
BSUS: Q433_01310
BSS: BSUW23_01070(ybxI)
BST: GYO_0398
BSO: BSNT_06508(ybxI)
BSQ: B657_02090(ybxI)
BSX: C663_0197(ybxI)
BHT: DIC78_08975(blaOXA) DIC78_12830(blaOXA)
BCL: ABC3481
BPU: BPUM_2340
BPUM: BW16_12720
BPUS: UP12_11805
BJS: MY9_0208
BACW: QR42_11890
BACY: QF06_20195
BACL: BS34A_02640(ybxI)
BALM: BsLM_0213
BALT: CFN77_12510(blaBPU)
BRW: GOP56_17550(blaOXA)
PMS: KNP414_06766(ybxI)
PMW: B2K_32290
CSCI: HDCHBGLK_01362(mecR1)
NDA: Ndas_0427
NAL: B005_3299
TCU: Tcur_2040
SRO: Sros_8961
SYN: slr0319(blaOXA-3)
SYZ: MYO_127520(blaOXA-3)
SYY: SYNGTS_2726(blaOXA-3)
SYT: SYNGTI_2725(blaOXA-3)
SYS: SYNPCCN_2724(blaOXA-3)
SYQ: SYNPCCP_2724(blaOXA-3)
AMR: AM1_4306
ANA: all2480
AVA: Ava_0412
PUV: PUV_15980(bla)
CPI: Cpin_0907
CHIH: GWR21_20100(blaOXA)
SGN: SGRA_0359(ampC)
SDJ: NCTC13534_00301(bla)
CHU: CHU_1887
ZPR: ZPR_0717
RAR: RIA_2139
RAE: G148_1473
CLAC: EG342_00760 EG342_21975(blaOXA)
CPC: Cpar_0567
CLI: Clim_1276
PPH: Ppha_1109
PAA: Paes_1435
CTS: Ctha_1121
 » show all
Reference
  Authors
Poirel L, Naas T, Nordmann P
  Title
Diversity, epidemiology, and genetics of class D beta-lactamases.
  Journal
Antimicrob Agents Chemother 54:24-38 (2010)
DOI:10.1128/AAC.01512-08
Reference
  Authors
Walther-Rasmussen J, Hoiby N
  Title
OXA-type carbapenemases.
  Journal
J Antimicrob Chemother 57:373-83 (2006)
DOI:10.1093/jac/dki482

KEGG   ORTHOLOGY: K18790
Entry
K18790            Tight     KO                                     

Name
blaOXA-1
Definition
beta-lactamase class D OXA-1 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18790  blaOXA-1; beta-lactamase class D OXA-1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18790  blaOXA-1; beta-lactamase class D OXA-1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18790  blaOXA-1; beta-lactamase class D OXA-1
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K18790  blaOXA-1; beta-lactamase class D OXA-1
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
ECOS: EC958_A0124(blaOXA-1)
ECOJ: P423_25750
SEM: STMDT12_C39230
SFE: SFxv_1144
SFN: SFy_1442
SFS: SFyv_1491
KPY: KPNIH31_26525
KPX: PMK1_ndm00057(bla_2)
KLW: DA718_21445
CFD: CFNIH1_06150
AG: AAA91586(OXA-1) AAF72981(OXA-30) AAK52604(OXA-31) AAO84013(OXA-392) AAP69225(OXA-47) ABY84058(OXA-4) AEQ73521(OXA-224) AGR55864(OXA-320)
 » show all
Reference
PMID:2823258
  Authors
Ouellette M, Bissonnette L, Roy PH
  Title
Precise insertion of antibiotic resistance determinants into Tn21-like transposons: nucleotide sequence of the OXA-1 beta-lactamase gene.
  Journal
Proc Natl Acad Sci U S A 84:7378-82 (1987)
DOI:10.1073/pnas.84.21.7378
  Sequence

KEGG   ORTHOLOGY: K18791
Entry
K18791            Tight     KO                                     

Name
blaOXA-2
Definition
beta-lactamase class D OXA-2 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18791  blaOXA-2; beta-lactamase class D OXA-2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18791  blaOXA-2; beta-lactamase class D OXA-2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18791  blaOXA-2; beta-lactamase class D OXA-2
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K18791  blaOXA-2; beta-lactamase class D OXA-2
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
KOC: AB185_01230 AB185_02715 AB185_03255
KQU: AVR78_27120
PRG: RB151_017590(bla_2)
PRQ: CYG50_12860
KIN: AB182_00475
PMP: Pmu_03440(blaOXA-2)
ABC: ACICU_00226
AG: AAB05874(OXA-15) AAC23554(OXA-20) AAC41449(OXA-3) AAG33665(OXA-37) AAK55330(OXA-118) AAK58418(OXA-32) AAN41427(OXA-119) AAN63499(OXA-46) AAP43641(OXA-53) ACM67635(OXA-226) ACT09125(OXA-161) AEO92079(OXA-205) APC23886(OXA-539) CAA30246(OXA-2) CAA71699(OXA-21) CAQ77073(OXA-541)
Reference
PMID:2538329
  Authors
Mossakowska D, Ali NA, Dale JW
  Title
Oxacillin-hydrolysing beta-lactamases. A comparative analysis at nucleotide and amino acid sequence levels.
  Journal
Eur J Biochem 180:309-18 (1989)
DOI:10.1111/j.1432-1033.1989.tb14649.x
  Sequence

KEGG   ORTHOLOGY: K19098
Entry
K19098            Tight     KO                                     

Name
blaOXA-9
Definition
beta-lactamase class D OXA-9 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K19098  blaOXA-9; beta-lactamase class D OXA-9
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19098  blaOXA-9; beta-lactamase class D OXA-9
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K19098  blaOXA-9; beta-lactamase class D OXA-9
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K19098  blaOXA-9; beta-lactamase class D OXA-9
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
KPV: KPNIH29_26635
KPG: KPNIH32_27935
KPA: KPNJ1_05668 KPNJ1_05816
CFQ: C2U38_26805
CIR: C2U53_00290
CIE: AN232_27690(blaOXA)
EBC: C2U52_00375
AG: AAA98406(OXA-9)
Reference
PMID:8382826
  Authors
Tolmasky ME, Crosa JH
  Title
Genetic organization of antibiotic resistance genes (aac(6')-Ib, aadA, and oxa9) in the multiresistance transposon Tn1331.
  Journal
Plasmid 29:31-40 (1993)
DOI:10.1006/plas.1993.1004
  Sequence

KEGG   ORTHOLOGY: K18792
Entry
K18792            Tight     KO                                     

Name
blaOXA-10
Definition
beta-lactamase class D OXA-10 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18792  blaOXA-10; beta-lactamase class D OXA-10
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18792  blaOXA-10; beta-lactamase class D OXA-10
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18792  blaOXA-10; beta-lactamase class D OXA-10
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K18792  blaOXA-10; beta-lactamase class D OXA-10
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
YRE: HEC60_24130
ABY: ABAYE3619(oxa-10)
AG: AAA93528(OXA-14) AAB60534(OXA-10) AAB97924(OXA-16) AAC15074(OXA-17) AAC46344(OXA-13) AAD02245(OXA-19) AAF72942(OXA-28) AAK49460(OXA-35) AAR32651(OXA-56) ACN85419(OXA-145) ACO72579(OXA-147) AER57903(OXA-251) AHC31001(OXA-246) CAA41211(OXA-5) CAA53242(OXA-7) CAA80304(OXA-11) CAH69530(OXA-74) CAL85435(OXA-101) CAP69660(OXA-129) CCE94500(OXA-256)
Reference
PMID:3126705
  Authors
Huovinen P, Huovinen S, Jacoby GA
  Title
Sequence of PSE-2 beta-lactamase.
  Journal
Antimicrob Agents Chemother 32:134-6 (1988)
DOI:10.1128/AAC.32.1.134
  Sequence

KEGG   ORTHOLOGY: K19213
Entry
K19213            Tight     KO                                     

Name
blaOXA-12
Definition
beta-lactamase class D OXA-12 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K19213  blaOXA-12; beta-lactamase class D OXA-12
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19213  blaOXA-12; beta-lactamase class D OXA-12
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K19213  blaOXA-12; beta-lactamase class D OXA-12
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K19213  blaOXA-12; beta-lactamase class D OXA-12
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
AHA: AHA_4258
AHY: AHML_22170
AHD: AI20_19220
AHR: V428_23160
AHP: V429_23195
AHJ: V469_22925
AHH: RY45_22105
AHI: VU14_00075
AAJ: BOQ57_00155
ASA: ASA_4346(ampS)
AVR: B565_4000
AMED: B224_5390
ACAV: VI35_21095
AEL: NCTC12917_04230(ampS)
AG: AAA83417(OXA-12) ALG65432(OXA-504)
 » show all
Reference
PMID:7811022
  Authors
Rasmussen BA, Keeney D, Yang Y, Bush K
  Title
Cloning and expression of a cloxacillin-hydrolyzing enzyme and a cephalosporinase from Aeromonas sobria AER 14M in Escherichia coli: requirement for an E. coli chromosomal mutation for efficient expression of the class D enzyme.
  Journal
Antimicrob Agents Chemother 38:2078-85 (1994)
DOI:10.1128/AAC.38.9.2078
  Sequence

KEGG   ORTHOLOGY: K21276
Entry
K21276            Tight     KO                                     

Name
blaOXA-22
Definition
beta-lactamase class D OXA-22 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K21276  blaOXA-22; beta-lactamase class D OXA-22
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K21276  blaOXA-22; beta-lactamase class D OXA-22
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K21276  blaOXA-22; beta-lactamase class D OXA-22
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K21276  blaOXA-22; beta-lactamase class D OXA-22
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
RPI: Rpic_3817
RPF: Rpic12D_3930
RMN: TK49_18990
RIN: ACS15_5491
AG: AAD12233(OXA-22) BAQ55593(OXA-443)
Reference
  Authors
Nordmann P, Poirel L, Kubina M, Casetta A, Naas T
  Title
Biochemical-genetic characterization and distribution of OXA-22, a chromosomal and inducible class D beta-lactamase from Ralstonia (Pseudomonas) pickettii.
  Journal
Antimicrob Agents Chemother 44:2201-4 (2000)
DOI:10.1128/AAC.44.8.2201-2204.2000
  Sequence

KEGG   ORTHOLOGY: K18793
Entry
K18793            Tight     KO                                     

Name
blaOXA-23
Definition
beta-lactamase class D OXA-23 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18793  blaOXA-23; beta-lactamase class D OXA-23
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18793  blaOXA-23; beta-lactamase class D OXA-23
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18793  blaOXA-23; beta-lactamase class D OXA-23
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K18793  blaOXA-23; beta-lactamase class D OXA-23
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
ABN: AB57_06435(oxa23) AB57_06525(oxa23)
ABZ: ABZJ_01990
ABR: ABTJ_p0085
ABD: ABTW07_2597
ABJ: BJAB07104_01927
ABAB: BJAB0715_00989
ABAJ: BJAB0868_01950
ABAU: IX87_16825 IX87_21860
ABW: BL01_p0470
ARJ: DOM24_04840
AG: 18195058-1(OXA-102) 18195058-2(OXA-103) 18195058-3(OXA-105) AAG35609(OXA-27) ACE63186(OXA-133) ACI28281(OXA-146) CAB69042(OXA-23)
 » show all
Reference
  Authors
Donald HM, Scaife W, Amyes SG, Young HK
  Title
Sequence analysis of ARI-1, a novel OXA beta-lactamase, responsible for imipenem resistance in Acinetobacter baumannii 6B92.
  Journal
Antimicrob Agents Chemother 44:196-9 (2000)
DOI:10.1128/AAC.44.1.196-199.2000
  Sequence

KEGG   ORTHOLOGY: K18971
Entry
K18971            Tight     KO                                     

Name
blaOXA-24
Definition
beta-lactamase class D OXA-24 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18971  blaOXA-24; beta-lactamase class D OXA-24
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18971  blaOXA-24; beta-lactamase class D OXA-24
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18971  blaOXA-24; beta-lactamase class D OXA-24
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K18971  blaOXA-24; beta-lactamase class D OXA-24
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
AG: AAG35607(OXA-25) AAG35608(OXA-26) AAM34291(OXA-40) ABP87779(OXA-72) ACX70402(OXA-143) ADB28891(OXA-160) ADK92148(OXA-182) AFJ03881(OXA-231) AFK28473(OXA-207) AGK07368(OXA-253) AGK07369(OXA-255) CAB92323(OXA-24)
Reference
  Authors
Bou G, Oliver A, Martinez-Beltran J
  Title
OXA-24, a novel class D beta-lactamase with carbapenemase activity in an Acinetobacter baumannii clinical strain.
  Journal
Antimicrob Agents Chemother 44:1556-61 (2000)
DOI:10.1128/AAC.44.6.1556-1561.2000
  Sequence
Reference
  Authors
Heritier C, Poirel L, Aubert D, Nordmann P
  Title
Genetic and functional analysis of the chromosome-encoded carbapenem-hydrolyzing oxacillinase OXA-40 of Acinetobacter baumannii.
  Journal
Antimicrob Agents Chemother 47:268-73 (2003)
DOI:10.1128/AAC.47.1.268-273.2003
  Sequence

KEGG   ORTHOLOGY: K22352
Entry
K22352            Tight     KO                                     

Name
blaOXA-29
Definition
beta-lactamase class D OXA-29 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K22352  blaOXA-29; beta-lactamase class D OXA-29
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K22352  blaOXA-29; beta-lactamase class D OXA-29
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K22352  blaOXA-29; beta-lactamase class D OXA-29
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K22352  blaOXA-29; beta-lactamase class D OXA-29
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
LPN: lpg1618
LPH: LPV_1872
LPO: LPO_1645 LPO_p0062
LPU: LPE509_01579
LPM: LP6_1596(blaD)
LPF: lpl1405
LPP: lpp1588 plpp0077
LPC: LPC_1045
LPE: lp12_1556
LLO: LLO_1201
LFA: LFA_3043(bla)
LHA: LHA_pA0030(bla)
LSH: CAB17_10175(blaOXA) CAB17_19165
LCJ: NCTC11976_01236(bla)
AG: CAC35728(OXA-29)
 » show all
Reference
  Authors
Franceschini N, Boschi L, Pollini S, Herman R, Perilli M, Galleni M, Frere JM, Amicosante G, Rossolini GM
  Title
Characterization of OXA-29 from Legionella (Fluoribacter) gormanii: molecular class D beta-lactamase with unusual properties.
  Journal
Antimicrob Agents Chemother 45:3509-16 (2001)
DOI:10.1128/AAC.45.12.3509-3516.2001
  Sequence

KEGG   ORTHOLOGY: K19209
Entry
K19209            Tight     KO                                     

Name
blaOXA-42
Definition
beta-lactamase class D OXA-42 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K19209  blaOXA-42; beta-lactamase class D OXA-42
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19209  blaOXA-42; beta-lactamase class D OXA-42
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K19209  blaOXA-42; beta-lactamase class D OXA-42
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K19209  blaOXA-42; beta-lactamase class D OXA-42
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
BPS: BPSS1997(oxa)
BPM: BURPS1710b_A1106(oxa)
BPL: BURPS1106A_A2719(oxa)
BPD: BURPS668_A2872(oxa)
BPSE: BDL_5411
BPSM: BBQ_4131
BPSU: BBN_5465
BPSD: BBX_4577
BPZ: BP1026B_II2145(oxa)
BPQ: BPC006_II2679
BPK: BBK_4740
BPSH: DR55_5732
BPSA: BBU_4011
BPSO: X996_5535
BUT: X994_5095
BTE: BTH_II0373(oxa)
BTQ: BTQ_3666
BTJ: BTJ_4699
BTZ: BTL_5486
BTV: BTHA_4717
BTHE: BTN_5156
BTHM: BTRA_5425
BTHA: DR62_5286
BTHL: BG87_5498
AG: CAD32564(OXA-42) CAD32565(OXA-43) CAF74882(OXA-57) CAG15145(OXA-59)
 » show all
Reference
  Authors
Niumsup P, Wuthiekanun V
  Title
Cloning of the class D beta-lactamase gene from Burkholderia pseudomallei and studies on its expression in ceftazidime-susceptible and -resistant strains.
  Journal
J Antimicrob Chemother 50:445-55 (2002)
DOI:10.1093/jac/dkf165
  Sequence

KEGG   ORTHOLOGY: K18976
Entry
K18976            Tight     KO                                     

Name
blaOXA-48
Definition
beta-lactamase class D OXA-48 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18976  blaOXA-48; beta-lactamase class D OXA-48
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18976  blaOXA-48; beta-lactamase class D OXA-48
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18976  blaOXA-48; beta-lactamase class D OXA-48
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K18976  blaOXA-48; beta-lactamase class D OXA-48
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
SON: SO_0837(blaA)
SHE: Shewmr4_0694
SHM: Shewmr7_3328
SHN: Shewana3_3440
SHF: CEQ32_12270(blaOXA)
SBJ: CF168_03605
AG: AAP70012(OXA-48) AAR89917(OXA-54) ADG27454(OXA-162) ADY06444(OXA-163) AEP16366(OXA-181) AFC95894(OXA-199) AFU91598(OXA-204) AGC60012(OXA-244) AGC60013(OXA-245) AGC70814(OXA-247) AGD91915(OXA-232) AHF71363(OXA-370) AJA30430(OXA-405) AKH90740(OXA-416) AMN85820(OXA-514) AMN85821(OXA-515)
Reference
  Authors
Poirel L, Heritier C, Tolun V, Nordmann P
  Title
Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae.
  Journal
Antimicrob Agents Chemother 48:15-22 (2004)
DOI:10.1128/AAC.48.1.15-22.2004
  Sequence

KEGG   ORTHOLOGY: K18973
Entry
K18973            Tight     KO                                     

Name
blaOXA-50
Definition
beta-lactamase class D OXA-50 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18973  blaOXA-50; beta-lactamase class D OXA-50
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18973  blaOXA-50; beta-lactamase class D OXA-50
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18973  blaOXA-50; beta-lactamase class D OXA-50
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K18973  blaOXA-50; beta-lactamase class D OXA-50
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
PAE: PA5514
PAEV: N297_5702
PAEI: N296_5701
PAU: PA14_72760
PAG: PLES_59101
PAF: PAM18_5635
PNC: NCGM2_6294
PAEB: NCGM1900_6373
PDK: PADK2_29310
PRP: M062_29035
PAEP: PA1S_29760
PAEM: U769_30265
PAEL: T223_30225
PAEG: AI22_04225
PAEC: M802_5699
PAEO: M801_5566
AG: AAQ76277(OXA-50) AAQ76278(OXA-488) AAQ76280(OXA-395) AAQ76281(OXA-396) AAT09617(OXA-486) AAT09621(OXA-494)
 » show all
Reference
  Authors
Girlich D, Naas T, Nordmann P
  Title
Biochemical characterization of the naturally occurring oxacillinase OXA-50 of Pseudomonas aeruginosa.
  Journal
Antimicrob Agents Chemother 48:2043-8 (2004)
DOI:10.1128/AAC.48.6.2043-2048.2004
  Sequence

KEGG   ORTHOLOGY: K18794
Entry
K18794            Tight     KO                                     

Name
blaOXA-51
Definition
beta-lactamase class D OXA-51 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18794  blaOXA-51; beta-lactamase class D OXA-51
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18794  blaOXA-51; beta-lactamase class D OXA-51
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18794  blaOXA-51; beta-lactamase class D OXA-51
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K18794  blaOXA-51; beta-lactamase class D OXA-51
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
ACB: A1S_1517
ABM: ABSDF2125(bla-OXA-75)
ABY: ABAYE2122(bla-OXA-69)
ABC: ACICU_01560
ABN: AB57_1757(oxa-Ab)
ABB: ABBFA_01938(blaOXA-Ab)
ABX: ABK1_2018
ABZ: ABZJ_01722
ABR: ABTJ_02147
ABD: ABTW07_1237 ABTW07_1749
ABH: M3Q_1912
ABAD: ABD1_15230
ABAZ: P795_9600
ABAU: IX87_02560
ABAA: IX88_09585
AG: AAW51373(OXA-75) AAW81336(OXA-64) AAW81337(OXA-65) AAW81338(OXA-66) AAW81339(OXA-68) AAW81340(OXA-69) AAW81341(OXA-70) AAW81342(OXA-71) AAX51233(OXA-77) AAX51234(OXA-76) AAZ78361(OXA-86) ABC26006(OXA-84) ABC26007(OXA-83) ABC61637(OXA-92) ABC84263(OXA-87) ABD48715(OXA-88) ABE03012(OXA-89) ABF47914(OXA-91) ABF47916(OXA-93) ABF47917(OXA-94) ABF47918(OXA-95) ABI53716(OXA-99) ABQ52429(OXA-104) ABS71123(OXA-115) ABV31686(OXA-106) ABV31687(OXA-107) ABV31688(OXA-108) ABV31689(OXA-109) ABV31690(OXA-110) ABV31691(OXA-111) ABV31692(OXA-112) ABV71246(OXA-79) ABV71247(OXA-80) ABV71248(OXA-82) ABW70410(OXA-113) ABY77907(OXA-128) ACD84986(OXA-90) ACD84988(OXA-130) ACD84989(OXA-131) ACD84990(OXA-132) ACX31140(OXA-148) ACX31141(OXA-149) ACX31142(OXA-150) ADI58616(OXA-172) ADI58617(OXA-173) ADI58618(OXA-174) ADI58619(OXA-175) ADI58620(OXA-176) ADI58621(OXA-177) ADI58622(OXA-178) ADM26744(OXA-179) ADM26745(OXA-180) ADX07745(OXA-200) ADX07746(OXA-201) ADX07747(OXA-202) ADX07748(OXA-203) AEB98920(OXA-194) AEB98921(OXA-195) AEB98922(OXA-196) AEB98923(OXA-197) AEL17179(OXA-219) AEL88491(OXA-223) AEO44980(OXA-217) AFO55201(OXA-241) AFO55202(OXA-242) AFZ84681(OXA-402) AFZ84683(OXA-510) AFZ84684(OXA-441) AGU69248(OXA-121) AGU69250(OXA-312) AGU69251(OXA-313) AGU69252(OXA-314) AGU69253(OXA-315) AGU69254(OXA-316) AGU69255(OXA-317) AHI63011(OXA-365) AHL30272(OXA-385) AHL30273(OXA-386) AHL30274(OXA-374) AHL30275(OXA-375) AHL30276(OXA-376) AHL30277(OXA-377) AHL30278(OXA-378) AHL30279(OXA-379) AHL30280(OXA-380) AHL30281(OXA-383) AHL30282(OXA-384) AHL30283(OXA-390) AHL30284(OXA-388) AHL30285(OXA-381) AHL30286(OXA-382) AHL30287(OXA-389) AHN07452(OXA-336) AHN07453(OXA-337) AHN07454(OXA-338) AHN07456(OXA-339) AHN07457(OXA-340) AHN07458(OXA-341) AHN07460(OXA-342) AHN07461(OXA-343) AHN07462(OXA-344) AHN07463(OXA-345) AHN07464(OXA-346) AJA32742(OXA-424) AJA32743(OXA-425) AJA32744(OXA-426) AJD07401(OXA-414) AJD07402(OXA-406) AJD07403(OXA-407) AJD07404(OXA-408) AJD07405(OXA-409) AJD07406(OXA-411) AJD07407(OXA-412) AJD07408(OXA-413) AJD77428(OXA-410) AJG01375(OXA-429) AJG01376(OXA-430) AJG01377(OXA-431) AJG01378(OXA-432) AJG01379(OXA-433) BAL15076(OXA-206) BAN10684(OXA-254) CAC83905(OXA-51) CCA94649(OXA-216) CCJ32595(OXA-120) CCJ32596(OXA-248) CCJ32597(OXA-249) CCJ32598(OXA-250) ENU54757(OXA-260) ENW35072(OXA-261) ENW43915(OXA-263) ENW50687(OXA-262) ENW61294(OXA-259) KRW26153(OXA-497)
 » show all
Reference
  Authors
Brown S, Young HK, Amyes SG
  Title
Characterisation of OXA-51, a novel class D carbapenemase found in genetically unrelated clinical strains of Acinetobacter baumannii from Argentina.
  Journal
Clin Microbiol Infect 11:15-23 (2005)
DOI:10.1111/j.1469-0691.2004.01016.x
  Sequence

KEGG   ORTHOLOGY: K18972
Entry
K18972            Tight     KO                                     

Name
blaOXA-58
Definition
beta-lactamase class D OXA-58 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18972  blaOXA-58; beta-lactamase class D OXA-58
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18972  blaOXA-58; beta-lactamase class D OXA-58
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18972  blaOXA-58; beta-lactamase class D OXA-58
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K18972  blaOXA-58; beta-lactamase class D OXA-58
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
ABC: ACICU_p0019 ACICU_p0024
ABAB: BJAB0715_p0053
AJO: RZ95_19145
ADV: DJ533_02250
AG: AAW57529(OXA-58) ABF47919(OXA-96) ABO33299(OXA-97) ADK34116(OXA-164)
Reference
  Authors
Poirel L, Marque S, Heritier C, Segonds C, Chabanon G, Nordmann P
  Title
OXA-58, a novel class D {beta}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii.
  Journal
Antimicrob Agents Chemother 49:202-8 (2005)
DOI:10.1128/AAC.49.1.202-208.2005
  Sequence

KEGG   ORTHOLOGY: K21277
Entry
K21277            Tight     KO                                     

Name
blaOXA-60
Definition
beta-lactamase class D OXA-60 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K21277  blaOXA-60; beta-lactamase class D OXA-60
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K21277  blaOXA-60; beta-lactamase class D OXA-60
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K21277  blaOXA-60; beta-lactamase class D OXA-60
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K21277  blaOXA-60; beta-lactamase class D OXA-60
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
RPI: Rpic_3962
RPF: Rpic12D_4075
RMN: TK49_20190
RIN: ACS15_5682(bla)
AG: AAQ08905(OXA-60) BAQ55594(OXA-444)
Reference
  Authors
Girlich D, Naas T, Nordmann P
  Title
OXA-60, a chromosomal, inducible, and imipenem-hydrolyzing class D beta-lactamase from Ralstonia pickettii.
  Journal
Antimicrob Agents Chemother 48:4217-25 (2004)
DOI:10.1128/AAC.48.11.4217-4225.2004
  Sequence

KEGG   ORTHOLOGY: K19210
Entry
K19210            Tight     KO                                     

Name
blaOXA-61
Definition
beta-lactamase class D OXA-61 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K19210  blaOXA-61; beta-lactamase class D OXA-61
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19210  blaOXA-61; beta-lactamase class D OXA-61
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K19210  blaOXA-61; beta-lactamase class D OXA-61
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K19210  blaOXA-61; beta-lactamase class D OXA-61
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
CJE: Cj0299
CJB: BN148_0299
CJU: C8J_0276
CJI: CJSA_0273
CJS: CJS3_0285
CJP: A911_01440
CJEJ: N564_00283
CJEU: N565_00334
CJEN: N755_00333
CJEI: N135_00345
CJY: QZ67_00299(bla)
CJQ: UC78_0287(bla)
CJR: CJE0344
CCQ: N149_0295
CCF: YSQ_08395
CCY: YSS_01260
CCOI: YSU_07395
CCOO: ATE51_03620(bla)
AG: AAT01092(OXA-61) AGZ20772(OXA-489) CAL34450(OXA-193)
 » show all
Reference
  Authors
Alfredson DA, Korolik V
  Title
Isolation and expression of a novel molecular class D beta-lactamase, OXA-61, from Campylobacter jejuni.
  Journal
Antimicrob Agents Chemother 49:2515-8 (2005)
DOI:10.1128/AAC.49.6.2515-2518.2005
  Sequence

KEGG   ORTHOLOGY: K19211
Entry
K19211            Tight     KO                                     

Name
blaOXA-62
Definition
beta-lactamase class D OXA-62 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K19211  blaOXA-62; beta-lactamase class D OXA-62
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19211  blaOXA-62; beta-lactamase class D OXA-62
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K19211  blaOXA-62; beta-lactamase class D OXA-62
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K19211  blaOXA-62; beta-lactamase class D OXA-62
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
PPK: U875_04665
PPNO: DA70_21740
PPNM: LV28_08570
PRB: X636_04770
PPUL: RO07_02765
PSPU: NA29_23685
PAPI: SG18_02980
POX: MB84_23690
PFG: AB870_05940
PNR: AT302_02370
PFIB: PI93_009105(blaOXA)
AG: AAR32134(OXA-62) ALA99185(OXA-151) ALA99186(OXA-152) ALA99187(OXA-153) ALA99188(OXA-154) ALA99189(OXA-155) ALA99190(OXA-156) ALA99191(OXA-157) ALA99192(OXA-158) ALA99193(OXA-159)
 » show all
Reference
  Authors
Schneider I, Queenan AM, Bauernfeind A
  Title
Novel carbapenem-hydrolyzing oxacillinase OXA-62 from Pandoraea pnomenusa.
  Journal
Antimicrob Agents Chemother 50:1330-5 (2006)
DOI:10.1128/AAC.50.4.1330-1335.2006
  Sequence

KEGG   ORTHOLOGY: K19212
Entry
K19212            Tight     KO                                     

Name
blaOXA-63
Definition
beta-lactamase class D OXA-63 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K19212  blaOXA-63; beta-lactamase class D OXA-63
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19212  blaOXA-63; beta-lactamase class D OXA-63
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K19212  blaOXA-63; beta-lactamase class D OXA-63
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K19212  blaOXA-63; beta-lactamase class D OXA-63
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
BPO: BP951000_1338
BPJ: B2904_orf2576
BPW: WESB_0148
AG: AAU88145(OXA-63) ABW76134(OXA-136) ABW76138(OXA-137) ADZ54048(OXA-192) ALC79285(OXA-470) ALC79286(OXA-471) ALC79287(OXA-472) ALC79288(OXA-473) ALC79289(OXA-474) ALC79290(OXA-475) ALC79291(OXA-476) ALC79292(OXA-477) ALC79293(OXA-478) ALC79294(OXA-479)
Reference
  Authors
Meziane-Cherif D, Lambert T, Dupechez M, Courvalin P, Galimand M
  Title
Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442.
  Journal
Antimicrob Agents Chemother 52:1264-8 (2008)
DOI:10.1128/AAC.00684-07
  Sequence

KEGG   ORTHOLOGY: K22335
Entry
K22335            Tight     KO                                     

Name
blaOXA-114
Definition
beta-lactamase class D OXA-114 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K22335  blaOXA-114; beta-lactamase class D OXA-114
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K22335  blaOXA-114; beta-lactamase class D OXA-114
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K22335  blaOXA-114; beta-lactamase class D OXA-114
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K22335  blaOXA-114; beta-lactamase class D OXA-114
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
AXN: AX27061_4146
AXX: ERS451415_04165(bla)
ADT: APT56_24215
AG: ABX38721(OXA-114a) ADI23933(OXA-114b) ADI23934(OXA-114c) ADI25068(OXA-114d) ADI25069(OXA-114e) ADO14462(OXA-114f) ADO14463(OXA-114g) AFQ90085(OXA-243) AFR53898(OXA-364) ALC76097(OXA-455) ALC76098(OXA-456) ALC76099(OXA-457) ALC76100(OXA-458) ALC76101(OXA-459) ALX18471(OXA-513) CCE73593(OXA-258)
Reference
  Authors
Doi Y, Poirel L, Paterson DL, Nordmann P
  Title
Characterization of a naturally occurring class D beta-lactamase from Achromobacter xylosoxidans.
  Journal
Antimicrob Agents Chemother 52:1952-6 (2008)
DOI:10.1128/AAC.01463-07
  Sequence

KEGG   ORTHOLOGY: K19319
Entry
K19319            Tight     KO                                     

Name
blaOXA-134
Definition
beta-lactamase class D OXA-134 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K19319  blaOXA-134; beta-lactamase class D OXA-134
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19319  blaOXA-134; beta-lactamase class D OXA-134
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K19319  blaOXA-134; beta-lactamase class D OXA-134
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K19319  blaOXA-134; beta-lactamase class D OXA-134
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
ABAL: ABLAC_13990
ASJ: AsACE_CH00016(bla)
ALW: FOB21_09915(blaOXA)
AG: ADM47435(OXA-134) AFH36330(OXA-235) AFH36331(OXA-237) AFH36332(OXA-236) AGI65307(OXA-278) AGW16417(OXA-335) AGZ83156(OXA-360) AHA11124(OXA-361) AHA11125(OXA-362) AHA11126(OXA-363) ENU64030(OXA-282) ENV13583(OXA-276) ENV45890(OXA-277) ENX16434(OXA-284) ENX25499(OXA-283) ENX26326(OXA-285)
Reference
  Authors
Figueiredo S, Poirel L, Seifert H, Mugnier P, Benhamou D, Nordmann P
  Title
OXA-134, a naturally occurring carbapenem-hydrolyzing class D beta-lactamase from Acinetobacter lwoffii.
  Journal
Antimicrob Agents Chemother 54:5372-5 (2010)
DOI:10.1128/AAC.00629-10
  Sequence

KEGG   ORTHOLOGY: K22331
Entry
K22331            Tight     KO                                     

Name
blaOXA-184
Definition
beta-lactamase class D OXA-184 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K22331  blaOXA-184; beta-lactamase class D OXA-184
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K22331  blaOXA-184; beta-lactamase class D OXA-184
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K22331  blaOXA-184; beta-lactamase class D OXA-184
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K22331  blaOXA-184; beta-lactamase class D OXA-184
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
CJM: CJM1_0277
AG: AFO09968(OXA-184) AFO09969(OXA-185) AKI29907(OXA-446) AKI29908(OXA-447) AKI29909(OXA-448) AKI29910(OXA-449) AKI29912(OXA-465) AKI29913(OXA-466)
Reference
  Authors
Weis AM, Storey DB, Taff CC, Townsend AK, Huang BC, Kong NT, Clothier KA, Spinner A, Byrne BA, Weimer BC
  Title
Genomic Comparison of Campylobacter spp. and Their Potential for Zoonotic Transmission between Birds, Primates, and Livestock.
  Journal
Appl Environ Microbiol 82:7165-7175 (2016)
DOI:10.1128/AEM.01746-16

KEGG   ORTHOLOGY: K22351
Entry
K22351            Tight     KO                                     

Name
blaOXA-209
Definition
beta-lactamase class D OXA-209 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K22351  blaOXA-209; beta-lactamase class D OXA-209
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K22351  blaOXA-209; beta-lactamase class D OXA-209
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K22351  blaOXA-209; beta-lactamase class D OXA-209
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K22351  blaOXA-209; beta-lactamase class D OXA-209
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
RAR: RIA_0366
RAG: B739_0031
RAE: G148_1768
RAT: M949_0460 M949_0466
MOD: AS202_10895
AG: AEM66528(OXA-209) AET35493(OXA-347)
Reference
  Authors
Chen YP, Lee SH, Chou CH, Tsai HJ
  Title
Detection of florfenicol resistance genes in Riemerella anatipestifer isolated from ducks and geese.
  Journal
Vet Microbiol 154:325-31 (2012)
DOI:10.1016/j.vetmic.2011.07.012
  Sequence

KEGG   ORTHOLOGY: K19320
Entry
K19320            Tight     KO                                     

Name
blaOXA-211
Definition
beta-lactamase class D OXA-211 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K19320  blaOXA-211; beta-lactamase class D OXA-211
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19320  blaOXA-211; beta-lactamase class D OXA-211
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K19320  blaOXA-211; beta-lactamase class D OXA-211
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K19320  blaOXA-211; beta-lactamase class D OXA-211
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
AJO: RZ95_00065
AG: AEV91550(OXA-211) AEV91551(OXA-212) AGW16415(OXA-333) AGW16416(OXA-334) CCW28916(OXA-309) CDM87362(OXA-373) ENU38533(OXA-281) ENV74419(OXA-280)
Reference
  Authors
Figueiredo S, Bonnin RA, Poirel L, Duranteau J, Nordmann P
  Title
Identification of the naturally occurring genes encoding carbapenem-hydrolysing oxacillinases from Acinetobacter haemolyticus, Acinetobacter johnsonii, and Acinetobacter calcoaceticus.
  Journal
Clin Microbiol Infect 18:907-13 (2012)
DOI:10.1111/j.1469-0691.2011.03708.x
  Sequence

KEGG   ORTHOLOGY: K19318
Entry
K19318            Tight     KO                                     

Name
blaOXA-213
Definition
beta-lactamase class D OXA-213 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K19318  blaOXA-213; beta-lactamase class D OXA-213
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19318  blaOXA-213; beta-lactamase class D OXA-213
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K19318  blaOXA-213; beta-lactamase class D OXA-213
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K19318  blaOXA-213; beta-lactamase class D OXA-213
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
ACC: BDGL_000903(bla)
ALC: OTEC02_10540
ACAL: BUM88_08380
ACD: AOLE_11070
ACW: A0J50_09815
AG: AEV91552(OXA-213) AGW16404(OXA-322) AGW16405(OXA-323) AGW16406(OXA-324) AGW16407(OXA-325) AGW16408(OXA-326) AGW16409(OXA-327) AGW16410(OXA-328) AGW16411(OXA-329) AGW16412(OXA-330) AGW16413(OXA-331) AGW16414(OXA-332) AGW83446(OXA-348) AGW83447(OXA-349) AGW83448(OXA-350) AGW83449(OXA-351) AGW83450(OXA-352) AGW83451(OXA-353) AGW83452(OXA-354) AGZ83153(OXA-357) AGZ83154(OXA-358) AGZ83155(OXA-359) AIZ00987(OXA-421) ENU09033(OXA-268) ENV02983(OXA-305) ENV93423(OXA-267) ENW12288(OXA-273) ENW16915(OXA-272) ENX45276(OXA-304) EOQ63861(OXA-269) EOQ69512(OXA-270) EOQ72432(OXA-271)
Reference
  Authors
Figueiredo S, Bonnin RA, Poirel L, Duranteau J, Nordmann P
  Title
Identification of the naturally occurring genes encoding carbapenem-hydrolysing oxacillinases from Acinetobacter haemolyticus, Acinetobacter johnsonii, and Acinetobacter calcoaceticus.
  Journal
Clin Microbiol Infect 18:907-13 (2012)
DOI:10.1111/j.1469-0691.2011.03708.x
  Sequence

KEGG   ORTHOLOGY: K19321
Entry
K19321            Tight     KO                                     

Name
blaOXA-214
Definition
beta-lactamase class D OXA-214 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K19321  blaOXA-214; beta-lactamase class D OXA-214
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19321  blaOXA-214; beta-lactamase class D OXA-214
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K19321  blaOXA-214; beta-lactamase class D OXA-214
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K19321  blaOXA-214; beta-lactamase class D OXA-214
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
AHL: AHTJS_00875
AG: AEV91553(OXA-214) AEV91554(OXA-215) ENW20318(OXA-264) ENW22086(OXA-265)
Reference
  Authors
Figueiredo S, Bonnin RA, Poirel L, Duranteau J, Nordmann P
  Title
Identification of the naturally occurring genes encoding carbapenem-hydrolysing oxacillinases from Acinetobacter haemolyticus, Acinetobacter johnsonii, and Acinetobacter calcoaceticus.
  Journal
Clin Microbiol Infect 18:907-13 (2012)
DOI:10.1111/j.1469-0691.2011.03708.x
  Sequence

KEGG   ORTHOLOGY: K19322
Entry
K19322            Tight     KO                                     

Name
blaOXA-229
Definition
beta-lactamase class D OXA-229 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K19322  blaOXA-229; beta-lactamase class D OXA-229
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19322  blaOXA-229; beta-lactamase class D OXA-229
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K19322  blaOXA-229; beta-lactamase class D OXA-229
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K19322  blaOXA-229; beta-lactamase class D OXA-229
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
AG: AFM55000(OXA-229) AFM55001(OXA-228) AFM55002(OXA-230) AGK07370(OXA-257) AGW83453(OXA-355) AGW83454(OXA-356) AIN56719(OXA-418) ENV20093(OXA-300) ENV90372(OXA-301)
Reference
  Authors
Bonnin RA, Ocampo-Sosa AA, Poirel L, Guet-Revillet H, Nordmann P
  Title
Biochemical and genetic characterization of carbapenem-hydrolyzing beta-lactamase OXA-229 from Acinetobacter bereziniae.
  Journal
Antimicrob Agents Chemother 56:3923-7 (2012)
DOI:10.1128/AAC.00257-12
  Sequence

KEGG   ORTHOLOGY: K21266
Entry
K21266            Tight     KO                                     

Name
blaOXA-286
Definition
beta-lactamase class D OXA-286 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K21266  blaOXA-286; beta-lactamase class D OXA-286
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K21266  blaOXA-286; beta-lactamase class D OXA-286
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K21266  blaOXA-286; beta-lactamase class D OXA-286
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K21266  blaOXA-286; beta-lactamase class D OXA-286
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
AG: ENU21708(OXA-286) ENU93232(OXA-294) ENV10177(OXA-287) ENW83134(OXA-293) ENW94121(OXA-291) ENX09209(OXA-297) ENX18112(OXA-302) ENX19403(OXA-295) ENX33046(OXA-307) ENX38336(OXA-306) ENX40034(OXA-298) ENX53612(OXA-292) ENX56371(OXA-303) ENX60508(OXA-288)
Reference
  Authors
Perichon B, Goussard S, Walewski V, Krizova L, Cerqueira G, Murphy C, Feldgarden M, Wortman J, Clermont D, Nemec A, Courvalin P
  Title
Identification of 50 class D beta-lactamases and 65 Acinetobacter-derived cephalosporinases in Acinetobacter spp.
  Journal
Antimicrob Agents Chemother 58:936-49 (2014)
DOI:10.1128/AAC.01261-13
  Sequence

KEGG   ORTHOLOGY: K22334
Entry
K22334            Tight     KO                                     

Name
blaOXA-464
Definition
beta-lactamase class D OXA-464 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K22334  blaOXA-464; beta-lactamase class D OXA-464
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K22334  blaOXA-464; beta-lactamase class D OXA-464
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K22334  blaOXA-464; beta-lactamase class D OXA-464
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K22334  blaOXA-464; beta-lactamase class D OXA-464
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
ABU: Abu_1478
ABT: ABED_1379
ABL: A7H1H_1494
AG: AGR77778(OXA-491) ANW35663(OXA-464)

KEGG   ORTHOLOGY: K22333
Entry
K22333            Tight     KO                                     

Name
blaOXA-493
Definition
beta-lactamase class D OXA-493 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K22333  blaOXA-493; beta-lactamase class D OXA-493
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K22333  blaOXA-493; beta-lactamase class D OXA-493
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K22333  blaOXA-493; beta-lactamase class D OXA-493
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K22333  blaOXA-493; beta-lactamase class D OXA-493
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
CLA: CLA_1382
CLR: UPTC16701_1351
CLM: UPTC16712_1375
CLN: UPTC3659_1595
CLL: CONCH_1329
CIS: CINS_1329
CVO: CVOL_1370
CAMR: CAQ16704_1391
CSM: CSUB8521_1571
CSF: CSUB8523_1667
AG: ACM64698(OXA-493) AMR98919(OXA-518)
 » show all

KEGG   ORTHOLOGY: K22332
Entry
K22332            Tight     KO                                     

Name
blaOXA-548
Definition
beta-lactamase class D OXA-548 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K22332  blaOXA-548; beta-lactamase class D OXA-548
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K22332  blaOXA-548; beta-lactamase class D OXA-548
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K22332  blaOXA-548; beta-lactamase class D OXA-548
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class D [MT]
    K22332  blaOXA-548; beta-lactamase class D OXA-548
Other DBs
COG: COG2602
GO: 0008800 0008658
Genes
SBL: Sbal_3522
SBM: Shew185_0813
SBN: Sbal195_0845
SBP: Sbal223_0838
SBT: Sbal678_0870
SBS: Sbal117_3663
SBB: Sbal175_0847
SHEW: CKQ84_12220
AG: AQX43448(OXA-548)

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