KEGG   ORTHOLOGY: K17940Help
Entry
K17940                      KO                                     

Name
pqsH
Definition
2-heptyl-3-hydroxy-4(1H)-quinolone synthase [EC:1.14.13.182]
Pathway
ko00405  Phenazine biosynthesis
ko01130  Biosynthesis of antibiotics
ko02024  Quorum sensing
ko02025  Biofilm formation - Pseudomonas aeruginosa
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00405 Phenazine biosynthesis
    K17940  pqsH; 2-heptyl-3-hydroxy-4(1H)-quinolone synthase
 09140 Cellular Processes
  09145 Cellular community - prokaryotes
   02024 Quorum sensing
    K17940  pqsH; 2-heptyl-3-hydroxy-4(1H)-quinolone synthase
   02025 Biofilm formation - Pseudomonas aeruginosa
    K17940  pqsH; 2-heptyl-3-hydroxy-4(1H)-quinolone synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.182  2-heptyl-3-hydroxy-4(1H)-quinolone synthase
     K17940  pqsH; 2-heptyl-3-hydroxy-4(1H)-quinolone synthase
BRITE hierarchy
Other DBs
RN: R10467
COG: COG0654
Genes
PAE: PA2587(pqsH)
PAEV: N297_2666
PAEI: N296_2666
PAU: PA14_30630(pqsH)
PAP: PSPA7_2611
PAG: PLES_26011(pqsH)
PAF: PAM18_2406(pqsH)
PNC: NCGM2_3602(pqsH)
PAEB: NCGM1900_3928(pqsH)
PDK: PADK2_11725
PAEP: PA1S_12675
PAEM: U769_12240
PAEL: T223_13295
PAEU: BN889_02851(pqsH)
PAEG: AI22_21235
PAEC: M802_2663
PAEO: M801_2532
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Schertzer JW, Brown SA, Whiteley M
  Title
Oxygen levels rapidly modulate Pseudomonas aeruginosa social behaviours via substrate limitation of PqsH.
  Journal
Mol Microbiol 77:1527-38 (2010)
DOI:10.1111/j.1365-2958.2010.07303.x
  Sequence

KEGG   ENZYME: 1.14.13.182Help
Entry
EC 1.14.13.182              Enzyme                                 

Name
2-heptyl-3-hydroxy-4(1H)-quinolone synthase;
PqsH;
2-heptyl-3,4-dihydroxyquinoline synthase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
2-heptyl-4(1H)-quinolone,NADH:oxygen oxidoreductase (3-hydroxylating)
Reaction(IUBMB)
2-heptyl-4(1H)-quinolone + NADH + H+ + O2 = 2-heptyl-3-hydroxy-4(1H)-quinolone + NAD+ + H2O [RN:R10467]
Reaction(KEGG)
Substrate
2-heptyl-4(1H)-quinolone [CPD:C20643];
NADH [CPD:C00004];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
2-heptyl-3-hydroxy-4(1H)-quinolone [CPD:C11848];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Comment
The enzyme from the bacterium Pseudomonas aeruginosa catalyses the terminal step in biosynthesis of the signal molecule 2-heptyl-3,4-dihydroxyquinoline that plays a role in regulation of virulence genes.
History
EC 1.14.13.182 created 2013
Pathway
ec00405  Phenazine biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K17940  2-heptyl-3-hydroxy-4(1H)-quinolone synthase
Genes
PAE: PA2587(pqsH)
PAEV: N297_2666
PAEI: N296_2666
PAU: PA14_30630(pqsH)
PAP: PSPA7_2611
PAG: PLES_26011(pqsH)
PAF: PAM18_2406(pqsH)
PNC: NCGM2_3602(pqsH)
PAEB: NCGM1900_3928(pqsH)
PDK: PADK2_11725
PAEP: PA1S_12675
PAEM: U769_12240
PAEL: T223_13295
PAEU: BN889_02851(pqsH)
PAEG: AI22_21235
PAEC: M802_2663
PAEO: M801_2532
 » show all
Taxonomy
Reference
1  [PMID:20662781]
  Authors
Schertzer JW, Brown SA, Whiteley M
  Title
Oxygen levels rapidly modulate Pseudomonas aeruginosa social behaviours via substrate limitation of PqsH.
  Journal
Mol Microbiol 77:1527-38 (2010)
DOI:10.1111/j.1365-2958.2010.07303.x
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.182
IUBMB Enzyme Nomenclature: 1.14.13.182
ExPASy - ENZYME nomenclature database: 1.14.13.182
BRENDA, the Enzyme Database: 1.14.13.182

KEGG   REACTION: R10467Help
Entry
R10467                      Reaction                               

Name
2-heptyl-4(1H)-quinolone,NADH:oxygen oxidoreductase (3-hydroxylating)
Definition
2-Heptyl-4(1H)-quinolone + NADH + H+ + Oxygen <=> 2-Heptyl-3-hydroxy-quinolone + NAD+ + H2O
Equation
Reaction class
RC00001  C00003_C00004
RC00236  C11848_C20643
Enzyme
Pathway
rn00405  Phenazine biosynthesis
rn01130  Biosynthesis of antibiotics
Orthology
K17940  2-heptyl-3-hydroxy-4(1H)-quinolone synthase [EC:1.14.13.182]
Other DBs
RHEA: 37874

DBGET integrated database retrieval system