KEGG   ORTHOLOGY: K18049
Entry
K18049            Tight     KO                                     
Symbol
mpnS
Name
methylphosphonate synthase [EC:1.13.11.73]
Pathway
map00440  Phosphonate and phosphinate metabolism
map01100  Metabolic pathways
Reaction
R10191  2-hydroxyethylphosphonate:O2 1,2-oxidoreductase (methylphosphonate forming)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00440 Phosphonate and phosphinate metabolism
    K18049  mpnS; methylphosphonate synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.73  methylphosphonate synthase
     K18049  mpnS; methylphosphonate synthase
Genes
NMR: Nmar_0155
Reference
PMID:22936780
  Authors
Metcalf WW, Griffin BM, Cicchillo RM, Gao J, Janga SC, Cooke HA, Circello BT, Evans BS, Martens-Habbena W, Stahl DA, van der Donk WA
  Title
Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean.
  Journal
Science 337:1104-7 (2012)
DOI:10.1126/science.1219875
  Sequence
[nmr:Nmar_0155]

  All links  
Gene (1)   
   OC (1)   
All databases (1)   

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KEGG   ENZYME: 1.13.11.73
Entry
EC 1.13.11.73               Enzyme                                 
Name
methylphosphonate synthase;
mpnS (gene name);
2-hydroxyethylphosphonate:O2 1,2-oxidoreductase (methylphosphonate-forming)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
2-hydroxyethylphosphonate:oxygen 1,2-oxidoreductase (methylphosphonate-forming)
Reaction(IUBMB)
2-hydroxyethylphosphonate + O2 = methylphosphonate + hydrogen carbonate [RN:R10191]
Reaction(KEGG)
R10191
Substrate
2-hydroxyethylphosphonate [CPD:C06451];
O2 [CPD:C00007]
Product
methylphosphonate [CPD:C20396];
hydrogen carbonate [CPD:C00288]
Comment
Isolated from the marine archaeon Nitrosopumilus maritimus.
History
EC 1.13.11.73 created 2012
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec01100  Metabolic pathways
Orthology
K18049  methylphosphonate synthase
Genes
NMR: Nmar_0155
Reference
1  [PMID:22936780]
  Authors
Metcalf WW, Griffin BM, Cicchillo RM, Gao J, Janga SC, Cooke HA, Circello BT, Evans BS, Martens-Habbena W, Stahl DA, van der Donk WA
  Title
Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean.
  Journal
Science 337:1104-7 (2012)
DOI:10.1126/science.1219875
  Sequence
[nmr:Nmar_0155]
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.73
IUBMB Enzyme Nomenclature: 1.13.11.73
ExPASy - ENZYME nomenclature database: 1.13.11.73
BRENDA, the Enzyme Database: 1.13.11.73

  All links  
Protein sequence (24)   
   UniProt (6)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
   PDBSTR (16)   
DNA sequence (3)   
   RefSeq(nuc) (1)   
   GenBank (1)   
   EMBL (1)   
3D Structure (2)   
   PDB (2)   
Protein domain (5)   
   InterPro (5)   
All databases (34)   

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KEGG   REACTION: R10191
Entry
R10191                      Reaction                               
Name
2-hydroxyethylphosphonate:O2 1,2-oxidoreductase (methylphosphonate forming)
Definition
2-Hydroxyethylphosphonate + Oxygen <=> Methylphosphonate + HCO3-
Equation
C06451 + C00007 <=> C20396 + C00288
Reaction class
RC03075  C06451_C20396
Enzyme
1.13.11.73
Pathway
rn00440  Phosphonate and phosphinate metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.73
     R10191  2-Hydroxyethylphosphonate + Oxygen <=> Methylphosphonate + HCO3-
Orthology
K18049  methylphosphonate synthase [EC:1.13.11.73]
Other DBs
RHEA: 34618

  All links  
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