KEGG   ORTHOLOGY: K18057Help
Entry
K18057                      KO                                     

Name
pntD, penD, ptlD
Definition
pentalenolactone F synthase [EC:1.14.11.36]
Pathway
ko00999  Biosynthesis of various secondary metabolites - part 1
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00819  Pentalenolactone biosynthesis, farnesyl-PP => pentalenolactone
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00999 Biosynthesis of various secondary metabolites - part 1
    K18057  pntD, penD, ptlD; pentalenolactone F synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.36  pentalenolactone F synthase
     K18057  pntD, penD, ptlD; pentalenolactone F synthase
BRITE hierarchy
Other DBs
RN: R10145
COG: COG2175
Genes
SMA: SAVERM_2995(ptlD)
SBH: SBI_09677
SCI: B446_29685
SCW: TU94_27395
SLE: sle_13180(sle_13180)
SSIA: A7J05_09250
TaxonomyKoalaUniProt
Reference
  Authors
Seo MJ, Zhu D, Endo S, Ikeda H, Cane DE
  Title
Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone.
  Journal
Biochemistry 50:1739-54 (2011)
DOI:10.1021/bi1019786
  Sequence

KEGG   ENZYME: 1.14.11.36Help
Entry
EC 1.14.11.36               Enzyme                                 

Name
pentalenolactone F synthase;
penD (gene name);
pntD (gene name);
ptlD (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
BRITE hierarchy
Sysname
pentalenolactone-D,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
pentalenolactone D + 2 2-oxoglutarate + 2 O2 = pentalenolactone F + 2 succinate + 2 CO2 + H2O (overall reaction) [RN:R10145];
(1a) pentalenolactone D + 2-oxoglutarate + O2 = pentalenolactone E + succinate + CO2 + H2O [RN:R10143];
(1b) pentalenolactone E + 2-oxoglutarate + O2 = pentalenolactone F + succinate + CO2 [RN:R10144]
Reaction(KEGG)
Substrate
pentalenolactone D [CPD:C20399];
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
pentalenolactone E [CPD:C20398]
Product
pentalenolactone F [CPD:C20397];
succinate [CPD:C00042];
CO2 [CPD:C00011];
H2O [CPD:C00001];
pentalenolactone E [CPD:C20398]
Comment
Requires Fe(II) and ascorbate. Isolated from the bacteria Streptomyces exfoliatus, Streptomyces arenae and Streptomyces avermitilis. Part of the pentalenolactone biosynthesis pathway.
History
EC 1.14.11.36 created 2012
Pathway
ec00999  Biosynthesis of various secondary metabolites - part 1
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K18057  pentalenolactone F synthase
Genes
SMA: SAVERM_2995(ptlD)
SBH: SBI_09677
SCI: B446_29685
SCW: TU94_27395
SLE: sle_13180(sle_13180)
SSIA: A7J05_09250
Taxonomy
Reference
1  [PMID:21250661]
  Authors
Seo MJ, Zhu D, Endo S, Ikeda H, Cane DE
  Title
Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final  steps of the biosynthesis of pentalenolactone and neopentalenolactone.
  Journal
Biochemistry 50:1739-54 (2011)
DOI:10.1021/bi1019786
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.36
IUBMB Enzyme Nomenclature: 1.14.11.36
ExPASy - ENZYME nomenclature database: 1.14.11.36
BRENDA, the Enzyme Database: 1.14.11.36

KEGG   REACTION: R10145Help
Entry
R10145                      Reaction                               

Name
pentalenolactone-D,2-oxoglutarate:oxygen oxidoreductase
Definition
Pentalenolactone D + 2 2-Oxoglutarate + 2 Oxygen <=> Pentalenolactone F + 2 Succinate + 2 CO2 + H2O
Equation
C20399 + 2 C00026 + 2 C00007 <=> C20397 + 2 C00042 + 2 C00011 + C00001
Comment
two-step reaction (see R10143+R10144)
Reaction class
RC03061  C20397_C20399
Enzyme
Pathway
rn00999  Biosynthesis of various secondary metabolites - part 1
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00819  Pentalenolactone biosynthesis, farnesyl-PP => pentalenolactone
Orthology
K18057  pentalenolactone F synthase [EC:1.14.11.36]
Other DBs
RHEA: 34582

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