KEGG   ORTHOLOGY: K18072
Entry
K18072                      KO                                     

Name
parS
Definition
two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3]
Pathway
ko01501  beta-Lactam resistance
ko01503  Cationic antimicrobial peptide (CAMP) resistance
ko02020  Two-component system
Module
M00745  Imipenem resistance, repression of porin OprD
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
   01503 Cationic antimicrobial peptide (CAMP) resistance
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
  09183 Protein families: signaling and cellular processes
   02022 Two-component system
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
   01504 Antimicrobial resistance genes
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.13  Protein-histidine kinases
    2.7.13.3  histidine kinase
     K18072  parS; two-component system, OmpR family, sensor kinase ParS
Protein kinases [BR:ko01001]
 Histidine kinases
  OmpR family
   K18072  parS; two-component system, OmpR family, sensor kinase ParS
Two-component system [BR:ko02022]
 OmpR family
  ParS-ParR (polymyxin-adaptive resistance)
   K18072  parS; two-component system, OmpR family, sensor kinase ParS
Antimicrobial resistance genes [BR:ko01504]
 Gene sets
  beta-Lactam resistance modules
   Imipenem resistance, repression of porin OprD
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
Other DBs
COG: COG0642
GO: 0000155
Genes
SML: Smlt3730
SMT: Smal_3143
BUJ: BurJV3_3177
SMZ: SMD_3333
STEN: CCR98_16365
STEM: CLM74_16690
STES: MG068_16225
LCP: LC55x_3348
LYT: DWG18_07690
VHR: AL538_25580
PAE: PA1798(parS)
PAEV: N297_1852
PAEI: N296_1852
PAU: PA14_41270
PAP: PSPA7_3499
PAG: PLES_35301
PAF: PAM18_3246
PNC: NCGM2_2708
PAEB: NCGM1900_4702
PDK: PADK2_16675
PSG: G655_16165
PRP: M062_09405
PAEP: PA1S_16975
PAER: PA1R_gp5421
PAEM: U769_16690
PAEL: T223_18030
PAES: SCV20265_3606
PAEU: BN889_01932
PAEG: AI22_17015
PAEC: M802_1850
PAEO: M801_1851
PFL: PFL_2638
PPRC: PFLCHA0_c27050(rstB1)
PPRO: PPC_2687
PFO: Pfl01_3390
PFS: PFLU_3483
PFE: PSF113_2430
PFC: PflA506_2548
PFN: HZ99_01210
PFB: VO64_0594
PMAN: OU5_0718
PTV: AA957_27695
PVR: PverR02_17250
PAZO: AYR47_23880
POI: BOP93_13980
PFW: PF1751_v1c29120
PFF: PFLUOLIPICF721625
PFX: A7318_12015
PBA: PSEBR_a3303
PSK: U771_18585
PCH: EY04_12105
PCZ: PCL1606_35440
PCP: JM49_17760
PSEM: TO66_12910
PSOS: POS17_2645
PKR: AYO71_18695
PFK: PFAS1_27180
PANR: A7J50_3186
PYM: AK972_2784
PKE: DLD99_17105
SDN: Sden_0558
SBL: Sbal_0750
SBP: Sbal223_3500
SBS: Sbal117_0886
SLO: Shew_0803
SWD: Swoo_3977
SPSW: Sps_04160
SHEW: CKQ84_03510
CPS: CPS_0680
COM: CMT41_02685
COV: EKO29_03700
MVS: MVIS_3106
GAP: GAPWK_0245
JEU: BJP62_16570
AMAH: DLM_3613
AXY: AXYL_03210 AXYL_03323
AXO: NH44784_028521 NH44784_045751 NH44784_046591 NH44784_052491
AXN: AX27061_2752 AX27061_2832 AX27061_3374 AX27061_5464
AXX: ERS451415_02732(rstB_1) ERS451415_02814(rstB_2) ERS451415_03355(rstB_3) ERS451415_05490(rstB_4)
ADT: APT56_14225 APT56_14645 APT56_25140
AIS: BUW96_05950 BUW96_06500 BUW96_12520
ASW: CVS48_11405
ACHR: C2U31_11540 C2U31_20555 C2U31_20700 C2U31_25185
ACHB: DVB37_23420
TIN: Tint_0822
THI: THI_1066
OTR: OTERR_23400(ragB)
DEY: HYN24_04295
BEBA: BWI17_03985 BWI17_20150
DTO: TOL2_C04000
MRM: A7982_13202
NIY: FQ775_08500
BAPI: BBC0122_004440
 » show all
Reference
  Authors
Muller C, Plesiat P, Jeannot K
  Title
A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa.
  Journal
Antimicrob Agents Chemother 55:1211-21 (2011)
DOI:10.1128/AAC.01252-10
  Sequence
[pae:PA1798]
Reference
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12
Reference
  Authors
Vettoretti L, Plesiat P, Muller C, El Garch F, Phan G, Attree I, Ducruix A, Llanes C
  Title
Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.
  Journal
Antimicrob Agents Chemother 53:1987-97 (2009)
DOI:10.1128/AAC.01024-08

  All links  
Ontology (7)   
   KEGG BRITE (5)   
   GO (1)   
   COG (1)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (114)   
   KEGG GENES (111)   
   OC (3)   
Protein sequence (66)   
   UniProt (66)   
Literature (3)   
   PubMed (3)   
All databases (198)   

Download RDF
DBGET integrated database retrieval system