KEGG   ORTHOLOGY: K18072
Entry
K18072                      KO                                     

Name
parS
Definition
two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3]
Pathway
ko01501  beta-Lactam resistance
ko01503  Cationic antimicrobial peptide (CAMP) resistance
ko02020  Two-component system
Module
M00745  Imipenem resistance, repression of porin OprD
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
   01503 Cationic antimicrobial peptide (CAMP) resistance
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
  09183 Protein families: signaling and cellular processes
   02022 Two-component system
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
   01504 Antimicrobial resistance genes
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.13  Protein-histidine kinases
    2.7.13.3  histidine kinase
     K18072  parS; two-component system, OmpR family, sensor kinase ParS
Protein kinases [BR:ko01001]
 Histidine kinases
  OmpR family
   K18072  parS; two-component system, OmpR family, sensor kinase ParS
Two-component system [BR:ko02022]
 OmpR family
  ParS-ParR (polymyxin-adaptive resistance)
   K18072  parS; two-component system, OmpR family, sensor kinase ParS
Antimicrobial resistance genes [BR:ko01504]
 Gene sets
  beta-Lactam resistance modules
   Imipenem resistance, repression of porin OprD
    K18072  parS; two-component system, OmpR family, sensor kinase ParS
Other DBs
COG: COG0642
GO: 0000155
Genes
SML: Smlt3730
SMT: Smal_3143
BUJ: BurJV3_3177
SMZ: SMD_3333
STEN: CCR98_16365
STEM: CLM74_16690
STES: MG068_16225
LCP: LC55x_3348
LYT: DWG18_07690
VHR: AL538_25580
PAE: PA1798(parS)
PAEV: N297_1852
PAEI: N296_1852
PAEP: PA1S_16975
PAEM: U769_16690
PAEL: T223_18030
PAEG: AI22_17015
PAEC: M802_1850
PAEO: M801_1851
PFL: PFL_2638
PPRC: PFLCHA0_c27050(rstB1)
PPRO: PPC_2687
PFS: PFLU_3483
PFB: VO64_0594
PMAN: OU5_0718
PSEM: TO66_12910
PSOS: POS17_2645
PANR: A7J50_3186
SDN: Sden_0558
SBL: Sbal_0750
SLO: Shew_0803
SWD: Swoo_3977
SPSW: Sps_04160
CPS: CPS_0680
MVS: MVIS_3106
AMAH: DLM_3613
AXX: ERS451415_02732(rstB_1) ERS451415_02814(rstB_2) ERS451415_03355(rstB_3) ERS451415_05490(rstB_4)
TIN: Tint_0822
THI: THI_1066
OTR: OTERR_23400(ragB)
 » show all
Reference
  Authors
Muller C, Plesiat P, Jeannot K
  Title
A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa.
  Journal
Antimicrob Agents Chemother 55:1211-21 (2011)
DOI:10.1128/AAC.01252-10
  Sequence
[pae:PA1798]
Reference
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12
Reference
  Authors
Vettoretti L, Plesiat P, Muller C, El Garch F, Phan G, Attree I, Ducruix A, Llanes C
  Title
Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.
  Journal
Antimicrob Agents Chemother 53:1987-97 (2009)
DOI:10.1128/AAC.01024-08

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