KEGG   ORTHOLOGY: K18073
Entry
K18073                      KO                                     

Name
parR
Definition
two-component system, OmpR family, response regulator ParR
Pathway
ko01501  beta-Lactam resistance
ko01503  Cationic antimicrobial peptide (CAMP) resistance
ko02020  Two-component system
Module
M00745  Imipenem resistance, repression of porin OprD
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K18073  parR; two-component system, OmpR family, response regulator ParR
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18073  parR; two-component system, OmpR family, response regulator ParR
   01503 Cationic antimicrobial peptide (CAMP) resistance
    K18073  parR; two-component system, OmpR family, response regulator ParR
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02022 Two-component system
    K18073  parR; two-component system, OmpR family, response regulator ParR
   01504 Antimicrobial resistance genes
    K18073  parR; two-component system, OmpR family, response regulator ParR
Two-component system [BR:ko02022]
 OmpR family
  ParS-ParR (polymyxin-adaptive resistance)
   K18073  parR; two-component system, OmpR family, response regulator ParR
Antimicrobial resistance genes [BR:ko01504]
 Gene sets
  beta-Lactam resistance modules
   Imipenem resistance, repression of porin OprD
    K18073  parR; two-component system, OmpR family, response regulator ParR
Other DBs
COG: COG0745
GO: 0000156
Genes
SMT: Smal_3142
BUJ: BurJV3_3176
SMZ: SMD_3332
STEN: CCR98_16360
STEM: CLM74_16685
STES: MG068_16220
PAE: PA1799(parR)
PAEV: N297_1853
PAEI: N296_1853
PAU: PA14_41260
PAEP: PA1S_16970
PAEM: U769_16685
PAEL: T223_18025
PAEG: AI22_17020
PAEC: M802_1851
PAEO: M801_1852
PFL: PFL_2637
PPRC: PFLCHA0_c27040(rstA1)
PPRO: PPC_2686
PFS: PFLU_3484
PFE: PSF113_2429(rstA2)
PFB: VO64_0595
PMAN: OU5_0719
PSEM: TO66_12905
PSOS: POS17_2644
PANR: A7J50_3187
AXX: ERS451415_02731(rstA_1)
LVS: LOKVESSMR4R_03115(cssR)
 » show all
Reference
  Authors
Muller C, Plesiat P, Jeannot K
  Title
A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa.
  Journal
Antimicrob Agents Chemother 55:1211-21 (2011)
DOI:10.1128/AAC.01252-10
  Sequence
[pae:PA1799]
Reference
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12
Reference
  Authors
Vettoretti L, Plesiat P, Muller C, El Garch F, Phan G, Attree I, Ducruix A, Llanes C
  Title
Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.
  Journal
Antimicrob Agents Chemother 53:1987-97 (2009)
DOI:10.1128/AAC.01024-08

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