KEGG   ORTHOLOGY: K18091Help
Entry
K18091                      KO                                     

Name
pntE, penE, ptlE
Definition
pentalenolactone D synthase [EC:1.14.13.170 1.14.13.171]
Pathway
ko00999  Biosynthesis of various secondary metabolites - part 1
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00819  Pentalenolactone biosynthesis, farnesyl-PP => pentalenolactone
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00999 Biosynthesis of various secondary metabolites - part 1
    K18091  pntE, penE, ptlE; pentalenolactone D synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.170  pentalenolactone D synthase
     K18091  pntE, penE, ptlE; pentalenolactone D synthase
    1.14.13.171  neopentalenolactone D synthase
     K18091  pntE, penE, ptlE; pentalenolactone D synthase
BRITE hierarchy
Other DBs
RN: R10154 R10155
COG: COG2072
Genes
SMA: SAVERM_2994(ptlE)
SBH: SBI_09676
SCI: B446_29680
SCW: TU94_27390
SLE: sle_13190(sle_13190)
SSIA: A7J05_09255
AG: ADO85575(pntE) ADO85591(penE)
TaxonomyKoalaUniProt
Reference
  Authors
Seo MJ, Zhu D, Endo S, Ikeda H, Cane DE
  Title
Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final steps of the biosynthesis of pentalenolactone and neopentalenolactone.
  Journal
Biochemistry 50:1739-54 (2011)
DOI:10.1021/bi1019786
  Sequence

KEGG   ENZYME: 1.14.13.170Help
Entry
EC 1.14.13.170              Enzyme                                 

Name
pentalenolactone D synthase;
penE (gene name);
pntE (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
1-deoxy-11-oxopentalenate,NADH:oxygen oxidoreductase (pentalenolactone-D forming)
Reaction(IUBMB)
1-deoxy-11-oxopentalenate + NADPH + H+ + O2 = pentalenolactone D + NADP+ + H2O [RN:R10154]
Reaction(KEGG)
Substrate
1-deoxy-11-oxopentalenate [CPD:C20400];
NADPH [CPD:C00005];
H+ [CPD:C00080];
O2 [CPD:C00007]
Product
pentalenolactone D [CPD:C20399];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Comment
A FAD-dependent oxygenase. Isolated from the bacteria Streptomyces exfoliatus and Streptomyces arenae. The ketone undergoes a biological Baeyer-Villiger reaction. Part of the pathway of pentalenolactone biosynthesis.
History
EC 1.14.13.170 created 2012
Pathway
ec00999  Biosynthesis of various secondary metabolites - part 1
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K18091  pentalenolactone D synthase
Genes
SMA: SAVERM_2994(ptlE)
SBH: SBI_09676
SCI: B446_29680
SCW: TU94_27390
SLE: sle_13190(sle_13190)
SSIA: A7J05_09255
Taxonomy
Reference
1  [PMID:21250661]
  Authors
Seo MJ, Zhu D, Endo S, Ikeda H, Cane DE
  Title
Genome mining in Streptomyces. Elucidation of the role of Baeyer-Villiger monooxygenases and non-heme iron-dependent dehydrogenase/oxygenases in the final  steps of the biosynthesis of pentalenolactone and neopentalenolactone.
  Journal
Biochemistry 50:1739-54 (2011)
DOI:10.1021/bi1019786
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.14.13.170
IUBMB Enzyme Nomenclature: 1.14.13.170
ExPASy - ENZYME nomenclature database: 1.14.13.170
BRENDA, the Enzyme Database: 1.14.13.170

KEGG   REACTION: R10154Help
Entry
R10154                      Reaction                               

Name
1-deoxy-11-oxopentalenate,NADH:oxygen oxidoreductase (pentalenolactone-D forming)
Definition
1-Deoxy-11-oxopentalenate + NADPH + H+ + Oxygen <=> Pentalenolactone D + NADP+ + H2O
Equation
Reaction class
RC00001  C00005_C00006
RC01504  C20399_C20400
Enzyme
Pathway
rn00999  Biosynthesis of various secondary metabolites - part 1
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00819  Pentalenolactone biosynthesis, farnesyl-PP => pentalenolactone
Orthology
K18091  pentalenolactone D synthase [EC:1.14.13.170 1.14.13.171]
Other DBs
RHEA: 34638

DBGET integrated database retrieval system