KEGG   ORTHOLOGY: K18093
Entry
K18093                      KO                                     

Name
oprD
Definition
imipenem/basic amino acid-specific outer membrane pore [EC:3.4.21.-]
Pathway
ko01501  beta-Lactam resistance
ko02020  Two-component system
Module
M00745  Imipenem resistance, repression of porin OprD
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K18093  oprD; imipenem/basic amino acid-specific outer membrane pore
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18093  oprD; imipenem/basic amino acid-specific outer membrane pore
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K18093  oprD; imipenem/basic amino acid-specific outer membrane pore
   01504 Antimicrobial resistance genes
    K18093  oprD; imipenem/basic amino acid-specific outer membrane pore
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.-  
     K18093  oprD; imipenem/basic amino acid-specific outer membrane pore
Transporters [BR:ko02000]
 Other transporters
  Pores ion channels
   K18093  oprD; imipenem/basic amino acid-specific outer membrane pore
Antimicrobial resistance genes [BR:ko01504]
 Gene sets
  beta-Lactam resistance modules
   Imipenem resistance, repression of porin OprD
    K18093  oprD; imipenem/basic amino acid-specific outer membrane pore
Other DBs
TC: 1.B.25.1.1
Genes
PAE: PA0958(oprD)
PAEV: N297_194(oprD) N297_2782(oprD) N297_992(oprD)
PAEI: N296_194(oprD) N296_2782(oprD) N296_992(oprD)
PAU: PA14_02370 PA14_29220(opdB) PA14_51880(oprD)
PAP: PSPA7_0268 PSPA7_3977 PSPA7_4550(oprD)
PAG: PLES_01901 PLES_24041(opdB) PLES_43561(oprD)
PAF: PAM18_0189 PAM18_2272(opdB) PAM18_4079(oprD)
PNC: NCGM2_0197 NCGM2_1765(oprD) NCGM2_3727(opdB)
PAEB: NCGM1900_0182 NCGM1900_1757 NCGM1900_3798(opdB)
PDK: PADK2_00950 PADK2_11150 PADK2_20900
PAEC: M802_193(oprD) M802_2779(oprD) M802_988(oprD)
PAEO: M801_194(oprD) M801_2648(oprD) M801_992(oprD)
PMK: MDS_1296
PRE: PCA10_14050(opdB) PCA10_38280(opdB) PCA10_44360(oprD) PCA10_47200(opdB)
PPSE: BN5_3096(oprD5)
PCQ: PcP3B5_17110(oprD_5) PcP3B5_54660(oprD_9)
PPU: PP_1206(oprD)
PPUN: PP4_11450(oprD) PP4_33940(opdB)
PST: PSPTO_3987(oprD)
PSB: Psyr_1400
PSYR: N018_18665
PFL: PFL_4773(oprD) PFL_4993
PPRC: PFLCHA0_c47530(oprD11) PFLCHA0_c49690(oprD12)
PPRO: PPC_4781(oprD) PPC_4994
PFS: PFLU_4925
PFC: PflA506_4233(oprD)
PFB: VO64_1777
PEN: PSEEN2388 PSEEN4104(oprD)
PPUU: PputUW4_04307(oprD3)
PKC: PKB_1378(oprd3) PKB_2956(oprd7) PKB_3022(oprd9) PKB_4305(oprd11) PKB_5062(oprd13)
PSEC: CCOS191_4085(oprD2)
PSOS: POS17_2254 POS17_4748 POS17_5451(PMI29_00971)
PSIL: PMA3_23290
PLG: NCTC10937_01526(oprD_4) NCTC10937_02302(oprD_5) NCTC10937_02429(oprD_6)
CTES: O987_18520
WSU: WS0983
SULC: CVO_02730
CGRA: CGRAC_1221
CSPF: CSF_1013
AMYT: AMYT_1235
NIS: NIS_0526
SUN: SUN_1145
 » show all
Reference
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12
Reference
  Authors
Muller C, Plesiat P, Jeannot K
  Title
A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa.
  Journal
Antimicrob Agents Chemother 55:1211-21 (2011)
DOI:10.1128/AAC.01252-10
Reference
  Authors
Tamber S, Ochs MM, Hancock RE
  Title
Role of the novel OprD family of porins in nutrient uptake in Pseudomonas aeruginosa.
  Journal
J Bacteriol 188:45-54 (2006)
DOI:10.1128/JB.188.1.45-54.2006
Reference
PMID:8843159
  Authors
Yoshihara E, Gotoh N, Nishino T, Nakae T
  Title
Protein D2 porin of the Pseudomonas aeruginosa outer membrane bears the protease activity.
  Journal
FEBS Lett 394:179-82 (1996)
DOI:10.1016/0014-5793(96)00945-3

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