KEGG   ORTHOLOGY: K18094
Entry
K18094                      KO                                     

Name
mexX, amrA
Definition
membrane fusion protein, multidrug efflux system
Pathway
ko01501  beta-Lactam resistance
ko02020  Two-component system
Module
M00643  Multidrug resistance, efflux pump MexXY-OprM
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K18094  mexX, amrA; membrane fusion protein, multidrug efflux system
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18094  mexX, amrA; membrane fusion protein, multidrug efflux system
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K18094  mexX, amrA; membrane fusion protein, multidrug efflux system
   01504 Antimicrobial resistance genes
    K18094  mexX, amrA; membrane fusion protein, multidrug efflux system
Transporters [BR:ko02000]
 Other transporters
  Accessory factors involved in transport
   K18094  mexX, amrA; membrane fusion protein, multidrug efflux system
Antimicrobial resistance genes [BR:ko01504]
 Gene sets
  Multipdrug resistance modules
   Multidrug resistance, efflux pump MexXY-OprM
    K18094  mexX, amrA; membrane fusion protein, multidrug efflux system
Other DBs
COG: COG0845
TC: 8.A.1 2.A.6.2.21 2.A.6.2.24
Genes
PAE: PA2019
PAEV: N297_2083
PAEI: N296_2083
PAU: PA14_38395
PAP: PSPA7_3269
PAG: PLES_33041
PAF: PAM18_3025
PNC: NCGM2_2994
PAEB: NCGM1900_4467
PDK: PADK2_15550
PAEP: PA1S_15595
PAEM: U769_15180
PAEL: T223_16870
PAEG: AI22_18180
PAEC: M802_2081
PAEO: M801_2082
RPI: Rpic_0841
BMAL: DM55_2949
BMAE: DM78_1413
BMAQ: DM76_2932
BMAI: DM57_12
BMAZ: BM44_2229
BMAB: BM45_1794
BPS: BPSL1804(amrA)
BPM: BURPS1710b_2057(amrA)
BPL: BURPS1106A_1903(amrA)
BPD: BURPS668_1889(amrA)
BPSE: BDL_330
BPSM: BBQ_1667
BPSU: BBN_1793
BPSD: BBX_2269
BPZ: BP1026B_I1762(amrA)
BPK: BBK_3294
BPSH: DR55_2905
BPSA: BBU_505
BPSO: X996_2522
BUT: X994_975
BTE: BTH_I2445
BTJ: BTJ_881
BTZ: BTL_2124
BTD: BTI_2084
BTV: BTHA_2323
BTHE: BTN_2644
BTHM: BTRA_2403
BTHA: DR62_2791
BTHL: BG87_2345
BOK: DM82_1238
BOC: BG90_3452
BVE: AK36_2271
BCN: Bcen_1142
BCJ: BCAL1674(amrA)
BCEN: DM39_1589
BCEW: DM40_2256
BCEO: I35_1585(amrA)
BAM: Bamb_1520
BMJ: BMULJ_01628(acrA)
BMU: Bmul_1616
BMK: DM80_19
BMUL: NP80_1716
BCT: GEM_1793
BCED: DM42_76
BDL: AK34_1473
BCON: NL30_14975
BUB: BW23_105
BLAT: WK25_07990
BTEI: WS51_18650
BSEM: WJ12_08045
BPSL: WS57_26605
BMEC: WJ16_08140
BSTG: WT74_08375
BUK: MYA_1455
BUL: BW21_2151
PPNO: DA70_22500
PPNM: LV28_08220
PPUL: RO07_02350
PAPI: SG18_25025
AXY: AXYL_01446(amrA)
AXX: ERS451415_01359(acrA_1)
NEU: NE1113
MFA: Mfla_1361
MMB: Mmol_0005
MEP: MPQ_2659
AMU: Amuc_0889
AGL: PYTT_0666
 » show all
Reference
  Authors
Muller C, Plesiat P, Jeannot K
  Title
A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa.
  Journal
Antimicrob Agents Chemother 55:1211-21 (2011)
DOI:10.1128/AAC.01252-10
Reference
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12
Reference
  Authors
Vettoretti L, Plesiat P, Muller C, El Garch F, Phan G, Attree I, Ducruix A, Llanes C
  Title
Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.
  Journal
Antimicrob Agents Chemother 53:1987-97 (2009)
DOI:10.1128/AAC.01024-08
Reference
  Authors
Westbrock-Wadman S, Sherman DR, Hickey MJ, Coulter SN, Zhu YQ, Warrener P, Nguyen LY, Shawar RM, Folger KR, Stover CK
  Title
Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability.
  Journal
Antimicrob Agents Chemother 43:2975-83 (1999)
  Sequence
[pae:PA2019]

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