KEGG   ORTHOLOGY: K18095
Entry
K18095                      KO                                     

Name
mexY, amrB
Definition
multidrug efflux pump
Pathway
ko01501  beta-Lactam resistance
ko02020  Two-component system
Module
M00643  Multidrug resistance, efflux pump MexXY-OprM
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K18095  mexY, amrB; multidrug efflux pump
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18095  mexY, amrB; multidrug efflux pump
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K18095  mexY, amrB; multidrug efflux pump
   01504 Antimicrobial resistance genes
    K18095  mexY, amrB; multidrug efflux pump
Transporters [BR:ko02000]
 Other transporters
  Electrochemical potential-driven transporters
   K18095  mexY, amrB; multidrug efflux pump
Antimicrobial resistance genes [BR:ko01504]
 Gene sets
  Multipdrug resistance modules
   Multidrug resistance, efflux pump MexXY-OprM
    K18095  mexY, amrB; multidrug efflux pump
Other DBs
COG: COG0841
TC: 2.A.6.2.21 2.A.6.2.24
Genes
PAE: PA2018
PAEV: N297_2082
PAEI: N296_2082
PAU: PA14_38410(amrB)
PAP: PSPA7_3270
PAG: PLES_33051
PAF: PAM18_3026
PNC: NCGM2_2993(amrB)
PAEB: NCGM1900_4468(amrB)
PDK: PADK2_15555
PAEP: PA1S_15600
PAEM: U769_15185
PAEL: T223_16875
PAEG: AI22_18175
PAEC: M802_2080
PAEO: M801_2081
RPI: Rpic_0842
CNC: CNE_1c35530(acrD)
RME: Rmet_1121(acrD)
CTI: RALTA_A3058(acrD)
BMAL: DM55_2950
BMAE: DM78_1414
BMAQ: DM76_2933
BMAI: DM57_13
BMAZ: BM44_2228
BMAB: BM45_1793
BPS: BPSL1803(amrB)
BPM: BURPS1710b_2058(amrB)
BPL: BURPS1106A_1904(amrB)
BPD: BURPS668_1890(amrB)
BPSE: BDL_329
BPSM: BBQ_1666
BPSU: BBN_1792
BPSD: BBX_2268(acrB)
BPZ: BP1026B_I1761(amrB)
BPK: BBK_3293(acrB)
BPSH: DR55_2904
BPSA: BBU_504(acrB)
BPSO: X996_2521
BUT: X994_974
BTE: BTH_I2444
BTJ: BTJ_880(acrB)
BTZ: BTL_2123
BTD: BTI_2083(acrB)
BTV: BTHA_2322
BTHE: BTN_2645
BTHM: BTRA_2402(acrB)
BTHA: DR62_2792
BTHL: BG87_2344
BOK: DM82_1239
BOC: BG90_3451
BVE: AK36_2270
BCN: Bcen_1143
BCJ: BCAL1675(amrB)
BCEN: DM39_1590
BCEW: DM40_2257
BCEO: I35_1586(amrB)
BAM: Bamb_1521
BMJ: BMULJ_01629(acrB)
BMU: Bmul_1615
BMK: DM80_18
BMUL: NP80_1717
BCT: GEM_1792
BCED: DM42_75
BDL: AK34_1472
BCON: NL30_14970
BUB: BW23_104
BLAT: WK25_07995
BTEI: WS51_18655
BSEM: WJ12_08050
BPSL: WS57_26610
BMEC: WJ16_08145
BSTG: WT74_08380
BUK: MYA_1456
BUL: BW21_2150
PPUL: RO07_02345
PSPU: NA29_23375
PAPI: SG18_02650
AXY: AXYL_01445(amrB)
AXX: ERS451415_01358(acrB_1)
NEU: NE1112
MFA: Mfla_1360
MMB: Mmol_0006
AMU: Amuc_0890
AGL: PYTT_0667
 » show all
Reference
  Authors
Muller C, Plesiat P, Jeannot K
  Title
A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa.
  Journal
Antimicrob Agents Chemother 55:1211-21 (2011)
DOI:10.1128/AAC.01252-10
  Sequence
[pae:PA2018]
Reference
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12
Reference
  Authors
Vettoretti L, Plesiat P, Muller C, El Garch F, Phan G, Attree I, Ducruix A, Llanes C
  Title
Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.
  Journal
Antimicrob Agents Chemother 53:1987-97 (2009)
DOI:10.1128/AAC.01024-08

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