KEGG   ORTHOLOGY: K18129
Entry
K18129                      KO                                     

Name
mexZ
Definition
TetR/AcrR family transcriptional regulator, mexXY operon repressor
Pathway
ko01501  beta-Lactam resistance
Module
M00643  Multidrug resistance, efflux pump MexXY-OprM
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18129  mexZ; TetR/AcrR family transcriptional regulator, mexXY operon repressor
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K18129  mexZ; TetR/AcrR family transcriptional regulator, mexXY operon repressor
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18129  mexZ; TetR/AcrR family transcriptional regulator, mexXY operon repressor
Transcription factors [BR:ko03000]
 Prokaryotic type
  Helix-turn-helix
   TetR/AcrR family
    K18129  mexZ; TetR/AcrR family transcriptional regulator, mexXY operon repressor
Antimicrobial resistance genes [BR:ko01504]
 Gene sets
  Multipdrug resistance modules
   Multidrug resistance, efflux pump MexXY-OprM
    K18129  mexZ; TetR/AcrR family transcriptional regulator, mexXY operon repressor
Other DBs
COG: COG1309
Genes
PAE: PA2020
PAEV: N297_2084
PAEI: N296_2084
PAU: PA14_38380(amrR)
PAF: PAM18_3024
PNC: NCGM2_2995(amrR)
PAEB: NCGM1900_4466(amrR)
PDK: PADK2_15545
PSG: G655_15000
PAEP: PA1S_15590
PAEM: U769_15175
PAEG: AI22_18185
PAEC: M802_2082
PAEO: M801_2083
CVI: CV_2456
BMAL: DM55_2948
BMAE: DM78_1412
BMAQ: DM76_2931
BMAI: DM57_11
BMAZ: BM44_2230
BMAB: BM45_1795
BPS: BPSL1805(amrR)
BPM: BURPS1710b_2056(amrR)
BPL: BURPS1106A_1902(amrR)
BPD: BURPS668_1888(amrR)
BPSE: BDL_331
BPSM: BBQ_1668
BPSU: BBN_1794
BPSD: BBX_2270
BPZ: BP1026B_I1763(amrR)
BPK: BBK_3295
BPSH: DR55_2906
BPSA: BBU_506
BPSO: X996_2523
BUT: X994_976
BTE: BTH_I2446(amrR)
BTJ: BTJ_882
BTZ: BTL_2125
BTD: BTI_2085
BTV: BTHA_2324
BTHE: BTN_2643
BTHM: BTRA_2404
BTHA: DR62_2790
BTHL: BG87_2346
BOK: DM82_1237
BOC: BG90_3453
BVE: AK36_2272
BCN: Bcen_1141
BCEN: DM39_1588
BCEW: DM40_2255
BCEO: I35_1584
BAM: Bamb_1519
BMJ: BMULJ_01627(acrR)
BMU: Bmul_1617
BMK: DM80_20
BMUL: NP80_1715
BCT: GEM_1794
BCED: DM42_77
BDL: AK34_1474
BCON: NL30_14980
BUB: BW23_106
BLAT: WK25_07985
BTEI: WS51_18645
BSEM: WJ12_08040
BPSL: WS57_26600
BMEC: WJ16_08135
BSTG: WT74_08370
BUK: MYA_1454
BUL: BW21_2152
AXY: AXYL_01447(amrR)
AXX: ERS451415_01360(ttgR_2)
ACHR: C2U31_12305(axyZ)
NEU: NE1114
MFA: Mfla_1362
MMB: Mmol_0004
MEP: MPQ_2660
AGL: PYTT_0665
 » show all
Reference
  Authors
Muller C, Plesiat P, Jeannot K
  Title
A two-component regulatory system interconnects resistance to polymyxins, aminoglycosides, fluoroquinolones, and beta-lactams in Pseudomonas aeruginosa.
  Journal
Antimicrob Agents Chemother 55:1211-21 (2011)
DOI:10.1128/AAC.01252-10
Reference
  Authors
Vettoretti L, Plesiat P, Muller C, El Garch F, Phan G, Attree I, Ducruix A, Llanes C
  Title
Efflux unbalance in Pseudomonas aeruginosa isolates from cystic fibrosis patients.
  Journal
Antimicrob Agents Chemother 53:1987-97 (2009)
DOI:10.1128/AAC.01024-08
Reference
  Authors
Westbrock-Wadman S, Sherman DR, Hickey MJ, Coulter SN, Zhu YQ, Warrener P, Nguyen LY, Shawar RM, Folger KR, Stover CK
  Title
Characterization of a Pseudomonas aeruginosa efflux pump contributing to aminoglycoside impermeability.
  Journal
Antimicrob Agents Chemother 43:2975-83 (1999)
  Sequence
[pae:PA2020]

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