KEGG   ORTHOLOGY: K18131
Entry
K18131                      KO                                     

Name
mexR
Definition
MarR family transcriptional regulator, repressor of the mexAB-oprM multidrug resistance operon
Pathway
ko01501  beta-Lactam resistance
Module
M00718  Multidrug resistance, efflux pump MexAB-OprM
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18131  mexR; MarR family transcriptional regulator, repressor of the mexAB-oprM multidrug resistance operon
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K18131  mexR; MarR family transcriptional regulator, repressor of the mexAB-oprM multidrug resistance operon
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18131  mexR; MarR family transcriptional regulator, repressor of the mexAB-oprM multidrug resistance operon
Transcription factors [BR:ko03000]
 Prokaryotic type
  Helix-turn-helix
   MarR family
    K18131  mexR; MarR family transcriptional regulator, repressor of the mexAB-oprM multidrug resistance operon
Antimicrobial resistance genes [BR:ko01504]
 Gene sets
  Multipdrug resistance modules
   Multidrug resistance, efflux pump MexAB-OprM
    K18131  mexR; MarR family transcriptional regulator, repressor of the mexAB-oprM multidrug resistance operon
Other DBs
COG: COG1846
Genes
PAE: PA0424(mexR)
PAEV: N297_435(mexR)
PAEI: N296_435(mexR)
PAU: PA14_05520(mexR)
PAP: PSPA7_0524(mexR)
PAG: PLES_04221(mexR)
PAF: PAM18_0424(mexR)
PNC: NCGM2_5773(mexR)
PAEB: NCGM1900_0432(mexR)
PDK: PADK2_02135
PAEM: U769_02185
PAEL: T223_02145
PAEU: BN889_00493(mexR)
PAEG: AI22_01750
PAEC: M802_434(mexR)
PAEO: M801_435(mexR)
PCQ: PcP3B5_05640(mexR)
PKC: PKB_0443
 » show all
Reference
  Authors
Cao L, Srikumar R, Poole K
  Title
MexAB-OprM hyperexpression in NalC-type multidrug-resistant Pseudomonas aeruginosa: identification and characterization of the nalC gene encoding a repressor of PA3720-PA3719.
  Journal
Mol Microbiol 53:1423-36 (2004)
DOI:10.1111/j.1365-2958.2004.04210.x
Reference
  Authors
Fernandez L, Hancock RE
  Title
Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.
  Journal
Clin Microbiol Rev 25:661-81 (2012)
DOI:10.1128/CMR.00043-12
Reference
  Authors
Poole K, Srikumar R
  Title
Multidrug efflux in Pseudomonas aeruginosa: components, mechanisms and clinical significance.
  Journal
Curr Top Med Chem 1:59-71 (2001)
DOI:10.2174/1568026013395605
Reference
PMID:8878574
  Authors
Poole K, Tetro K, Zhao Q, Neshat S, Heinrichs DE, Bianco N
  Title
Expression of the multidrug resistance operon mexA-mexB-oprM in Pseudomonas aeruginosa: mexR encodes a regulator of operon expression.
  Journal
Antimicrob Agents Chemother 40:2021-8 (1996)
  Sequence
[pae:PA0424]

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