KEGG   ORTHOLOGY: K18240
Entry
K18240                      KO                                     

Name
xanB2
Definition
chorismate lyase / 3-hydroxybenzoate synthase [EC:4.1.3.40 4.1.3.45]
Pathway
ko00130  Ubiquinone and other terpenoid-quinone biosynthesis
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00117  Ubiquinone biosynthesis, prokaryotes, chorismate => ubiquinone
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K18240  xanB2; chorismate lyase / 3-hydroxybenzoate synthase
  09108 Metabolism of cofactors and vitamins
   00130 Ubiquinone and other terpenoid-quinone biosynthesis
    K18240  xanB2; chorismate lyase / 3-hydroxybenzoate synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.3  Oxo-acid-lyases
    4.1.3.40  chorismate lyase
     K18240  xanB2; chorismate lyase / 3-hydroxybenzoate synthase
    4.1.3.45  3-hydroxybenzoate synthase
     K18240  xanB2; chorismate lyase / 3-hydroxybenzoate synthase
Other DBs
RN: R01302 R10597
Genes
XFA: XF_0769
XFT: PD_1889(fkbO)
XFM: Xfasm12_2072
XFN: XfasM23_1994
XFF: XFLM_03915
XFL: P303_00390
XFS: D934_13290
XFH: XFHB_11425
XTW: AB672_11600
XCC: XCC4014(rapK)
XCB: XC_4103
XCP: XCR_0248
XCV: XCV4191
XAX: XACM_3971
XAC: XAC4103(rapK)
XCI: XCAW_00197(rapK)
XFU: XFF4834R_chr39700(xanB2)
XOM: XOO4072(XOO4072)
XOO: XOO4322(rapK)
XOP: PXO_03739(pigB)
XOR: XOC_0424(pigB)
XAL: XALC_0126
XPH: XppCFBP6546_13945(XppCFBP6546P_13945)
PSUW: WQ53_09330
PSD: DSC_00450
LAQ: GLA29479_4083(xanB2)
LEZ: GLE_4979
LEM: LEN_0460
DKO: I596_56
CJA: CJA_0104(fkbO)
MCA: MCA1495
MMAI: sS8_2838
NOC: Noc_2127
NHL: Nhal_2765
NWA: Nwat_0961
NTT: TAO_1291
TGR: Tgr7_0320
PSE: NH8B_1247
BCN: Bcen_2143
BCJ: BCAL0847
BCEN: DM39_2849
BCEO: I35_2824
BAM: Bamb_2809
BCT: GEM_0684
BCED: DM42_2314
BCON: NL30_26875
BTEI: WS51_24135
BSEM: WJ12_13795
BPSL: WS57_32540
HYB: Q5W_08420
HPSE: HPF_20785
MPT: Mpe_A1331
HAR: HEAR2873
THI: THI_2616
RGE: RGE_38580
TBD: Tbd_2762
MEH: M301_2326
SLT: Slit_0372
SPLB: SFPGR_17920(rapK)
SNIV: SFSGTM_28320(rapK)
DAR: Daro_4196
AZO: azo3920
AZA: AZKH_1770
AOA: dqs_4064
RVA: Rvan_0758
ACR: Acry_3477
AFR: AFE_0789
STRM: M444_37805
SMAL: SMALA_1276
SALJ: SMD11_2789
OTE: Oter_2220
AMU: Amuc_1292
AGL: PYTT_0059
TTF: THTE_3291
AGV: OJF2_50090(rutC)
PDI: BDI_0624
DORI: FH5T_03195
FLN: FLA_4714
AG: AGO98693(cuv10)
 » show all
Reference
  Authors
Zhou L, Wang JY, Wu J, Wang J, Poplawsky A, Lin S, Zhu B, Chang C, Zhou T, Zhang LH, He YW
  Title
The diffusible factor synthase XanB2 is a bifunctional chorismatase that links the shikimate pathway to ubiquinone and xanthomonadins biosynthetic pathways.
  Journal
Mol Microbiol 87:80-93 (2013)
DOI:10.1111/mmi.12084
  Sequence

KEGG   ENZYME: 4.1.3.45
Entry
EC 4.1.3.45                 Enzyme                                 

Name
3-hydroxybenzoate synthase;
chorismatase/3-hydroxybenzoate synthase;
hyg5 (gene name);
bra8 (gene name);
XanB2
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
Sysname
chorismate pyruvate-lyase (3-hydroxybenzoate-forming)
Reaction(IUBMB)
chorismate = 3-hydroxybenzoate + pyruvate [RN:R10597]
Reaction(KEGG)
R10597
Substrate
chorismate [CPD:C00251]
Product
3-hydroxybenzoate [CPD:C00587];
pyruvate [CPD:C00022]
Comment
The enzyme, found in several bacterial species is involved in biosynthesis of secondary products. The enzyme from the bacterium Xanthomonas campestris pv. campestris also has the activity of EC 4.1.3.40, chorismate lyase [3].
History
EC 4.1.3.45 created 2013
Pathway
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
Orthology
K18240  chorismate lyase / 3-hydroxybenzoate synthase
Genes
XFA: XF_0769
XFT: PD_1889(fkbO)
XFM: Xfasm12_2072
XFN: XfasM23_1994
XFF: XFLM_03915
XFL: P303_00390
XFS: D934_13290
XFH: XFHB_11425
XTW: AB672_11600
XCC: XCC4014(rapK)
XCB: XC_4103
XCP: XCR_0248
XCV: XCV4191
XAX: XACM_3971
XAC: XAC4103(rapK)
XCI: XCAW_00197(rapK)
XFU: XFF4834R_chr39700(xanB2)
XOM: XOO4072(XOO4072)
XOO: XOO4322(rapK)
XOP: PXO_03739(pigB)
XOR: XOC_0424(pigB)
XAL: XALC_0126
XPH: XppCFBP6546_13945(XppCFBP6546P_13945)
PSUW: WQ53_09330
PSD: DSC_00450
LAQ: GLA29479_4083(xanB2)
LEZ: GLE_4979
LEM: LEN_0460
DKO: I596_56
CJA: CJA_0104(fkbO)
MCA: MCA1495
MMAI: sS8_2838
NOC: Noc_2127
NHL: Nhal_2765
NWA: Nwat_0961
NTT: TAO_1291
TGR: Tgr7_0320
PSE: NH8B_1247
BCN: Bcen_2143
BCJ: BCAL0847
BCEN: DM39_2849
BCEO: I35_2824
BAM: Bamb_2809
BCT: GEM_0684
BCED: DM42_2314
BCON: NL30_26875
BTEI: WS51_24135
BSEM: WJ12_13795
BPSL: WS57_32540
HYB: Q5W_08420
HPSE: HPF_20785
MPT: Mpe_A1331
HAR: HEAR2873
THI: THI_2616
RGE: RGE_38580
TBD: Tbd_2762
MEH: M301_2326
SLT: Slit_0372
SPLB: SFPGR_17920(rapK)
SNIV: SFSGTM_28320(rapK)
DAR: Daro_4196
AZO: azo3920
AZA: AZKH_1770
AOA: dqs_4064
RVA: Rvan_0758
ACR: Acry_3477
AFR: AFE_0789
STRM: M444_37805
SMAL: SMALA_1276
SALJ: SMD11_2789
OTE: Oter_2220
AMU: Amuc_1292
AGL: PYTT_0059
TTF: THTE_3291
AGV: OJF2_50090(rutC)
PDI: BDI_0624
DORI: FH5T_03195
FLN: FLA_4714
 » show all
Reference
1  [PMID:21383123]
  Authors
Andexer JN, Kendrew SG, Nur-e-Alam M, Lazos O, Foster TA, Zimmermann AS, Warneck TD, Suthar D, Coates NJ, Koehn FE, Skotnicki JS, Carter GT, Gregory MA, Martin CJ, Moss SJ, Leadlay PF, Wilkinson B
  Title
Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.
  Journal
Proc Natl Acad Sci U S A 108:4776-81 (2011)
DOI:10.1073/pnas.1015773108
  Sequence
Reference
2  [PMID:23824670]
  Authors
Jiang Y, Wang H, Lu C, Ding Y, Li Y, Shen Y
  Title
Identification and characterization of the cuevaene A biosynthetic gene cluster in streptomyces sp. LZ35.
  Journal
Chembiochem 14:1468-75 (2013)
DOI:10.1002/cbic.201300316
  Sequence
Reference
3  [PMID:23113660]
  Authors
Zhou L, Wang JY, Wu J, Wang J, Poplawsky A, Lin S, Zhu B, Chang C, Zhou T, Zhang LH, He YW
  Title
The diffusible factor synthase XanB2 is a bifunctional chorismatase that links the shikimate pathway to ubiquinone and xanthomonadins biosynthetic pathways.
  Journal
Mol Microbiol 87:80-93 (2013)
DOI:10.1111/mmi.12084
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.45
IUBMB Enzyme Nomenclature: 4.1.3.45
ExPASy - ENZYME nomenclature database: 4.1.3.45
BRENDA, the Enzyme Database: 4.1.3.45

KEGG   REACTION: R10597
Entry
R10597                      Reaction                               

Name
chorismate pyruvate-lyase (3-hydroxybenzoate-forming)
Definition
Chorismate <=> 3-Hydroxybenzoate + Pyruvate
Equation
Reaction class
RC02148  C00022_C00251
RC03212  C00251_C00587
Enzyme
Pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
Orthology
K18240  chorismate lyase / 3-hydroxybenzoate synthase [EC:4.1.3.40 4.1.3.45]
Other DBs
RHEA: 38318

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