KEGG   ORTHOLOGY: K18279Help
Entry
K18279                      KO                                     

Name
FTMPT3
Definition
verruculogen prenyltransferase [EC:2.5.1.107]
Pathway
ko00404  Staurosporine biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K18279  FTMPT3; verruculogen prenyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01006 Prenyltransferases
    K18279  FTMPT3; verruculogen prenyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.107  verruculogen prenyltransferase
     K18279  FTMPT3; verruculogen prenyltransferase
Prenyltransferases [BR:ko01006]
 Compound prenylation
  Indole prenyltransferase
   K18279  FTMPT3; verruculogen prenyltransferase
BRITE hierarchy
Other DBs
RN: R10341
Genes
NFI: NFIA_093400
TaxonomyKoalaUniProt
Reference
  Authors
Mundt K, Wollinsky B, Ruan HL, Zhu T, Li SM
  Title
Identification of the verruculogen prenyltransferase FtmPT3 by a combination of chemical, bioinformatic and biochemical approaches.
  Journal
Chembiochem 13:2583-92 (2012)
DOI:10.1002/cbic.201200523
  Sequence

KEGG   ENZYME: 2.5.1.107Help
Entry
EC 2.5.1.107                Enzyme                                 

Name
verruculogen prenyltransferase;
FtmPT3
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
dimethylallyl-diphosphate:verruculogen dimethylallyl-O-transferase
Reaction(IUBMB)
dimethylallyl diphosphate + verruculogen = diphosphate + fumitremorgin A [RN:R10341]
Reaction(KEGG)
Substrate
dimethylallyl diphosphate [CPD:C00235];
verruculogen [CPD:C20045]
Product
diphosphate [CPD:C00013];
fumitremorgin A [CPD:C20564]
Comment
Found in a number of fungi. Catalyses the last step in the biosynthetic pathway of the indole alkaloid fumitremorgin A. The enzyme from the fungus Neosartorya fischeri is also active with fumitremorgin B and 12alpha,13alpha-dihydroxyfumitremorgin C.
History
EC 2.5.1.107 created 2013
Pathway
ec00404  Staurosporine biosynthesis
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K18279  verruculogen prenyltransferase
Genes
NFI: NFIA_093400
Taxonomy
Reference
1  [PMID:23109474]
  Authors
Mundt K, Wollinsky B, Ruan HL, Zhu T, Li SM
  Title
Identification of the verruculogen prenyltransferase FtmPT3 by a combination of chemical, bioinformatic and biochemical approaches.
  Journal
Chembiochem 13:2583-92 (2012)
DOI:10.1002/cbic.201200523
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.107
IUBMB Enzyme Nomenclature: 2.5.1.107
ExPASy - ENZYME nomenclature database: 2.5.1.107
BRENDA, the Enzyme Database: 2.5.1.107

KEGG   REACTION: R10341Help
Entry
R10341                      Reaction                               

Name
dimethylallyl-diphosphate:verruculogen dimethylallyl-O-transferase
Definition
Dimethylallyl diphosphate + Verruculogen <=> Diphosphate + Fumitremorgin A
Equation
Reaction class
RC00451  C20045_C20564
Enzyme
Pathway
rn00404  Staurosporine biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
Orthology
K18279  verruculogen prenyltransferase [EC:2.5.1.107]
Other DBs
RHEA: 35982

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