KEGG   ORTHOLOGY: K18280
Entry
K18280                      KO                                     

Name
FTMD
Definition
6-hydroxytryprostatin B O-methyltransferase [EC:2.1.1.293]
Pathway
ko00404  Staurosporine biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K18280  FTMD; 6-hydroxytryprostatin B O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.293  6-hydroxytryprostatin B O-methyltransferase
     K18280  FTMD; 6-hydroxytryprostatin B O-methyltransferase
Other DBs
RN: R10588
Genes
NHE: NECHADRAFT_63896
AFM: AFUA_8G00200
NFI: NFIA_093710
AOR: AO090010000047
ANG: ANI_1_2036014(An01g15010)
AFV: AFLA_116210
TMF: PMAA_001900 PMAA_100900
TRG: TRUGW13939_04213 TRUGW13939_04351
ABE: ARB_02574 ARB_07989
TVE: TRV_04616 TRV_05502
PTE: PTT_20107
 » show all
Reference
  Authors
Kato N, Suzuki H, Okumura H, Takahashi S, Osada H
  Title
A point mutation in ftmD blocks the fumitremorgin biosynthetic pathway in Aspergillus fumigatus strain Af293.
  Journal
Biosci Biotechnol Biochem 77:1061-7 (2013)
DOI:10.1271/bbb.130026
  Sequence

KEGG   ENZYME: 2.1.1.293
Entry
EC 2.1.1.293                Enzyme                                 

Name
6-hydroxytryprostatin B O-methyltransferase;
ftmD (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:6-hydroxytryprostatin B O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 6-hydroxytryprostatin B = S-adenosyl-L-homocysteine + tryprostatin A [RN:R10588]
Reaction(KEGG)
R10588
Substrate
S-adenosyl-L-methionine [CPD:C00019];
6-hydroxytryprostatin B [CPD:C20513]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
tryprostatin A [CPD:C20607]
Comment
Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen.
History
EC 2.1.1.293 created 2013
Pathway
ec00404  Staurosporine biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K18280  6-hydroxytryprostatin B O-methyltransferase
Genes
NHE: NECHADRAFT_63896
AFM: AFUA_8G00200
NFI: NFIA_093710
AOR: AO090010000047
ANG: ANI_1_2036014(An01g15010)
AFV: AFLA_116210
TMF: PMAA_001900 PMAA_100900
TRG: TRUGW13939_04213 TRUGW13939_04351
ABE: ARB_02574 ARB_07989
TVE: TRV_04616 TRV_05502
PTE: PTT_20107
 » show all
Reference
1  [PMID:23649274]
  Authors
Kato N, Suzuki H, Okumura H, Takahashi S, Osada H
  Title
A point mutation in ftmD blocks the fumitremorgin biosynthetic pathway in Aspergillus fumigatus strain Af293.
  Journal
Biosci Biotechnol Biochem 77:1061-7 (2013)
DOI:10.1271/bbb.130026
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.293
IUBMB Enzyme Nomenclature: 2.1.1.293
ExPASy - ENZYME nomenclature database: 2.1.1.293
BRENDA, the Enzyme Database: 2.1.1.293

KEGG   REACTION: R10588
Entry
R10588                      Reaction                               

Name
S-adenosyl-L-methionine:6-hydroxytryprostatin B O-methyltransferase
Definition
S-Adenosyl-L-methionine + 6-Hydroxytryprostatin B <=> S-Adenosyl-L-homocysteine + Tryprostatin A
Equation
Reaction class
RC00003  C00019_C00021
RC00392  C20513_C20607
Enzyme
Pathway
rn00404  Staurosporine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
Orthology
K18280  6-hydroxytryprostatin B O-methyltransferase [EC:2.1.1.293]
Other DBs
RHEA: 37906

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