KEGG   ORTHOLOGY: K18280
Entry
K18280            Tight     KO                                     
Symbol
FTMD
Name
6-hydroxytryprostatin B O-methyltransferase [EC:2.1.1.293]
Pathway
map00404  Staurosporine biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
Reaction
R10588  S-adenosyl-L-methionine:6-hydroxytryprostatin B O-methyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K18280  FTMD; 6-hydroxytryprostatin B O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.293  6-hydroxytryprostatin B O-methyltransferase
     K18280  FTMD; 6-hydroxytryprostatin B O-methyltransferase
Genes
AFM: AFUA_8G00200
NFI: NFIA_093710
Reference
PMID:23649274
  Authors
Kato N, Suzuki H, Okumura H, Takahashi S, Osada H
  Title
A point mutation in ftmD blocks the fumitremorgin biosynthetic pathway in Aspergillus fumigatus strain Af293.
  Journal
Biosci Biotechnol Biochem 77:1061-7 (2013)
DOI:10.1271/bbb.130026
  Sequence
[afm:AFUA_8G00200]

  All links  
Gene (1)   
   OC (1)   
All databases (1)   

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KEGG   ENZYME: 2.1.1.293
Entry
EC 2.1.1.293                Enzyme                                 
Name
6-hydroxytryprostatin B O-methyltransferase;
ftmD (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:6-hydroxytryprostatin B O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 6-hydroxytryprostatin B = S-adenosyl-L-homocysteine + tryprostatin A [RN:R10588]
Reaction(KEGG)
R10588
Substrate
S-adenosyl-L-methionine [CPD:C00019];
6-hydroxytryprostatin B [CPD:C20513]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
tryprostatin A [CPD:C20607]
Comment
Involved in the biosynthetic pathways of several indole alkaloids such as tryprostatins, fumitremorgins and verruculogen.
History
EC 2.1.1.293 created 2013
Pathway
ec00404  Staurosporine biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K18280  6-hydroxytryprostatin B O-methyltransferase
Genes
AFM: AFUA_8G00200
NFI: NFIA_093710
Reference
1  [PMID:23649274]
  Authors
Kato N, Suzuki H, Okumura H, Takahashi S, Osada H
  Title
A point mutation in ftmD blocks the fumitremorgin biosynthetic pathway in Aspergillus fumigatus strain Af293.
  Journal
Biosci Biotechnol Biochem 77:1061-7 (2013)
DOI:10.1271/bbb.130026
  Sequence
[afm:AFUA_8G00200]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.293
IUBMB Enzyme Nomenclature: 2.1.1.293
ExPASy - ENZYME nomenclature database: 2.1.1.293
BRENDA, the Enzyme Database: 2.1.1.293

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Protein sequence (16)   
   UniProt (13)   
   SWISS-PROT (3)   
DNA sequence (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (5)   
   InterPro (5)   
All databases (23)   

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KEGG   REACTION: R10588
Entry
R10588                      Reaction                               
Name
S-adenosyl-L-methionine:6-hydroxytryprostatin B O-methyltransferase
Definition
S-Adenosyl-L-methionine + 6-Hydroxytryprostatin B <=> S-Adenosyl-L-homocysteine + Tryprostatin A
Equation
C00019 + C20513 <=> C00021 + C20607
Reaction class
RC00003  C00019_C00021
RC00392  C20513_C20607
Enzyme
2.1.1.293
Pathway
rn00404  Staurosporine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.293
     R10588  S-Adenosyl-L-methionine + 6-Hydroxytryprostatin B <=> S-Adenosyl-L-homocysteine + Tryprostatin A
Orthology
K18280  6-hydroxytryprostatin B O-methyltransferase [EC:2.1.1.293]
Other DBs
RHEA: 37906

  All links  
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