KEGG   ORTHOLOGY: K18281
Entry
K18281                      KO                                     

Name
FTMA
Definition
brevianamide F synthase [EC:6.3.2.-]
Pathway
ko00404  Staurosporine biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00404 Staurosporine biosynthesis
    K18281  FTMA; brevianamide F synthase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.-  
     K18281  FTMA; brevianamide F synthase
Other DBs
RN: R10661
COG: COG1020
Genes
AFM: AFUA_8G00170
NFI: NFIA_093690
Reference
  Authors
Maiya S, Grundmann A, Li SM, Turner G
  Title
The fumitremorgin gene cluster of Aspergillus fumigatus: identification of a gene encoding brevianamide F synthetase.
  Journal
Chembiochem 7:1062-9 (2006)
DOI:10.1002/cbic.200600003
  Sequence

KEGG   REACTION: R10661
Entry
R10661                      Reaction                               

Definition
L-Tryptophan + L-Proline + 2 ATP <=> Brevianamide F + 2 AMP + 2 Diphosphate
Equation
C00078 + C00148 + 2 C00002 <=> C20563 + 2 C00020 + 2 C00013
Comment
cyclo(L-Trp-L-Pro) synthase
Reaction class
RC03348  C00078_C20563
RC03349  C00148_C20563
Pathway
rn00404  Staurosporine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00786  Fumitremorgin alkaloid biosynthesis, tryptophan + proline => fumitremorgin C/A
Orthology
K18281  brevianamide F synthase [EC:6.3.2.-]

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