KEGG   ORTHOLOGY: K18316
Entry
K18316                      KO                                     

Name
cpmA, carA
Definition
carbapenam-3-carboxylate synthase [EC:6.3.3.6]
Pathway
ko00332  Carbapenem biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko02024  Quorum sensing
Module
M00675  Carbapenem-3-carboxylate biosynthesis, pyrroline-5-carboxylate + malonyl-CoA => carbapenem-3-carboxylate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18316  cpmA, carA; carbapenam-3-carboxylate synthase
 09140 Cellular Processes
  09145 Cellular community - prokaryotes
   02024 Quorum sensing
    K18316  cpmA, carA; carbapenam-3-carboxylate synthase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.3  Cyclo-ligases
    6.3.3.6  carbapenam-3-carboxylate synthase
     K18316  cpmA, carA; carbapenam-3-carboxylate synthase
Other DBs
RN: R10556
COG: COG0367
Genes
SERA: Ser39006_009920
SERQ: CWC46_09915
DZE: Dd1591_0213
DAQ: DAQ1742_04174(cpmA)
PAO: Pat9b_5317
PLU: plu0182(cpmA)
PLUM: A4R40_00880
PTT: VY86_09615
PRG: RB151_027380(carA_2)
BGP: BGL_2c27620
AG: AAD38229(carA)
 » show all
Reference
  Authors
Raber ML, Arnett SO, Townsend CA
  Title
A conserved tyrosyl-glutamyl catalytic dyad in evolutionarily linked enzymes: carbapenam synthetase and beta-lactam synthetase.
  Journal
Biochemistry 48:4959-71 (2009)
DOI:10.1021/bi900432n
  Sequence

KEGG   ORTHOLOGY: K18317
Entry
K18317                      KO                                     

Name
cpmB, carB
Definition
carboxymethylproline synthase [EC:2.3.1.226]
Pathway
ko00332  Carbapenem biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko02024  Quorum sensing
Module
M00675  Carbapenem-3-carboxylate biosynthesis, pyrroline-5-carboxylate + malonyl-CoA => carbapenem-3-carboxylate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18317  cpmB, carB; carboxymethylproline synthase
 09140 Cellular Processes
  09145 Cellular community - prokaryotes
   02024 Quorum sensing
    K18317  cpmB, carB; carboxymethylproline synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.226  carboxymethylproline synthase
     K18317  cpmB, carB; carboxymethylproline synthase
Other DBs
RN: R10485
COG: COG1024
Genes
SERA: Ser39006_009925
SERQ: CWC46_09920
DZE: Dd1591_0212
DAQ: DAQ1742_04175(cpmB)
PAO: Pat9b_5316
PLU: plu0183(cpmB)
PLUM: A4R40_00885
PTT: VY86_09610
PRG: RB151_027390(echA8)
BGP: BGL_2c27610
PFT: JBW_01239
 » show all
Reference
  Authors
Stapon A, Li R, Townsend CA
  Title
Carbapenem biosynthesis: confirmation of stereochemical assignments and the role of CarC in the ring stereoinversion process from L-proline.
  Journal
J Am Chem Soc 125:8486-93 (2003)
DOI:10.1021/ja034248a

KEGG   ORTHOLOGY: K18315
Entry
K18315                      KO                                     

Name
cpmC, carC
Definition
(5R)-carbapenem-3-carboxylate synthase [EC:1.14.20.3]
Pathway
ko00332  Carbapenem biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko02024  Quorum sensing
Module
M00675  Carbapenem-3-carboxylate biosynthesis, pyrroline-5-carboxylate + malonyl-CoA => carbapenem-3-carboxylate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18315  cpmC, carC; (5R)-carbapenem-3-carboxylate synthase
 09140 Cellular Processes
  09145 Cellular community - prokaryotes
   02024 Quorum sensing
    K18315  cpmC, carC; (5R)-carbapenem-3-carboxylate synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.20  With 2-oxoglutarate as one donor, and the other dehydrogenated
    1.14.20.3  (5R)-carbapenem-3-carboxylate synthase
     K18315  cpmC, carC; (5R)-carbapenem-3-carboxylate synthase
Other DBs
RN: R10415
COG: COG2175
Genes
SERA: Ser39006_009930
SERQ: CWC46_09925
DZE: Dd1591_0211
DAQ: DAQ1742_04176(cpmC)
PAO: Pat9b_5315
PLU: plu0184(cpmC)
PLUM: A4R40_00890
PTT: VY86_09605
PRG: RB151_027400(carC)
PRJ: NCTC6933_00419
 » show all
Reference
  Authors
Stapon A, Li R, Townsend CA
  Title
Carbapenem biosynthesis: confirmation of stereochemical assignments and the role of CarC in the ring stereoinversion process from L-proline.
  Journal
J Am Chem Soc 125:8486-93 (2003)
DOI:10.1021/ja034248a

KEGG   ORTHOLOGY: K18318
Entry
K18318                      KO                                     

Name
cpmD, carD
Definition
carbapenem biosynthesis protein, putative proline dehydrogenase [EC:1.5.-.-]
Pathway
ko00332  Carbapenem biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko02024  Quorum sensing
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18318  cpmD, carD; carbapenem biosynthesis protein, putative proline dehydrogenase
 09140 Cellular Processes
  09145 Cellular community - prokaryotes
   02024 Quorum sensing
    K18318  cpmD, carD; carbapenem biosynthesis protein, putative proline dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.-  Acting on the CH-NH group of donors
    1.5.-.-  
     K18318  cpmD, carD; carbapenem biosynthesis protein, putative proline dehydrogenase
Other DBs
RN: R10507
COG: COG0506
Genes
SERA: Ser39006_009935
SERQ: CWC46_09930
DZE: Dd1591_0210
DAQ: DAQ1742_04177(cpmD)
PAO: Pat9b_5314
PLU: plu0185(cpmD)
PLUM: A4R40_00895
PTT: VY86_09600
PRG: RB151_027410(putA_2)
SDJ: NCTC13534_03197

KEGG   ORTHOLOGY: K18319
Entry
K18319                      KO                                     

Name
cpmE, carE
Definition
carbapenem biosynthesis protein CpmE
Pathway
ko00332  Carbapenem biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko02024  Quorum sensing
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18319  cpmE, carE; carbapenem biosynthesis protein CpmE
 09140 Cellular Processes
  09145 Cellular community - prokaryotes
   02024 Quorum sensing
    K18319  cpmE, carE; carbapenem biosynthesis protein CpmE
Other DBs
RN: R10507
COG: COG0633
Genes
SERA: Ser39006_009940
SERQ: CWC46_09935
DZE: Dd1591_0209
PLU: plu0186(cpmE)
PLUM: A4R40_00900
PTT: VY86_09595
PRG: RB151_027420(ascD_3)
RLE: pRL100075

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