Entry |
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Symbol |
PDE8
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Name |
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 [EC: 3.1.4.53]
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Pathway |
map04927 | Cortisol synthesis and secretion |
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Reaction |
R00191 | adenosine 3',5'-phosphate 5'-nucleotidohydrolase |
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Disease |
H00260 | Pigmented micronodular adrenocortical disease |
H01570 | Autosomal dominant striatal degeneration |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09104 Nucleotide metabolism
00230 Purine metabolism
K18437 PDE8; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8
09150 Organismal Systems
09152 Endocrine system
04927 Cortisol synthesis and secretion
K18437 PDE8; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8
09160 Human Diseases
09165 Substance dependence
05032 Morphine addiction
K18437 PDE8; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8
09167 Endocrine and metabolic disease
04934 Cushing syndrome
K18437 PDE8; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8
Enzymes [BR:ko01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.53 3',5'-cyclic-AMP phosphodiesterase
K18437 PDE8; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8
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Other DBs |
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Genes |
» show all
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Reference |
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Authors |
Omori K, Kotera J |
Title |
Overview of PDEs and their regulation. |
Journal |
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Reference |
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Authors |
Fisher DA, Smith JF, Pillar JS, St Denis SH, Cheng JB |
Title |
Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase. |
Journal |
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Sequence |
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