KEGG   ORTHOLOGY: K18583
Entry
K18583                      KO                                     
Symbol
thnE
Name
carboxymethylproline synthase [EC:2.3.1.226]
Pathway
map00332  Carbapenem biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R10485  malonyl-CoA:(S)-1-pyrroline-5-carboxylate malonyltransferase (cyclizing)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18583  thnE; carboxymethylproline synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.226  carboxymethylproline synthase
     K18583  thnE; carboxymethylproline synthase
Other DBs
COG: COG1024
Genes
BAUT: QA635_32915 QA635_32930
BBRA: QA636_34575
BRAY: ML401_37740 ML401_37745
SFA: Sfla_0164
STRP: F750_6857
SFIY: F0344_10135
SCAJ: O1G22_15275
SCT: SCAT_p0824(thnE)
SCY: SCATT_p09110
MENO: Jiend_48450
Reference
PMID:21263049
  Authors
Rodriguez M, Nunez LE, Brana AF, Mendez C, Salas JA, Blanco G
  Title
Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya.
  Journal
Antimicrob Agents Chemother 55:1638-49 (2011)
DOI:10.1128/AAC.01366-10
  Sequence
[sct:SCAT_p0824]
Reference
PMID:19090510
  Authors
Hamed RB, Batchelar ET, Mecinovic J, Claridge TD, Schofield CJ
  Title
Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline.
  Journal
Chembiochem 10:246-50 (2009)
DOI:10.1002/cbic.200800652
Reference
PMID:21913298
  Authors
Bodner MJ, Li R, Phelan RM, Freeman MF, Moshos KA, Lloyd EP, Townsend CA
  Title
Definition of the common and divergent steps in carbapenem beta-lactam antibiotic biosynthesis.
  Journal
Chembiochem 12:2159-65 (2011)
DOI:10.1002/cbic.201100366

  All links  
Ontology (3)   
   KEGG BRITE (2)   
   COG (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (13)   
   KEGG GENES (12)   
   OC (1)   
Literature (3)   
   PubMed (3)   
All databases (29)   

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KEGG   ORTHOLOGY: K18317
Entry
K18317                      KO                                     
Symbol
cpmB, carB
Name
carboxymethylproline synthase [EC:2.3.1.226]
Pathway
map00332  Carbapenem biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map02024  Quorum sensing
Module
M00675  Carbapenem-3-carboxylate biosynthesis, pyrroline-5-carboxylate + malonyl-CoA => carbapenem-3-carboxylate
Reaction
R10485  malonyl-CoA:(S)-1-pyrroline-5-carboxylate malonyltransferase (cyclizing)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00332 Carbapenem biosynthesis
    K18317  cpmB, carB; carboxymethylproline synthase
 09140 Cellular Processes
  09145 Cellular community - prokaryotes
   02024 Quorum sensing
    K18317  cpmB, carB; carboxymethylproline synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.226  carboxymethylproline synthase
     K18317  cpmB, carB; carboxymethylproline synthase
Other DBs
COG: COG1024
Genes
SERA: Ser39006_009925
SERQ: CWC46_09920
PARI: I2D83_01755
PPAV: LOZ86_02765
PCAC: OI450_17090
PACB: M9782_00170
DZE: Dd1591_0212
DAQ: DAQ1742_04175(cpmB)
PROD: PCO85_15485
PAO: Pat9b_5316
PLU: plu0183(cpmB)
PLUM: A4R40_00885
PTT: VY86_09610
PRG: RB151_027390(echA8)
VSR: Vspart_02936(echA8)
VRU: RND59_08415
BGP: BGL_2c27610
BPLA: bpln_2g27650
BVZ: BRAD3257_7533
PFT: JBW_01239
 » show all
Reference
PMID:12848554
  Authors
Stapon A, Li R, Townsend CA
  Title
Carbapenem biosynthesis: confirmation of stereochemical assignments and the role of CarC in the ring stereoinversion process from L-proline.
  Journal
J Am Chem Soc 125:8486-93 (2003)
DOI:10.1021/ja034248a

  All links  
Ontology (3)   
   KEGG BRITE (2)   
   COG (1)   
Pathway (9)   
   KEGG PATHWAY (8)   
   KEGG MODULE (1)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Gene (21)   
   KEGG GENES (20)   
   OC (1)   
Literature (1)   
   PubMed (1)   
All databases (38)   

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