KEGG   ORTHOLOGY: K18607
Entry
K18607                      KO                                     

Name
pno
Definition
pyridoxine 4-oxidase [EC:1.1.3.12]
Pathway
ko00750  Vitamin B6 metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00750 Vitamin B6 metabolism
    K18607  pno; pyridoxine 4-oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.3  With oxygen as acceptor
    1.1.3.12  pyridoxine 4-oxidase
     K18607  pno; pyridoxine 4-oxidase
Other DBs
RN: R01711
COG: COG2303
GO: 0050237
Genes
MLO: mll6785
MLN: A9174_14005
MCI: Mesci_2014
MAM: Mesau_02077
MESW: A9K65_010510
MESM: EJ066_21210
MESP: C1M53_04640
MHUA: MCHK_0406
MJR: EB229_14120
MERD: EB233_10970
OCH: CES85_3502(pno)
PLEO: OHA_1_03156(pno)
MMED: Mame_00118(pno)
HDI: HDIA_0247(pno)
 » show all
Reference
  Authors
Yuan B, Yoshikane Y, Yokochi N, Ohnishi K, Yagi T
  Title
The nitrogen-fixing symbiotic bacterium Mesorhizobium loti has and expresses the gene encoding pyridoxine 4-oxidase involved in the degradation of vitamin B6.
  Journal
FEMS Microbiol Lett 234:225-30 (2004)
DOI:10.1016/j.femsle.2004.03.031
  Sequence
[mlo:mll6785]

KEGG   ENZYME: 1.1.3.12
Entry
EC 1.1.3.12                 Enzyme                                 

Name
pyridoxine 4-oxidase;
pyridoxin 4-oxidase;
pyridoxol 4-oxidase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
Sysname
pyridoxine:oxygen 4-oxidoreductase
Reaction(IUBMB)
pyridoxine + O2 = pyridoxal + H2O2 [RN:R01711]
Reaction(KEGG)
R01711
Substrate
pyridoxine [CPD:C00314];
O2 [CPD:C00007]
Product
pyridoxal [CPD:C00250];
H2O2 [CPD:C00027]
Comment
A flavoprotein. Can also use 2,6-dichloroindophenol as an acceptor.
History
EC 1.1.3.12 created 1972, modified 1976
Pathway
ec00750  Vitamin B6 metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18607  pyridoxine 4-oxidase
Genes
MLO: mll6785
MLN: A9174_14005
MCI: Mesci_2014
MAM: Mesau_02077
MESW: A9K65_010510
MESM: EJ066_21210
MESP: C1M53_04640
MHUA: MCHK_0406
MJR: EB229_14120
MERD: EB233_10970
OCH: CES85_3502(pno)
PLEO: OHA_1_03156(pno)
MMED: Mame_00118(pno)
HDI: HDIA_0247(pno)
 » show all
Reference
1  [PMID:5769992]
  Authors
Sundaram TK, Snell EE.
  Title
The bacterial oxidation of vitamin B6. V. The enzymatic formation of pyridoxal and isopyridoxal from pyridoxine.
  Journal
J Biol Chem 244:2577-84 (1969)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.12
IUBMB Enzyme Nomenclature: 1.1.3.12
ExPASy - ENZYME nomenclature database: 1.1.3.12
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.3.12
BRENDA, the Enzyme Database: 1.1.3.12
CAS: 37250-82-1

KEGG   REACTION: R01711
Entry
R01711                      Reaction                               

Name
pyridoxine:oxygen oxidoreductase (deaminating)
Definition
Pyridoxine + Oxygen <=> Pyridoxal + Hydrogen peroxide
Equation
Reaction class
RC00116  C00250_C00314
RC02755  C00007_C00027
Enzyme
1.1.3.12        1.4.3.5
Pathway
rn00750  Vitamin B6 metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K00275  pyridoxamine 5'-phosphate oxidase [EC:1.4.3.5]
K18607  pyridoxine 4-oxidase [EC:1.1.3.12]
K23998  pyridoxal 5'-phosphate synthase / NAD(P)H-hydrate epimerase [EC:1.4.3.5 5.1.99.6]
Other DBs
RHEA: 15036

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