KEGG   ORTHOLOGY: K18614Help
Entry
K18614                      KO                                     

Name
K18614
Definition
2-(acetamidomethylene)succinate hydrolase [EC:3.5.1.29]
Pathway
ko00750  Vitamin B6 metabolism
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00750 Vitamin B6 metabolism
    K18614  K18614; 2-(acetamidomethylene)succinate hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.29  2-(acetamidomethylene)succinate hydrolase
     K18614  K18614; 2-(acetamidomethylene)succinate hydrolase
BRITE hierarchy
Other DBs
RN: R01649
COG: COG0596
GO: 0047411
Genes
MLO: mlr6787
MLN: A9174_14015
MAM: Mesau_02079
MESP: C1M53_04630
MEY: TM49_03755
MMED: Mame_00121(fac-dex_1)
TaxonomyKoalaUniProt
Reference
  Authors
Mukherjee T, Hilmey DG, Begley TP
  Title
PLP catabolism: identification of the 2-(Acetamidomethylene)succinate hydrolase gene in Mesorhizobium loti MAFF303099.
  Journal
Biochemistry 47:6233-41 (2008)
DOI:10.1021/bi8004158
  Sequence
[mlo:mlr6787]

KEGG   ENZYME: 3.5.1.29Help
Entry
EC 3.5.1.29                 Enzyme                                 

Name
2-(acetamidomethylene)succinate hydrolase;
alpha-(N-acetylaminomethylene)succinic acid hydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
BRITE hierarchy
Sysname
2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)
Reaction(IUBMB)
2-(acetamidomethylene)succinate + 2 H2O = acetate + succinate semialdehyde + NH3 + CO2 [RN:R01649]
Reaction(KEGG)
R01649;
(other) R06134
Show
Substrate
2-(acetamidomethylene)succinate [CPD:C01215];
H2O [CPD:C00001]
Product
acetate [CPD:C00033];
succinate semialdehyde [CPD:C00232];
NH3 [CPD:C00014];
CO2 [CPD:C00011]
Comment
Involved in the degradation of pyridoxin in Pseudomonas.
History
EC 3.5.1.29 created 1972
Pathway
ec00750  Vitamin B6 metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K18614  2-(acetamidomethylene)succinate hydrolase
Genes
MLO: mlr6787
MLN: A9174_14015
MAM: Mesau_02079
MESP: C1M53_04630
MEY: TM49_03755
MMED: Mame_00121(fac-dex_1)
Taxonomy
Reference
1  [PMID:3972793]
  Authors
Huynh MS, Snell EE.
  Title
Enzymes of vitamin B6 degradation. Purification and properties of two N-acetylamidohydrolases.
  Journal
J Biol Chem 260:2379-83 (1985)
Reference
2  [PMID:5769993]
  Authors
Nyns EJ, Zach D, Snell EE.
  Title
The bacterial oxidation of vitamin B6. 8. Enzymatic breakdown of alpha-(N-acetylaminomethylene) succinic acid.
  Journal
J Biol Chem 244:2601-5 (1969)
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.29
IUBMB Enzyme Nomenclature: 3.5.1.29
ExPASy - ENZYME nomenclature database: 3.5.1.29
UM-BBD (Biocatalysis/Biodegradation Database): 3.5.1.29
BRENDA, the Enzyme Database: 3.5.1.29
CAS: 37289-09-1

KEGG   REACTION: R01649Help
Entry
R01649                      Reaction                               

Name
2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating)
Definition
2-(Acetamidomethylene)succinate + 2 H2O <=> Acetate + Succinate semialdehyde + Ammonia + CO2
Equation
Reaction class
RC00300  C00033_C01215
RC00575  C00232_C01215
Enzyme
Pathway
rn00750  Vitamin B6 metabolism
rn01120  Microbial metabolism in diverse environments
Orthology
K18614  2-(acetamidomethylene)succinate hydrolase [EC:3.5.1.29]
Other DBs
RHEA: 10435

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