KEGG   ORTHOLOGY: K18687
Entry
K18687                      KO                                     

Name
fadD3
Definition
HIP---CoA ligase [EC:6.2.1.41]
Pathway
ko00984  Steroid degradation
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00984 Steroid degradation
    K18687  fadD3; HIP---CoA ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.41  3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate---CoA ligase
     K18687  fadD3; HIP---CoA ligase
Other DBs
RN: R10769
COG: COG0318
Genes
RGL: CS053_01725
VAF: D1115_23235
PRE: PCA10_43630
PPUT: L483_14110
PPUN: PP4_27170
PPUU: PputUW4_01676
PKC: PKB_4307 PKB_4315
PFZ: AV641_10585
PLQ: AA042_20385
PPSY: AOC04_07885
PSET: THL1_4405
PSIL: PMA3_11755
SPL: Spea_2126
SHL: Shal_2098
PHA: PSHAa2132
PAT: Patl_4047
REH: H16_B0644(h16_B0644)
BCJ: BCAM1643
BCEN: DM39_6207
BCEO: I35_5503
BCED: DM42_6315
BCON: NL30_03970
BTEI: WS51_05840
BPSL: WS57_05870
BMEC: WJ16_26950
BFN: OI25_4610
CABA: SBC2_46940(fadD3_2) SBC2_48800(fadD3_3)
BPAR: BN117_3786
BPA: BPP0910
BBR: BB1002
BHO: D560_0414
BHM: D558_0412
NAR: Saro_3767
SPHM: G432_04705
SSAN: NX02_14695
SPKC: KC8_01165
SHUM: STHU_12860
TMO: TMO_0599(lcfB)
MTU: Rv3561(fadD3)
MTV: RVBD_3561
MTC: MT3666
MRA: MRA_3600(fadD3)
MTUR: CFBS_3777(fadD3)
MTO: MTCTRI2_3625(fadD3)
MTD: UDA_3561(fadD3)
MTN: ERDMAN_3906(fadD3)
MTUE: J114_19045
MTUH: I917_24990
MTUL: TBHG_03501
MTUT: HKBT1_3762(fadD3)
MTUU: HKBT2_3771(fadD3)
MTQ: HKBS1_3774(fadD3)
MBO: BQ2027_MB3591(fadD3)
MBB: BCG_3625(fadD3)
MBT: JTY_3626(fadD3)
MBM: BCGMEX_3623(fadD3)
MBX: BCGT_3427
MAF: MAF_35730(fadD3)
MMIC: RN08_3938
MCE: MCAN_35721(fadD3)
MCQ: BN44_110053(fadD)
MCV: BN43_90059(fadD)
MCX: BN42_90058(fadD)
MCZ: BN45_100060(fadD)
MPA: MAP_0506c(fadD3) MAP_0780(fadD3) MAP_2402
MLP: MLM_0744
MUL: MUL_4126(fadD3)
MMI: MMAR_4027 MMAR_4688(fadD3_2) MMAR_5050(fadD3)
MMAE: MMARE11_45140(fadD3_2) MMARE11_48650(fadD3)
MLI: MULP_05308(fadD3)
MHAD: B586_04505
MSHG: MSG_04223 MSG_04547(fadD3)
MSG: MSMEI_4650 MSMEI_5853(fadD3)
MPHL: MPHLCCUG_01891(lcfB_1) MPHLCCUG_03698(lcfB_8)
MTHN: 4412656_01417(hcl_3) 4412656_02988(fadD_12) 4412656_04084(fadD_18)
MHAS: MHAS_00809(fadD3_2) MHAS_01072(fadD3_4) MHAS_03765(fadD3_6)
MAB: MAB_0596c
MABB: MASS_0566
MCHE: BB28_02845
MSTE: MSTE_00554
MJD: JDM601_3404 JDM601_3424(fadD3_2) JDM601_3717(fadD3)
MTER: 4434518_03390(hcl) 4434518_03408(fadD3_2) 4434518_03719(fadD3)
MMIN: MMIN_12410(fadD3)
ASD: AS9A_0944
MKR: MKOR_35470(fadD3)
NFA: NFA_4830
NFR: ERS450000_03753(fadD_8)
RER: RER_08900
REY: O5Y_03940
ROP: ROP_45400
REQ: REQ_07020
RRT: 4535765_00602(fadD_1) 4535765_04305(fadK_8)
GBR: Gbro_3996
GOR: KTR9_3925(fadD3)
GRU: GCWB2_20060(lcfB19)
GOM: D7316_02344(fadD3_4) D7316_04486(fadD3_6)
TPR: Tpau_3836
SMA: SAVERM_3806(fadD16)
SGR: SGR_3014
SGB: WQO_20655
SCT: SCAT_2351
SHY: SHJG_3994
SVE: SVEN_3097
SDV: BN159_5012(fadD16)
SFI: SFUL_4340
SLD: T261_4786
STRM: M444_15600
SPRI: SPRI_4275
SRW: TUE45_04305(lcfB_5)
SLAU: SLA_3151
SLX: SLAV_16680(lcfB3) SLAV_27185(fadD)
SFK: KY5_3519c
SGE: DWG14_04793(fadD3_2)
SRJ: SRO_4198
NCA: Noca_2768
NDK: I601_0619 I601_0635(lcfB_1)
TCU: Tcur_3475
SRO: Sros_2101
FAL: FRAAL3421
AMD: AMED_3385
AMN: RAM_17220
AMM: AMES_3346
AMZ: B737_3346
AOI: AORI_2499
AMYY: YIM_33170(lcfB8)
PDX: Psed_2463
PSEH: XF36_18400
PAUT: Pdca_08270(fadD3)
KAL: KALB_5110
ALO: CRK57775
SAQ: Sare_2861
ACTN: L083_7150
CWO: Cwoe_2360
RCA: Rcas_3967
CAG: Cagg_0813
 » show all
Reference
  Authors
Horinouchi M, Hayashi T, Koshino H, Kudo T
  Title
ORF18-disrupted mutant of Comamonas testosteroni TA441 accumulates significant amounts of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid and its derivatives after incubation with steroids.
  Journal
J Steroid Biochem Mol Biol 101:78-84 (2006)
DOI:10.1016/j.jsbmb.2006.06.006
  Sequence
Reference
  Authors
Casabon I, Crowe AM, Liu J, Eltis LD
  Title
FadD3 is an acyl-CoA synthetase that initiates catabolism of cholesterol rings C and D in actinobacteria.
  Journal
Mol Microbiol 87:269-83 (2013)
DOI:10.1111/mmi.12095
  Sequence
[mtu:Rv3561]

KEGG   ENZYME: 6.2.1.41
Entry
EC 6.2.1.41                 Enzyme                                 

Name
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate---CoA ligase;
fadD3 (gene name);
HIP---CoA ligase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + CoA = AMP + diphosphate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA [RN:R10769]
Reaction(KEGG)
R10769
Substrate
ATP [CPD:C00002];
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate [CPD:C20199];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA [CPD:C20838]
Comment
The enzyme, characterized from actinobacterium Mycobacterium tuberculosis, catalyses a step in the degradation of cholesterol and cholate. The enzyme is very specific for its substrate, and requires that the side chain at C17 is completely removed.
History
EC 6.2.1.41 created 2014
Pathway
ec00984  Steroid degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18687  HIP---CoA ligase
Genes
RGL: CS053_01725
VAF: D1115_23235
PRE: PCA10_43630
PPUT: L483_14110
PPUN: PP4_27170
PPUU: PputUW4_01676
PKC: PKB_4307 PKB_4315
PFZ: AV641_10585
PLQ: AA042_20385
PPSY: AOC04_07885
PSET: THL1_4405
PSIL: PMA3_11755
SPL: Spea_2126
SHL: Shal_2098
PHA: PSHAa2132
PAT: Patl_4047
REH: H16_B0644(h16_B0644)
BCJ: BCAM1643
BCEN: DM39_6207
BCEO: I35_5503
BCED: DM42_6315
BCON: NL30_03970
BTEI: WS51_05840
BPSL: WS57_05870
BMEC: WJ16_26950
BFN: OI25_4610
CABA: SBC2_46940(fadD3_2) SBC2_48800(fadD3_3)
BPAR: BN117_3786
BPA: BPP0910
BBR: BB1002
BHO: D560_0414
BHM: D558_0412
NAR: Saro_3767
SPHM: G432_04705
SSAN: NX02_14695
SPKC: KC8_01165
SHUM: STHU_12860
TMO: TMO_0599(lcfB)
MTU: Rv3561(fadD3)
MTV: RVBD_3561
MTC: MT3666
MRA: MRA_3600(fadD3)
MTUR: CFBS_3777(fadD3)
MTO: MTCTRI2_3625(fadD3)
MTD: UDA_3561(fadD3)
MTN: ERDMAN_3906(fadD3)
MTUE: J114_19045
MTUH: I917_24990
MTUL: TBHG_03501
MTUT: HKBT1_3762(fadD3)
MTUU: HKBT2_3771(fadD3)
MTQ: HKBS1_3774(fadD3)
MBO: BQ2027_MB3591(fadD3)
MBB: BCG_3625(fadD3)
MBT: JTY_3626(fadD3)
MBM: BCGMEX_3623(fadD3)
MBX: BCGT_3427
MAF: MAF_35730(fadD3)
MMIC: RN08_3938
MCE: MCAN_35721(fadD3)
MCQ: BN44_110053(fadD)
MCV: BN43_90059(fadD)
MCX: BN42_90058(fadD)
MCZ: BN45_100060(fadD)
MPA: MAP_0506c(fadD3) MAP_0780(fadD3) MAP_2402
MLP: MLM_0744
MUL: MUL_4126(fadD3)
MMI: MMAR_4027 MMAR_4688(fadD3_2) MMAR_5050(fadD3)
MMAE: MMARE11_45140(fadD3_2) MMARE11_48650(fadD3)
MLI: MULP_05308(fadD3)
MHAD: B586_04505
MSHG: MSG_04223 MSG_04547(fadD3)
MSG: MSMEI_4650 MSMEI_5853(fadD3)
MPHL: MPHLCCUG_01891(lcfB_1) MPHLCCUG_03698(lcfB_8)
MTHN: 4412656_01417(hcl_3) 4412656_02988(fadD_12) 4412656_04084(fadD_18)
MHAS: MHAS_00809(fadD3_2) MHAS_01072(fadD3_4) MHAS_03765(fadD3_6)
MAB: MAB_0596c
MABB: MASS_0566
MCHE: BB28_02845
MSTE: MSTE_00554
MJD: JDM601_3404 JDM601_3424(fadD3_2) JDM601_3717(fadD3)
MTER: 4434518_03390(hcl) 4434518_03408(fadD3_2) 4434518_03719(fadD3)
MMIN: MMIN_12410(fadD3)
ASD: AS9A_0944
MKR: MKOR_35470(fadD3)
NFA: NFA_4830
NFR: ERS450000_03753(fadD_8)
RER: RER_08900
REY: O5Y_03940
ROP: ROP_45400
REQ: REQ_07020
RRT: 4535765_00602(fadD_1) 4535765_04305(fadK_8)
GBR: Gbro_3996
GOR: KTR9_3925(fadD3)
GRU: GCWB2_20060(lcfB19)
GOM: D7316_02344(fadD3_4) D7316_04486(fadD3_6)
TPR: Tpau_3836
SMA: SAVERM_3806(fadD16)
SGR: SGR_3014
SGB: WQO_20655
SCT: SCAT_2351
SHY: SHJG_3994
SVE: SVEN_3097
SDV: BN159_5012(fadD16)
SFI: SFUL_4340
SLD: T261_4786
STRM: M444_15600
SPRI: SPRI_4275
SRW: TUE45_04305(lcfB_5)
SLAU: SLA_3151
SLX: SLAV_16680(lcfB3) SLAV_27185(fadD)
SFK: KY5_3519c
SGE: DWG14_04793(fadD3_2)
SRJ: SRO_4198
NCA: Noca_2768
NDK: I601_0619 I601_0635(lcfB_1)
TCU: Tcur_3475
SRO: Sros_2101
FAL: FRAAL3421
AMD: AMED_3385
AMN: RAM_17220
AMM: AMES_3346
AMZ: B737_3346
AOI: AORI_2499
AMYY: YIM_33170(lcfB8)
PDX: Psed_2463
PSEH: XF36_18400
PAUT: Pdca_08270(fadD3)
KAL: KALB_5110
ALO: CRK57775
SAQ: Sare_2861
ACTN: L083_7150
CWO: Cwoe_2360
RCA: Rcas_3967
CAG: Cagg_0813
 » show all
Reference
1  [PMID:16891113]
  Authors
Horinouchi M, Hayashi T, Koshino H, Kudo T
  Title
ORF18-disrupted mutant of Comamonas testosteroni TA441 accumulates significant amounts of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid and its derivatives after incubation with steroids.
  Journal
J Steroid Biochem Mol Biol 101:78-84 (2006)
DOI:10.1016/j.jsbmb.2006.06.006
  Sequence
Reference
2  [PMID:23146019]
  Authors
Casabon I, Crowe AM, Liu J, Eltis LD
  Title
FadD3 is an acyl-CoA synthetase that initiates catabolism of cholesterol rings C  and D in actinobacteria.
  Journal
Mol Microbiol 87:269-83 (2013)
DOI:10.1111/mmi.12095
  Sequence
[mtu:Rv3561]
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.41
IUBMB Enzyme Nomenclature: 6.2.1.41
ExPASy - ENZYME nomenclature database: 6.2.1.41
BRENDA, the Enzyme Database: 6.2.1.41

KEGG   REACTION: R10769
Entry
R10769                      Reaction                               

Name
3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate:CoA ligase (AMP-forming)
Definition
ATP + 3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + CoA <=> AMP + Diphosphate + 3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA
Equation
Reaction class
RC00004  C00010_C20838
RC00014  C20199_C20838
Enzyme
Pathway
rn00984  Steroid degradation
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Orthology
K18687  HIP---CoA ligase [EC:6.2.1.41]
Other DBs
RHEA: 41643

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