KEGG   ORTHOLOGY: K18698
Entry
K18698            Tight     KO                                     

Name
blaTEM
Definition
beta-lactamase class A TEM [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18698  blaTEM; beta-lactamase class A TEM
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18698  blaTEM; beta-lactamase class A TEM
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18698  blaTEM; beta-lactamase class A TEM
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class A [MT]
    K18698  blaTEM; beta-lactamase class A TEM
Other DBs
RN: R06363
COG: COG2367
GO: 0008800
Genes
EOI: ECO111_p1-129
ESL: O3K_25812
ESO: O3O_25195
ESM: O3M_00505
ELR: ECO55CA74_26309
ECOS: EC958_A0053(blaTEM-1)
ECM: EcSMS35_A0130(blaT)
EUM: ECUMN_4830(bla)
ELN: NRG857_30085
ECOJ: P423_25770
EFE: EFER_1643(bla) EFER_p0036(bla)
STY: HCM1.216(bla)
SEC: SCH_018(tem-1)
SEH: SeHA_C1580(blaT)
SEW: SeSA_B0046(blaT)
ECLX: LI66_24190
ECLY: LI62_00205
ECLZ: LI64_22450
KPJ: N559_5242
KPNE: KU54_01195
KPNU: LI86_28450
EAR: CCG28759
CFQ: C2U38_26795(blaTEM)
CIR: C2U53_00280(blaTEM)
CIE: AN232_27700(blaTEM) AN232_30620(blaTEM)
EBC: C2U52_00385(blaTEM)
PRG: RB151_017480(bla_1)
HIT: NTHI2055
HIU: HIB_01180(bla)
HIZ: R2866_0574(bla)
ABN: AB57_06335(blaTEM)
ABAU: IX87_12750
NSI: A6J88_09500(blaTEM)
KKI: KKKWG1_0925(blaT)
BWW: bwei_5861(blaTEM-116)
AG: 10543745-1(TEM-44) 10543745-2(TEM-57) 10543745-3(TEM-65) 10543745-4(TEM-66) 10543745-5(TEM-73) 10543745-6(TEM-74) 10639384-1(TEM-56) 12384377-1(TEM-103) 12878521-1(TEM-102) 1416892-1(TEM-26) 2073111-1(TEM-13) 2073111-2(TEM-18) 21947397-1(TEM-181) 2506109-1(TEM-7) 2550326-1(TEM-5) 2665644-1(TEM-61) 7726509-1(TEM-37) 7726509-2(TEM-38) 7726509-3(TEM-39) 7726515-1(TEM-27) 7840586-1(TEM-25) 8067742-1(TEM-31) 8067742-2(TEM-35) 8067742-3(TEM-36) 8257123-1(TEM-32) 8585729-1(TEM-40) 8585729-2(TEM-41) 9174192-1(TEM-50) 9371365-1(TEM-51) 9559800-1(TEM-58) 9624494-1(TEM-60) AAA25053(TEM-12) AAB59737(TEM-1) AAC32889(TEM-43) AAC32891(TEM-28) AAC72362(TEM-10) AAD22538(TEM-53) AAD22539(TEM-54) AAD33116(TEM-67) AAD45935(TEM-59) AAF05611(TEM-79) AAF05612(TEM-78) AAF05613(TEM-76) AAF05614(TEM-77) AAF19151(TEM-72) AAF66653(TEM-92) AAG44570(TEM-87) AAK14792(TEM-88) AAK17194(TEM-63) AAK30619(TEM-90) AAK71474(TEM-89) AAL03985(TEM-71) AAL29433(TEM-81) AAL29434(TEM-82) AAL29435(TEM-83) AAL29436(TEM-84) AAL68923(TEM-110) AAM15527(TEM-80) AAN04881(TEM-115) AAN05028(TEM-75) AAN05029(TEM-118) AAO85882(TEM-120) AAQ75087(TEM-121) AAQ95605(TEM-116) AAQ98890(TEM-122) AAR10958(TEM-131) AAR84298(TEM-132) AAR89358(TEM-127) AAR89359(TEM-128) AAS19171(TEM-133) AAS79107(TEM-134) AAS89982(TEM-112) AAS89983(TEM-113) AAS89984(TEM-114) AAT45742(TEM-126) AAT46413(TEM-109) AAT46414(TEM-125) AAV83795(TEM-136) AAW47922(TEM-138) AAW66604(TEM-11) AAX56615(TEM-141) AAZ23494(TEM-139) ABC96711(TEM-149) ABG77582(TEM-155) ABI74447(TEM-152) ABI74448(TEM-151) ABM54869(TEM-159) ABM54870(TEM-160) ABQ00181(TEM-158) ABX71157(TEM-164) ACO07310(TEM-154) ACP18864(TEM-169) ACR22829(TEM-168) ADL13944(TEM-33) ADM61585(TEM-187) ADP20705(TEM-182) ADR71220(TEM-183) AEL17198(TEM-188) AEQ59620(TEM-192) AEQ59621(TEM-191) AET99222(TEM-186) AFN21551(TEM-19) AFN69127(TEM-199) AGA83484(TEM-153) AGE11905(TEM-34) AIF78090(TEM-210) AIW68620(TEM-220) BAB16308(TEM-91) CAA38429(TEM-2) CAA41038(TEM-6) CAA45828(TEM-3) CAA46344(TEM-8) CAA46345(TEM-24) CAA46346(TEM-16) CAA64682(TEM-45) CAA65888(TEM-178) CAA66659(TEM-42) CAA71322(TEM-47) CAA71323(TEM-48) CAA71324(TEM-49) CAA73933(TEM-52) CAA74912(TEM-17) CAA76793(TEM-20) CAA76794(TEM-21) CAA76795(TEM-22) CAA76796(TEM-29) CAB92324(TEM-68) CAC43229(TEM-85) CAC43230(TEM-86) CAC67290(TEM-95) CAC85660(TEM-93) CAC85661(TEM-94) CAD24670(TEM-30) CAG25427(TEM-135) CAG34105(TEM-129) CAJ17558(TEM-144) CAL08007(TEM-137) CAO98721(TEM-15) CBJ06718(TEM-177) CDR98216(TEM-4)
 » show all
Reference
PMID:358200
  Authors
Sutcliffe JG
  Title
Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322.
  Journal
Proc Natl Acad Sci U S A 75:3737-41 (1978)
DOI:10.1073/pnas.75.8.3737
  Sequence
Reference
  Authors
Bradford PA
  Title
Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.
  Journal
Clin Microbiol Rev 14:933-51, table of contents (2001)
DOI:10.1128/CMR.14.4.933-951.2001

KEGG   ORTHOLOGY: K18699
Entry
K18699            Tight     KO                                     

Name
blaSHV
Definition
beta-lactamase class A SHV [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18699  blaSHV; beta-lactamase class A SHV
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18699  blaSHV; beta-lactamase class A SHV
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18699  blaSHV; beta-lactamase class A SHV
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class A [MT]
    K18699  blaSHV; beta-lactamase class A SHV
Other DBs
RN: R06363
COG: COG2367
GO: 0008800
Genes
ECLE: ECNIH2_24885
ECLN: ECNIH4_23090
ECLI: ECNIH5_22870
ECLY: LI62_012635
ECLA: ECNIH3_23450
KPN: KPN_01607 KPN_pKPN4p07050
KPU: KP1_2635(blaSHV-11)
KPM: KPHS_25220
KPP: A79E_2629
KPH: KPNIH24_15650 KPNIH24_27130
KPT: VK055_0891(bla)
KPR: KPR_2492
KPJ: N559_2715
KPX: PMK1_03928(bla_1)
AG: 15081091-1(SHV-23) 17913717-1(SHV-90) 17913717-2(SHV-91) 2694955-1(SHV-4) 9087500-1(SHV-10) AAA87176(SHV-7) AAB37395(SHV-9) AAB51384(SHV-8) AAC98092(SHV-16) AAD37412(SHV-1) AAD37413(SHV-2) AAD43815(SHV-13) AAF34333(SHV-19) AAF34334(SHV-20) AAF34335(SHV-21) AAF34336(SHV-22) AAF36719(SHV-26) AAF37209(SHV-25) AAF64386(SHV-18) AAG01039(SHV-27) AAG17550(SHV-14) AAG49894(SHV-29) AAK64187(SHV-34) AAK69828(SHV-32) AAK69829(SHV-33) AAL40899(SHV-43) AAL79576(SHV-38) AAN04882(SHV-40) AAN04883(SHV-41) AAN04884(SHV-42) AAO53445(SHV-46) AAO66446(SHV-57) AAP03063(SHV-48) AAP33454(SHV-31) AAP82228(SHV-44) AAS98184(SHV-49) AAT75225(SHV-30) AAY42633(SHV-70) ABA60809(SHV-89) ABC54571(SHV-85) ABH04327(SHV-92) ABS72342(SHV-102) ABS72351(SHV-103) ABV72593(SHV-101) ABX71158(SHV-104) ACB73258(SHV-56) ACI22621(SHV-105) ACM04459(SHV-109) ADE08533(SHV-129) ADE58494(SHV-128) AEX99752(SHV-142) AFQ23953(SHV-147) AFQ23954(SHV-148) AFQ23955(SHV-149) AFQ23956(SHV-150) AFQ23957(SHV-151) AFQ23958(SHV-152) AFQ23959(SHV-153) AFQ23960(SHV-154) AFQ23961(SHV-155) AFQ23962(SHV-156) AFQ23963(SHV-157) AFQ23964(SHV-158) AFQ23965(SHV-159) AFQ23966(SHV-160) AFQ23967(SHV-161) AFQ23968(SHV-162) AFQ23969(SHV-163) AFQ23970(SHV-165) AFW16978(SHV-168) ANN24025(SHV-194) BAA84973(SHV-24) BAF95849(SHV-111) BAF99008(SHV-110) BAM28879(SHV-167) CAA37813(SHV-2a) CAA39164(SHV-5) CAA66729(SHV-11) CAA66733(SHV-12) CAA71948(SHV-6) CAI10727(SHV-55) CAI30649(SHV-60) CAI30650(SHV-61) CAI30651(SHV-62) CAJ32371(SHV-84) CAJ47126(SHV-71) CAJ47127(SHV-72) CAJ47128(SHV-73) CAJ47129(SHV-74) CAJ47130(SHV-75) CAJ47131(SHV-76) CAJ47132(SHV-77) CAJ47133(SHV-78) CAJ47134(SHV-79) CAJ47135(SHV-80) CAJ47136(SHV-81) CAJ47137(SHV-82) CAJ47138(SHV-83) CAQ03503(SHV-98) CAQ03504(SHV-99) CAQ03505(SHV-100) CAQ03506(SHV-106) CAQ03507(SHV-107) CAQ03508(SHV-108) P30896(SHV-3)
 » show all
Reference
PMID:3260490
  Authors
Barthelemy M, Peduzzi J, Labia R
  Title
Complete amino acid sequence of p453-plasmid-mediated PIT-2 beta-lactamase (SHV-1).
  Journal
Biochem J 251:73-9 (1988)
DOI:10.1042/bj2510073
Reference
  Authors
Bradford PA
  Title
Automated thermal cycling is superior to traditional methods for nucleotide sequencing of bla(SHV) genes.
  Journal
Antimicrob Agents Chemother 43:2960-3 (1999)
  Sequence
Reference
  Authors
Bradford PA
  Title
Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.
  Journal
Clin Microbiol Rev 14:933-51, table of contents (2001)
DOI:10.1128/CMR.14.4.933-951.2001

KEGG   ORTHOLOGY: K18796
Entry
K18796            Tight     KO                                     

Name
blaLEN
Definition
beta-lactamase class A LEN [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18796  blaLEN; beta-lactamase class A LEN
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18796  blaLEN; beta-lactamase class A LEN
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18796  blaLEN; beta-lactamase class A LEN
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class A [MT]
    K18796  blaLEN; beta-lactamase class A LEN
Other DBs
COG: COG2367
GO: 0008800
Genes
KVA: Kvar_2736
KPE: KPK_2780 KPK_2800
KPK: A593_22675
KVD: KR75_20505
KVQ: SP68_01480
KQU: AVR78_17155
KQV: B8P98_14450
EBU: CUC76_02955
AG: AAK69830(LEN-2) AAZ79401(LEN-17) AEY11240(LEN-26) AQL16015(LEN-13) CAA28198(LEN-1) CAP12346(LEN-18) CAP12347(LEN-19) CAP12348(LEN-20) CAP12349(LEN-21) CAP12350(LEN-22) CAP12351(LEN-23) CAP12352(LEN-24)
Reference
PMID:3533626
  Authors
Arakawa Y, Ohta M, Kido N, Fujii Y, Komatsu T, Kato N
  Title
Close evolutionary relationship between the chromosomally encoded beta-lactamase gene of Klebsiella pneumoniae and the TEM beta-lactamase gene mediated by R plasmids.
  Journal
FEBS Lett 207:69-74 (1986)
DOI:10.1016/0014-5793(86)80014-X
  Sequence

KEGG   ORTHOLOGY: K18767
Entry
K18767            Tight     KO                                     

Name
blaCTX-M
Definition
beta-lactamase class A CTX-M [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18767  blaCTX-M; beta-lactamase class A CTX-M
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18767  blaCTX-M; beta-lactamase class A CTX-M
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18767  blaCTX-M; beta-lactamase class A CTX-M
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class A [MT]
    K18767  blaCTX-M; beta-lactamase class A CTX-M
Other DBs
RN: R06363
COG: COG2367
GO: 0008800
Genes
ESL: O3K_25787
ECOS: EC958_A0119(blaCTX-M-15)
ECOJ: P423_07345
KPM: KPHS_p100340 KPHS_p301310
KPY: KPNIH31_23215
KPJ: N559_5233
KPX: PMK1_04637(bla_2) PMK1_ndm00052(bla_1)
KPB: FH42_25820
KOE: A225_R1p0210
KLW: DA718_21395
CIE: AN232_26695(blaCTX-M)
METY: MRY16398_p20490(blaCTX-M-2)
VG: 29081721(J46_0066)
AG: AAC32890(CTX-M-5) AAF04388(CTX-M-8) AAF05311(CTX-M-9) AAF65843(CTX-M-10) AAF72530(CTX-M-14) AAF72531(CTX-M-13) AAG34108(CTX-M-12) AAK32961(CTX-M-16) AAK55533(CTX-M-18) AAK55534(CTX-M-19) AAK71471(CTX-M-17) AAL02127(CTX-M-15) AAL86924(CTX-M-22) AAL99990(CTX-M-23) AAM70498(CTX-M-25) AAN75444(CTX-M-26) AAO61597(CTX-M-27) AAO88912(CTX-M-33) AAP22736(CTX-M-29) AAP43508(CTX-M-30) AAR99493(CTX-M-34) AAV28215(CTX-M-40) AAV97952(CTX-M-47) AAV97953(CTX-M-48) AAV97954(CTX-M-49) AAV97955(CTX-M-50) AAV97956(CTX-M-46) AAV97957(CTX-M-72) AAX33264(CTX-M-37) AAX54694(CTX-M-39) AAY43008(CTX-M-41) AAY84742(CTX-M-42) AAZ14955(CTX-M-43) ABB59946(CTX-M-82) ABB72225(CTX-M-53) ABC18328(CTX-M-54) ABD73290(CTX-M-59) ABG80523(CTX-M-57) ABI34705(CTX-M-55) ABN09669(CTX-M-61) ABN48311(CTX-M-56) ABO09821(CTX-M-79) ABP04245(CTX-M-62) ABQ45409(CTX-M-66) ABS90365(CTX-M-67) ABV57756(CTX-M-81) ABV81082(CTX-M-68) ABW86620(CTX-M-80) ABW87621(CTX-M-65) ABY91281(CTX-M-69) ACB41777(CTX-M-87) ACI29345(CTX-M-83) ACI29346(CTX-M-84) ACI29347(CTX-M-85) ACI29348(CTX-M-86) ACP18863(CTX-M-88) ACR56321(CTX-M-89) ACS32293(CTX-M-74) ACS32294(CTX-M-75) ACV92002(CTX-M-71) ACY74743(CTX-M-92) ADK11041(CTX-M-94) ADM08178(CTX-M-97) ADN26580(CTX-M-93) ADO17948(CTX-M-98) ADY02545(CTX-M-101) ADY02546(CTX-M-102) ADY02554(CTX-M-105) ADY02555(CTX-M-104) ADZ31262(CTX-M-106) AEI70324(CTX-M-116) AEM44648(CTX-M-110) AEM44649(CTX-M-111) AEM44650(CTX-M-107) AEM44651(CTX-M-108) AEM44652(CTX-M-112) AEM44653(CTX-M-113) AEM44654(CTX-M-109) AET99223(CTX-M-117) AEW46676(CTX-M-131) AFA51699(CTX-M-121) AFA51701(CTX-M-123) AFH88134(CTX-M-124) AFQ94051(CTX-M-132) AHA80107(CTX-M-138) AHC31002(CTX-M-137) AHX39588(CTX-M-144) AHX39589(CTX-M-148) AIT97310(CTX-M-158) AOF41435(CTX-M-190) ARQ19295(CTX-M-199) BAA07082(CTX-M-44) BAA28282(CTX-M-45) BAF63422(CTX-M-64) BAL72196(CTX-M-126) CAA06311(CTX-M-6) CAA06312(CTX-M-7) CAA63262(CTX-M-1) CAA63263(CTX-M-2) CAA71321(CTX-M-3) CAA74573(CTX-M-4) CAC95175(CTX-M-20) CAD08929(CTX-M-21) CAD70280(CTX-M-28) CAD89606(CTX-M-32) CAD99181(CTX-M-31) CAJ00132(CTX-M-24) CAQ42481(CTX-M-78) CBW46935(CTX-M-100) CDG50843(CTX-M-103)
 » show all
Reference
PMID:8834913
  Authors
Bauernfeind A, Stemplinger I, Jungwirth R, Ernst S, Casellas JM
  Title
Sequences of beta-lactamase genes encoding CTX-M-1 (MEN-1) and CTX-M-2 and relationship of their amino acid sequences with those of other beta-lactamases.
  Journal
Antimicrob Agents Chemother 40:509-13 (1996)
  Sequence
Reference
  Authors
Bradford PA
  Title
Extended-spectrum beta-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat.
  Journal
Clin Microbiol Rev 14:933-51, table of contents (2001)
DOI:10.1128/CMR.14.4.933-951.2001

KEGG   ORTHOLOGY: K18797
Entry
K18797            Tight     KO                                     

Name
blaPER
Definition
beta-lactamase class A PER [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18797  blaPER; beta-lactamase class A PER
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18797  blaPER; beta-lactamase class A PER
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18797  blaPER; beta-lactamase class A PER
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class A [MT]
    K18797  blaPER; beta-lactamase class A PER
Other DBs
COG: COG2367
GO: 0008800
Genes
PRQ: CYG50_12810
ABX: ABK1_0262
AJO: RZ95_17865
AG: ADD80743(PER-6) AEI54993(PER-7) CAA63714(PER-2) CAA79968(PER-1)
Reference
PMID:8141562
  Authors
Nordmann P, Naas T
  Title
Sequence analysis of PER-1 extended-spectrum beta-lactamase from Pseudomonas aeruginosa and comparison with class A beta-lactamases.
  Journal
Antimicrob Agents Chemother 38:104-14 (1994)
DOI:10.1128/AAC.38.1.104
  Sequence

KEGG   ORTHOLOGY: K19097
Entry
K19097            Tight     KO                                     

Name
blaVEB
Definition
beta-lactamase class A VEB [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K19097  blaVEB; beta-lactamase class A VEB
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19097  blaVEB; beta-lactamase class A VEB
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K19097  blaVEB; beta-lactamase class A VEB
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class A [MT]
    K19097  blaVEB; beta-lactamase class A VEB
Other DBs
COG: COG2367
GO: 0008800
Genes
KPJ: N559_5248
ABY: ABAYE3623(veb-1)
AAJ: BOQ57_11405
AG: AAD01435(VEB-1) AAK14293(VEB-9) AAK29174(VEB-2) AAS48620(VEB-3) ABM54868(VEB-4) ACA34904(VEB-6) ALB25884(VEB-13) ALB25885(VEB-14) ALB25886(VEB-15) ALB25887(VEB-16) ANU78819(VEB-18)
Reference
  Authors
Poirel L, Naas T, Guibert M, Chaibi EB, Labia R, Nordmann P
  Title
Molecular and biochemical characterization of VEB-1, a novel class A extended-spectrum beta-lactamase encoded by an Escherichia coli integron gene.
  Journal
Antimicrob Agents Chemother 43:573-81 (1999)
  Sequence

KEGG   ORTHOLOGY: K19317
Entry
K19317            Tight     KO                                     

Name
blaBEL
Definition
beta-lactamase class A BEL [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K19317  blaBEL; beta-lactamase class A BEL
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19317  blaBEL; beta-lactamase class A BEL
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K19317  blaBEL; beta-lactamase class A BEL
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class A [MT]
    K19317  blaBEL; beta-lactamase class A BEL
Other DBs
COG: COG2367
GO: 0008800
Genes
AG: AAZ04368(BEL-1) ACT09140(BEL-3) ACV69996(BEL-2)
Reference
  Authors
Poirel L, Brinas L, Verlinde A, Ide L, Nordmann P
  Title
BEL-1, a novel clavulanic acid-inhibited extended-spectrum beta-lactamase, and the class 1 integron In120 in Pseudomonas aeruginosa.
  Journal
Antimicrob Agents Chemother 49:3743-8 (2005)
DOI:10.1128/AAC.49.9.3743-3748.2005
  Sequence

KEGG   ORTHOLOGY: K18768
Entry
K18768            Tight     KO                                     

Name
blaKPC
Definition
beta-lactamase class A KPC [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18768  blaKPC; beta-lactamase class A KPC
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18768  blaKPC; beta-lactamase class A KPC
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18768  blaKPC; beta-lactamase class A KPC
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class A [MT]
    K18768  blaKPC; beta-lactamase class A KPC
Other DBs
COG: COG2367
GO: 0008800
Genes
ECLE: ECNIH2_24690 ECNIH2_25815 ECNIH2_26880
ECLN: ECNIH4_23585
ECLI: ECNIH5_23470
ECLX: LI66_24385
ECLY: LI62_00245
ECLZ: LI64_22410
EHM: AB284_00545
ECLA: ECNIH3_24215
ECLC: ECR091_23505
ECLS: LI67_024640 LI67_024910
KPNE: KU54_01135
KPNU: LI86_28510
AG: AAG13410(KPC-1) AAK70220(KPC-2) AAL05630(KPC-3) ABY91240(KPC-5) ACB71165(KPC-6) ACE62798(KPC-7) ACL01102(KPC-4) ACM91559(KPC-9) ACS35345(KPC-10) ADH95186(KPC-11) AGF70638(KPC-15) AGJ01153(KPC-16) AGJ01154(KPC-17) ANY26940(KPC-26)
 » show all
Reference
  Authors
Yigit H, Queenan AM, Anderson GJ, Domenech-Sanchez A, Biddle JW, Steward CD, Alberti S, Bush K, Tenover FC
  Title
Novel carbapenem-hydrolyzing beta-lactamase, KPC-1, from a carbapenem-resistant strain of Klebsiella pneumoniae.
  Journal
Antimicrob Agents Chemother 45:1151-61 (2001)
DOI:10.1128/AAC.45.4.1151-1161.2001
  Sequence

KEGG   ORTHOLOGY: K18970
Entry
K18970            Tight     KO                                     

Name
blaGES
Definition
beta-lactamase class A GES [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18970  blaGES; beta-lactamase class A GES
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18970  blaGES; beta-lactamase class A GES
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18970  blaGES; beta-lactamase class A GES
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class A [MT]
    K18970  blaGES; beta-lactamase class A GES
Other DBs
COG: COG2367
GO: 0008800
Genes
AG: AAF27723(GES-1) AAF28763(GES-7) AAK18183(GES-8) AAK58421(GES-2) AAR97270(GES-5) AAR97271(GES-6) AAY43207(GES-9) ACS44714(GES-11) ACS73598(GES-10) ACZ54536(GES-13) ADC91899(GES-14) ADP21506(GES-12) AEX59144(GES-18) AEZ05107(GES-19) AEZ05108(GES-20) AFU25739(GES-22) AMY16492(GES-31) AOE46846(GES-32) BAD06399(GES-3) BAD08689(GES-4)
Reference
  Authors
Poirel L, Le Thomas I, Naas T, Karim A, Nordmann P
  Title
Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae.
  Journal
Antimicrob Agents Chemother 44:622-32 (2000)
DOI:10.1128/AAC.44.3.622-632.2000
  Sequence
Reference
  Authors
Poirel L, Carattoli A, Bernabeu S, Bruderer T, Frei R, Nordmann P
  Title
A novel IncQ plasmid type harbouring a class 3 integron from Escherichia coli.
  Journal
J Antimicrob Chemother 65:1594-8 (2010)
DOI:10.1093/jac/dkq166

KEGG   ORTHOLOGY: K19316
Entry
K19316            Tight     KO                                     

Name
blaIMI
Definition
beta-lactamase class A IMI [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K19316  blaIMI; beta-lactamase class A IMI
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19316  blaIMI; beta-lactamase class A IMI
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K19316  blaIMI; beta-lactamase class A IMI
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class A [MT]
    K19316  blaIMI; beta-lactamase class A IMI
Other DBs
COG: COG2367
GO: 0008800
Genes
AG: AAA93461(IMI-1) ABA00479(IMI-2) ACX71212(IMI-3) AME15649(IMI-5) AME15652(IMI-6) AOZ61019(IMI-9)
Reference
PMID:8878585
  Authors
Rasmussen BA, Bush K, Keeney D, Yang Y, Hare R, O'Gara C, Medeiros AA
  Title
Characterization of IMI-1 beta-lactamase, a class A carbapenem-hydrolyzing enzyme from Enterobacter cloacae.
  Journal
Antimicrob Agents Chemother 40:2080-6 (1996)
  Sequence

KEGG   ORTHOLOGY: K22346
Entry
K22346            Tight     KO                                     

Name
blaSME
Definition
beta-lactamase class A SME [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00851  Carbapenem resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K22346  blaSME; beta-lactamase class A SME
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K22346  blaSME; beta-lactamase class A SME
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K22346  blaSME; beta-lactamase class A SME
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class A [MT]
    K22346  blaSME; beta-lactamase class A SME
Other DBs
COG: COG2367
GO: 0008800
Genes
AG: AAG29813(SME-2) AAS92558(SME-3) CAA82281(SME-1)
Reference
PMID:8092824
  Authors
Naas T, Vandel L, Sougakoff W, Livermore DM, Nordmann P
  Title
Cloning and sequence analysis of the gene for a carbapenem-hydrolyzing class A beta-lactamase, Sme-1, from Serratia marcescens S6.
  Journal
Antimicrob Agents Chemother 38:1262-70 (1994)
DOI:10.1128/AAC.38.6.1262
  Sequence

KEGG   ORTHOLOGY: K18795
Entry
K18795            Tight     KO                                     

Name
blaCARB-1
Definition
beta-lactamase class A CARB-1, PSE family [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18795  blaCARB-1; beta-lactamase class A CARB-1, PSE family
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18795  blaCARB-1; beta-lactamase class A CARB-1, PSE family
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18795  blaCARB-1; beta-lactamase class A CARB-1, PSE family
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class A [MT]
    K18795  blaCARB-1; beta-lactamase class A CARB-1, PSE family
Other DBs
COG: COG2367
GO: 0008800
Genes
SEND: DT104_38651
SENI: CY43_20110
KOK: KONIH1_31110
CFQ: C2U38_21210
EBC: C2U52_01470
AEA: C2U39_10270 C2U39_23825
NBL: GJV52_06015
AG: AAA25741(CARB-2) AAB19430(CARB-3) AAC09012(CARB-4) AAD19217(CARB-6) AAG23870(CARB-11) AAK96394(CARB-1) AAM74565(CARB-7) AAP22374(CARB-9) BAA24531(CARB-12)
Reference
PMID:1804019
  Authors
Huovinen P, Jacoby GA
  Title
Sequence of the PSE-1 beta-lactamase gene.
  Journal
Antimicrob Agents Chemother 35:2428-30 (1991)
DOI:10.1128/AAC.35.11.2428
  Sequence
Reference
PMID:1650733
  Authors
Lachapelle J, Dufresne J, Levesque RC
  Title
Characterization of the blaCARB-3 gene encoding the carbenicillinase-3 beta-lactamase of Pseudomonas aeruginosa.
  Journal
Gene 102:7-12 (1991)
DOI:10.1016/0378-1119(91)90530-O
  Sequence

KEGG   ORTHOLOGY: K19218
Entry
K19218            Tight     KO                                     

Name
blaCARB-5
Definition
beta-lactamase class A CARB-5, RTG family [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K19218  blaCARB-5; beta-lactamase class A CARB-5, RTG family
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19218  blaCARB-5; beta-lactamase class A CARB-5, RTG family
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K19218  blaCARB-5; beta-lactamase class A CARB-5, RTG family
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class A [MT]
    K19218  blaCARB-5; beta-lactamase class A CARB-5, RTG family
Other DBs
COG: COG2367
GO: 0008800
Genes
AG: AAF61417(CARB-5) AAO59455(CARB-8) ACJ61335(CARB-10) AFI72872(CARB-14) CCW43444(CARB-16)
Reference
PMID:2786828
  Authors
Paul G, Joly-Guillou ML, Bergogne-Berezin E, Nevot P, Philippon A
  Title
Novel carbenicillin-hydrolyzing beta-lactamase (CARB-5) from Acinetobacter calcoaceticus var. anitratus.
  Journal
FEMS Microbiol Lett 50:45-50 (1989)
DOI:10.1111/j.1574-6968.1988.tb02909.x
  Sequence

KEGG   ORTHOLOGY: K19217
Entry
K19217            Tight     KO                                     

Name
blaCARB-17
Definition
beta-lactamase class A CARB-17 [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K19217  blaCARB-17; beta-lactamase class A CARB-17
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19217  blaCARB-17; beta-lactamase class A CARB-17
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K19217  blaCARB-17; beta-lactamase class A CARB-17
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  beta-Lactamase genes
   Class A [MT]
    K19217  blaCARB-17; beta-lactamase class A CARB-17
Other DBs
COG: COG2367
GO: 0008800
Genes
VPA: VPA0477
VPK: M636_01615
VPF: M634_24140
VPH: VPUCM_21162
VHA: VIBHAR_06370
VCA: M892_20315
VAG: N646_4682
VEX: VEA_001392
VDB: AL552_01025
VHR: AL538_26690(blaCARB)
AG: AGQ96135(CARB-20) AIL92326(CARB-17) KED80204(CARB-46) KHF09587(CARB-45) KHF12803(CARB-44)
 » show all
Reference
  Authors
Chiou J, Li R, Chen S
  Title
CARB-17 family of beta-lactamases mediates intrinsic resistance to penicillins in Vibrio parahaemolyticus.
  Journal
Antimicrob Agents Chemother 59:3593-5 (2015)
DOI:10.1128/AAC.00047-15
  Sequence

KEGG   ORTHOLOGY: K17836
Entry
K17836                      KO                                     

Name
penP
Definition
beta-lactamase class A [EC:3.5.2.6]
Pathway
ko00311  Penicillin and cephalosporin biosynthesis
ko01501  beta-Lactam resistance
Module
M00627  beta-Lactam resistance, Bla system
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00311 Penicillin and cephalosporin biosynthesis
    K17836  penP; beta-lactamase class A
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K17836  penP; beta-lactamase class A
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K17836  penP; beta-lactamase class A
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K17836  penP; beta-lactamase class A
Antimicrobial resistance genes [BR:ko01504]
 Gene sets
  beta-Lactam resistance modules
   beta-Lactam resistance, Bla system
    K17836  penP; beta-lactamase class A
Other DBs
RN: R06363
COG: COG2367
GO: 0008800
Genes
ENR: H650_03175
CRO: ROD_12321
CKO: CKO_01737
CFAR: CI104_14705
HDE: HDEF_1020
ROR: RORB6_05655
RON: TE10_15580
KCO: BWI95_16515
KOT: EH164_11520(bla)
PSTS: E05_01430(bla) E05_01440
YEN: YE2019(blaA)
YEY: Y11_09911
YEW: CH47_1455(bla)
YET: CH48_3830(bla)
YEE: YE5303_18681(blaA)
YIN: CH53_3963(bla)
YRO: CH64_563(bla)
YHI: D5F51_08815(bla)
YCA: F0T03_10920(blaA)
RAA: Q7S_24896
PAM: PANA_1760(bla)
PLF: PANA5342_2445(bla)
PAJ: PAJ_1103(bla)
PVA: Pvag_pPag30396(bla)
PAY: PAU_02294(blaA)
PHAU: PH4a_16465
PCIB: F9282_10335(bla)
PCOL: F1325_10305(bla)
XBO: XBJ1_2301
XBV: XBW1_2050
XNE: XNC1_2406
XDO: XDD1_2196(bla)
XPO: XPG1_1685
ANS: ArsFIN_07340(blaP)
LRI: NCTC12151_03187(bla)
PAET: NCTC13378_01616(penP)
MHAY: VK67_13375
APA: APP7_A0003(bla)
BTO: WQG_950
BTRH: F543_22910
BTRA: F544_3200
XCC: XCC3039(bla)
XCB: XC_1119
XCP: XCR_3367
XCV: XCV3293(penP)
XAX: XACM_3081(penP)
XAC: XAC3162(bla)
XCI: XCAW_03448(penP)
XOM: XOO1261(XOO1261)
XOO: XOO1370(bla)
XOR: XOC_3372
XAL: XALC_2439(PenP)
XPH: XppCFBP6546_03430(XppCFBP6546P_03430)
XHY: FZ025_02090(bla)
XCZ: EBN15_13880(bla)
SML: Smlt3722
SMT: Smal_3136
SMZ: SMD_3327
STES: MG068_16185(blaL2)
LAB: LA76x_0889(blaL2)
LAQ: GLA29479_3075(blaL2)
LEZ: GLE_4415
RGL: CS053_17460(bla)
DKO: I596_231
VFI: VF_1099
VSA: VSAL_I1245(ampC)
PCQ: PcP3B5_44400(blaP)
PPUH: B479_27189
PLUL: FOB45_06685(blaLUT)
PKC: PKB_4017(blaP)
PSEC: CCOS191_3403(bla)
MCT: MCR_1591(bro-2)
MBAH: HYN46_13510(bla)
SMAI: EXU30_01990(bla)
MAQ: Maqu_1080
CJA: CJA_3110
LLO: LLO_3101
LFA: LFA_0266
LHA: LHA_1330(bla)
LLG: 44548918_02714(bla)
LCJ: NCTC11976_00995(per1)
LWA: SAMEA4504053_1505(per1)
TMC: LMI_2127(blaA)
FTU: FTT_0611c FTT_0681c(blaA)
FTF: FTF0611c FTF0681c(blaA)
FTW: FTW_1047(blaA) FTW_1117
FTT: FTV_0571 FTV_0640(blaA)
FTG: FTU_0655 FTU_0724(blaA)
FTH: FTH_0865(bla) FTH_0935(penP)
FTI: FTS_0870(bla) FTS_0937(blaA)
FTM: FTM_0686 FTM_1177(blaA)
FTN: FTN_1002(blaA) FTN_1072
FNA: OOM_1372
FRC: KX01_1452
FMI: F0R74_02395(bla) F0R74_04295(bla)
AFRI: E3E15_03445(bla)
HCH: HCH_02299(penP)
HAHE: ENC22_10445(bla)
HEL: HELO_1444(blaA)
HAM: HALO0878
KUY: FY550_02115(bla)
ADI: B5T_03409
AXE: P40_16010
DNO: DNO_1203
CRZ: D1345_08755(bla)
RME: Rmet_4436(bla)
BMA: BMAA1283(penA)
BMV: BMASAVP1_0257(blaA)
BML: BMA10229_0527(blaA)
BMN: BMA10247_A1040(blaA)
BMAL: DM55_4239(bla)
BMAE: DM78_3933(bla)
BMAQ: DM76_4939(bla)
BMAI: DM57_10615
BMAF: DM51_4939(bla)
BMAZ: BM44_4202(bla)
BMAB: BM45_3324
BPS: BPSS0946(penA)
BPL: BURPS1106A_A1301(blaA)
BPD: BURPS668_A1381(blaA)
BPSE: BDL_4236(blaCTX)
BPSM: BBQ_5190(blaCTX-M-14)
BPSU: BBN_4406(blaCTX-M-27)
BPSD: BBX_6077(blaCTX-M-27)
BPZ: BP1026B_II1037(penA)
BPK: BBK_3489(blaCTX-M-27)
BPSH: DR55_4388(bla)
BPSA: BBU_5083(blaCTX)
BPSO: X996_4184(bla)
BUT: X994_6176(bla)
BTQ: BTQ_4737(bla)
BTJ: BTJ_5679(bla)
BTZ: BTL_4218(bla)
BTD: BTI_5761(bla)
BTV: BTHA_3739(bla)
BTHE: BTN_3473(bla)
BTHM: BTRA_4224(bla)
BTHA: DR62_3546
BTHL: BG87_4194(bla)
BOK: DM82_5116(bla)
BOC: BG90_5478(bla)
BVE: AK36_3450(bla) AK36_4179
BCN: Bcen_3438
BCJ: BCAM2165(penA)
BCEN: DM39_5687(bla)
BCEW: DM40_4597(bla) DM40_4883
BCEO: I35_6047(penA)
BAM: Bamb_4360
BMU: Bmul_3689
BMK: DM80_5070(blaCTX)
BMUL: NP80_4859(bla)
BCT: GEM_3511
BCED: DM42_5829(blaCTX)
BDL: AK34_3586
BUB: BW23_3365 BW23_5419(bla)
BSEM: WJ12_30695
BPSL: WS57_03310
BMEC: WJ16_29295
BGU: KS03_4540(bla)
BGO: BM43_2788 BM43_3975(bla) BM43_4871(bla)
BUL: BW21_5448(bla)
PMEG: FNZ07_21845(bla)
PPNM: LV28_09535
CABA: SBC2_65760
BPA: BPP2606
BBR: BB2049
BHO: D560_3154
BHM: D558_3125
BHZ: ACR54_01737(bla)
PUT: PT7_2256
PIG: EGT29_19600(bla)
POS: DT070_20005(bla)
POO: F7R28_10555(bla)
AJS: Ajs_2328
ACRA: BSY15_3121
ACIO: EAG14_11040(bla)
DAC: Daci_4574
CTES: O987_12510
HYB: Q5W_01915
HYN: F9K07_16780(bla)
DIH: G7047_00305(bla) G7047_11300(bla)
HAR: HEAR0606(blaA)
MMS: mma_0570(penP)
JAS: FJQ89_23840(bla)
HSE: Hsero_3349(penP)
HHF: E2K99_17380(bla)
CFU: CFU_1378(penA)
CARE: LT85_3388
MALI: EYF70_15800(bla)
MUM: FCL38_02640(bla)
MFLA: GO485_27985(bla)
MPLI: E1742_00455(bla)
OFO: BRW83_1540(per1_1) BRW83_1541(per1_2)
UPV: EJN92_03320(bla)
DUG: HH213_29015(bla)
RGE: RGE_19960
XYK: GT347_13145(bla)
PBH: AAW51_1673(penP)
NET: Neut_1060
AZA: AZKH_3652(ampC)
GUR: Gura_3441
GLO: Glov_2580
DPS: DP1876
SAT: SYN_01571
DBR: Deba_2488
MES: Meso_2215
PMOB: HG718_08410(bla)
SFH: SFHH103_00676(bla)
EAD: OV14_1976
ATU: Atu3376
ARA: Arad_1449(bla)
ATF: Ach5_32280(penP)
AGC: BSY240_1515(blaP)
RET: RHE_CH01220(bla)
REL: REMIM1_CH01222(blaP)
REP: IE4803_CH01248(blaP)
REI: IE4771_CH01291(blaP)
RHL: LPU83_1203(bla)
RHN: AMJ98_CH01258(blaP)
RPHA: AMC79_CH01267(blaP)
RHX: AMK02_CH01262(blaP)
REZ: AMJ99_CH01337(blaP)
RJG: CCGE525_06465(bla)
RGR: FZ934_02745(bla)
RAD: CO657_04610(bla)
SHZ: shn_06000
ABAW: D5400_02235(bla)
BJA: bll0941(bla)
BRA: BRADO4063
BBT: BBta_4439
BRS: S23_68730(bla)
AOL: S58_35750
BRAD: BF49_7245
BBET: F8237_13655(bla)
RPA: RPA0362(penP)
RPC: RPC_2728
RPE: RPE_1865
RPT: Rpal_0366
NWI: Nwi_0351
NHA: Nham_0446
OCA: OCAR_6709
BOF: FQV39_25230(bla)
VGO: GJW-30_1_01316(bla)
AZC: AZC_4278
LNE: FZC33_08165(bla)
MET: M446_1390
MNO: Mnod_1011
MOR: MOC_4786
MAQU: Maq22A_c00970(penP)
MMES: MMSR116_05025(bla)
BID: Bind_1435
MSL: Msil_0088
HMC: HYPMC_4554(bla)
BVR: BVIR_499
BLAG: BLTE_21890
MMED: Mame_03023
MCG: GL4_1374
METG: HT051_11710(bla)
BDM: EQG53_08030(bla)
BRF: E4M01_00815(bla)
BREV: E7T10_06040(bla)
BMED: GYM46_11865(bla)
PSF: PSE_3735
PGA: PGA1_c09800(bla)
PGL: PGA2_c09680(bla)
PHP: PhaeoP97_00950(bla)
LEJ: ETW24_01595(bla)
RSU: NHU_03651
LABP: FJ695_27230(bla)
LABT: FIU93_26165(blaP)
SPSE: SULPSESMR1_02829(blaP)
RMM: ROSMUCSMR3_03309(bla)
TAW: EI545_17800(bla)
LIT: FPZ52_06390(bla)
OCD: FHY55_01645(bla)
SIW: GH266_19200(bla)
ZMO: ZMO1967
ZMN: Za10_1202
ZMM: Zmob_1222
ZMI: ZCP4_1240
ZMC: A265_01229(blaP)
ZMR: A254_01228(blaP)
NTD: EGO55_11950(bla) EGO55_15765(bla)
NOG: GKE62_08940(bla)
SAL: Sala_0174
SPHX: E5675_03130(bla)
SPHU: SPPYR_0214
SWI: Swit_0788
SPHD: HY78_22755
SPHM: G432_02170
STAX: MC45_13665
SPKC: KC8_07880
SFLA: SPHFLASMR4Y_03323(smeA)
SPZR: G5C33_01885(bla) G5C33_13365(bla)
ERF: FIU90_00880(per1) FIU90_15310(bla)
AAY: WYH_02622(per1)
ANH: A6F65_00201(per1_1) A6F65_01500(per1_2) A6F65_02522(bla_2)
ALB: AEB_P0900
GDI: GDI1971(bla)
APK: APA386B_1P81(bla)
ASZ: ASN_1094 ASN_2809(bla)
RMUC: FOB66_19620(bla)
NTN: D5366_08690(bla)
BOMB: GT348_07785(bla)
RRU: Rru_A0228
RRF: F11_01145
MAGX: XM1_1292
AZL: AZL_a02580(penP)
TMO: TMO_b0165
TXI: TH3_03980
ECOG: FIV45_15195(bla)
BSU: BSU18800(penP)
BSR: I33_2109
BSL: A7A1_2750
BSH: BSU6051_18800(penP)
BSUT: BSUB_02022(penP)
BSUL: BSUA_02022(penP)
BSUS: Q433_11120
BSS: BSUW23_10070(penP)
BST: GYO_2268
BSQ: B657_18800(penP)
BSX: C663_1943(penP)
BLI: BL01642(blaP)
BLD: BLi00280(penP)
BLH: BaLi_c02980(penP)
BAY: RBAM_012080(bla)
BAQ: BACAU_1160(bla1)
BYA: BANAU_1140(penP1)
BAMP: B938_06160
BAML: BAM5036_1114(penP)
BAMA: RBAU_1162(penP)
BAMN: BASU_1142(penP)
BAMB: BAPNAU_2584(bla1)
BAMT: AJ82_06780
BAMY: V529_11500(penP)
BMP: NG74_01229(penP)
BAO: BAMF_1288(penP)
BAZ: BAMTA208_11135(penP)
BQL: LL3_01297(penP)
BXH: BAXH7_02279(penP)
BQY: MUS_1287(penP)
BAMI: KSO_013535
BAMC: U471_12090
BAMF: U722_06275
BSON: S101395_02086(penP)
BAN: BA_2507(bla1)
BAR: GBAA_2507(bla1)
BAT: BAS2328
BAH: BAMEG_2095(bla1)
BAI: BAA_2563(bla1)
BANT: A16_25350
BANR: A16R_25660
BANS: BAPAT_2397
BANV: DJ46_1287(penPC)
BCE: BC2473
BCA: BCE_2539
BCZ: BCE33L2247(bla)
BCR: BCAH187_A2595(bla1)
BCU: BCAH820_2522(bla1)
BCQ: BCQ_2417(bla)
BCX: BCA_2591(bla1)
BAL: BACI_c24760(bla2)
BNC: BCN_2412
BCF: bcf_12555
BCER: BCK_22475
BTK: BT9727_2291(bla)
BTL: BALH_2254
BTB: BMB171_C2234(bla1)
BTM: MC28_0176(blaZ) MC28_1711(blaCI) MC28_1922
BTG: BTB_c25770(bla) BTB_c32940(blaZ)
BTW: BF38_3693(penPC)
BWW: bwei_2413(blaZ2) bwei_2507(penPC) bwei_4089(blaZ1)
BMYO: BG05_3403(blaZ) BG05_3529(penPC) BG05_4977(blaZ)
BMYC: DJ92_419(blaZ) DJ92_5322 DJ92_5561(penPC)
BCL: ABC0264(penP)
BMQ: BMQ_1482 BMQ_3358(penP)
BMD: BMD_1464 BMD_3363(penP)
BMEG: BG04_274(penP) BG04_3773
BACP: SB24_03775
BACB: OY17_09145
BACY: QF06_08525
BACL: BS34A_20820(penP)
BALM: BsLM_2003
BGY: BGLY_2792
LSP: Bsph_2288
VPN: A21D_02032(blaZ)
AQT: FN924_01255(bla)
PSYO: PB01_20255
GRC: GI584_23080(bla)
LIN: lin0199
LWE: lwe0137
LSG: lse_0140
LIV: LIV_0130
PPY: PPE_02407
PPOY: RE92_24010
PMS: KNP414_02412(penP)
PMW: B2K_13525
BTS: Btus_1014
SIV: SSIL_1575
KZO: NCTC404_00527(penP)
KEB: GXN75_06325(bla)
SAG: SAG0795
SAN: gbs0815
SAK: SAK_0920
SGC: A964_0799
SAGM: BSA_8840
SAGI: MSA_9400
SAGR: SAIL_9410
SAGE: EN72_04715
SAGG: EN73_04415
STL: stu0721
STE: STER_0765
STN: STND_0712
STW: Y1U_C0690
STHE: T303_04830
SSA: SSA_0722
SGO: SGO_1598
SUB: SUB1241
SDA: GGS_1318
SIK: K710_0623
LPL: lp_0469(bla1) lp_2341(bla2)
LPJ: JDM1_0396(bla1) JDM1_1958(bla2)
LPT: zj316_0635(bla1) zj316_2316(bla2)
LPS: LPST_C0396(bla1) LPST_C1946(bla2)
LAC: LBA1639
LAD: LA14_1640
LAF: SD55_1642
LSA: LCA_1706
LBU: LBUL_1760
LBR: LVIS_2002
LCA: LSEI_2771
LCS: LCBD_0369(ampC) LCBD_2987
LCE: LC2W_0365(ampC) LC2W_2975
LPAP: LBPC_2716
LRE: Lreu_1541
LRF: LAR_1451
LRT: LRI_0419
LHE: lhv_1743
LHL: LBHH_1658
LHV: lhe_0475
LHH: LBH_1464
LHD: HUO_09795
LFR: LC40_1005
LRH: LGG_02773
LRG: LRHM_2667
LRA: LRHK_2877
LCR: LCRIS_01666(penP)
LAM: LA2_09225
LBH: Lbuc_1247
LKE: WANG_1213
LAE: LBAT_1367
PPE: PEPE_0055
PPEN: T256_00275
PCE: PECL_121(bla2) PECL_450
EFA: EF1502
EFL: EF62_1882
EFS: EFS1_1256
EFN: DENG_01669(ampC)
EFQ: DR75_506
ECAS: ECBG_02908
MPS: MPTP_1048
MPX: MPD5_0900
OOE: OEOE_1067
CML: BN424_713(penPC)
CARC: NY10_1814
CAC: CA_C0190
CAE: SMB_G0195
CAY: CEA_G0195
CPE: CPE1184
CPF: CPF_1388
CPR: CPR_1202
CBY: CLM_0798
CBK: CLL_A2831
CBT: CLH_2558
CBE: Cbei_0999
CBZ: Cbs_0999
CBEI: LF65_01051
CKL: CKL_2902(bla)
CKR: CKR_2572
CSQ: CSCA_1531
AMT: Amet_2066
AOE: Clos_0923
ASF: SFBM_1060
ASM: MOUSESFB_0990(bla)
ASB: RATSFB_0905(bla)
CTH: Cthe_1169
CCE: Ccel_0725
CSD: Clst_0497
FPR: FP2_23450
SALQ: SYNTR_1861
HMO: HM1_2490
TMR: Tmar_1657
SAY: TPY_1381
THX: Thet_1963
TIT: Thit_1866
MTA: Moth_2055
MTHO: MOTHE_c21030(yocH3)
MTHZ: MOTHA_c21800(yocH3)
APR: Apre_0567
VPR: Vpar_0488
MHG: MHY_24350
AIN: Acin_0469(ampC) Acin_1310(ampC) Acin_1664 Acin_2267(ampC)
LPIL: LIP_3021
MTU: Rv2068c(blaC)
MTC: MT2128(bla)
MRA: MRA_2082(blaC)
MTUR: CFBS_2189(blaC)
MTO: MTCTRI2_2106(blaC)
MTD: UDA_2068c(blaC)
MTN: ERDMAN_2283(blaC)
MTUC: J113_14275
MTUE: J114_11070
MTUH: I917_14570
MTUL: TBHG_02026
MTUT: HKBT1_2183(blaC)
MTUU: HKBT2_2184(blaC)
MTQ: HKBS1_2188(blaC)
MBO: BQ2027_MB2094C(blaC)
MBB: BCG_2087c(blaC)
MBT: JTY_2081(blaC)
MBM: BCGMEX_2071c(blaC)
MBX: BCGT_1892
MAF: MAF_20830(blaC)
MMIC: RN08_2293
MCE: MCAN_20911(blaC)
MCQ: BN44_40360(blaC)
MCV: BN43_31261(blaC)
MCX: BN42_30379(blaC)
MCZ: BN45_50375(blaC)
MUL: MUL_2294(blaC)
MMC: Mmcs_2102
MKM: Mkms_2148
MJL: Mjls_2085
MMI: MMAR_3050(blaC)
MMAE: MMARE11_29730(blaC)
MGRO: FZ046_16685(bla)
MVA: Mvan_2352
MGI: Mflv_4021
MPHL: MPHLCCUG_03177(blaF)
MVQ: MYVA_2244
MTHN: 4412656_01717(blaF)
MHAS: MHAS_02405(blaF)
MAB: MAB_2875
MABB: MASS_2816
MSTE: MSTE_02838
MSAL: DSM43276_02595(bla)
CJK: jk0411
CUR: cu1572
COA: DR71_1886
NFA: NFA_23080
NFR: ERS450000_01790(bla)
RER: RER_09980
REY: O5Y_04490
REQ: REQ_40330
RFA: A3L23_02154(blaF)
RHS: A3Q41_01224(blaF)
RRT: 4535765_00935(blaB) 4535765_00937(blaF)
GOR: KTR9_0321
GRU: GCWB2_01400(blaB)
GOM: D7316_03732(blaB)
TPR: Tpau_3972
SRT: Srot_2182
SCO: SCO0088(SCJ11.17c) SCO3774(SCH63.21)
SMA: SAVERM_4452(blaA3)
SGR: SGR_457
SCT: SCAT_0807 SCAT_5692(blaA)
SFA: Sfla_0196
SVE: SVEN_0089
STRP: F750_6823
SGU: SGLAU_11480(blaF)
STRM: M444_08250
SRW: TUE45_00520(blaB) TUE45_00522(bla)
SLE: sle_04180(sle_04180)
STRD: NI25_18515
SALF: SMD44_04975(penP) SMD44_06062(penP)
SALJ: SMD11_0193(penP) SMD11_0196(penP) SMD11_6895(penP)
SKY: D0C37_13615(bla) D0C37_31805(bla)
KSK: KSE_57690
LXX: Lxx01020
CMI: CMM_2676(blaC) CMM_2818
CMS: CMS3023
CMC: CMN_02784
MTS: MTES_1815
CQF: GBG65_02635(bla)
ARM: ART_0616
CELZ: E5225_16105(bla)
BLIN: BLSMQ_3316
AEF: GEV26_07510(bla)
NAL: B005_3868(penP) B005_3870(blaB)
STRR: EKD16_18715(blaB) EKD16_18725(blaZ)
SACC: EYD13_15475(blaB)
AMD: AMED_5122 AMED_5124(ampC) AMED_6962(ampC)
AOI: AORI_2619(ampC) AORI_3397(ampC) AORI_3399(ampC) AORI_3649(ampC) AORI_4231(ampC) AORI_4233(ampC)
AMQ: AMETH_2276(penP) AMETH_2278(ampC)
AMYY: YIM_08600 YIM_39155(penPC) YIM_40010(blaB2)
PSEA: WY02_19635
PAUT: Pdca_07880
AHG: AHOG_04020(penPC) AHOG_04030(blaB) AHOG_13710 AHOG_17515(penP)
ALO: CRK59788
BLL: BLJ_0695
BAD: BAD_1308
BBI: BBIF_1359(ampC) BBIF_1524
BBRU: Bbr_0236
BBRE: B12L_0198
BBRV: B689b_0216
BBRJ: B7017_0222
BBRC: B7019_0218
BBRN: B2258_0216
BBRS: BS27_0244
BBRD: BBBR_0189
RXY: Rxyl_1712
SYN: slr0121
SYY: SYNGTS_2697(slr0121)
SYT: SYNGTI_2696(slr0121)
SYS: SYNPCCN_2695(slr0121)
SYQ: SYNPCCP_2695(slr0121)
SYC: syc0060_d(ampC)
SYW: SYNW0718
SYG: sync_0964
CYA: CYA_0811
CYB: CYB_1894
SYNR: KR49_04930
SYND: KR52_06525
TEL: tll2115
THN: NK55_07240(pbpA)
PMA: Pro_1145(penP)
PMT: PMT_1133
PMF: P9303_08971(penP)
PMJ: P9211_11351(penP)
PME: NATL1_15311(penP)
PRM: EW15_1593
AMR: AM1_1804
MAR: MAE_18700
MPK: VL20_4751
CYL: AA637_05505(blaZ)
CYT: cce_2988
GLJ: GKIL_0854(ampC)
NAZ: Aazo_4223
CALH: IJ00_10780
NSP: BMF81_00007(penP)
DOU: BMF77_03174(pse1)
CEO: ETSB_1059
RCA: Rcas_2152
TRO: trd_1353
ATM: ANT_12090
DRA: DR_0433
AMU: Amuc_0183
AGL: PYTT_1668
PLH: VT85_16365(blaB) VT85_24625(per1)
GES: VT84_19440(per1)
PBOR: BSF38_01680(carB6)
AGV: OJF2_16120(blaF)
ACA: ACP_3424
ABAC: LuPra_06285(smeA)
FNU: FN1584
SBR: SY1_01420
GAU: GAU_3209
BTH: BT_4507
BTHO: Btheta7330_03574(per1)
BFR: BF1250
BFS: BF9343_1140(cepA)
BVU: BVU_3257
BXY: BXY_36210
BOA: Bovatus_04722(per1)
BCEL: BcellWH2_04769(per1)
BIS: DXK01_013180(bla)
DUN: FDZ78_12915(bla)
DYS: G7050_14655(bla)
BUY: D8S85_21205(cfxA)
ALD: GFH31_00335(bla)
MBAS: ALGA_1704
RMR: Rmar_2815
FLN: FLA_0770
SGN: SGRA_1440(ampC)
PHE: Phep_3104
SMIZ: 4412673_01869(blaP) 4412673_02131(per1)
SPHE: GFH32_01440(bla)
FAE: FAES_1414 FAES_5233(per1)
RAG: B739_0036
RAE: G148_1774
MARM: YQ22_12570
CBAL: M667_10685
CBAT: M666_10690
DDO: I597_2226
NDO: DDD_1506
ELB: VO54_01170(per1)
ELZ: FCS00_01845(bla) FCS00_03580(blaCME)
MPW: MPR_1730
CIO: CEQ15_09860(bla-A)
CSHA: EG350_08430(bla-A)
CJT: EG359_03900(bla) EG359_07170(bla)
CLAC: EG342_21215(bla-A)
SPON: HME9304_01756(penP)
CNR: EB819_03610(bla) EB819_07035(bla)
EBV: F0358_00095(bla) F0358_13190(bla)
APIB: G8C43_04175(bla)
MESQ: C7H62_2446
FBA: FIC_00927
SAAL: L336_0491
AG: CAB51471(ACI-1)
 » show all
Reference
  Authors
Bush K
  Title
Proliferation and significance of clinically relevant beta-lactamases.
  Journal
Ann N Y Acad Sci 1277:84-90 (2013)
DOI:10.1111/nyas.12023
Reference
  Authors
Babic M, Hujer AM, Bonomo RA
  Title
What's new in antibiotic resistance? Focus on beta-lactamases.
  Journal
Drug Resist Updat 9:142-56 (2006)
DOI:10.1016/j.drup.2006.05.005
Reference
  Authors
Walther-Rasmussen J, Hoiby N
  Title
Class A carbapenemases.
  Journal
J Antimicrob Chemother 60:470-82 (2007)
DOI:10.1093/jac/dkm226

KEGG   ORTHOLOGY: K18766
Entry
K18766                      KO                                     

Name
blaZ
Definition
beta-lactamase class A BlaZ [EC:3.5.2.6]
Pathway
ko01501  beta-Lactam resistance
Module
M00627  beta-Lactam resistance, Bla system
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01501 beta-Lactam resistance
    K18766  blaZ; beta-lactamase class A BlaZ
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18766  blaZ; beta-lactamase class A BlaZ
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.6  beta-lactamase
     K18766  blaZ; beta-lactamase class A BlaZ
Antimicrobial resistance genes [BR:ko01504]
 Gene sets
  beta-Lactam resistance modules
   beta-Lactam resistance, Bla system
    K18766  blaZ; beta-lactamase class A BlaZ
Other DBs
RN: R06363
COG: COG2367
GO: 0008800
Genes
VGA: BSQ33_18960
AGU: AS4_15070
PSEO: OM33_17620
SAU: SAP010(blaZ)
SAH: SaurJH1_2827
SAJ: SaurJH9_2749
SAS: pSAS19(blaZ)
SAR: SAR1831(blaZ)
SAX: pUSA300HOUMR0011(blaZ)
SUJ: SAA6159_p11(blaZ)
SUK: SAA6008_02629(blaZ)
SUX: SAEMRSA15_18340(blaZ)
SUW: SATW20_27120(blaZ)
SUG: SAPIG2020
SUF: SARLGA251_00250(blaZ)
SAUA: SAAG_00701
SAUE: RSAU_001811(blaZ)
SAUZ: SAZ172_2690(blaZ)
SAUB: C248_2004(blaZ)
SAUM: BN843_p90
SAUC: CA347_2797(blaZ)
SAUR: SABB_01983(blaZ)
SAUI: AZ30_14230
SUH: SAMSHR1132_p190(blaZ)
SER: SEA0003(blaZ-2) SERP1461(blaZ-1)
SEP: SE1608
SEPP: SEB_01595
SHA: SH1764(blaZ)
SHH: ShL2_02380(blaZ)
SSP: SSP2186
SDT: SPSE_1776(blaZ-1) SPSE_2387(blaZ-2)
SXO: SXYL_02347(blaZ)
SSCZ: RN70_01425
SAGQ: EP23_00820(blaZ)
SSCU: CEP64_12965(bla)
SKL: C7J89_02525(bla)
SCAR: DWB96_13140(blaZ)
SCHR: DWB92_08940(blaZ)
MCL: MCCL_plsB0024(blaZm)
MCAK: MCCS_00780
MHA: HF1_12520
MHF: MHF_1331
SIR: SiRe_0603
 » show all

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