KEGG   ORTHOLOGY: K18818
Entry
K18818                      KO                                     

Name
mgs
Definition
mannosylglycerate synthase [EC:2.4.1.269]
Pathway
ko00051  Fructose and mannose metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00051 Fructose and mannose metabolism
    K18818  mgs; mannosylglycerate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.269  mannosylglycerate synthase
     K18818  mgs; mannosylglycerate synthase
Other DBs
RN: R09666
CAZy: GT78
Genes
RMR: Rmar_1220
RMG: Rhom172_1264
Reference
  Authors
Martins LO, Empadinhas N, Marugg JD, Miguel C, Ferreira C, da Costa MS, Santos H
  Title
Biosynthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus. Biochemical and genetic characterization of a mannosylglycerate synthase.
  Journal
J Biol Chem 274:35407-14 (1999)
DOI:10.1074/jbc.274.50.35407
  Sequence
[rmr:Rmar_1220]

KEGG   ENZYME: 2.4.1.269
Entry
EC 2.4.1.269                Enzyme                                 

Name
mannosylglycerate synthase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
GDP-alpha-D-mannose:D-glycerate 2-alpha-D-mannosyltransferase
Reaction(IUBMB)
GDP-alpha-D-mannose + D-glycerate = GDP + 2-O-(alpha-D-mannopyranosyl)-D-glycerate [RN:R09666]
Reaction(KEGG)
R09666
Substrate
GDP-alpha-D-mannose [CPD:C00096];
D-glycerate [CPD:C00258]
Product
GDP [CPD:C00035];
2-O-(alpha-D-mannopyranosyl)-D-glycerate [CPD:C11544]
Comment
Rhodothermus marinus can also form mannosylglycerate via a two-step pathway catalysed by EC 2.4.1.217 (mannosyl-3-phosphoglycerate synthase) and EC 3.1.3.70 (mannosyl-3-phosphoglycerate phosphatase) [1]. Depending on experimental conditions mannosylglycerate synthase is more or less specific for the GDP-mannose and D-glycerate [1,2].
History
EC 2.4.1.269 created 2011
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
Orthology
K18818  mannosylglycerate synthase
Genes
RMR: Rmar_1220
RMG: Rhom172_1264
Reference
1  [PMID:10585410]
  Authors
Martins LO, Empadinhas N, Marugg JD, Miguel C, Ferreira C, da Costa MS, Santos H
  Title
Biosynthesis of mannosylglycerate in the thermophilic bacterium Rhodothermus marinus. Biochemical and genetic characterization of a mannosylglycerate synthase.
  Journal
J Biol Chem 274:35407-14 (1999)
DOI:10.1074/jbc.274.50.35407
  Sequence
[rmr:Rmar_1220]
Reference
2  [PMID:15951819]
  Authors
Flint J, Taylor E, Yang M, Bolam DN, Tailford LE, Martinez-Fleites C, Dodson EJ, Davis BG, Gilbert HJ, Davies GJ
  Title
Structural dissection and high-throughput screening of mannosylglycerate synthase.
  Journal
Nat Struct Mol Biol 12:608-14 (2005)
DOI:10.1038/nsmb950
  Sequence
[rmr:Rmar_1220]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.269
IUBMB Enzyme Nomenclature: 2.4.1.269
ExPASy - ENZYME nomenclature database: 2.4.1.269
BRENDA, the Enzyme Database: 2.4.1.269

KEGG   REACTION: R09666
Entry
R09666                      Reaction                               

Name
GDP-mannose:D-glycerate 2-alpha-D-mannosyltransferase
Definition
GDP-mannose + D-Glycerate <=> GDP + 2-O-(alpha-D-Mannosyl)-D-glycerate
Equation
Reaction class
RC00005  C00035_C00096
RC00397  C00258_C11544
Enzyme
Pathway
rn00051  Fructose and mannose metabolism
rn01100  Metabolic pathways
Orthology
K18818  mannosylglycerate synthase [EC:2.4.1.269]
Other DBs
RHEA: 30642

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