KEGG   ORTHOLOGY: K18856
Entry
K18856                      KO                                     

Name
vanC, vanE, vanG
Definition
D-alanine---D-serine ligase [EC:6.3.2.35]
Pathway
ko01502  Vancomycin resistance
ko02020  Two-component system
Module
M00652  Vancomycin resistance, D-Ala-D-Ser type
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K18856  vanC, vanE, vanG; D-alanine---D-serine ligase
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01502 Vancomycin resistance
    K18856  vanC, vanE, vanG; D-alanine---D-serine ligase
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18856  vanC, vanE, vanG; D-alanine---D-serine ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.35  D-alanine---D-serine ligase
     K18856  vanC, vanE, vanG; D-alanine---D-serine ligase
Antimicrobial resistance genes [BR:ko01504]
 Gene sets
  Vancomycin resistance modules
   Vancomycin resistance, D-Ala-D-Ser type
    K18856  vanC, vanE, vanG; D-alanine---D-serine ligase
Other DBs
COG: COG1181
Genes
BBE: BBR47_05870
BFM: BP422_28590(vanB)
PBJ: VN24_01315(vanB)
SANS: DK43_03860(vanB)
ECAS: ECBG_02849
EGA: AL523_09465
VCP: H9L18_13855(vanC)
CLB: Clo1100_2030
CACE: CACET_c25480(vanA)
CFM: BJL90_20410(vanB)
CARG: RSJ17_11295(vanB)
AOE: Clos_2860
FPLA: A4U99_10115(vanB)
OVA: OBV_09510
CSO: CLS_04660
HSD: SD1D_0541(ddl2)
ACEL: acsn021_25810(vanG)
CDF: CD630_16260(vanG)
PDC: CDIF630_01803(vanG)
CDC: CD196_1549(vanG)
CDL: CDR20291_1524(vanG)
PDF: CD630DERM_16260(vanG)
ABUT: Ami103574_02975(vanG) Ami103574_07960(vanG)
CAD: Curi_c05060(vanG)
EUC: EC1_04100
AARG: Aargi30884_01290(vanG)
ABSI: A9CBEGH2_02850(vanG)
ERM: EYR00_02855(vanG)
AG: AAA24786(vanC)
 » show all
Reference
  Authors
Nishiyama M, Iguchi A, Suzuki Y
  Title
Identification of Enterococcus faecium and Enterococcus faecalis as vanC-type Vancomycin-Resistant Enterococci (VRE) from sewage and river water in the provincial city of Miyazaki, Japan.
  Journal
J Environ Sci Health A Tox Hazard Subst Environ Eng 50:16-25 (2015)
DOI:10.1080/10934529.2015.964599
Reference
  Authors
Boyd DA, Cabral T, Van Caeseele P, Wylie J, Mulvey MR
  Title
Molecular characterization of the vanE gene cluster in vancomycin-resistant Enterococcus faecalis N00-410 isolated in Canada.
  Journal
Antimicrob Agents Chemother 46:1977-9 (2002)
DOI:10.1128/AAC.46.6.1977-1979.2002
Reference
  Authors
Meziane-Cherif D, Saul FA, Haouz A, Courvalin P
  Title
Structural and functional characterization of VanG D-Ala:D-Ser ligase associated with vancomycin resistance in Enterococcus faecalis.
  Journal
J Biol Chem 287:37583-92 (2012)
DOI:10.1074/jbc.M112.405522

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