KEGG   ORTHOLOGY: K18856
Entry
K18856                      KO                                     
Symbol
vanC, vanE, vanG
Name
D-alanine---D-serine ligase [EC:6.3.2.35]
Pathway
map01502  Vancomycin resistance
map02020  Two-component system
Module
M00652  Vancomycin resistance, D-Ala-D-Ser type
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    K18856  vanC, vanE, vanG; D-alanine---D-serine ligase
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01502 Vancomycin resistance
    K18856  vanC, vanE, vanG; D-alanine---D-serine ligase
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K18856  vanC, vanE, vanG; D-alanine---D-serine ligase
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.35  D-alanine---D-serine ligase
     K18856  vanC, vanE, vanG; D-alanine---D-serine ligase
Antimicrobial resistance genes [BR:ko01504]
 Gene sets
  Vancomycin resistance modules
   Vancomycin resistance, D-Ala-D-Ser type
    K18856  vanC, vanE, vanG; D-alanine---D-serine ligase
Other DBs
COG: COG1181
Genes
CGOT: J1899_06180(vanG)
ALKL: MM271_03695(vanG)
BBE: BBR47_05870
BFM: BP422_28590(vanB)
BBOR: RFB14_20030(vanG)
BRUM: NDK47_11545(vanG) NDK47_20795(vanG)
PBJ: VN24_01315(vanB)
PSOP: KP014_14540(vanG)
PTHI: NDS46_12310(vanG)
PMAH: PTQ21_20225(vanG)
PDY: QJQ58_09795(vanG)
PSPN: L1F29_01965(vanG)
PPAB: KET34_16100(vanG)
CHEB: HH215_23270(vanG)
PLIG: NAG76_22720
SANS: DK43_03860(vanB)
ECAS: ECBG_02849
EGA: AL523_09465
EIE: ENLAB_26750(ddlA_2)
ENI: CXM95_04560
VCP: H9L18_13855(vanC)
VFV: K5K99_04105(vanC)
CLB: Clo1100_2030
CACE: CACET_c25480(vanA)
CFM: BJL90_20410(vanB)
CARG: RSJ17_11295(vanB)
RPAY: P0092_11950(vanG)
FPLA: A4U99_10115(vanB)
RGV: NQ502_15010(vanG)
OVA: OBV_09510
PFAA: MM59RIKEN_12790(vanG)
VCOP: MM50RIKEN_08120(vanG)
LASA: L9O85_05970
CFEM: HCR03_19250(vanG)
DGI: Desgi_1749
IBU: IB211_01760
CSO: CLS_04660
LXA: OW255_13715(vanG)
HSD: SD1D_0541(ddl2)
ACEL: acsn021_25810(vanG)
ACHT: bsdcttw_22890(vanG)
QDO: H9Q78_03830(vanG)
WHJ: H9Q79_01750(vanG)
KIB: RBB56_07950(vanG)
CLE: Clole_1511
VGU: HYG85_23280(vanG)
ABUT: Ami103574_02975(vanG) Ami103574_07960(vanG)
ETM: CE91St48_02960(vanG)
AOE: Clos_2860
CDF: CD630_16260(vanG)
PDC: CDIF630_01803(vanG)
CDC: CD196_1549(vanG)
CDL: CDR20291_1524(vanG)
PDF: CD630DERM_16260(vanG)
CAD: Curi_c05060(vanG)
SEDZ: JYG23_10725
EUC: EC1_04100
AARG: Aargi30884_01290(vanG)
ABSI: A9CBEGH2_02850(vanG)
LCG: L3BBH23_19070(vanG)
ERB: A4V01_15880
CIU: G4D55_13020
ERM: EYR00_02855(vanG)
CALK: HUE98_13540(vanG)
RTS: CE91St31_07130(vanG)
AG: AAA24786(vanC)
 » show all
Reference
PMID:25438128
  Authors
Nishiyama M, Iguchi A, Suzuki Y
  Title
Identification of Enterococcus faecium and Enterococcus faecalis as vanC-type Vancomycin-Resistant Enterococci (VRE) from sewage and river water in the provincial city of Miyazaki, Japan.
  Journal
J Environ Sci Health A Tox Hazard Subst Environ Eng 50:16-25 (2015)
DOI:10.1080/10934529.2015.964599
Reference
PMID:12019119
  Authors
Boyd DA, Cabral T, Van Caeseele P, Wylie J, Mulvey MR
  Title
Molecular characterization of the vanE gene cluster in vancomycin-resistant Enterococcus faecalis N00-410 isolated in Canada.
  Journal
Antimicrob Agents Chemother 46:1977-9 (2002)
DOI:10.1128/AAC.46.6.1977-1979.2002
Reference
PMID:22969085
  Authors
Meziane-Cherif D, Saul FA, Haouz A, Courvalin P
  Title
Structural and functional characterization of VanG D-Ala:D-Ser ligase associated with vancomycin resistance in Enterococcus faecalis.
  Journal
J Biol Chem 287:37583-92 (2012)
DOI:10.1074/jbc.M112.405522

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Ontology (4)   
   KEGG BRITE (3)   
   COG (1)   
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (811)   
   KEGG GENES (68)   
   KEGG MGENES (637)   
   RefGene (105)   
   OC (1)   
Literature (3)   
   PubMed (3)   
All databases (824)   

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