KEGG   ORTHOLOGY: K18884Help
Entry
K18884                      KO                                     

Name
FGAMT
Definition
4-dimethylallyltryptophan N-methyltransferase [EC:2.1.1.261]
Pathway
ko00901  Indole alkaloid biosynthesis
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K18884  FGAMT; 4-dimethylallyltryptophan N-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.261  4-dimethylallyltryptophan N-methyltransferase
     K18884  FGAMT; 4-dimethylallyltryptophan N-methyltransferase
BRITE hierarchy
Other DBs
RN: R10166
Genes
MAW: MAC_06987
MAJ: MAA_06738
PLJ: VFPFJ_09684
GLZ: GLAREA_05928
AFM: AFUA_2G18060
ABE: ARB_04647
TVE: TRV_01861
AG: ACI43096(fgaMT)
TaxonomyKoalaUniProt
Reference
  Authors
Rigbers O, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus. Overproduction and biochemical characterization of a 4-dimethylallyltryptophan N-methyltransferase.
  Journal
J Biol Chem 283:26859-68 (2008)
DOI:10.1074/jbc.M804979200
  Sequence

KEGG   ENZYME: 2.1.1.261Help
Entry
EC 2.1.1.261                Enzyme                                 

Name
4-dimethylallyltryptophan N-methyltransferase;
fgaMT (gene name);
easF (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:4-(3-methylbut-2-enyl)-L-tryptophan N-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 4-dimethylallyl-L-tryptophan = S-adenosyl-L-homocysteine + 4-dimethylallyl-L-abrine [RN:R10166]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
4-dimethylallyl-L-tryptophan [CPD:C04290]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
4-dimethylallyl-L-abrine [CPD:C20410]
Comment
The enzyme catalyses a step in the pathway leading to biosynthesis of ergot alkaloids in certain fungi.
History
EC 2.1.1.261 created 2012
Pathway
ec00901  Indole alkaloid biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K18884  4-dimethylallyltryptophan N-methyltransferase
Genes
MAW: MAC_06987
MAJ: MAA_06738
PLJ: VFPFJ_09684
GLZ: GLAREA_05928
AFM: AFUA_2G18060
ABE: ARB_04647
TVE: TRV_01861
Taxonomy
Reference
1  [PMID:18678866]
  Authors
Rigbers O, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus. Overproduction and biochemical characterization of a 4-dimethylallyltryptophan N-methyltransferase.
  Journal
J Biol Chem 283:26859-68 (2008)
DOI:10.1074/jbc.M804979200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.261
IUBMB Enzyme Nomenclature: 2.1.1.261
ExPASy - ENZYME nomenclature database: 2.1.1.261
BRENDA, the Enzyme Database: 2.1.1.261

KEGG   REACTION: R10166Help
Entry
R10166                      Reaction                               

Name
S-adenosyl-L-methionine:4-(3-methylbut-2-enyl)-L-tryptophan N-methyltransferase
Definition
4-(3-Methylbut-2-enyl)-L-tryptophan + S-Adenosyl-L-methionine <=> 4-Dimethylallyl-L-abrine + S-Adenosyl-L-homocysteine
Equation
Reaction class
RC00003  C00019_C00021
RC00190  C04290_C20410
Enzyme
Pathway
rn00901  Indole alkaloid biosynthesis
rn01130  Biosynthesis of antibiotics
Orthology
K18884  4-dimethylallyltryptophan N-methyltransferase [EC:2.1.1.261]
Other DBs
RHEA: 34438

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