KEGG   ORTHOLOGY: K19102Help
Entry
K19102                      KO                                     

Name
nocA
Definition
nocardicin nonribosomal peptide synthetase NocA
Pathway
ko00261  Monobactam biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00736  Nocardicin A biosynthesis, L-pHPG + arginine + serine => nocardicin A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00261 Monobactam biosynthesis
    K19102  nocA; nocardicin nonribosomal peptide synthetase NocA
BRITE hierarchy
Other DBs
RN: R10880
Genes
AMI: Amir_4589
TaxonomyKoalaUniProt
Reference
  Authors
Gunsior M, Breazeale SD, Lind AJ, Ravel J, Janc JW, Townsend CA
  Title
The biosynthetic gene cluster for a monocyclic beta-lactam antibiotic, nocardicin A.
  Journal
Chem Biol 11:927-38 (2004)
DOI:10.1016/j.chembiol.2004.04.012

KEGG   ORTHOLOGY: K19103Help
Entry
K19103                      KO                                     

Name
nocB
Definition
nocardicin nonribosomal peptide synthetase NocB
Pathway
ko00261  Monobactam biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00736  Nocardicin A biosynthesis, L-pHPG + arginine + serine => nocardicin A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00261 Monobactam biosynthesis
    K19103  nocB; nocardicin nonribosomal peptide synthetase NocB
BRITE hierarchy
Other DBs
RN: R10880
Genes
AMI: Amir_4588
TaxonomyKoalaUniProt
Reference
  Authors
Gunsior M, Breazeale SD, Lind AJ, Ravel J, Janc JW, Townsend CA
  Title
The biosynthetic gene cluster for a monocyclic beta-lactam antibiotic, nocardicin A.
  Journal
Chem Biol 11:927-38 (2004)
DOI:10.1016/j.chembiol.2004.04.012

KEGG   ORTHOLOGY: K05375Help
Entry
K05375                      KO                                     

Name
mbtH, nocI
Definition
MbtH protein
Pathway
ko00261  Monobactam biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00736  Nocardicin A biosynthesis, L-pHPG + arginine + serine => nocardicin A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00261 Monobactam biosynthesis
    K05375  mbtH, nocI; MbtH protein
BRITE hierarchy
Other DBs
RN: R10880
COG: COG3251
Genes
GQU: AWC35_18930
KCO: BWI95_06450 BWI95_06465
KOT: EH164_03305 EH164_03320
YEL: LC20_00745
YFR: AW19_2625(mbtH)
YKR: CH54_3163
YRU: BD65_1349
YRB: UGYR_07470
YMA: DA391_07270
YHI: D5F51_19220
SPE: Spro_3428
SPLY: Q5A_018145
PEC: W5S_3875
DDQ: DDI_2788
DAQ: DAQ1742_01262(ybdZ)
PLU: plu1216
XBO: XBJ1_1440
XBV: XBW1_1501(mbtH)
XNE: XNC1_0647
XNM: XNC2_0636
XAL: XALC_1065
LAQ: GLA29479_3543(mbtH)
LEZ: GLE_3677
LEM: LEN_2514
VAG: N646_0835
VAN: VAA_02077
PAE: PA2412
PAEV: N297_2484
PAEI: N296_2484
PAEP: PA1S_13565
PAEM: U769_13175
PAEL: T223_14780
PAEG: AI22_20300
PAEC: M802_2481
PMY: Pmen_2864
PMK: MDS_1797
PPU: PP_3808
PPF: Pput_1961
PPT: PPS_3261
PPI: YSA_09290
PPX: T1E_2583
PPUH: B479_16220
PPUT: L483_19850
PPUN: PP4_19980
PPUD: DW66_3688
PMON: X969_15710
PMOT: X970_15355
PSB: Psyr_1947
PSYR: N018_09050
PFL: PFL_4178
PPRO: PPC_4275
PFS: PFLU_4377
PFB: VO64_5157
PMAN: OU5_1480
PEN: PSEEN3329
PPUU: PputUW4_01501(mbtH)
PSES: PSCI_2663
PSEM: TO66_21970
PSOS: POS17_4265
PANR: A7J50_4055
PSIL: PMA3_07305
AMAL: I607_20292
AMAE: I876_01380
AMAO: I634_01480
AMAI: I635_21584
MVS: MVIS_0630
MYA: MORIYA_0140(mbtH)
CJA: CJA_1874
LFA: LFA_3269
LHA: LHA_2608
MAH: MEALZ_1535(mbtH)
MMAI: sS8_1097
HCH: HCH_03820
HAM: HALO3671
ABO: ABO_2094
APAC: S7S_05285
CVI: CV_2232
REH: H16_B1689(mbtH)
CGD: CR3_3308(mbtH)
BPSE: BDL_246 BDL_310 BDL_4559(mbtH)
BPSA: BBU_421 BBU_4787(mbtH) BBU_484
BTE: BTH_I2426
BTJ: BTJ_863
BTZ: BTL_2106
BTD: BTI_2068 BTI_5318(mbtH)
BTV: BTHA_2305
BTHE: BTN_2662
BTHM: BTRA_2385
BTHA: DR62_2809
BTHL: BG87_2327
BVE: AK36_2267
BCN: Bcen_1153
BCJ: BCAL1689(orbH)
BCEN: DM39_1599
BCEW: DM40_2266
BCEO: I35_1600(orbH)
BAM: Bamb_1530
BMU: Bmul_1605
BMJ: BMULJ_01638(mbtH)
BMUL: NP80_1726
BCT: GEM_1783
BCED: DM42_61
BDL: AK34_1467
BCON: NL30_14930
BUB: BW23_95
BLAT: WK25_08035
BTEI: WS51_18695
BSEM: WJ12_08095
BPSL: WS57_26650
BUK: MYA_1459
BXE: Bxe_B0518
BXB: DR64_5851
BPH: Bphy_4046
BFN: OI25_6224
PPUL: RO07_24110
PSPU: NA29_12760
PLG: NCTC10937_03969(mbtH)
AXY: AXYL_02592(mbtH)
DAC: Daci_4760
JAG: GJA_1385 GJA_157 GJA_1730(mbtH) GJA_3058(mbtH)
CFU: CFU_2303
CPRA: CPter91_2947(orbH)
PBH: AAW51_2387(glbE) AAW51_2779(mbtH)
MXA: MXAN_3118
SCL: sce3255
CCRO: CMC5_005690(mbtH)
PACA: ID47_05185
ATU: Atu3678
RET: RHE_PF00458(vbsG)
REC: RHECIAT_PC0000683(vbsG)
RPC: RPC_1861
XAU: Xaut_2787
BVR: BVIR_3120
THD: BHV28_07250(mbtH)
CID: P73_3983
ABS: AZOBR_p350077(mbtH)
TMO: TMO_b0320(mbtH) TMO_c0612(mbtH)
BSR: I33_3286
BSH: BSU6051_31959(ybdZ)
BSUT: BSUB_03413
BSUL: BSUA_03413(ybdZ)
BSUS: Q433_17475
BSS: BSUW23_15535(ybdZ)
BST: GYO_3486
BSX: C663_3054(mbtH)
BLI: BL04025
BLD: BLi03897
BAQ: BACAU_2928(ybdZ)
BYA: BANAU_3089(ybdZ)
BAMP: B938_14840
BAML: BAM5036_2816(ybdZ)
BAMA: RBAU_3031(ybdZ)
BAMN: BASU_2822(ybdZ)
BAMB: BAPNAU_3079(ybdZ)
BAMT: AJ82_16415
BAMY: V529_31600
BAO: BAMF_2991(RBAM029000)
BQL: LL3_03264
BQY: MUS_3487
BAMI: KSO_004645
BAMC: U471_30060
BAMF: U722_15630
BAN: BA_2373
BAR: GBAA_2373
BAT: BAS2209
BAI: BAA_2431
BANT: A16_24060
BANR: A16R_24330
BANS: BAPAT_2267
BANV: DJ46_1162(mbtH)
BCE: BC2309
BCA: BCE_2403
BCZ: BCE33L2132(mbtH)
BCQ: BCQ_2299(mbtH)
BCX: BCA_2440
BAL: BACI_c23180(mbtH)
BNC: BCN_2294
BCF: bcf_11805
BCER: BCK_23050
BTK: BT9727_2148(mbtH)
BTL: BALH_2112
BTT: HD73_2594
BTHI: BTK_12880
BTM: MC28_1579
BTI: BTG_08295
BTW: BF38_3558(mbtH)
BWW: bwei_2662(pmxB)
BMYO: BG05_3687
BMYC: DJ92_4948(mbtH)
BPUS: UP12_19000
BJS: MY9_3207
BACW: QR42_18510
BACP: SB24_14225
BACB: OY17_17825
BACY: QF06_14300
BALM: BsLM_3190
BEO: BEH_16970
BGY: BGLY_4304
OIH: OB0959
SIV: SSIL_0952
PFT: JBW_01675
MTU: Rv2377c
MTC: MT2445.1(mbtH)
MRA: MRA_2400(mbtH)
MTUR: CFBS_2516(mbtH)
MTO: MTCTRI2_2420(mbtH)
MTD: UDA_2377c(mbtH)
MTN: ERDMAN_2612(mbtH)
MTUC: J113_16480
MTUE: J114_12730
MTUH: I917_16705
MTUL: TBHG_02315
MTUT: HKBT1_2507(mbtH)
MTUU: HKBT2_2510(mbtH)
MTQ: HKBS1_2514(mbtH)
MBO: BQ2027_MB2398C(mbtH)
MBB: BCG_2391c(mbtH)
MBT: JTY_2385(mbtH)
MBM: BCGMEX_2380c(mbtH)
MBX: BCGT_2201
MAF: MAF_23910(mbtH)
MMIC: RN08_2635
MCE: MCAN_24091(mbtH)
MCQ: BN44_50344(mbtH)
MCV: BN43_40021(mbtH)
MCX: BN42_40310(mbtH)
MCZ: BN45_50747(mbtH)
MPA: MAP_1872c(mbtH)
MUL: MUL_1704(mbtH_2) MUL_2381(mbtH) MUL_3639(mbtH_1)
MMC: Mmcs_3463
MKM: Mkms_3526
MJL: Mjls_3474
MMI: MMAR_2519(mbtH_2) MMAR_3173(mbtH) MMAR_3265 MMAR_3696(mbtH_1)
MMAE: MMARE11_30740(mbtH) MMARE11_36030(mbtH_1)
MLI: MULP_03399(mbtH) MULP_03945(mbtH_1)
MHAD: B586_12220
MSHG: MSG_02412(mbtH) MSG_03372
MSG: MSMEI_0018(mbtH) MSMEI_4396(mbtH)
MVA: Mvan_3842
MGI: Mflv_2699
MVQ: MYVA_3662
MTHN: 4412656_02804(mbtH_1)
MHAS: MHAS_01360(ybdZ_1)
MAB: MAB_4692c
MSTE: MSTE_02189
MTER: 4434518_01445(mbtH)
ASD: AS9A_0661
CJK: jk1783
CUR: cu0325
CVA: CVAR_2847
CSP: WM42_1385(mbtH)
NFR: ERS450000_03681(mbtH_1) ERS450000_04830(mbtH_2)
RER: RER_09800
REY: O5Y_04395
ROP: ROP_48150
RRT: 4535765_00701(mbtH)
GOM: D7316_04968(ybdZ_1) D7316_04975(ybdZ_2) D7316_04990(ybdZ_3)
TPR: Tpau_3985
SRT: Srot_0737
SCO: SCO0489(SCF34.08c) SCO3218(SCE8.11c)
SCT: SCAT_2690(ybdZ) SCAT_p0178 SCAT_p0625(mbtH)
SLD: T261_7683
SAMB: SAM23877_5639(mbtH) SAM23877_7042(cchH)
SRW: TUE45_00364 TUE45_06410 TUE45_pSRc_0206(TUE45_pSRTUE45c_0206) TUE45_pSRc_0455(TUE45_pSRTUE45c_0455)
SLE: sle_06560(sle_06560) sle_62440(sle_62440)
SALJ: SMD11_0621(mbtH) SMD11_0928 SMD11_1380(mbtH) SMD11_6084(mbtH) SMD11_6688(mbtH)
ART: Arth_3099
ACH: Achl_1745
DCO: SAMEA4475696_0062(mbtH)
KFL: Kfla_4109
TFU: Tfu_1863
NDA: Ndas_4310
AMD: AMED_3103(mbtH) AMED_4036(mbtH) AMED_4768(mbtH) AMED_4793(mbtH) AMED_5031(mbtH) AMED_6236(mbtH)
AMM: AMES_3069(mbtH) AMES_3988(mbtH) AMES_4709(mbtH) AMES_4734(mbtH) AMES_4971(mbtH) AMES_6146(mbtH)
AMZ: B737_3070(mbtH) B737_3988(mbtH) B737_4709(mbtH) B737_4734(mbtH) B737_4971(mbtH) B737_6146(mbtH)
AOI: AORI_1481(mbtH) AORI_3676(mbtH) AORI_4539(mbtH) AORI_4675(mbtH)
PDX: Psed_6162
PSEA: WY02_00145
MIL: ML5_5608
SNA: Snas_4056
CYT: cce_3047
CTHE: Chro_3733
OTE: Oter_1960
SACI: Sinac_7053
CABY: Cabys_1384(mbtH)
NDE: NIDE2156
NJA: NSJP_3904
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Davidsen JM, Bartley DM, Townsend CA
  Title
Non-ribosomal propeptide precursor in nocardicin A biosynthesis predicted from adenylation domain specificity dependent on the MbtH family protein NocI.
  Journal
J Am Chem Soc 135:1749-59 (2013)
DOI:10.1021/ja307710d
Reference
  Authors
Gunsior M, Breazeale SD, Lind AJ, Ravel J, Janc JW, Townsend CA
  Title
The biosynthetic gene cluster for a monocyclic beta-lactam antibiotic, nocardicin A.
  Journal
Chem Biol 11:927-38 (2004)
DOI:10.1016/j.chembiol.2004.04.012

KEGG   REACTION: R10880Help
Entry
R10880                      Reaction                               

Definition
5 ATP + 3 L-4-Hydroxyphenylglycine + L-Arginine + L-Serine + H2O <=> 5 AMP + 5 Diphosphate + Nocardicin G + L-4-Hydroxyphenylglycyl-L-arginine
Equation
Comment
nocardicin nonribosomal peptide synthetase
(1) 3 L-pHPG + L-Arg + L-Ser + 5 ATP <=> Pro-nocardicin G + 5 AMP + 5 Diphosphate
(2) Pro-nocardicin G + H2O <=> Nocardicin G + L-pHPG-L-Arg
Reaction class
RC00064  C00062_C20910
RC00141  C12323_C20910
RC03296  C12323_C17355
RC03297  C12323_C17355
RC03298  C00065_C17355
Pathway
rn00261  Monobactam biosynthesis
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00736  Nocardicin A biosynthesis, L-pHPG + arginine + serine => nocardicin A
Orthology
K05375  MbtH protein
K19102  nocardicin nonribosomal peptide synthetase NocA
K19103  nocardicin nonribosomal peptide synthetase NocB
Reference
1  [PMID:25624104]
  Authors
Gaudelli NM, Long DH, Townsend CA.
  Title
beta-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis.
  Journal
Nature (2015)
DOI:10.1038/nature14100
Reference
2  [PMID:24531841]
  Authors
Gaudelli NM, Townsend CA.
  Title
Epimerization and substrate gating by a TE domain in beta-lactam antibiotic biosynthesis.
  Journal
Nat Chem Biol 10:251-8 (2014)
DOI:10.1038/nchembio.1456

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