KEGG   ORTHOLOGY: K19183Help
Entry
K19183                      KO                                     

Name
FGAFS
Definition
festuclavine dehydrogenase [EC:1.5.1.44]
Pathway
ko00901  Indole alkaloid biosynthesis
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K19183  FGAFS; festuclavine dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.44  festuclavine dehydrogenase
     K19183  FGAFS; festuclavine dehydrogenase
BRITE hierarchy
Other DBs
RN: R10163
Genes
MAJ: MAA_06737
GLZ: GLAREA_05927
AFM: AFUA_2G17970
PBL: PAAG_05656
PBN: PADG_07739
TaxonomyKoalaUniProt
Reference
  Authors
Wallwey C, Matuschek M, Xie XL, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3.
  Journal
Org Biomol Chem 8:3500-8 (2010)
DOI:10.1039/c003823g
  Sequence

KEGG   ENZYME: 1.5.1.44Help
Entry
EC 1.5.1.44                 Enzyme                                 

Name
festuclavine dehydrogenase;
FgaFS;
festuclavine synthase
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
festuclavine:NAD+ oxidoreductase
Reaction(IUBMB)
festuclavine + NAD+ = 6,8-dimethyl-6,7-didehydroergoline + NADH + H+ [RN:R10163]
Reaction(KEGG)
Substrate
festuclavine [CPD:C20408];
NAD+ [CPD:C00003]
Product
6,8-dimethyl-6,7-didehydroergoline [CPD:C20409];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family. The reaction proceeds in vivo in the opposite direction to the one shown here.
History
EC 1.5.1.44 created 2012
Pathway
ec00901  Indole alkaloid biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K19183  festuclavine dehydrogenase
Genes
MAJ: MAA_06737
GLZ: GLAREA_05927
AFM: AFUA_2G17970
PBL: PAAG_05656
PBN: PADG_07739
Taxonomy
Reference
1  [PMID:20526482]
  Authors
Wallwey C, Matuschek M, Xie XL, Li SM
  Title
Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3.
  Journal
Org Biomol Chem 8:3500-8 (2010)
DOI:10.1039/c003823g
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.44
IUBMB Enzyme Nomenclature: 1.5.1.44
ExPASy - ENZYME nomenclature database: 1.5.1.44
BRENDA, the Enzyme Database: 1.5.1.44

KEGG   REACTION: R10163Help
Entry
R10163                      Reaction                               

Name
festuclavine:NAD+ oxidoreductase
Definition
Festuclavine + NAD+ <=> 6,8-Dimethyl-6,7-didehydroergoline + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC03068  C20408_C20409
Enzyme
Pathway
rn00901  Indole alkaloid biosynthesis
rn01130  Biosynthesis of antibiotics
Orthology
K19183  festuclavine dehydrogenase [EC:1.5.1.44]
Other DBs
RHEA: 34058

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