KEGG   ORTHOLOGY: K19188
Entry
K19188                      KO                                     

Name
dhponh
Definition
2,6-dihydroxypseudooxynicotine hydrolase [EC:3.7.1.19]
Pathway
ko00760  Nicotinate and nicotinamide metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Module
M00810  Nicotine degradation, pyridine pathway, nicotine => 2,6-dihydroxypyridine/succinate semialdehyde
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K19188  dhponh; 2,6-dihydroxypseudooxynicotine hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.7  Acting on carbon-carbon bonds
   3.7.1  In ketonic substances
    3.7.1.19  2,6-dihydroxypseudooxynicotine hydrolase
     K19188  dhponh; 2,6-dihydroxypseudooxynicotine hydrolase
Other DBs
RN: R07515
GO: 0034948
Genes
ROP: ROP_27470
ROA: Pd630_LPD07472
ARX: ARZXY2_4560
NCA: Noca_0613
AG: CAD47941(pnh)
Reference
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
  Sequence

KEGG   ENZYME: 3.7.1.19
Entry
EC 3.7.1.19                 Enzyme                                 

Name
2,6-dihydroxypseudooxynicotine hydrolase
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
Sysname
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one hydrolase
Reaction(IUBMB)
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O = 2,6-dihydroxypyridine + 4-methylaminobutanoate [RN:R07515]
Reaction(KEGG)
R07515
Substrate
1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one [CPD:C15986];
H2O [CPD:C00001]
Product
2,6-dihydroxypyridine [CPD:C03056];
4-methylaminobutanoate
Comment
The enzyme, characterized from the soil bacterium Arthrobacter nicotinovorans, participates in nicotine degradation.
History
EC 3.7.1.19 created 2012
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K19188  2,6-dihydroxypseudooxynicotine hydrolase
Genes
ROP: ROP_27470
ROA: Pd630_LPD07472
ARX: ARZXY2_4560
NCA: Noca_0613
Reference
1  [PMID:5835946]
  Authors
Gherna RL, Richardson SH, Rittenberg SC.
  Title
The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine.
  Journal
J Biol Chem 240:3669-74 (1965)
Reference
2  [PMID:16321959]
  Authors
Sachelaru P, Schiltz E, Igloi GL, Brandsch R.
  Title
An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans.
  Journal
J Bacteriol 187:8516-9 (2005)
DOI:10.1128/JB.187.24.8516-8519.2005
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.7.1.19
IUBMB Enzyme Nomenclature: 3.7.1.19
ExPASy - ENZYME nomenclature database: 3.7.1.19
BRENDA, the Enzyme Database: 3.7.1.19

KEGG   REACTION: R07515
Entry
R07515                      Reaction                               

Name
2,6-dihydroxypseudooxynicotine hydrolase
Definition
2,6-Dihydroxypseudooxynicotine + H2O <=> 2,6-Dihydroxypyridine + 4-Methylaminobutyrate
Equation
Reaction class
RC00800  C15986_C15987
RC01921  C03056_C15986
Enzyme
Pathway
rn00760  Nicotinate and nicotinamide metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Module
M00810  Nicotine degradation, pyridine pathway, nicotine => 2,6-dihydroxypyridine/succinate semialdehyde
Orthology
K19188  2,6-dihydroxypseudooxynicotine hydrolase [EC:3.7.1.19]
Other DBs
RHEA: 34170

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