KEGG ORTHOLOGY: K19330

ORTHOLOGY: K19330

Entry

K19330                      KO

Symbol

RUBCN

Name

run domain Beclin-1 interacting and cysteine-rich containing protein

Pathway

map04140

Autophagy - animal

Disease

H01891

Autosomal recessive spinocerebellar ataxias

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K19330  RUBCN; run domain Beclin-1 interacting and cysteine-rich containing protein
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K19330  RUBCN; run domain Beclin-1 interacting and cysteine-rich containing protein
Membrane trafficking [BR:ko04131]
Autophagy
  Other autophagy associated proteins
   Others
    K19330  RUBCN; run domain Beclin-1 interacting and cysteine-rich containing protein

Genes

HSA:	9711(RUBCN)

PTR:	129143667(RUBCN)

PPS:	100968040(RUBCN)

GGO:	101140611(RUBCN)

PON:	100446059(RUBCN)

PPYG:

129032768(RUBCN)

NLE:	100598560 115837325(RUBCN)

HMH:	116480009(RUBCN)

SSYN:

134733198(RUBCN)

MCF:	101865638(RUBCN)

MTHB:

126947918

MNI:	105470758(RUBCN)

CSAB:

103242017(RUBCN)

CATY:

105575105(KIAA0226)

PANU:

101025995(RUBCN)

TGE:	112618203(RUBCN)

MLEU:

105538774(KIAA0226)

RRO:	104676392(RUBCN)

RBB:	108524421(RUBCN)

TFN:	117084487(RUBCN)

PTEH:

111544352(RUBCN)

CANG:

105525562(KIAA0226)

CJC:	100410533(RUBCN)

SBQ:	101029795(KIAA0226)

CIMI:

108312849(RUBCN)

ANAN:

105710703(RUBCN)

CSYR:

103266049(RUBCN)

MMUR:

105879751(RUBCN)

LCAT:

123630447(RUBCN)

PCOQ:

105807778(KIAA0226)

OGA:	100940483(RUBCN)

MMU:	100502698(Rubcn)

MCAL:

110311739(Rubcn)

MPAH:

110329570(Rubcn)

RNO:	303885(Rubcn)

MCOC:

116086270(Rubcn)

ANU:	117718103(Rubcn)

ASYL:

127666250(Rubcn)

MUN:	110547650(Rubcn)

CGE:	100754353(Rubcn)

MAUA:

101832630(Rubcn)

PROB:

127227088(Rubcn)

PLEU:

114685398(Rubcn)

MORG:

121461670(Rubcn)

MFOT:

126512166

AAMP:

119824456(Rubcn)

NGI:	103738522(Rubcn)

HGL:	101699241(Rubcn)

CPOC:

100724599(Rubcn)

CCAN:

109699922(Rubcn)

DORD:

105988002(Kiaa0226)

DSP:	122099536(Rubcn)

DMER:

138832269(Rubcn)

PLOP:

125351803(Rubcn)

NCAR:

124992660

MMMA:

107143197(Rubcn)

ITI:	101968792(Rubcn)

OCU:

100351083

OPI:	101523572(RUBCN)

TUP:	102499783(RUBCN)

GVR:	103588875(KIAA0226)

CFA:	100856511(RUBCN)

CLUD:

112676732(RUBCN)

VVP:	112913520(RUBCN)

VLG:	121496642(RUBCN)

NPO:	129503775(RUBCN)

AML:	100479402(RUBCN)

UMR:	103678946(RUBCN)

UAH:	113252781(RUBCN)

UAR:	123802112(RUBCN)

ELK:

111154945

LLV:

125102869

MPUF:

101688244(KIAA0226)

MNP:	132011886(RUBCN)

MLK:	131824653(RUBCN)

NVS:	122908845(RUBCN)

ORO:	101372221(KIAA0226)

EJU:	114207033(RUBCN)

ZCA:	113917794(RUBCN)

MLX:	118006990(RUBCN)

NSU:	110582371(RUBCN)

LWW:	102751044(RUBCN)

FCA:	101098570(RUBCN)

PYU:	121036371(RUBCN)

PCOO:

112849649(RUBCN)

PBG:	122491544(RUBCN)

PVIV:

125175013(RUBCN)

LRUF:

124526280

LGF:	123611005(RUBCN)

AJU:

106983367

PTG:	102960751(RUBCN)

PPAD:

109266529(RUBCN)

PUC:

125921040

PLEZ:

122229446(RUBCN)

HHV:	120244383(RUBCN)

BTA:	508354(RUBCN)

BOM:	102285151(RUBCN)

BIU:	109556059(RUBCN)

BBUB:

102416215(RUBCN)

BBIS:

104984536(KIAA0226)

CHX:	102171376(RUBCN)

OAS:	101122159(RUBCN)

BTAX:

128047736(RUBCN)

CSUM:

138078310(RUBCN)

ODA:	120870000(RUBCN)

CCAD:

122444665(RUBCN)

MREE:

136173269(RUBCN)

OVR:	110137312(RUBCN)

MBEZ:

129539378(RUBCN)

SSC:

100153714

CFR:	102507339(RUBCN)

CBAI:

105072401(KIAA0226)

CDK:	105101299(RUBCN)

VPC:	102532662(RUBCN)

BACU:

103013869(RUBCN)

BMUS:

118894118(RUBCN)

LVE:	103068394(KIAA0226)

OOR:	101276866(RUBCN)

LALB:

132521126(RUBCN)

GMF:	115854710(RUBCN)

DLE:	111171963(RUBCN)

PCAD:

102985768(RUBCN)

PSIU:

116753088(RUBCN)

PPHC:

136122316(RUBCN)

NASI:

112406080(RUBCN)

ECB:	100070138(RUBCN)

EPZ:	103540409(RUBCN)

EAI:	106824421(RUBCN)

MYB:	102242975(RUBCN)

MYD:	102755423(RUBCN)

MMYO:

118676261(RUBCN)

MLF:	102435535(RUBCN)

MDT:	132230303(RUBCN)

MYUM:

139003935(RUBCN)

PKL:	118724120(RUBCN)

EFUS:

103304751(RUBCN)

MNA:	107527260(RUBCN)

DRO:	112320519(RUBCN)

SHON:

118978286(RUBCN)

AJM:	119039177(RUBCN)

PDIC:

114490437(RUBCN)

PHAS:

123827065(RUBCN)

MMF:	118617339(RUBCN)

PPAM:

129071807(RUBCN)

HAI:	109387131(RUBCN)

RFQ:	117033622(RUBCN)

PALE:

102882946(RUBCN)

PGIG:

120593012(RUBCN)

PVP:	105309176(RUBCN)

RAY:	107505256(RUBCN)

MJV:	108394585(RUBCN)

TOD:	119257434(RUBCN)

SARA:

101538033(KIAA0226)

SFUM:

130035427(RUBCN)

SETR:

126026176(RUBCN)

LAV:	100673487(RUBCN)

TMU:

101343242

ETF:	101649640(RUBCN)

DNM:	101423204(RUBCN)

MDO:	100021393(RUBCN)

GAS:	123242341(RUBCN)

AFZ:

127554179

PCW:	110208157(RUBCN)

TVP:	118837661(RUBCN)

PBRV:

138143739(RUBCN)

MLAO:

141507253(RUBCN)

OAA:	100092703(RUBCN)

TACU:

119923390(RUBCN)

GGA:	424920(RUBCN)

PCOC:

116235358(RUBCN)

MGP:	100538382(RUBCN)

CJO:	107318179(RUBCN)

TPAI:

128082598(RUBCN)

LMUT:

125697407(RUBCN)

NMEL:

110397971(RUBCN)

APLA:

101799342(RUBCN)

ACYG:

106044815(RUBCN)

CATA:

118247096(RUBCN)

AFUL:

116492781(RUBCN)

TGU:	100224007(RUBCN)

LSR:	110478120(RUBCN)

SCAN:

103815619(RUBCN)

PMOA:

120504392(RUBCN)

OTC:	121336482(RUBCN)

PRUF:

121353616(RUBCN)

ATRC:

139595004(RUBCN)

GFR:	102036519(RUBCN)

FAB:	101810879(RUBCN)

OMA:	130256735(RUBCN)

PHI:	102101224(KIAA0226)

PMAJ:

107208760(RUBCN)

CCAE:

111945703(RUBCN)

CCW:	104687942(RUBCN)

CBRC:

103625204(RUBCN)

ACOE:

138114836(RUBCN)

ETL:	114057571(RUBCN)

ZAB:	102071292(RUBCN)

ZLE:	135451703(RUBCN)

ACHL:

103812213(KIAA0226)

SVG:	106850381(RUBCN)

MMEA:

130574157(RUBCN)

HRT:	120756930(RUBCN)

SATI:

136365461(RUBCN)

CCIC:

134047572(RUBCN)

FPG:	101915450(RUBCN)

FCH:	102058055(RUBCN)

CCRI:

104158537(KIAA0226)

NNT:	104406422(KIAA0226)

SHAB:

115611190(RUBCN)

ACUN:

113483284(RUBCN)

TALA:

104365439(RUBCN)

ACHC:

115347217(RUBCN)

HALD:

104319021(KIAA0226)

HLE:	104835175(KIAA0226)

AGEN:

126039438

HHAR:

128148993(RUBCN)

GCL:

127019981

CSTI:

104562409(KIAA0226)

LDI:	104343948(KIAA0226)

MNB:	103776816(KIAA0226)

DPUB:

104302946(KIAA0226)

PPUS:

135187099(RUBCN)

AVIT:

104273594(KIAA0226)

BRHI:

104499016(KIAA0226)

EGZ:	104123368(RUBCN)

NNI:	104015658(KIAA0226)

PCRI:

104034074(KIAA0226)

PCAO:

104053552(KIAA0226)

PADL:

103916573(KIAA0226)

AFOR:

103901472(RUBCN)

FGA:	104079584(KIAA0226)

GSTE:

104254891(KIAA0226) 104259173

CBOY:

140654202(RUBCN)

CLV:	102085242(RUBCN)

CNIC:

135991756(RUBCN)

MUI:	104536197(KIAA0226)

PGUU:

104460844(KIAA0226)

PLET:

104625950(KIAA0226)

EHS:	104515105(KIAA0226)

CMAC:

104481317

CUCA:

104063178(RUBCN)

TEO:	104383725(KIAA0226)

BREG:

104640105(KIAA0226)

OHA:	104326434(KIAA0226)

ACAR:

104525416(RUBCN)

CPEA:

104390601(KIAA0226)

CVF:	104284962(KIAA0226)

RTD:	128911087(RUBCN)

CRID:

134517944(RUBCN)

AAM:	106498290(RUBCN)

AROW:

112968498(RUBCN)

NPD:	112952536(RUBCN)

TGT:	104565368(KIAA0226)

DNE:	112979365(RUBCN)

SCAM:

104148813(KIAA0226)

ASN:	102381133(RUBCN)

AMJ:	102562317(RUBCN)

CPOO:

109308532(RUBCN)

GGN:	109288083(RUBCN)

PSS:	102446406(RUBCN)

CMY:	102937560(RUBCN)

CCAY:

125642818(RUBCN)

DCC:	119861486(RUBCN)

CPIC:

101934689(RUBCN)

TST:	117882713(RUBCN)

CABI:

116823037(RUBCN)

MRV:	120371643(RUBCN)

ACS:	100567356(rubcn)

ASAO:

132770381(RUBCN)

PVT:	110070087(RUBCN)

SUND:

121925336(RUBCN)

PBI:	103067119(RUBCN)

PMUR:

107298468(RUBCN)

CTIG:

120320315(RUBCN)

TSR:	106542378(KIAA0226)

APRI:

131200675(RUBCN)

PTEX:

113450495(RUBCN)

NSS:	113426750(RUBCN)

VKO:	123036769(RUBCN)

PRAF:

128413326(RUBCN)

ZVI:	118093449(RUBCN)

HCG:	128350856(RUBCN)

GJA:	107122830(RUBCN)

STOW:

125438081(RUBCN)

EMC:	129331652(RUBCN)

XLA:	108704678(rubcn.L)

XTR:	100497647(rubcn)

NPR:	108800188(RUBCN)

RTEM:

120936894(RUBCN)

ACAT:

141139899(RUBCN)

BBUF:

120998005(RUBCN)

BGAR:

122934602(RUBCN)

DTC:	141100706(RUBCN)

PWL:	138265289(RUBCN)

MUO:	115478589(RUBCN)

GSH:	117367149(RUBCN)

DRE:	100000896(rubcn)

SRX:	107720396 107732676

SANH:

107679062 107701215

SGH:	107551360 107568258

CCAR:

109073737 109085408

CAUA:

113039757 113065166

CGIB:

127943157 127987020

PTET:

122327768(rubcn)

LROH:

127153647(rubcn)

GRF:

141338438

OMC:	131530667(rubcn)

PPRM:

120491859(rubcn)

RKG:	130093062(rubcn)

MAMB:

125254580(rubcn)

CIDE:

127520924

CERY:

137027595(rubcn)

MASI:

127438443 127438681

TROS:

130549272(rubcn)

TDW:	130429411(rubcn)

MANU:

129453624(rubcn)

PDAB:

135740874(rubcn)

IPU:

108270923

IFU:	128614145(rubcn)

PHYP:

113536599(rubcn)

SMEO:

124391475(rubcn)

TFD:	113652648(rubcn)

TVC:	132855055(rubcn)

CGAR:

128542531(rubcn)

NGRA:

132899348(rubcn)

TRN:	134331650(rubcn)

AMEX:

103027127(rubcn)

CMAO:

118818937(rubcn)

EEE:	113575402(rubcn)

CHAR:

105896451(rubcn)

SPIL:

134102341(rubcn)

TRU:	101070012(rubcn)

TFS:	130528181(rubcn)

TNG:	GSTEN00028954G001

LCO:	104923513(rubcn)

NCC:	104951928(kiaa0226)

TBEN:

117495481(rubcn)

CGOB:

115006762(rubcn)

PGEO:

117445536(rubcn)

GACU:

117559717(rubcn)

EMAC:

134869211(rubcn)

ELY:	117254222(rubcn)

EFO:	125895595(rubcn)

PLEP:

121965725(rubcn)

SLUC:

116055220(rubcn)

ECRA:

117950012(rubcn)

ESP:	116694991(rubcn)

PFLV:

114560927(rubcn)

GAT:	120823856(rubcn)

PPUG:

119216501(rubcn)

AFB:	129094515(rubcn)

CLUM:

117729282(rubcn)

PSWI:

130193727(rubcn)

CANA:

137793450(rubcn)

CVE:	137886767(rubcn)

MSAM:

119900589(rubcn)

SCHU:

122878351(rubcn)

CUD:	121511954(rubcn)

SPUL:

138607086(rubcn)

LMIX:

132965549(rubcn)

ALAT:

119028295(rubcn)

ASTR:

137598608(rubcn)

MZE:	101483120(rubcn)

ONL:	100710968(rubcn)

OAU:	116334681(rubcn)

OLA:	101157851(rubcn)

OML:	112150388(rubcn)

CSAI:

133458506(rubcn)

XMA:	102232608(rubcn)

XCO:	114150954(rubcn)

XHE:	116725457(rubcn)

PRET:

103463467(rubcn)

PFOR:

103130413(rubcn)

PLAI:

106952600(rubcn)

PMEI:

106932500(rubcn)

GAF:	122838526(rubcn)

PPRL:

129373446(rubcn)

CVG:	107097578(rubcn)

CTUL:

119787684(rubcn)

GMU:	124873703(rubcn)

NFU:	107392741(rubcn)

KMR:	108234354(rubcn)

ALIM:

106510904(kiaa0226)

NWH:	119430611(rubcn)

EJA:	138200609(rubcn)

BFRE:

138623020(rubcn)

MCEP:

125008867(rubcn)

CSEM:

103394211(rubcn)

POV:	109625757(rubcn)

SSEN:

122780564(rubcn)

SSOE:

131465473(rubcn)

HHIP:

117760074(rubcn)

HSP:	118120793(rubcn)

PPLT:

128447592(rubcn)

SMAU:

118317942(rubcn)

LCF:

108881236

SDU:	111216331(rubcn)

SLAL:

111650055(rubcn)

XGL:	120790864(rubcn)

HCQ:	109519073(rubcn)

SSCV:

125968647(rubcn)

SBIA:

133503499(rubcn)

PEE:	133406012(rubcn)

PTAO:

133480626(rubcn)

BPEC:

110160183(rubcn)

ENY:	140353373(rubcn)

MALB:

109958197(rubcn)

BSPL:

114852943(rubcn)

SJO:	128361744(rubcn)

SSCO:

133984582(rubcn)

GMH:	115555463(rubcn)

SASA:

106574180(rubcn)

STRU:

115151504 115157953 115182040

OTW:	112236744 112238210

OMY:	110524002 110529671

OGO:	123996802 123997459

ONE:	115108052(rubcn) 115116877

OKI:	109889024 109902250

OKE:	118386777 118400695

OMM:	135512527 135524771

OCLA:

139408962 139417773

SALP:

111975589(rubcn) 112069804

SNH:	120053614 120054604

CCLU:

121533775 121576505

ELS:	105025355(rubcn)

OEP:	134010964(rubcn)

SFM:	108921443(rubcn) 108940479

PKI:	111853574(rubcn) 111860514

AANG:

118224512 118230014

AROT:

135252158 135256820

CCOG:

133126171 133128697(rubcn)

LOC:	102689338(rubcn)

PSPA:

121322900 121326921

ARUT:

117416807 117423513

PSEX:

120536333(rubcn)

LCM:	102349921(RUBCN)

CMK:	103183742(rubcn)

RTP:	109938448(rubcn)

CPLA:

122556027(rubcn)

HOC:	132821842(rubcn)

LERI:

129703222(rubcn)

HAKA:

140725618(rubcn)

PMRN:

116952445(RUBCN) 116956789

LRJ:

BFO:

BBEL:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG12772(Rubicon)

DER:

6549707

DSE:

6619841

DSI:	Dsimw501_GD16910(Dsim_GD16910)

DYA:	Dyak_GE15796

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21481

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135957047(Rubicon)

GFS:

ECOE:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AMRS:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ000668

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108728232(Rubicon)

PBAR:

105434015

VEM:

105567442

COBS:

139111661(Rubicon)

TLN:	139821496(Rubicon)

HST:

DQU:

CFO:

FEX:

PMEC:

138936795(Rubicon)

LHU:	105673763(Rubicon)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

VCAN:

CCIN:

AROA:

TCA:

TMOL:

138130333(Rubicon)

DPA:

109540320

ESIM:

136419529(Rubicon)

EFOR:

136344257(Rubicon)

SOY:

ATD:

CSET:

HAXR:

AGB:

DVV:

NVL:

APLN:

PPYR:

OTU:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106683220(Rubicon)

NLU:

111054780

HVI:

124365013

MQU:

128999739

PHU:	Phum_PHUM136060

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138696745(Rubicon)

SGRE:

BROR:

IEL:

FCD:

DMK:

DPZ:

AFRA:

PVM:	113808258(Rubicon)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123765256(Rubicon)

PTRU:

123516235

MNZ:

135204277

MRJ:	136846789(Rubicon)

PORN:

139755354(Rubicon)

HAZT:

108668236

LSM:	121116830(Rubicon)

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

GOE:

TUT:

CSCU:

CVS:	136968359(Rubicon)

PTEP:

ABRU:

UDV:

SDM:

BMY:	BM_BM6875(Bm6875)

LOA:	LOAG_18612

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LAK:	106157986 106172906

SMM:	Smp_161860

SHX:	MS3_00008599

OVI:	T265_02979

EGL:

LLON:

NVE:

EPA:

ATEN:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

AQU:

SRE:	PTSG_12367

DDI:	DDB_G0295483

DPP:	DICPUDRAFT_153601

DFA:

DFA_03215

» show all

Reference

PMID:22423967

Authors

Yang CS, Rodgers M, Min CK, Lee JS, Kingeter L, Lee JY, Jong A, Kramnik I, Lin X, Jung JU

Title

The autophagy regulator Rubicon is a feedback inhibitor of CARD9-mediated host innate immunity.

Journal

Cell Host Microbe 11:277-89 (2012)
DOI:10.1016/j.chom.2012.01.019

Sequence

[hsa:9711]

All links

Gene (901)   
   MGENES (265)   
   RefGene (625)   
   OC (11)   
All databases (901)   

Download RDF

DBGET integrated database retrieval system