KEGG   ORTHOLOGY: K19548
Entry
K19548                      KO                                     

Name
bacC
Definition
dihydroanticapsin dehydrogenase [EC:1.1.1.385]
Pathway
ko00998  Biosynthesis of various secondary metabolites - part 2
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00787  Bacilysin biosynthesis, prephenate => bacilysin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various secondary metabolites - part 2
    K19548  bacC; dihydroanticapsin dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.385  dihydroanticapsin dehydrogenase
     K19548  bacC; dihydroanticapsin dehydrogenase
Other DBs
RN: R10917
COG: COG1028
Genes
BSU: BSU37720(bacC)
BSR: I33_3920
BSL: A7A1_0191
BSH: BSU6051_37720(bacC)
BSY: I653_18505
BSUT: BSUB_04008(bacC)
BSUL: BSUA_04008(bacC)
BSUS: Q433_20775
BSS: BSUW23_18630(bacC)
BST: GYO_4158
BSO: BSNT_10430(ywfD)
BSQ: B657_37720(bacC)
BSX: C663_3677(bacC)
BAY: RBAM_034910(bacC)
BAQ: BACAU_3520(bacC)
BYA: BANAU_3673(bacC)
BAMP: B938_17915(bacC)
BAML: BAM5036_3421(bacC)
BAMA: RBAU_3629(bacC)
BAMN: BASU_3405(bacC)
BAMB: BAPNAU_3687(bacC)
BAMT: AJ82_19700
BAMY: V529_37630(bacC)
BMP: NG74_03666(gdhIV_2)
BAO: BAMF_3605(bacC)
BAZ: BAMTA208_19090(bacC)
BQL: LL3_03916(bacC)
BXH: BAXH7_03908(bacC)
BQY: MUS_4150(bacC3)
BAMI: KSO_001605
BAMC: U471_36360
BAMF: U722_18650
BHT: DIC78_12115(bacC)
BPU: BPUM_3422
BPUM: BW16_18170
BPUS: UP12_17615
BJS: MY9_3863
BACW: QR42_17170
BACP: SB24_11240
BACB: OY17_01120
BACY: QF06_17300
BACL: BS34A_40900(bacC)
BALM: BsLM_3802
BFD: NCTC4823_00566(bacC) NCTC4823_03981(cpnA_2)
 » show all
Reference
  Authors
Steinborn G, Hajirezaei MR, Hofemeister J
  Title
bac genes for recombinant bacilysin and anticapsin production in Bacillus host strains.
  Journal
Arch Microbiol 183:71-9 (2005)
DOI:10.1007/s00203-004-0743-8
  Sequence
[bsu:BSU37720]
Reference
  Authors
Ozcengiz G, Ogulur I
  Title
Biochemistry, genetics and regulation of bacilysin biosynthesis and its significance more than an antibiotic.
  Journal
N Biotechnol 32:612-9 (2015)
DOI:10.1016/j.nbt.2015.01.006

KEGG   ENZYME: 1.1.1.385
Entry
EC 1.1.1.385                Enzyme                                 

Name
dihydroanticapsin dehydrogenase;
BacC;
ywfD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-dihydroanticapsin:NAD+ oxidoreductase
Reaction(IUBMB)
L-dihydroanticapsin + NAD+ = L-anticapsin + NADH + H+ [RN:R10917]
Reaction(KEGG)
R10917
Substrate
L-dihydroanticapsin [CPD:C20940];
NAD+ [CPD:C00003]
Product
L-anticapsin [CPD:C20941];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Bacillus subtilis, is involved in the biosynthesis of the nonribosomally synthesized dipeptide antibiotic bacilysin, composed of L-alanine and L-anticapsin.
History
EC 1.1.1.385 created 2015
Pathway
ec00998  Biosynthesis of various secondary metabolites - part 2
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K19548  dihydroanticapsin dehydrogenase
Genes
BSU: BSU37720(bacC)
BSR: I33_3920
BSL: A7A1_0191
BSH: BSU6051_37720(bacC)
BSY: I653_18505
BSUT: BSUB_04008(bacC)
BSUL: BSUA_04008(bacC)
BSUS: Q433_20775
BSS: BSUW23_18630(bacC)
BST: GYO_4158
BSO: BSNT_10430(ywfD)
BSQ: B657_37720(bacC)
BSX: C663_3677(bacC)
BAY: RBAM_034910(bacC)
BAQ: BACAU_3520(bacC)
BYA: BANAU_3673(bacC)
BAMP: B938_17915(bacC)
BAML: BAM5036_3421(bacC)
BAMA: RBAU_3629(bacC)
BAMN: BASU_3405(bacC)
BAMB: BAPNAU_3687(bacC)
BAMT: AJ82_19700
BAMY: V529_37630(bacC)
BMP: NG74_03666(gdhIV_2)
BAO: BAMF_3605(bacC)
BAZ: BAMTA208_19090(bacC)
BQL: LL3_03916(bacC)
BXH: BAXH7_03908(bacC)
BQY: MUS_4150(bacC3)
BAMI: KSO_001605
BAMC: U471_36360
BAMF: U722_18650
BHT: DIC78_12115(bacC)
BPU: BPUM_3422
BPUM: BW16_18170
BPUS: UP12_17615
BJS: MY9_3863
BACW: QR42_17170
BACP: SB24_11240
BACB: OY17_01120
BACY: QF06_17300
BACL: BS34A_40900(bacC)
BALM: BsLM_3802
BFD: NCTC4823_00566(bacC) NCTC4823_03981(cpnA_2)
 » show all
Reference
1  [PMID:23317005]
  Authors
Parker JB, Walsh CT
  Title
Action and timing of BacC and BacD in the late stages of biosynthesis of the dipeptide antibiotic bacilysin.
  Journal
Biochemistry 52:889-901 (2013)
DOI:10.1021/bi3016229
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.385
IUBMB Enzyme Nomenclature: 1.1.1.385
ExPASy - ENZYME nomenclature database: 1.1.1.385
BRENDA, the Enzyme Database: 1.1.1.385

KEGG   REACTION: R10917
Entry
R10917                      Reaction                               

Name
L-dihydroanticapsin:NAD+ oxidoreductase
Definition
L-Dihydroanticapsin + NAD+ <=> L-Anticapsin + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00154  C20940_C20941
Enzyme
Pathway
rn00998  Biosynthesis of various secondary metabolites - part 2
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00787  Bacilysin biosynthesis, prephenate => bacilysin
Orthology
K19548  dihydroanticapsin dehydrogenase [EC:1.1.1.385]
Other DBs
RHEA: 44631

DBGET integrated database retrieval system