KEGG   ORTHOLOGY: K19566Help
Entry
K19566                      KO                                     

Name
elmGT
Definition
8-demethyltetracenomycin C L-rhamnosyltransferase [EC:2.4.1.331]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00784  Elloramycin biosynthesis, 8-demethyltetracenomycin C => elloramycin A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K19566  elmGT; 8-demethyltetracenomycin C L-rhamnosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.331  8-demethyltetracenomycin C L-rhamnosyltransferase
     K19566  elmGT; 8-demethyltetracenomycin C L-rhamnosyltransferase
BRITE hierarchy
Other DBs
RN: R10955
CAZy: GT1
Genes
AG: CAP12607(elmGT)
TaxonomyKoalaUniProt
Reference
  Authors
Blanco G, Patallo EP, Brana AF, Trefzer A, Bechthold A, Rohr J, Mendez C, Salas JA
  Title
Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin.
  Journal
Chem Biol 8:253-63 (2001)
DOI:10.1016/S1074-5521(01)00010-2
  Sequence

KEGG   ENZYME: 2.4.1.331Help
Entry
EC 2.4.1.331                Enzyme                                 

Name
8-demethyltetracenomycin C L-rhamnosyltransferase;
elmGT
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
dTDP-beta-L-rhamnose:8-demethyltetracenomycin C 3-alpha-L-rhamnosyltransferase
Reaction(IUBMB)
dTDP-beta-L-rhamnose + 8-demethyltetracenomycin C = dTDP + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C [RN:R10955]
Reaction(KEGG)
Substrate
dTDP-beta-L-rhamnose [CPD:C03319];
8-demethyltetracenomycin C [CPD:C12379]
Product
dTDP [CPD:C00363];
8-demethyl-8-alpha-L-rhamnosyltetracenomycin C [CPD:C20974]
Comment
Isolated from Streptomyces olivaceus Tu2353. Involved in elloramycin biosynthesis. In vitro it can also utilize other 6-deoxy D- or L-hexoses.
History
EC 2.4.1.331 created 2014
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K19566  8-demethyltetracenomycin C L-rhamnosyltransferase
Reference
1  [PMID:11306350]
  Authors
Blanco G, Patallo EP, Brana AF, Trefzer A, Bechthold A, Rohr J, Mendez C, Salas JA
  Title
Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin.
  Journal
Chem Biol 8:253-63 (2001)
DOI:10.1016/S1074-5521(01)00010-2
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.331
IUBMB Enzyme Nomenclature: 2.4.1.331
ExPASy - ENZYME nomenclature database: 2.4.1.331
BRENDA, the Enzyme Database: 2.4.1.331

KEGG   REACTION: R10955Help
Entry
R10955                      Reaction                               

Name
dTDP-beta-L-rhamnose:8-demethyltetracenomycin-C alpha-L-rhamnosyltransferase
Definition
dTDP-L-rhamnose + 8-Demethyltetracenomycin C <=> dTDP + 8-Demethyl-8-alpha-L-rhamnosyltetracenomycin C
Equation
Reaction class
RC00005  C00363_C03319
RC00171  C12379_C20974
Enzyme
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00784  Elloramycin biosynthesis, 8-demethyltetracenomycin C => elloramycin A
Orthology
K19566  8-demethyltetracenomycin C L-rhamnosyltransferase [EC:2.4.1.331]
Other DBs
RHEA: 42851

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