| Entry |
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| Name |
8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase;
ElmMI
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + 8-demethyl-8-alpha-L-rhamnosyltetracenomycin C = S-adenosyl-L-homocysteine + 8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [RN: R10956]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
8-demethyl-8-alpha-L-rhamnosyltetracenomycin C [CPD: C20974]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
8-demethyl-8-(2-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [CPD: C20975]
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| Comment |
The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin.
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| History |
EC 2.1.1.305 created 2014
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| Pathway |
| ec01057 | Biosynthesis of type II polyketide products |
| ec01130 | Biosynthesis of antibiotics |
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| Orthology |
| K19567 | 8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase |
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| Reference |
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| Authors |
Patallo EP, Blanco G, Fischer C, Brana AF, Rohr J, Mendez C, Salas JA. |
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| Title |
Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.1.1.305 |
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