KEGG   ORTHOLOGY: K19569Help
Entry
K19569                      KO                                     

Name
elmMIII
Definition
8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase [EC:2.1.1.307]
Pathway
ko01057  Biosynthesis of type II polyketide products
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00784  Elloramycin biosynthesis, 8-demethyltetracenomycin C => elloramycin A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01057 Biosynthesis of type II polyketide products
    K19569  elmMIII; 8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.307  8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase
     K19569  elmMIII; 8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase
BRITE hierarchy
Other DBs
RN: R10958
Genes
SCW: TU94_23010
SLE: sle_21920(sle_21920)
FRI: FraEuI1c_5710
SEN: SACE_0650(cloP)
AG: CAP12609(elmMIII)
TaxonomyKoalaUniProt
Reference
  Authors
Patallo EP, Blanco G, Fischer C, Brana AF, Rohr J, Mendez C, Salas JA
  Title
Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes.
  Journal
J Biol Chem 276:18765-74 (2001)
DOI:10.1074/jbc.M101225200
  Sequence

KEGG   ENZYME: 2.1.1.307Help
Entry
EC 2.1.1.307                Enzyme                                 

Name
8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase;
ElmMIII
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:8-demethyl-8-(2,3-di-O-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + 8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)tetracenomycin C = S-adenosyl-L-homocysteine + 8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [RN:R10958]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [CPD:C20976]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)tetracenomycin C [CPD:C20977]
Comment
The enzyme from the bacterium Streptomyces olivaceus is involved in the biosynthesis of the polyketide elloramycin.
History
EC 2.1.1.307 created 2014
Pathway
ec01057  Biosynthesis of type II polyketide products
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K19569  8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase
Genes
SCW: TU94_23010
SLE: sle_21920(sle_21920)
FRI: FraEuI1c_5710
SEN: SACE_0650(cloP)
Taxonomy
Reference
1  [PMID:11376004]
  Authors
Patallo EP, Blanco G, Fischer C, Brana AF, Rohr J, Mendez C, Salas JA.
  Title
Deoxysugar methylation during biosynthesis of the antitumor polyketide elloramycin by Streptomyces olivaceus. Characterization of three methyltransferase genes.
  Journal
J Biol Chem 276:18765-74 (2001)
DOI:10.1074/jbc.M101225200
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.307
IUBMB Enzyme Nomenclature: 2.1.1.307
ExPASy - ENZYME nomenclature database: 2.1.1.307
BRENDA, the Enzyme Database: 2.1.1.307

KEGG   REACTION: R10958Help
Entry
R10958                      Reaction                               

Name
S-adenosyl-L-methionine:8-demethyl-8-(2,3-di-O-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase
Definition
S-Adenosyl-L-methionine + 8-Demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)tetracenomycin C <=> S-Adenosyl-L-homocysteine + 8-Demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)tetracenomycin C
Equation
Reaction class
RC00003  C00019_C00021
RC00466  C20976_C20977
Enzyme
Pathway
rn01057  Biosynthesis of type II polyketide products
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00784  Elloramycin biosynthesis, 8-demethyltetracenomycin C => elloramycin A
Orthology
K19569  8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase [EC:2.1.1.307]

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