Entry |
|
Symbol |
dfrB, dfr2
|
Name |
dihydrofolate reductase (trimethoprim resistance protein) [EC: 1.5.1.3]
|
Pathway |
|
Reaction |
R00936 | 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase |
R00939 | 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase |
|
Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
K19645 dfrB, dfr2; dihydrofolate reductase (trimethoprim resistance protein)
00670 One carbon pool by folate
K19645 dfrB, dfr2; dihydrofolate reductase (trimethoprim resistance protein)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
01504 Antimicrobial resistance genes
K19645 dfrB, dfr2; dihydrofolate reductase (trimethoprim resistance protein)
Enzymes [BR:ko01000]
1. Oxidoreductases
1.5 Acting on the CH-NH group of donors
1.5.1 With NAD+ or NADP+ as acceptor
1.5.1.3 dihydrofolate reductase
K19645 dfrB, dfr2; dihydrofolate reductase (trimethoprim resistance protein)
Antimicrobial resistance genes [BR:ko01504]
Gene variants
Trimethoprim resistance genes
Dihydrofolate reductases
K19645 dfrB, dfr2; dihydrofolate reductase (trimethoprim resistance protein)
Antimicrobial resistance: KEGG signatures [br01600.html]
Signature KOs for antimicrobial resistance
K19645
|
Other DBs |
|
Genes |
|
Reference |
|
Authors |
Alonso H, Gready JE |
Title |
Integron-sequestered dihydrofolate reductase: a recently redeployed enzyme. |
Journal |
|
Sequence |
|
Reference |
|
Authors |
Howell EE |
Title |
Searching sequence space: two different approaches to dihydrofolate reductase catalysis. |
Journal |
|