KEGG   ORTHOLOGY: K19653Help
Entry
K19653                      KO                                     

Name
geoA
Definition
geraniol dehydrogenase (NAD+) [EC:1.1.1.347]
Pathway
ko00281  Geraniol degradation
ko01130  Biosynthesis of antibiotics
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00281 Geraniol degradation
    K19653  geoA; geraniol dehydrogenase (NAD+)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.347  geraniol dehydrogenase (NAD+)
     K19653  geoA; geraniol dehydrogenase (NAD+)
BRITE hierarchy
Other DBs
RN: R10308
Genes
CDN: BN940_14111
AG: CCF55024(geoA)
TaxonomyKoalaUniProt
Reference
  Authors
Luddeke F, Wulfing A, Timke M, Germer F, Weber J, Dikfidan A, Rahnfeld T, Linder D, Meyerdierks A, Harder J
  Title
Geraniol and geranial dehydrogenases induced in anaerobic monoterpene degradation by Castellaniella defragrans.
  Journal
Appl Environ Microbiol 78:2128-36 (2012)
DOI:10.1128/AEM.07226-11
  Sequence

KEGG   ENZYME: 1.1.1.183Help
Entry
EC 1.1.1.183                Enzyme                                 

Name
geraniol dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
geraniol:NADP+ oxidoreductase
Reaction(IUBMB)
geraniol + NADP+ = geranial + NADPH + H+ [RN:R03581]
Reaction(KEGG)
Substrate
geraniol [CPD:C01500];
NADP+ [CPD:C00006]
Product
geranial [CPD:C01499];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Also acts, more slowly on farnesol but not on nerol. The enzyme produces a mixture known as citral, which includes geranial and neral. It is still not known whether neral is produced directly by the enzyme, or by isomerization of geranial.
History
EC 1.1.1.183 created 1983
Pathway
ec00281  Geraniol degradation
ec01130  Biosynthesis of antibiotics
Reference
1
  Authors
Potty, V.H. and Bruemmer, J.H.
  Title
Oxidation of geraniol by an enzyme system from orange.
  Journal
Phytochemistry 9:1001-1007 (1970)
Reference
2  [PMID:11743782]
  Authors
Sekiwa-Iijima Y, Aizawa Y, Kubota K
  Title
Geraniol dehydrogenase activity related to aroma formation in ginger (Zingiber officinale Roscoe).
  Journal
J Agric Food Chem 49:5902-6 (2001)
DOI:10.1021/jf0102970
Reference
3  [PMID:21636906]
  Authors
Saito Y, Ito S, Koltunow AM, Sakai H
  Title
Crystallization and preliminary X-ray analysis of geraniol dehydrogenase from Backhousia citriodora (lemon myrtle).
  Journal
Acta Crystallogr Sect F Struct Biol Cryst Commun 67:665-7 (2011)
DOI:10.1107/S1744309111006920
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.183
IUBMB Enzyme Nomenclature: 1.1.1.183
ExPASy - ENZYME nomenclature database: 1.1.1.183
UM-BBD (Biocatalysis/Biodegradation Database): 1.1.1.183
BRENDA, the Enzyme Database: 1.1.1.183
CAS: 56802-96-1

KEGG   ENZYME: 1.1.1.347Help
Entry
EC 1.1.1.347                Enzyme                                 

Name
geraniol dehydrogenase (NAD+);
GeDH;
geoA (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
geraniol:NAD+ oxidoreductase
Reaction(IUBMB)
geraniol + NAD+ = geranial + NADH + H+ [RN:R10308]
Reaction(KEGG)
Substrate
geraniol [CPD:C01500];
NAD+ [CPD:C00003]
Product
geranial [CPD:C01499];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme from the bacterium Castellaniella defragrans is most active in vitro with perillyl alcohol [2]. The enzyme from the prune mite Carpoglyphus lactis also acts (more slowly) on farnesol but not on nerol [1].
History
EC 1.1.1.347 created 2013
Pathway
ec00281  Geraniol degradation
ec01130  Biosynthesis of antibiotics
Orthology
K19653  geraniol dehydrogenase (NAD+)
Genes
CDN: BN940_14111
Taxonomy
Reference
1  [PMID:18422649]
  Authors
Noge K, Kato M, Mori N, Kataoka M, Tanaka C, Yamasue Y, Nishida R, Kuwahara Y
  Title
Geraniol dehydrogenase, the key enzyme in biosynthesis of the alarm pheromone, from the astigmatid mite Carpoglyphus lactis (Acari: Carpoglyphidae).
  Journal
FEBS J 275:2807-17 (2008)
DOI:10.1111/j.1742-4658.2008.06421.x
Reference
2  [PMID:22286981]
  Authors
Luddeke F, Wulfing A, Timke M, Germer F, Weber J, Dikfidan A, Rahnfeld T, Linder D, Meyerdierks A, Harder J
  Title
Geraniol and geranial dehydrogenases induced in anaerobic monoterpene degradation by Castellaniella defragrans.
  Journal
Appl Environ Microbiol 78:2128-36 (2012)
DOI:10.1128/AEM.07226-11
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.347
IUBMB Enzyme Nomenclature: 1.1.1.347
ExPASy - ENZYME nomenclature database: 1.1.1.347
BRENDA, the Enzyme Database: 1.1.1.347

KEGG   REACTION: R03581Help
Entry
R03581                      Reaction                               

Name
geraniol:NADP+ oxidoreductase
Definition
Geraniol + NADP+ <=> Geranial + NADPH + H+
Equation
Comment
NADP+ (ec 1.1.1.347, see R10308)
Reaction class
RC00001  C00005_C00006
RC00649  C01499_C01500
Enzyme
Pathway
rn00281  Geraniol degradation
rn01130  Biosynthesis of antibiotics
Other DBs
RHEA: 14524

KEGG   REACTION: R10308Help
Entry
R10308                      Reaction                               

Name
geraniol:NAD+ oxidoreductase
Definition
Geraniol + NAD+ <=> Geranial + NADH + H+
Equation
Comment
NADP+ (ec 1.1.1.183, see R03581)
Reaction class
RC00001  C00003_C00004
RC00649  C01499_C01500
Enzyme
Pathway
rn00281  Geraniol degradation
rn01130  Biosynthesis of antibiotics
Orthology
K19653  geraniol dehydrogenase (NAD+) [EC:1.1.1.347]
Other DBs
RHEA: 34350

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