KEGG   ORTHOLOGY: K19725Help
Entry
K19725            Tight     KO                                     

Name
dcsD
Definition
O-ureido-L-serine/cysteine synthase [EC:2.6.99.3 2.5.1.47]
Pathway
ko00997  Biosynthesis of various secondary metabolites - part 3
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00785  Cycloserine biosynthesis, arginine/serine => cycloserine
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00997 Biosynthesis of various secondary metabolites - part 3
    K19725  dcsD; O-ureido-L-serine/cysteine synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.47  cysteine synthase
     K19725  dcsD; O-ureido-L-serine/cysteine synthase
  2.6  Transferring nitrogenous groups
   2.6.99  Transferring other nitrogenous groups
    2.6.99.3  O-ureido-L-serine synthase
     K19725  dcsD; O-ureido-L-serine/cysteine synthase
BRITE hierarchy
Other DBs
RN: R10461
COG: COG0031
GO: 0004124
Genes
AG: BAI70378(dcsD)
TaxonomyKoalaUniProt
Reference
  Authors
Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
  Title
Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
  Journal
Antimicrob Agents Chemother 54:1132-9 (2010)
DOI:10.1128/AAC.01226-09
  Sequence

KEGG   ENZYME: 2.6.99.3Help
Entry
EC 2.6.99.3                 Enzyme                                 

Name
O-ureido-L-serine synthase;
dcsD (gene name)
Class
Transferases;
Transferring nitrogenous groups;
Transferring other nitrogenous groups
BRITE hierarchy
Sysname
O-acetyl-L-serine:hydroxyurea 2-amino-2-carboxyethyltransferase
Reaction(IUBMB)
O-acetyl-L-serine + hydroxyurea = O-ureido-L-serine + acetate [RN:R10461]
Reaction(KEGG)
Substrate
O-acetyl-L-serine [CPD:C00979];
hydroxyurea [CPD:C07044]
Product
O-ureido-L-serine [CPD:C20639];
acetate [CPD:C00033]
Comment
The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species. Also catalyses EC 2.5.1.47, cysteine synthase.
History
EC 2.6.99.3 created 2013
Pathway
ec00997  Biosynthesis of various secondary metabolites - part 3
ec01100  Metabolic pathways
ec01130  Biosynthesis of antibiotics
Orthology
K19725  O-ureido-L-serine/cysteine synthase
Reference
1  [PMID:20086163]
  Authors
Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M
  Title
Molecular cloning and heterologous expression of a biosynthetic gene cluster for  the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.
  Journal
Antimicrob Agents Chemother 54:1132-9 (2010)
DOI:10.1128/AAC.01226-09
  Sequence
Reference
2  [PMID:23529730]
  Authors
Uda N, Matoba Y, Kumagai T, Oda K, Noda M, Sugiyama M
  Title
Establishment of an in vitro D-cycloserine-synthesizing system by using O-ureido-L-serine synthase and D-cycloserine synthetase found in the biosynthetic pathway.
  Journal
Antimicrob Agents Chemother 57:2603-12 (2013)
DOI:10.1128/AAC.02291-12
Other DBs
ExplorEnz - The Enzyme Database: 2.6.99.3
IUBMB Enzyme Nomenclature: 2.6.99.3
ExPASy - ENZYME nomenclature database: 2.6.99.3
BRENDA, the Enzyme Database: 2.6.99.3

KEGG   REACTION: R10461Help
Entry
R10461                      Reaction                               

Name
O-acetyl-L-serine:hydroxyurea 2-amino-2-carboxyethyltransferase
Definition
O-Acetyl-L-serine + Hydroxyurea <=> O-Ureido-L-serine + Acetate
Equation
Reaction class
RC00020  C00033_C00979
RC03179  C07044_C20639
Enzyme
Pathway
rn00997  Biosynthesis of various secondary metabolites - part 3
rn01100  Metabolic pathways
rn01130  Biosynthesis of antibiotics
Module
M00785  Cycloserine biosynthesis, arginine/serine => cycloserine
Orthology
K19725  O-ureido-L-serine/cysteine synthase [EC:2.6.99.3 2.5.1.47]
Other DBs
RHEA: 36266

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